检索结果-南通市图书馆

Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第45期15卷 5712-5715页

作者： Takayuki Takeichi Shinji Uemoto Sachiko Minamiguchi izumi Takeyoshi Yukihiro Inomata koichi Tanaka Eiji Kobayashi Department of Transplantation and Immunology Kyoto University Hospital 54 Kawara-cho ShogoinSakyo-ku Kyoto 606-8507 Japan Second Department of Surgery Gunma University School of Medicine 3-39-15 Showa-machi Maebashi Gunma 371-8511 Japan Department of Trans-plantation and Pediatric Surgery Postgraduate School of Medical Science Kumamoto University Kumamoto 1-1-1 Honjyo Ku-mamoto 860-8556 Japan Laboratory of Anatomic Pathology Kyoto University Hospital 54 Kawara-cho Shogoin Sakyo-ku Kyoto 606-8507 Japan Division of Organ Replacement Research Center for Molecular Medicine Jichi Medical School Minami-kawachi-machi Kawachi-gun Tochigi 329-0498 Japan

AIM: To investigate the effects of a novel Leukotriene B4 receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model. METHODS: Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus). RESULTS: There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more signif icantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls. CONCLUSION: This study demonstrated that pretreat-ment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver isch-emia-reperfusion injury.

关键词：再灌注损伤缺血再灌注肝损伤大鼠模型受体拮抗剂谷草转氨酶联合生产加性效应

A case of a patient positive for anti-cardiolipin antibodies with recurrent fetal wastage and cerebral infarction who was successfully treated with Sairei-to, low dose aspirin, and heparin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2012年第4期2卷 398-401页

作者： Taro Nonaka Makoto Chihara izumi Ooki Masaki Tamura Takumi Kurabayashi koichi Takakuwa Department of Obstetrics and Gynecology Niigata City General Hospital Niigata Japan Department of Obstetrics and Gynecology Niigata University General Hospital of Medical and Dental Sciences Niigata Japan

We report a successful case of a pregnant female positive for anti-cardiolipin antibodies who experienced two abnormal pregnancies with postpartum cerebral hemispheric infarctions. A 38-year-old female diagnosed as being positive for anti-cardiolipin antibodies was referred to our hospital due to her strong desire to have a baby. The administration of Japanese herbal medicine, Sairei-to, as immunosuppressive therapy, and low dose aspirin, as anti-coagulation therapy, were initiated prior to the patient’s pregnancy. Five months after beginning the treatment, the patient conceived spontaneously. At 34 weeks of gestation, emergency cesarean section was performed due to increasing genital bleeding resulting from coincidental placenta previa and the patient delivered an appropriate-for-date female infant (1970 g). Treatment with Japanese herbal medicine (Sairei-to) and low-dose aspirin is considered to be an effective treatment option for patients positive for anti-phospholipid antibodies with past histories of abnormal pregnancies.

关键词： Anti-Cardiolipin Antibody Postpartum Cerebral Hemispheric Infarction Abnormal Pregnancy Sairei-to Low Dose Aspirin

Fatal hemophagocytic lymphohistiocytosis presenting as Reye’s syndrome: Report of two cases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Pediatrics 2012年第2期2卷 161-164页

作者： Shinji Kounami koichi Minami Megumi Yoshiyama Genkichi izumi Noriyuki Aoyagi Norishige Yoshikawa Department of Pediatrics Wakayama Medical University Kimiidera Wakayama City Japan

We report two cases of rapidly fatal hemophagocytic lymphohistiocytosis (HLH) that presented as Reye’s syndrome (RS). The patients were referred to our hospital because of altered level of consciousness with hyperammonemia and hypoglycemia. The first patient, a 24-month-old girl (Case 1), died soon after arrival and was clinically diagnosed as having RS, but a diagnosis of HLH was established on the basis of autopsy findings. The other patient, a 4-month-old boy (Case 2), was diagnosed as having HLH in view of the bone marrow findings on admission, but immunosuppressive therapy failed to prevent a rapidly fatal course. Marked hypercytokinemia was found in both patients, and liver pathology demonstrated panlobular microvesicular steatosis of hepatocytes, resembling that in RS. Mononuclear cell infiltration with hemophagocytosis in the liver was evident in case 2, but not in case 1. In both cases, hypercytokinemia was thought to have caused mitochondrial dysfunction, resulting in RS-like microvesicular steatosis of hepatocytes. HLH is an important differential diagnosis of children presenting with RS-like picture.

关键词： Hemophagocytic Lymphohistiocytosis Reye’s Syndrome Cytokine Mitochondria Encephalopathy

原因不明习惯性流产患者封闭抗体活性与肿瘤坏死因子-α的关系

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

上海医学 2005年第9期28卷 741-743页

作者：朱洁萍高桑好一横尾朋和大木泉菊池朗田村正毅田中宪一上海交通大学附属第六人民医院妇产科 200233 日本新泻大学大学院产妇人科

目的观察原因不明习惯性流产(RSA)患者的封闭抗体效应与辅助性T细胞(Th)1型免疫之间的关系。方法以20例连续发生过3次以上早期自然流产的患者作为观察对象。采用比重离心法从外周血中提取淋巴细胞,以1×106/ml浓度加入含有1%小牛血清的R... 详细信息

目的观察原因不明习惯性流产(RSA)患者的封闭抗体效应与辅助性T细胞(Th)1型免疫之间的关系。方法以20例连续发生过3次以上早期自然流产的患者作为观察对象。采用比重离心法从外周血中提取淋巴细胞,以1×106/ml浓度加入含有1%小牛血清的RPMI中。每毫升淋巴细胞悬浮液中加入植物血凝素(PHA)2μg培养72 h。采用酶联免疫吸附试验(ELISA法)检测培养液中肿瘤坏死因子(TNF)-α的水平。采用混合淋巴细胞培养方法检测研究对象的封闭抗体效应(MLR-BE),>22%为阳性,≤22%为阴性。分析TNF-α水平与MLR-BE的关系。结果20例患者TNF-α的平均浓度为(561.0±522.9)pg/ml,平均MLR-BE为(-6.5±37.6)%(阴性14例、阳性6例)。MLR-BE阴性患者的TNF-α水平为(676.1±585.0)pg/ml,显著高于MLR-BE阳性患者的(292.5±159.5)pg/ml(P0.05)。结论MLR-BE可能影响母体Th1/Th2的平衡,从而导致习惯性流产的发生。

关键词：习惯性流产封闭抗体肿瘤坏死因子-α 辅助性T细胞1型/2型阴性患者原因不明抗体活性封闭酶联免疫吸附试验 TNF-α