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Y chromosome microdeletion screening using a new molecular diagnostic method in 1030 Japanese males with infertility

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Asian Journal of Andrology 2020年第4期22卷 368-371页

作者： Masashi Iijima Kazuyoshi Shigehara Hideki Igarashi koichi kyono Yasuo Suzuki Yuji Tsuji Yoshitomo Kobori Hideyuki Kobayashi Atsushi Mizokami Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical ScienceKanazawa 920-8641Japan kyono ART Clinic Sendai 980-0014Japan kyono ART Clinic TakanawaTokyo 108-0074Japan Suzuki Lady's Hospital Kanazawa 921-8033Japan Ebisu Tsuji Clinic Tokyo 150-0021Japan Tenjin Tsuji Clinic Fukuoka 810-0001Japan Dokkyo Medical University Koshigaya Hospital Saitama 343-8555Japan Department of Urology Faculty of MedicineToho UniversityTokyo 143-8541Japan

The azoospermia factor(AZF)region is important for spermatogenesis,and deletions within these regions are a common cause of oligozoospermia and azoospermia.Although several studies have reported this cause,the present research,to the best of our knowledge,is the first large-scale study assessing this factor in Japan.In this study,1030 male patients with infertility who were examined for Y chromosome microdeletion using the polymerase chain reaction-reverse sequence-specific oligonucleotide(PCR-rSSO)method,a newly developed method for Y chromosome microdeletion screening,were included.The study enrolled 250 patients with severe oligospermia and 717 patients with azoospermia.Among the 1030 patients,4,4,10,and 52 had AZFa,AZFb,AZFb+c,and AZFc deletions,respectively.The sperm recovery rate(SRR)of microdissection testicular sperm extraction in patients with AZFc deletions was significantly higher than that in those without AZF deletions(60.0%vs 28.7%,P=0.04).In patients with gr/gr deletion,SRR was 18.7%,which was lower than that in those without gr/gr deletion,but was not statistically significant.In conclusion,our study showed that the frequency of Y chromosome microdeletion in male patients in Japan was similar to that reported in patients from other countries,and SRR was higher in patients with AZFc deletion.

关键词： azoospermia factor Japanese infertile men sperm recovery rate Y chromosome microdeletion

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Assessing efficacy of standard impregnation techniques on die-cast aluminum alloys using X-ray micro-CT

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China Foundry 2024年第3期21卷 276-286页

作者： Ajith Bandara koichi Kan Katanaga Yusuke Natsuto Soga Akifumi Koike Toru Aoki Hamamatsu TSC Chuo Hatsumei Institute322 lida-choMinami-kuHamamatsu435-0028Japan Graduate School of Medical Photonics ShizuokaUniversityJohoku 3-5-1HamamatsuShizuoka432-8561Japan ANSeeN Inc Johoku 3-5-1HamamatsuShizuoka432-8561Japan Research Institute of Electronics ShizuokaUniversityJohoku 3-5-1HamamatsuShizuoka432-8561Japan

Utilizing lightweight Al alloys in various industrial applications requires achieving precise pressure tightness and leak requirements.Vacuum pressure impregnation(VPI)with thermosetting polymers is commonly used to address leakage defects in die-cast Al alloys.In this study,the efficacy of the VPI technique in sealing alloy parts was investigated using a combination of nondestructive micro X-ray computed tomography(micro XCT)and a standard leak test.The results demonstrate that the commonly used water leak test is insufficient for determining the sealing performance.Instead,micro XCT shows distinct advantages by enabling more comprehensive analysis.It reveals the presence of a low atomic number impregnates sealant within casting defects,which has low grey contrast and allows for visualizing primary leakage paths in 3D.The effective atomic number of impregnated resin is 6.75 and that of Al alloy is 13.69 by dual-energy X-ray CT.This research findings will contribute to enhancing the standard VPI process parameters and the properties of impregnating sealants to improve quality assurance for impregnation in industrial metals.

关键词： nondestructive testing Al alloy die-casting vacuum pressure impregnation micro X-ray computed tomography duel-energy X-ray CT

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Controlling a peristaltic robot inspired by inchworms

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Biomimetic Intelligence & Robotics 2024年第1期4卷 88-96页

作者： Yanhong Peng Hiroyuki Nabae Yuki Funabora koichi Suzumori Department of Information and Communication Engineering Graduate School of EngineeringNagoya UniversityNagoya 464-8601Japan Department of Mechanical Engineering Tokyo Institute of TechnologyTokyo 152-8550Japan

This study presents an innovative approach in soft robotics,focusing on an inchworm-inspired robot designed for enhanced transport capabilities.We explore the impact of various parameters on the robot’s performance,including the number of activated sections,object size and material,supplied air pressure,and command execution rate.Through a series of controlled experiments,we demonstrate that the robot can achieve a maximum transportation speed of 8.54 mm/s and handle loads exceeding 100 g,significantly outperforming existing models in both speed and load capacity.Our findings provide valuable insights into the optimization of soft robotic design for improved efficiency and adaptability in transport tasks.This research not only contributes to the advancement of soft robotics but also opens new avenues for practical applications in areas requiring precise and efficient object manipulation.The study underscores the potential of biomimetic designs in robotics and sets a new benchmark for future developments in the field.

关键词： McKibben artificial muscles Bionics Soft robotics Soft actuator Bio-inspired robotics

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High-temperature corrosion of sintered RE_(2)Si_(2)O_(7)(RE=Yb and Ho)environmental barrier coating materials by volcanic ash

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1628-1638页

作者： Ayahisa Okawa Son Thanh Nguyen Tadachika Nakayama Thi-Mai-Dung Do Hisayuki Suematsu Shu Yin Takuya Hasegawa Tsuneo Suzuki Takashi Goto koichi Niihara Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai 980-8577Japan Department of Creative Engineering National Institute of TechnologyKushiro 084-0916Japan Extreme Energy-Density Research Institute Nagaoka University of TechnologyNagaoka 940-2188Japan Advanced Institute for Materials Research(WPI-AIMR) Tohoku UniversitySendai 980-8577Japan

Rare-earth silicates are promising environmental barrier coatings(EBCs)that can protect SiC_(f)/Si C_(m)substrates in next-genera tion gas turbine blades.Notably,RE_(2)Si_(2)O_(7)(RE=Yb and Ho)shows potential as an EBC due to its coefficient of thermal expansion(CTE)compatible with substrates and high resistance to water vapor corrosion.The target operating temperature for next-generation tur bine blades is 1400°C.Corrosion is inevitable during adhesion to molten volcanic ash,and thus,understanding the corrosion behavior o the material is crucial to its reliability.This study investigates the high-temperature corrosion behavior of sintered RE_(2)Si_(2)O_(7)(RE=Yb and Ho).Samples were prepared using a solid-state reaction and hot-press method.They were then exposed to volcanic ash at 1400°C for 224,and 48 h.After 48 h of exposure,volcanic ash did not react with Yb_(2)Si_(2)O_(7)but penetrated its interior,causing damage.Meanwhile Ho_(2)Si_(2)O_(7)was partially dissolved in the molten volcanic ash,forming a reaction zone that prevented volcanic ash melts from penetrating the interior.With increasing heat treatment time,the reaction zone expanded,and the thickness of the acicular apatite grains increased The Ca:Si ratios in the residual volcanic ash were mostly unchanged for Yb_(2)Si_(2)O_(7)but decreased considerably over time for Ho_(2)Si_(2)O_(7).Th Ca in volcanic ash was consumed and formed apatite,indicating that RE^(3+)ions with large ionic radii(Ho>Yb)easily precipitated apatit from the volcanic ash.

关键词： environmental barrier coating volcanic ash rare-earth disilicate corrosion

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Severe aconite poisoning successfully treated with veno-arterial extracorporeal membrane oxygenation:A case report

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World Journal of Clinical Cases 2024年第2期12卷 399-404页

作者： Saeko Kohara Yoshito Kamijo Ryoko Kyan Ichiro Okada Eiju Hasegawa Soichiro Yamada koichi Imai Asuka Kaizaki-Mitsumoto Satoshi Numazawa Department of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical CenterTokyo 1900014Japan Department of Clinical Toxicology Saitama Medical UniversitySaitama 3500495Japan Saitama Prefectural Institute of Public Health Saitama Prefectural Institute of Public HealthSaitama 3550133Japan Division of Toxicology Department of PharmacologyToxicology and TherapeuticsShowa University School of PharmacyTokyo 1428555Japan

BACKGROUND Most species of aconite contain highly toxic aconitines,the oral ingestion of which can be fatal,primarily because they cause ventricular arrhythmias.We describe a case of severe aconite poisoning that was successfully treated through venoarterial extracorporeal membrane oxygenation(VA-ECMO)and in which detailed toxicological analyses of the aconite roots and biological samples were performed using liquid chromatography-tandem mass spectrometry(LC-MS/MS).CASE SUMMARY A 23-year-old male presented to the emergency room with circulatory collapse and ventricular arrhythmia after ingesting approximately half of a root labeled,“Aconitum japonicum Thunb”.Two hours after arrival,VA-ECMO was initiated as circulatory collapse became refractory to antiarrhythmics and vasopressors.Nine hours after arrival,an electrocardiogram revealed a return to sinus rhythm.The patient was weaned off VA-ECMO and the ventilator on hospital days 3 and 5,respectively.On hospital day 15,he was transferred to a psychiatric hospital.The other half of the root and his biological samples were toxicologically analyzed using LC-MS/MS,revealing 244.3 mg/kg of aconitine and 24.7 mg/kg of mesaconitine in the root.Serum on admission contained 1.50 ng/mL of aconitine.Beyond hospital day 2,neither were detected.Urine on admission showed 149.09 ng/mL of aconitine and 3.59 ng/mL of mesaconitine,but these rapidly decreased after hospital day 3.CONCLUSION The key to saving the life of a patient with severe aconite poisoning is to introduce VA-ECMO as soon as possible.

关键词： Aconite poisoning Fatal arrhythmia Veno-arterial extracorporeal membrane oxygenation Aconitine Mesaconitine Case report

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混合磁悬浮系统零功率抗偏载控制方法研究

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机械工程学报 2024年第8期60卷 360-369页

作者：赵川孙凤金俊杰徐方超张明 OKA koichi 沈阳工业大学机械工程学院沈阳110870 高知工科大学系统工学部高知7828502日本

针对混合磁悬浮洁净传送装置无法兼顾零功率和抗偏载悬浮的问题,提出一种磁铁可动式混合磁悬浮系统,并设计了其零功率抗偏载控制策略。该系统中一个磁极固定,其他两个磁铁可绕悬浮圆盘中心轴线转动,通过调节气隙长度和磁铁转动角度克服... 详细信息

针对混合磁悬浮洁净传送装置无法兼顾零功率和抗偏载悬浮的问题,提出一种磁铁可动式混合磁悬浮系统,并设计了其零功率抗偏载控制策略。该系统中一个磁极固定,其他两个磁铁可绕悬浮圆盘中心轴线转动,通过调节气隙长度和磁铁转动角度克服偏载引起的扰动力和扰动力矩,从而实现零稳态电流和抗偏载悬浮。首先建立系统的线性变参数模型,分析该系统实现零功率水平悬浮需要满足的条件。零功率抗偏载控制策略在比例-微分控制器中引入电流和气隙偏差的积分反馈,并应用质心观测器反求磁体转动角度,求解方法分别采用雅可比逆变换解析求解和查表法内插取值两种方法。试验结果表明,该系统能够在偏载条件下保持零功率水平悬浮,应用雅可比的连续控制策略具有更好的纠偏特性,稳态时电流波动范围小。

关键词：混合磁悬浮零功率控制抗偏载特性离散控制

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Preoperative albumin-bilirubin score and liver resection percentage determine postoperative liver regeneration after partial hepatectomy

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World Journal of Gastroenterology 2024年第14期30卷 2006-2017页

作者： Kazuhiro Takahashi Masahiko Gosho Yoshihiro Miyazaki Hiromitsu Nakahashi Osamu Shimomura Kinji Furuya Manami Doi Yohei Owada koichi Ogawa Yusuke Ohara Yoshimasa Akashi Tsuyoshi Enomoto Shinji Hashimoto Tatsuya Oda Department of Gastrointestinal and Hepatobiliary-Pancreatic Surgery University of TsukubaTsukuba 3058-575IbarakiJapan Department of Biostatistics University of TsukubaTsukuba 3058-575IbarakiJapan

BACKGROUND The success of liver resection relies on the ability of the remnant liver to regenerate.Most of the knowledge regarding the pathophysiological basis of liver regeneration comes from rodent studies,and data on humans are scarce.Additionally,there is limited knowledge about the preoperative factors that influence postoperative regeneration.AIM To quantify postoperative remnant liver volume by the latest volumetric software and investigate perioperative factors that affect posthepatectomy liver regenera-tion.METHODS A total of 268 patients who received partial hepatectomy were enrolled.Patients were grouped into right hepatectomy/trisegmentectomy(RH/Tri),left hepa-tectomy(LH),segmentectomy(Seg),and subsegmentectomy/nonanatomical hepatectomy(Sub/Non)groups.The regeneration index(RI)and late rege-neration rate were defined as(postoperative liver volume)/[total functional liver volume(TFLV)]×100 and(RI at 6-months-RI at 3-months)/RI at 6-months,respectively.The lower 25th percentile of RI and the higher 25th percentile of late regeneration rate in each group were defined as“low regeneration”and“delayed regeneration”.“Restoration to the original size”was defined as regeneration of the liver volume by more than 90%of the TFLV at 12 months postsurgery.RESULTS The numbers of patients in the RH/Tri,LH,Seg,and Sub/Non groups were 41,53,99 and 75,respectively.The RI plateaued at 3 months in the LH,Seg,and Sub/Non groups,whereas the RI increased until 12 months in the RH/Tri group.According to our multivariate analysis,the preoperative albumin-bilirubin(ALBI)score was an independent factor for low regeneration at 3 months[odds ratio(OR)95%CI=2.80(1.17-6.69),P=0.02;per 1.0 up]and 12 months[OR=2.27(1.01-5.09),P=0.04;per 1.0 up].Multivariate analysis revealed that only liver resection percentage[OR=1.03(1.00-1.05),P=0.04]was associated with delayed regeneration.Furthermore,multivariate analysis demonstrated that the preoperative ALBI score[OR=2.63(1.00-1.05),P=0.02;per 1.0 up]and liver resection percentage[OR=1.02(1.00

关键词： Liver regeneration Albumin-bilirubin score Liver resection percentage Partial hepatectomy Human Regeneration index

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Potential significance of CX3CR1 dynamics in stress resilience against neuronal disorders

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Neural Regeneration Research 2022年第10期17卷 2153-2156页

作者： koichi Inoue Department of Integrative Anatomy Nagoya City University Graduate School of Medical SciencesNagoyaJapan

Recent findings have implicated inflammatory responses in the central nervous system in a variety of neuropsychiatric and neurodegenerative diseases,and the understanding and control of immunological responses could be a major factor of future therapeutic strategies for neurological disorders.Microglia,derived from myelogenous cells,respond to a number of stimuli and make immune responses,resulting in a prominent role as cells that act on inflammation in the central nervous system.Fractalkine(FKN or CX3CL1)signaling is an important factor that influences the inflammatory response of microglia.The receptor for FKN,CX3CR1,is usually expressed in microglia in the brain,and therefore the inflammatory response of microglia is modified by FKN.Reportedly,FKN often suppresses inflammatory responses in microglia and activation of its receptor may be effective in the treatment of inflammatory neurological disorders.However,it has also been suggested that inflammatory responses facilitated by FKN signaling aggravate neurological disorders.Thus,further studies are still required to resolve the conflicting interpretation of the protective or deleterious contribution of microglial FKN signaling.Yet notably,regulation of FKN signaling has recently been shown to be beneficial in the treatment of human diseases,although not neurological diseases.In addition,a CX3CR1 inhibitor has been developed and successfully tested in animal models,and it is expected to be in human clinical trials in the future.In this review,I describe the potential therapeutic consideration of microglial CX3CR1 dynamics through altered FKN signaling.

关键词： Alzheimer’s disease CX3CR1 fractalkine inflammation knockout mice microglia resilience SARS-CoV-2 stress stroke

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Data-driven polarimetric imaging: a review

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Opto-Electronic Science 2024年第2期3卷 1-44页

作者： Kui Yang Fei Liu Shiyang Liang Meng Xiang Pingli Han Jinpeng Liu Xue Dong Yi Wei Bingjian Wang koichi Shimizu Xiaopeng Shao School of Optoelectronic Engineering Xidian UniversityXi’an 710071China School of Physics Xidian UniversityXi’an 710071China Graduate School of Information Production and SystemsWaseda UniversityKitakyushu 808-0135Japan Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311200China

This study reviews the recent advances in data-driven polarimetric imaging technologies based on a wide range of practical applications.The widespread international research and activity in polarimetric imaging techniques demonstrate their broad applications and interest.Polarization information is increasingly incorporated into convolutional neural networks(CNN)as a supplemental feature of objects to improve performance in computer vision task applications.Polarimetric imaging and deep learning can extract abundant information to address various challenges.Therefore,this article briefly reviews recent developments in data-driven polarimetric imaging,including polarimetric descattering,3D imaging,reflection removal,target detection,and biomedical imaging.Furthermore,we synthetically analyze the input,datasets,and loss functions and list the existing datasets and loss functions with an evaluation of their advantages and disadvantages.We also highlight the significance of data-driven polarimetric imaging in future research and development.

关键词： deep learning polarimetric imaging image processing

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Next-generation power delivery system with resiliency and environmental affinity

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Global Energy Interconnection 2022年第3期5卷 274-280页

作者： koichi Nara IEEE Life Fellow Prof.Emeritus Ibaraki University4-12-1 NakanarusawaHitachi Ibaraki 316-8511Japan

Renewable energy resources play an important role in the realization of the carbon neutrality.The microgrid can efficiently integrate numerous renewable energy systems into power distribution systems to realize power supply resiliency and environmental affinity.This paper reviews the current trend of microgrid and networked microgrid technologies worldwide,particularly in Japan,including the Flexible,Reliable,and Intelligent Energy Delivery System(FRIENDS)and some other examples of the networked microgrid.Some recent digitalized control functions of the microgrid and related systems are also introduced.

关键词： Microgrid Networked microgrid Resilience Carbon neutrality Digitalized control FRIENDS

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