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Spectroscopic Studies on Impurity Transport of Core and Edge Plasmas in LHD

Plasma Science and Technology 2006年第1期8卷 55-60页

作者： Shigeru MORITA Motoshi GOTO SadatsuguMUTO Ryuji KATAI Hisamichi YAMAZAKI Hideaki NOZATO AtsuslliI WAMAE Makoto ATAKE Takashi FUJIMOTO Atsushi SAKAUE Hiroaki NISHIMURA Ikuya SAKURAI Chiho MATSUMOTO Akihiro FURUZAWA Yuzuru TAWARA Mitsutoshi ARAMAKI Yuji OKUMURA koichi sasaki 龚先祖李建刚万宝年崔正英 National Institute for Fusion Science Toki 509-5292Japan Department of Fusion Science Graduate University for Advanced StudiesToki 509-5292Japan National Institute of Advanced Industrial Science and Technology Tsukuba 305-8563Japan Department of Engineering Physics Kyoto UniversityKyoto 606-8502Japan Institute of Laser Engineering Osaka UniversityOsaka 565-0871Japan Eco Topia Science Institute Nagoya UniversityNagoya 464-8603Japan Department of Electrical Engineering and Computer Science Nagoya UniversityNagoya 464-8603Japan Institute of Plasma Physics Chinese Academy of SciencesHefei 230031China Southwestern Institute of Physics Chengdu 610041China

Spectroscopic diagnostics have been extensively developed for studies of impurity and neutral particle transports at core and edge plasmas in LHD. Diagnostics of core plasmas are similar to a tokamak case, i.e., Zeff from visible bremsstrahlung, K-x-ray measurements from xray spectroscopy using Si（Li） detectors and a compact crystal spectrometer, and high-Z impurity diagnostics from VUV spectroscopy using a flat-field EUV spectrometer. A combination of impurity pellet injection and visible bremsstrahlung is an active tool for determination of the diffusion coeffici＇ent D and convective velocity V. Using this tool the spatial structures of D and V are obtained and discussed with a neoclassical effect. On the other hand, the spectroscopic method for edge diagnostics is considerably different from the tokamak case because of the existence of a thick ergodic layer in addition to the z-points necessarily included into the diagnostic chord view. In order to break this negative situation, Zeeman and polarization spectroscopy are adopted to LHD edge plasmas. As a result, 2-dimensional emission contours of HeI and Ha are successfully obtained. Laser absorption spectroscopy is tried to measure hydrogen neutrals directly. Radial profiles of edge impurities are also measured with a mirror-assembled 3 m VUV spectrometer. Recent results of and progress in LHD spectroscopy are briefly reviewed.

关键词： impurity transport plasma spectroscopy hydrogen neutral

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Application of monoclonal antibody against ginsenoside in ginseng research:a review

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Traditional Medicine Research 2021年第3期6卷 66-77页

作者： Yui sasaki koichi Shimizu Hitoshi Watanabe Yukihiro Shoyama Association for Health Economics Research and Social Insurance and Welfare Tokyo 105-0003Japan Center for Environment Health and Field SciencesChiba UniversityKashiwa 277-0882Japan Faculty of Pharmacy Nagasaki International UniversityNagasaki 859-3298Japan

Panax genus belonging to a family of Araliaceae grow in Asia(9 species)and in North America(2 species).Especially Panax ginseng was listed in Chinese medical book,Shennong's Classic of Materia Medica approximately 2 thousand years ago and Panax species are now one of the most important natural *** Panax species contain approximately 260 ginsenosides,its quality control and pharmacological movement of ginsenoside in body are not enough *** antibodies against ginsenosides were prepared and set up the enzyme linked immunosorbent assay system for the quality control of natural ***,we developed Eastern blotting system using monoclonal antibodies resulted that protopanaxadiol and protopanaxatriol group ginsenosides can be separately stained by two corresponding monoclonal antibodies,*** became evident that the ginseng slice was stained by Eastern blotting *** staining of ginseng can make clear the ginsenoside-Rb1 distribution in cells and *** Eastern blotting system facilitated by two monoclonal antibodies like anti-ginsenoside-Rb1 and anti-ginsenoside-Rg1 monoclonal antibodies gives several information such as sugar number,structure,and qualitative/quantitative *** column combined with monoclonal antibodies succeeded one-step isolation of ginsenoside and make it possible to prepare knockout extract of which only antigen molecule was removed suggesting the pharmacological and biological value of antigen molecule in the crude extract.

关键词： Panax species Ginsenoside Monoclonal antibody Pharmacological activity Eastern blotting Knockout extract

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The Adenosine Receptor Agonist 5’-N-Ethylcarboxamide-Adenosine Increases Mouse Serum Total Homocysteine Levels, Which Is a Risk Factor for Cardiovascular Diseases

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Pharmacology & Pharmacy 2015年第10期6卷 461-470页

作者： Shigeko Fujimoto Sakata koichi Matsuda Yoko Horikawa Yasuto sasaki Faculty of Nutrition Kobe Gakuin University Kobe Japan

An increase in total homocysteine (Hcy) levels (protein-bound and free Hcy in the serum) has been identified as a risk factor for vascular diseases. Hcy is a product of the methionine cycle and is a precursor of glutathione in the transsulfuration pathway. The methionine cycle mainly occurs in the liver, with Hcy being exported out of the liver and subsequently bound to serum proteins. When the non-specific adenosine receptor agonist 5’-N-ethylcarboxamide-adenosine (NECA;0.1 or 0.3 mg/kg body weight) was intraperitoneally administered to mice that had been fasted for 16 h, total Hcy levels in the serum significantly increased 1 h after its administration. The NECA treatment may have inhibited transsulfuration because glutathione levels were significantly decreased in the liver. After the intraperitoneal administration of a high dose of NECA (0.3 mg/kg body weight), elevations in total Hcy levels in the serum continued for up to 10 h. The mRNA expression of methionine metabolic enzymes in the liver was significantly reduced 6 h after the administration of NECA. NECA-induced elevations in total serum Hcy levels may be maintained in the long term through the attenuated expression of methionine metabolic enzymes.

关键词： Adenosine 5’-N-Ethylcarboxamide-Adenosine Glutathione Homocysteine

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The Adenosine Receptor Agonist 5’-N-Ethylcarboxamide-Adenosine Increases Glucose 6-Phosphatase Expression and Gluconeogenesis

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Pharmacology & Pharmacy 2014年第1期5卷 19-23页

作者： koichi Matsuda Yoko Horikawa Yasuto sasaki Shigeko F. Sakata Faculty of Nutrition Kobe Gakuin University Kobe Japan.

Intraperitoneal administration of the non-selective adenosine receptor agonist 5’-N-ethylcarboxamide-adenosine (NECA) (0.1 or 0.3 mg/kg) increased fasting serum glucose levels in mice. To clarify the mechanism responsible for this, the expression of liver glucose 6-phosphatase (G6Pase: a gluconeogenic enzyme) was analyzed, and it was found that G6Pase mRNA was increased by NECA treatment. Administration of 0.3 mg/kg NECA resulted in elevated serum glucose levels at 1 h and were further elevated at 6 h. Administration of 0.1 mg/kg NECA increased serum glucose levels at 1 h and had returned to control levels by 6 h. The increase in fasting serum glucose levels induced by NECA are thought to be caused, in part, by elevated G6Pase expression.

关键词： 5’-N-Ethylcarboxamide-Adenosine Glucose 6-Phosphatase Gluconeogenesis

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Preoperative evaluation of colorectal cancer using CT colonography, MRI, and PET/CT

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World Journal of Gastroenterology 2014年第45期20卷 16964-16975页

作者： Shigeyoshi Kijima Takahiro sasaki koichi Nagata Kenichi Utano Alan T Lefor Hideharu Sugimoto Department of Radiology Jichi Medical University Department of Surgery Jichi Medical University

Imaging studies are a major component in the evaluation of patients for the screening,staging and surveillance of colorectal *** review presents commonly encountered findings in the diagnosis and staging of patients with colorectal cancer using computed tomography(CT)colonography,magnetic resonance imaging(MRI),and positron emission tomography(PET)/CT *** colonography provides important information for the preoperative assessment of T *** deformities are associated with muscular or subserosal *** node metastases from colorectal cancer often present with *** is superior to detect calcified ***-dimensional CT to image the vascular anatomy facilitates laparoscopic surgery.T staging of rectal cancer by MRI is an established modality because MRI can diagnose rectal wall laminar structure.N staging in patients with colorectal cancer is still challenging using any imaging *** is more accurate than CT for the evaluation of liver ***/CT colonography isvaluable in the evaluation of extra-colonic and hepatic ***/CT colonography is useful for obstructing colorectal cancers that cannot be traversed ***/CT colonography is able to localize synchronous colon cancers proximal to the obstruction ***,there is no definite evidence to support the routine clinical use of PET/CT colonography.

关键词： Colorectal cancer Preoperative evaluation T stagin

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Myricetin and Hesperidin Inhibit Cerebral Thrombogenesis and Atherogenesis in Apoe-/-and Ldlr-/-Mice

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Food and Nutrition Sciences 2018年第1期9卷 20-31页

作者： Yasuto sasaki Kanae Hyodo Ayana Hoshino Eri Kisa koichi Matsuda Yoko Horikawa John C. Giddings Laboratory of Physiology Faculty of Nutrition Kobe Gakuin University Kobe Japan Laboratory of Biochemistry Faculty of Nutrition Kobe Gakuin University Kobe Japan Department of Haematology School of Medicine Cardiff University Cardiff UK

Flavonoids have been reported to possess strong antioxidant activities that moderate endothelial dysfunction and demonstrate protective effects on cardiovascular disease. Our previous studies confirmed that flavonoids, including hesperidin, naringin and nobiletin, inhibited thrombogenesis and hypertension in stroke prone spontaneously hypertensive rats (SHRSP) by protecting the endothelium from the adverse effects of free radical formation. We have now further investigated the protective effects of myricetin and hesperidin on cerebral thrombosis and atherogenesis in apolipoprotein E (apoE) and lowdensity lipoprotein receptor (LDLR) deficient (Apoe-/- and Ldlr-/- double knockout) mice. Three groups of mice were fed high fat diet alone and high fat diet mixed with myricetin (100 mg/kg/day and 200 mg/kg/day) or glucosyl hesperidin (G-hesperidin;250 mg/kg/day and 500 mg/kg/day) for 8 weeks. There were no differences in body weight related to administration of the flavonoids. Thrombotic tendency was assessed using a He-Ne laser technique in the murine cerebral pial vessels. In addition, atherogenesis was quantified histologically after dissection of the aorta from each mouse and staining with Oil Red O solution. The percentages of stained area to whole area of dissected aorta were calculated as indices of anti-atherogenic activity. Both myricetin and G-hesperidin significantly inhibited thrombogenesis in vivo and significantly inhibited atherogenesis compared to control mice (p < 0.001). These findings demonstrated that daily intake of myricetin and hesperidin suppressed the development of atherogenesis and thrombogenesis, possibly associated with the potent antioxidant effects of the flavonoids.

关键词： Myricetin Hesperidin Atherosclerosis Apoe-/- and Ldlr-/- Mice Thrombosis

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Phenotypes and Chronic Organ Damage May Be Different among Siblings with Wilson's Disease

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Journal of Clinical and Translational Hepatology 2017年第1期5卷 27-30页

作者： Shinsuke Yahata Seitetsu Yung Mari Mandai Takakazu Nagahara Daisaku Kuzume Hiroshi Sakaeda Shinya Wakusawa Ayako Kato Yasuaki Tatsumi koichi Kato Hisao Hayashi Ryohei Isaji Yoji sasaki Motoyoshi Yano Kazuhiko Hayashi Masatoshi Ishigami Hidemi Goto Division of Community Medicine and Career Development Kobe University Graduate School of Medicine2-1-5Arata-choHyogo-kuKobe 652-0032Japan Department of Gastroenterology Hyogo Prefectural Kakogawa Medical CenterKakogawaHyogoJapan Department of Gastroenterology and Hepatology Tottori Prefectural Kousei HospitalKurayoshiTottoriJapan Departments of Neurology and Gastroenterology Chikamori HospitalKochiJapan Medical Laboratory Sciences Nagoya University Graduate School of MedicineHigashi-kuNagoyaJapan Department of Medicine Aichi Gakuin University School of PharmacyChikusa-kuNagoyaJapan Department of Gastroenterology Konan Kosei HospitalTakaya-choKonanAichiJapan Department of Gastroenterology Yokkaichi Municipal HospitalYokkaichiMieJapan Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineShowa-kuNagoyaJapan

Background and Aims:Cloning of ATP7B provided evidence that Wilson's disease is a hepatic copper toxicosis with a variety of extrahepatic *** siblings with the same genetic background and exposure to similar environmental factors may be a good model for the study of genotype-phenotype ***:Twenty-three affected siblings in 11 families were selected from a *** first phenotypes were determined according to the international *** final types of chronic organ damage were re-evaluated for life-long ***:Phenotypes were identical in 5 of the families and different in 6 of the *** acute hepatic phenotype H1 was found in 3 younger siblings and 1 older *** survived an acute episode of hemolysis with underlying chronic liver *** also presented complication with neurological *** neurological phenotype N1 with neuropsychiatric symptoms and hepatic disease was found in 2 aged siblings of 1 family,in an older sibling in 3 families and in the oldest sibling in 1 *** in siblings were mainly split by either H1 occurring in random order or age-dependent *** of chronic organ damage were identical in 8 of the families and different in 3 of the *** same combination of chronic liver disease was found in 6 families and chronic liver disease complicated with neurological disease in 2 *** organ damage in siblings was found when an older sibling was complicated by neurological *** was no reverse combination of a younger sibling being complicated by neurological disease in any of the ***:Phenotype combinations of siblings were mainly modified by externally-induced hemolytic episodes,while chronic organ damage in siblings was split by age-dependent neurological complications.

关键词： Hemolysis Liver disease Neurological disease Wilson's disease

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Case of plasmablastic lymphoma of the sigmoid colon and literature review

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World Journal of Gastroenterology 2015年第24期21卷 7598-7603页

作者： Tomoko Haramura Masashi Haraguchi Junji Irie Shinichiro Ito Hirotaka Tokai Kazumasa Noda Masachika Kitajima Shigeki Minami Keiji Inoue Yuya sasaki koichi Oshima Susumu Eguchi Department of Surgery Nagasaki Harbor Medical Center City Hospital Department of Pathology Nagasaki Harbor Medical Center City Hospital Department of Pathology Kurume University Department of Surgery Nagasaki University Graduate School of Biomedical Sciences

Plasmablastic lymphoma(PBL) is a rare form of nonHodgkin's lymphoma that is associated with human immunodeficiency virus(HIV) infection. Although PBL is most commonly observed in the oral cavity of HIV-positive patients, it can also be observed at extra-oral sites in HIV-negative patients. This report represents an unusual case of HIV-negative PBL that occurred in the sigmoid colon. This patient had a history of systemic lupus erythematosus and an underlying immunosuppressive state from long term steroid therapy. The lymphoma cells were positive for CD138, kappa light chain restriction and Epstein-Barr virus and negative for CD20/L26, CD3, CD79 a, UCHL1(CD45RO) and cytokeratin(AE1/AE3). The patient died approximately 2 mo after the operation. In the present paper, we review cases of PBL of the colon in HIVnegative patients.

关键词： Plasmablastic lymphoma Sigmoid colon Humanimmunodeficiency virus-negative Immunosuppressive state Extra-oral site

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Efficient Solvent- and Catalyst-Free Syntheses of Imine Derivatives Applying the Pressure Reduction Technique: Remarkable Change of the Reaction Rate with the Phase Transition

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Green and Sustainable Chemistry 2018年第2期8卷 167-179页

作者： Shoko Suzuki Shujiro Sakaki Shinji Ishizuka Tomomichi Nishino Hiroyuki Ito Risehiro Nonaka Motoyoshi Noike Takeshi Kodama Hajime Nozaka Tsuneyuki Sato Hitoshi Agematsu koichi Maruyama Shun Oyamada Takashi Kuroishi Kazuma sasaki Kei Yagawa Mami Yoshioka Yasuo Yokoyama Faculty of Education Kyoto University of Education Kyoto Japan Department of Chemical and Biological Engineering National Institute of Technology Akita College Akita Japan Environment Systems Engineering Course National Institute of Technology Akita College Akita Japan Department of Applied Chemistry National Institute of Technology Akita College Akita Japan

Because imines could be used as convenient starting materials in various fields, the development of an easy synthetic method of imine was strongly desired. In response to this demand, we thought that it would be an effective synthesis method if an aldehyde and an amine could be reacted to give an imine in good yield under solvent- and catalyst-free conditions. In fact, we tried the reaction of benzaldehyde with various amines under solvent- and catalyst-free conditions followed by removal of water that was produced in the reaction system by a vacuum pump, and desired imines could be obtained in good yields. Observation of this reaction using a nuclear magnetic resonance spectrometer revealed that the reaction rate was extremely fast at the initial stage but slowed over time. However, the reaction of benzaldehyde with aniline differed greatly, and the reaction rate dramatically improved in 47 - 48 minutes after the start of the reaction. At this time, we found that the reaction system underwent a phase transition from the liquid phase to the solid phase.

关键词： Solvent-Free Catalyst-Free Pressure Reduction Technique Imine Reaction Rate Phase Transition

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Endoscopic removal of foreign bodies:A retrospective study in Japan

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World Journal of Gastrointestinal Endoscopy 2020年第1期12卷 33-41页

作者： Kenji JL Limpias Kamiya Naoki Hosoe Kaoru Takabayashi Yukie Hayashi Xi Sun Ryoichi Miyanaga Kayoko Fukuhara Seiichiro Fukuhara Makoto Naganuma Atsushi Nakayama Motohiko Kato Tadateru Maehata Rieko Nakamura koichi Ueno Junichi sasaki Yuko Kitagawa Naohisa Yahagi Haruhiko Ogata Takanori Kanai Division of Gastroenterology and Hepatology Department of Internal MedicineKeio University School of MedicineTokyo 160-8582Japan Center for Diagnostic and Therapeutic Endoscopy Keio University School of MedicineTokyo 160-8582Japan Department of Gastroenterology and Hepatology Chinese PLA General HospitalBeijing 100853China Division of Research and Development for Minimally Invasive Treatment Cancer CenterKeio University School of MedicineTokyo 160-8582Japan Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Emergency and Critical Care Medicine Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND The ingestion of foreign bodies(FBs)and food bolus impaction(FBI)in the digestive tract are commonly encountered clinical *** to handle such problems continue to evolve offering advantages,such as the avoidance of surgery,reduced cost,improved visualization,reduced morbidity,and high removal success ***,to date,no studies have evaluated the endoscopic management of FBs in *** To elucidate level of safety and efficacy in the endoscopic management of FBs and *** A total of 215 procedures were performed at Keio University Hospital between November 2007 and August *** were collected from medical charts,and endoscopic details were collected from an endoscopic reporting *** performed with a flexible gastrointestinal endoscope were only taken into *** who underwent a technique involving FB or FBI from the digestive tract were only *** on patient sex,patient age,outpatient,inpatient,FB type,FB location,procedure time,procedure type,removal device type,success,and technical complications were reviewed and analyzed *** Among the 215 procedures,136(63.3%)were performed in old adults(≥60 years),180(83.7%)procedures were performed in *** most common type of FBs were press-through-pack(PTP)medications[72(33.5%)cases],FBI[47(21.9%)],Anisakis parasite(AP)[41(19.1%)cases].Most FBs were located in the esophagus[130(60.5%)cases]followed by the stomach[68(31.6%)cases].AP was commonly found in the stomach[39(57.4%)cases],and it was removed using biopsy forceps in 97.5%of the *** most common FBs according to anatomical location were PTP medications(40%)and dental prostheses(DP)(40%)in the laryngopharynx,PTP(48.5%)in the esophagus,AP(57.4%)in the stomach,DP(37.5%)in the small intestine and video capsule endoscopy device(75%)in the colon.A transparent cap with grasping forceps was the most commonly used device[82(38.1%)cases].The success rate of the procedure was

关键词： Anisakis parasite Endoscopic removal Food bolus impaction Foreign body Grasping forceps

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