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En bloc pancreaticoduodenectomy and right hemicolectomy for locally advanced right-sided colon cancer

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World Journal of Gastrointestinal Oncology 2017年第9期9卷 372-378页

作者： Yuji Kaneda Hiroshi Noda Yuhei Endo Nao Kakizawa Kosuke Ichida Fumiaki Watanabe Takaharu Kato Yasuyuki Miyakura koichi suzuki Toshiki Rikiyama Department of Surgery Saitama Medical CenterJichi Medical UniversitySaitama 330-8503Japan

AIM To assess the usefulness of en bloc right hemicolectomy with pancreaticoduodenectomy(RHCPD) for locally advanced right-sided colon cancer(LARCC).METHODS We retrospectively reviewed the database of Saitama Medical Center, Jichi Medical University, between January 2009 and December 2016. During this time, 299 patients underwent radical right hemicolectomy for right-sided colon cancer. Among them, 5 underwent RHCPD for LARCC with tumor infiltration to adjacent organs. Preoperative computed tomography(CT) was routinely performed to evaluate local tumor infiltration into adjacent organs. During the operation, we evaluated the resectability and the amount of infiltration into the adjacent organs without dissecting the adherent organs from the cancer. When we confirmed that radical resection was feasible and could lead to R0 resection, we performed RHCPD. The clinical data were carefully reviewed, and the demographic variables, intraoperative data, and postoperative parameters were *** The median age of the 5 patients who underwent RHCPD for LARCC was 70 years. The tumors were located in the ascending colon(three patients) and transverse colon(two patients). Preoperative CT revealed infiltration of the tumor into the duodenum in all patients, the pancreas in four patients, the superior mesenteric vein(SMV) in two patients, and tumor thrombosis in the SMV in one patient. We performed RHCPD plus SMV resection in three patients. Major postoperative complications occurred in 3 patients(60%) as pancreatic fistula(grade B and grade C, according to International Study Group on Pancreatic Fistula Definition) and delayed gastric empty. None of the patients died during their hospital stay. A histological examination confirmed malignant infiltration into the duodenum and/or pancreas in 4 patients(80%), and no patients showed any malignant infiltration into the SMV. Two patients were histologically confirmed to have tumor thrombosis in the SMV. All of the tumors had c

关键词： Locally advanced right-sided colon cancer Right hemicolectomy Malignant infiltration Inflammatory adhesion Pancreaticoduodenectomy

Naked DNA in cells:An inducer of major histocompatibility complex molecules to evoke autoimmune responses?

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World Journal of Translational Medicine 2016年第1期5卷 46-52页

作者： Yuqian Luo Aya Yoshihara Kenzaburo Oda Yuko Ishido Naoki Hiroi koichi suzuki Department of Clinical Laboratory Science Faculty of Medical TechnologyTeikyo University Department of Education Planning and Development Faculty of MedicineToho University Division of Diabetes Metabolism and EndocrinologyDepartment of Internal MedicineToho University

The major histocompatibility complex(MHC) is the exclusive chaperone that presents intracellular antigens,either self or foreign to T ***,aberrant expression of MHC molecules has been reported in various autoimmune target tissues such as thyroid follicular cells in Grave's ***,we review the discovery of an unexpected effect of cytosolic doublestranded DNA(ds DNA),despite its origins,to induce antigen processing and presenting genes,including MHC molecules,in non-immune ***,we highlight several recent studies that suggest cell injury endows thyroid epithelial cells with a phenotype of mature antigen presenting cells by inducing multiple antigen processing and presenting genes via releasing genomic DNA fragments into the *** discuss the possibility that such cytosolic ds DNA,in naked form without binding to histone proteins,might be involved in the development of cell damage-triggered autoimmune *** also discuss the possible molecular mechanism by which cytosolic ds DNA can induce MHC *** is reasonable to speculate that cytosolic ds DNA-induced MHC class Ⅰ is partially due to an autocrine/paracrine effect of type Ⅰ interferon(IFN).While the mechanism of cytosolic ds DNA-induced MHC class Ⅱ expression appears,at least partially,distinct from that mediated by IFN-γ.Further in-depth are required to clarify this picture.

关键词： Cytosolic double-stranded DNA Major histocompatibility complex molecules Autoimmune response Antigen presentation Tissue injury

Cell Proliferation Inhibition by Sericin from the Wild Silkworm, Cricula trifenestrata

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Advances in Biological Chemistry 2016年第1期6卷 28-33页

作者： Wenqi Liu Mayumi Karimazawa Taku Ozaki Ying An Masao Miyazaki koichi suzuki Ken-ichi Tsutsumi Tetsuro Yamashita United Graduate School of Agricultural Sciences Iwate University Morioka Japan Office of Research Exchange Iwate University Morioka Japan Research Center for Child Mental Development Hirosaki University Graduate School of Medicine Hirosaki Japan

Sericin is a major silk protein, and recent studies have shown that sericin has numerous physiological activities against cultured cells. For example, it accelerates mammalian cell proliferation and protects insect cells against cell death. In this study, we examined the activities of sericin prepared from the wild silkworm, Cricula trifenestrata. The results presented here indicated that C. trifenestrata sericin has anti-proliferative activity against feline kidney cells, while sericin from Bombyx mori promoted cell proliferation. The components of the sericin preparation that played a role in inhibition of proliferation were analyzed by fractionation through partition chromatography (Folch method) and reversed-phase chromatography. Our analysis showed that at least two components in the C. trifenestrata sericin preparation promoted the anti-proliferative activity in an additive or even synergistic manner. Therefore, differences in components between insect species may contribute to different activities against cultured cells.

关键词： Sericin Wild Silkworm Cell Death Anti-Proliferative Activity

Vasoactive Intestinal Peptide (VIP) and VIP Receptors-Elucidation of Structure and Function for Therapeutic Applications

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International Journal of Clinical Medicine 2011年第4期2卷 500-508页

作者： Hisato Igarashi Nao Fujimori Tetsuhide Ito Taichi Nakamura Takamasa Oono Kazuhiko Nakamura koichi suzuki Robert T Jensen Ryoichi Takayanagi 不详

Vasoactive intestinal peptide (VIP) is a 28-amino acid polypeptide first isolated from swine duodenum. VIP is a neurotransmitter that is extensively distributed in tissues. According to published reports, VPAC1 and VPAC2 act as VIP receptors and are widely present in the central nervous system and peripheral tissues. VIP exerts diverse actions on the cardiovascular system, pancreas, digestive tract, respiratory system, and urological system. Recent reports indicated that VIP has immunological and neuroprotective effects and also affects cell growth. While primary investigations for developing therapeutic applications for various pathological conditions and diseases are underway, the structure and function of VIP should be analyzed in more detail.

关键词： Vasoactive Intestinal Peptide VIP VPAC

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泥砂运动随机模型应用于桥墩周围的局部冲刷

铁道建筑 1982年第5期 35-37页

作者： Hiroji Nakagawa ,koichi suzuki ,黄崇佑

一、冲刷过程的分析方法不同类型的水力结构物周围的局部冲刷问题是许多工程问题中最困难的一个,由于在不同时间与空间的水流、泥砂及河床形态之间的相互作用非常复杂,通常有两种分析方法:一种是一维的分析,它借助于冲刷坑形状相似性... 详细信息

一、冲刷过程的分析方法不同类型的水力结构物周围的局部冲刷问题是许多工程问题中最困难的一个,由于在不同时间与空间的水流、泥砂及河床形态之间的相互作用非常复杂,通常有两种分析方法:一种是一维的分析,它借助于冲刷坑形状相似性建立冲刷坑连续性方程式和现有的输砂率公式

关键词：局部冲刷概率最大冲刷深度桥墩泥砂周围

环境条件诱导的家蚕滞育系与非滞育系中游离核苷酸的动态变化(英文)

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分子细胞生物学报 2007年第2期40卷 91-97页

作者：宋红生安婴铃木幸一上海大学生命科学学院上海200444 岩手大学农学部生物科学和技术研究室

家蚕二化性品种卵的滞育性是由亲代卵胚胎期接受的环境条件决定。在生物体中,ATP和UTP不仅是遗传物质的原料和能量物质,也是重要的信号分子,它们作为神经递质可以激活许多生理过程。本研究利用高压液相色谱(HPLC)检测了家蚕二化性品种... 详细信息

家蚕二化性品种卵的滞育性是由亲代卵胚胎期接受的环境条件决定。在生物体中,ATP和UTP不仅是遗传物质的原料和能量物质,也是重要的信号分子,它们作为神经递质可以激活许多生理过程。本研究利用高压液相色谱(HPLC)检测了家蚕二化性品种大造刚孵化幼虫和终龄幼虫的游离核苷酸的含量。结果表明,预定次代产滞育卵[亲代卵高温(25℃)光照]比预定次代产非滞育卵[亲代卵低温(15℃)黑暗]的刚孵化幼虫整体特别是头部ATP和UTP含量高,并达到显著水平,随着发育到上簇阶段,这种差异显著增加。这些结果暗示,家蚕体内特别是头部游离核苷酸与由环境诱导的家蚕卵滞育性有关,为进一步研究家蚕脑对环境条件的接受、保持的机制提供了一条重要途径。

关键词：游离核苷酸滞育环境因子家蚕

Recent Progress in JAXA Project of Boiling Two-Phase Flow Experiment onboard ISS

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Journal of Physical Science and Application 2012年第4期2卷 71-79页

作者： Kiyosumi Fujii Masato Komasaki Takashi Kurimoto Haruo Kawasaki Kenichiro Sawada koichi suzuki Hitoshi Asano Osamu Kawanami Ryoji Imai Yasuhisa Shinmoto Haruhiko Ohta ISS Science Project Office Japan Aerospace Exploration Agency(JAXA) Tsukuba Ibaraki Japan Thermal System Group Japan Aerospace Exploration Agency(JAXA) Tsukuba Ibaraki Japan Tokyo Univ. Sci. Yamaguchi Yamaguchi Japan Kobe University Kobe Hyogo Japan University of Hyogo Himeji Hyogo Japan IHI Corporation Yokohama Kanagawa Japan Dept. Aeronautics and Astronautics Kyushu University Fukuoka Japan

The amount of waste heat in a space facility became larger, because of increase in the space platform size and its power consumption. It requires development of high-performance space thermal management systems handling a large amount of waste. Boiling two-phase flow could become powerful means for this system because a boiling and condensation system is one of the most efficient modes of heat transfer due to phase change （liquid-vapor）. However, gravity effects on boiling two-phase flow phenomena and the corresponding heat transfer characteristics are not clear. Therefore, we prepare the experiments of boiling two-phase flow utilizing a long-term microgravity environment onboard a Japanese Experimental Module ＂KIBO＂ in the International Space Station （ISS） as one of the JAXA official projects. In this paper, recent progress of the preparation for the project is reported.

关键词： Boiling two-phase flow space science space technology ISS experiment microgravity.

Effects of leaf age,elevation and light conditions on photosynthesis and leaf traits in saplings of two evergreen conifers,Abies veitchii and ***

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Journal of Plant Ecology 2020年第4期13卷 460-469页

作者： Rina suzuki koichi Takahashi Department of Science Graduate School of Science and TechnologyShinshu UniversityAsahi 3-1-1Matsumoto 390-8621Japan Department of Biology Faculty of ScienceShinshu UniversityMatsumoto 390-8621Japan Department of Mountain Ecosystem Institute for Mountain ScienceShinshu UniversityAsahi 3-1-1Matsumoto 390-8621Japan

Aims Subalpine coniferous species are distributed over a wide range of elevations in which they must contend with stressful conditions,such as high elevations and extended periods of *** evergreen coniferous species,Abies veitchii and Abies mariesii,dominate at low and high elevations,respectively,in the subalpine zone,central *** aim of this study is to examine the effects of leaf age,elevation and light conditions on photosynthetic rates through changes in morphological and physiological leaf traits in the two *** We here examined effects of leaf age,elevation and light conditions on photosynthesis,and leaf traits in *** and *** of the two conifers were sampled in the understory and canopy gaps at their lower(1600 m)and upper(2300 m)distribution *** Findings The two species showed similar responses to leaf age and different responses to elevation and light conditions in photosynthesis and leaf *** maximum photosynthetic rate of *** is correlated negatively with leaf mass per area(LMA)and non-structural carbohydrate(NSC)*** increased at high elevations in the two species,whereas NSC concentrations increased only in ***,the maximum photosynthetic rate of *** decreased at high ***,maximum photosynthetic rates correlate positively with nitrogen concentration in both *** the understory,leaf nitrogen concentrations decreased and increased in *** and ***,*** decreased and the chlorophyll-to-nitrogen ratio increased in understory conditions only for ***,suggesting it has a higher light-capture efficiency in dark conditions than does *** study concluded that *** has more shade-tolerant photosynthetic and leaf traits and its photosynthetic rate is less affected by elevation compared with ***,allowing *** to survive in the understory and to dominate at high elevations.

关键词： leaf chlorophyll leaf mass per area leaf nitrogen non-structural carbohydrate concentration stable carbon–isotope ratio

Enamel Matrix Derivative Stimulates Osteogenesis-and Chondrogenesis-related Transcription Factors in C3H10T1/2 Cells

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Acta Biochimica et Biophysica Sinica 2007年第1期39卷 1-7页

作者： Masataka NARUKAWA Naoto suzuki Tadahiro TAKAYAMA Yasuhiko YAMASHITA Kichibee OTSUKA koichi ITO Department of Periodontology Nihon University School of DentistryTokyo101-8310Japan Department of Biochemistry Nihon University School of DentustryTokyo 101-8310Japan Division of Functional Morphology Dental Research CenterNihon University School of DentistryTokyo 101-8310Japan Department of Biochemistry Nihon University School of DentistryTokyo101-8310Japan Division of Functional Morphology Dental Research CenterNihon University School of DentistryTokyo101-8310Japan Division of Advanced Dental Treatment Dental Research CenterNihon University School of DentistryTokyo101-8310Japan

Our purpose was to determine how enamel matrix derivative (EMD) affects the expression ofosteogenesis- and chondrogenesis-related transcription factors in undifferentiated mesenchymal cells.C3H10T1/2 cell line,a typical pluripotential mesenchymal cell line,was cultured with or without EMD forup to 7 *** of mRNAs encoding osteogenesis-and chondrogenesis-related transcription factors(Runx2, Osterix,AJ18,Dlx5,Msx2,Sox5,Sox9 and Zfp60) was measured using real-time polymerasechain ***2 and Sox9 protein expression and the presence of bone morphogenetic protein (BMP)-6-like molecules in EMD were determined by Western *** substantially increased mRNA levels ofosteogenesis-and chondrogenesis-related transcription *** also induced Runx2 and Sox9 *** blotting analysis of EMD using anti-BMP-6 antibody revealed immunoreactive bandscorresponding to about 14 kDa and 60 *** results suggest that EMD stimulates osteogenesis- andchondrogenesis-related transcription factors,and these activities may be mediated,at least in part,by BMP-6in EMD.

关键词： enamel matrix derivative osteogenesis chondrogenesis