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STRUCTURAL PHASE TRANSITION OF ALIPHATIC NYLONS VIEWED FROM THE WAXD/SAXS AND VIBRATIONAL SPECTRAL MEASUREMENTS AND MOLECULAR DYNAMICS CALCULATION

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Chinese Journal of Polymer Science 2007年第1期25卷 73-82页

作者： kohji Tashiro Department of Future Industry-Oriented Basic Science and Materials Toyota Technological InstituteTempakuNagoya 468-8511Japan

The crystalline phase transition of aliphatic nylon 10/10 has been investigated on the basis of the simultaneous measurement of wide-angle and small-angle X-ray scatterings, the infrared spectral measurement and the molecular dynamics calculation. An interpretation of infrared spectra taken for a series of nylon samples and the corresponding model compounds was successfully made, allowing us to assign the infrared bands of the planar-zigzag methylene segments reasonably. As a result the methylene segmental parts of molecular chains were found to experience an order-to-disorder transition in the Brill transition region, where the intermolecular hydrogen bonds are kept alive although the bond strength becomes weaker at higher temperature. The small-angle X-ray scattering data revealed a slight change in lamellar stacking mode in the transition region. The crystal structure has been found to change more remarkably in the temperature region immediately below the melting point, where the conformationally disordered chains experienced drastic rotational and translational motions without any constraints by hydrogen bonds, and the lamellar thickness increased largely along the chain axis. These experimental results were reasonably reproduced by the molecular dynamics calculation performed at the various temperatures.

关键词： Aliphatic nylon Phase transition Wide-angle X-ray diffraction Small-angle X-ray scattering Computer simulation.

Experimental and numerical study on hydrodynamics of riparian vegetation

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Journal of Hydrodynamics 2014年第5期26卷 796-806页

作者： UOTANI Takuya KANDA Keiichi MICHIOKU kohji Kobe City Bureau KobeJapan Department of Civil Engineering Akashi National College of TechnologyAkashiJapan Department of Civil and Environmental Engineering Hosei UniversityShinjukuTokyoJapan

Recently, many channelized rivers tend to be heavily vegetated due to regime shifts in hydrological, fluvial and ecological processes. Dense vegetation in a river frequently obstructs a flood flow and reduces conveyance capacity of channels. On the other hand, river vegetation provides various ecological services such as habitats for various species and life, natural cycle of organic and inorganic substances, etc.. It is of engineering importance to understand vegetation hydrodynamics in order to preserve vegetation nature and keep a certain level of flow conveyance capacity. In view that willows tend to be densely vegetated along the shoreline of floodplains or sandbars, a field measurement, a physical model experiment and a numerical analysis were carried out for investigating hydrodynamics in an open channel with riparian vegetation. Discussion was made focusing on flow and shear layer structures developed around the vegetation canopy.

关键词： open channel riparian vegetation drag force velocity profile laboratory experiment hydrodynamic model

Multiple subcellular localizations and functions of protein kinase Cδ in liver cancer

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World Journal of Gastroenterology 2022年第2期28卷 188-198页

作者： kohji Yamada Kiyotsugu Yoshida Department of Biochemistry The Jikei University School of MedicineTokyo 105-8461Japan

Protein kinase Cδ(PKCδ)is a member of the PKC family,and its implications have been reported in various biological and cancerous processes,including cell proliferation,cell death,tumor suppression,and tumor *** liver cancer cells,accumulating reports show the bi-functional regulation of PKCδin cell death and ***δfunction is defined by various factors,such as phosphorylation,catalytic domain cleavage,and subcellular ***δhas multiple intracellular distribution patterns,ranging from the cytosol to the *** recently found a unique extracellular localization of PKCδin liver cancer and its growth factor-like function in liver cancer *** this review,we first discuss the structural features of PKCδand then focus on the functional diversity of PKCδbased on its subcellular localization,such as the nucleus,cell surface,and extracellular *** findings improve our knowledge of PKCδinvolvement in the progression of liver cancer.

关键词： Protein kinase Cδ Liver cancer Subcellular localization Tumor suppression Tumor progression

Rational therapeutic strategy for T2 gallbladder carcinoma based on tumor spread

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World Journal of Gastroenterology 2010年第28期16卷 3567-3572页

作者： Naohiko Kohya Kenji Kitahara kohji Miyazaki Departmen of Surgery Saga University Faculty of Medicine5-1-1 Nabeshi maSaga 849-8501Japan

AIM:To evaluate the adequacy of surgical treatment of T2 gallbladder carcinoma(GBCa)according to tumor spread in the subserosal layer. METHODS:A series of 84 patients with GBCa were treated at Saga University Hospital,Japan between April 1989 and October *** tumor stage was graded according to the TNM staging for GBCa from the American Joint Committee on Cancer Manual 6th edition. Tumor staging revealed 30 patients with T2 tumors.T2 GBCa was divided into three groups histologically by the extent of tumor spread in the subserosal layer,using a score of ss minimum(ss min),ss medium(ss med)or ss massive(ss mas). RESULTS:For ss min GBCa,there was no positive pathological factor and patient survival was satisfactory with simple cholecystectomy,with or without extra-he- patic bile duct *** ss med GBCa,some pathological factors,h-inf(hepatic infiltration),ly(lymphatic invasion)and n(lymph node metastasis),were positive. For ss mas GBCa,there was a high incidence of positive pathological *** patient group with extra-hepatic bile duct resection with D2 lymph node dissection (BDR with D2)and those with S4a5 hepatectomy had significantly better survival ***:We suggest that radical surgery is not necessary for ss min GBCa,and partial hepatectomy and BDR are necessary for both ss med and ss mas GBCa.

关键词： Hepatectomy Bile duct resection Gallbladder carcinoma Tumor spread

Regenerative medicine of cornea by cell sheet engineering using temperature-responsive culture surfaces

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Chinese Science Bulletin 2013年第35期58卷 4349-4356页

作者： UMEMOTO Terumasa YAMATO Masayuki NISHIDA kohji OKANO Teruo Institute of Advanced Biomedical Engineering and Science Tokyo Women’s Medical University Tokyo 162-8666 Japan Department of Ophthalmology Osaka University Medical School Osaka 565-0871 Japan

Recently,regenerative medicine has been focused on as next-generation definitive therapies for several diseases or injuries for which there are currently no effective *** therapies have been rapidly developed through the effective fusion between different fields such as stem cell biology and *** far,we have proposed"cell sheet engineering"through our core technology that simply applies alterations of the temperature which allows regulation of the attachment or detachment of living cells on the culture surfaces grafted with the temperature-responsive polymer"poly(N-isoproplyacrylamide)".This technology enables us to construct bioengineered sheet-like tissues,termed"cell sheets",without the need of using biodegradable scaffolds and protease treatments that are traditionally ***,our carrier-free cell sheets not only are independent of the issues observed in conventional methods,but also showed further advantages in the reconstruction of the corneal epithelium or endothelium(*** of optical transparency and cell-cell interactions to host stroma in reconstructed tissues).Moreover,our approach does not have issues such as immune rejection or limited number of donors,due to the use of cell sheets derived from autologous limbal(in patients with unilateral disease)or oral mucosal epithelial cells(in patients with bilateral disorders).Indeed,we have successfully performed the clinical application for the reconstruction of ocular surfaces through the transplantation of our carrier-free corneal epithelial cell sheets,as evidenced by improved visual acuity as well as long-term maintenance of postoperative health conditions on ocular surfaces in all *** have also proposed a novel approach for the reconstruction of the corneal endothelium using corneal endothelial cell sheets by demonstrating its successful ***,our cell sheet engineering technique provides a breakthrough in the field of regenerative medicine appli

关键词：干细胞生物学角膜上皮表面重建再生医学调节温度工程化反应性角膜内皮细胞

Gallbladder cancer: Clinical and pathological approach

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World Journal of Clinical Cases 2014年第10期2卷 515-521页

作者： Keita Kai Shinichi Aishima kohji Miyazaki Department of Pathology and Microbiology Faculty of Medicine Saga University Department of Pathology Saga University Hospital Department of Surgery Faculty of Medicine Saga University

Gallbladder cancer(GBC) shows a marked geographical variation in its incidence. Middle-aged and elderly women are more commonly affected. Risk factors for its development include the presence of gallstones, chronic infection and pancreaticobiliary maljunction. Controversy remains in regard to the theory of carcinogenesis from adenomyomatosis, porcelain gallbladder and adenoma of the gallbladder. The surgical strategy and prognosis after surgery for GBC differ strikingly according to T-stage. Discrimination of favorable cases, particularly T2 or T3 lesions, is useful for the selection of surgical strategies for individual patients. Although many candidate factors predicting disease progression, such as depth of subserosal invasion, horizontal tumor spread, tumor budding, dedifferentiation, Ki-67 labeling index, p53 nuclear expression, CD8+ tumor-infiltrating lymphocytes, mitotic counts, Laminin-5-gamma-2 chain, hypoxia-inducible factor-1a, cyclooxygenase-2 and the Hedgehog signaling pathway have been investigated,useful prognostic makers or factors have not been established. As GBC is often discovered incidentally after routine cholecystectomy and accurate preoperative diagnosis is difficult, close mutual cooperation between surgeons and pathologists is essential for developing a rational surgical strategy for GBC.

关键词： Gallbladder cancer Surgical strategy Pathology Prognostic factors

Hyperbaric oxygenation promotes regeneration of biliary cells and improves cholestasis in rats

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World Journal of Gastroenterology 2011年第17期17卷 2229-2235页

作者： Akihito Idetsu Taketoshi Suehiro kohji Okada Tatsuo shimura Hiroyuki Kuwano Department of General Surgical Science Gunma University Graduate School of Medicine 3-39-22 Showamachi Maebashi Gunma 371-8511 Japan

AIM:To investigate the effects of hyperbaric oxygenation(HBO) on regeneration of the biliary ductal system and postoperative cholestasis in hepatectomized ***:HBO was performed in Wistar rats daily starting 12 h after a 70% partial *** liver weight,serum parameters and the proliferating cell nuclear antigen labeling index of hepatocytes and biliary ductal cells were *** growth factor(HGF),c-Met and transforming growth factor(TGF) β-1 mRNA expression levels were analyzed by quantitative reverse transcription polymerase chain ***:HBO improved the postoperative serum levels of total bile acid but not transaminase *** promoted hepatocyte and biliary ductal cell *** hematoxylin and eosin-stained specimens revealed fewer ballooned hepatocytes and higher cell densities in the HBO group compared to the control *** suppressed c-Met mRNA levels at 15 h but did not modulate HGF or TGF β-1 mRNA expression levels.

关键词： Hyperbaric oxygenation Liver regeneration Partial hepatectomy Cholestasis Ballooning

Two -Dimensional Wavelength Selective Diffraction by High-Order Three-Dimensional Composite Grating

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光学学报 2003年第S1期23卷 295-296页

作者： kohji Furuhashi Hideaki Okayama Hirochika Nakajima School of Science and Technology Waseda University 3-4-1 Ohkubo Shinjyuku-ku Tokyo 169-8555 JapanSchool of Science and Technology Waseda University 3-4-1 Ohkubo Shinjyuku-ku Tokyo 169-8555 JapanOCC Oki Electric Industry Co. Ltd.School of Science and Technology Waseda University 3-4-1 Ohkubo Shinjyuku-ku Tokyo 169-8555 Japan

We propose a wavelength selective diffraction using reflectors placed on three-dimensional grid cross points. Different wavelengths are separated into spots distributed in two-dimensional plane. Compact device with hi... 详细信息

关键词： into with as by Dimensional Wavelength Selective Diffraction by High-Order Three-Dimensional Composite Grating Two high

Primary hepatic leiomyosarcoma with liver metastasis of rectal cancer

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World Journal of Gastroenterology 2012年第38期18卷 5479-5484页

作者： Kiyoto Takehara Hideki Aoki Yuko Takehara Rie Yamasaki kohji Tanakaya Hitoshi Takeuchi Department of Gastroenterological Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan Department of Surgery National Hospital Organization Iwakuni Clinical Center Yamaguchi 740-8510 Japan Department of Clinical Examination National Hospital Organization Iwakuni Clinical Center Yamaguchi 740-8510 Japan

Primary hepatic leiomyosarcoma is a particularly rare tumor with a poor prognosis. Curative resection is currently the only effective treatment, and the efficacy of chemotherapy is unclear. This represents the first case report of a patient with primary hepatic leiomyosarcoma co-existing with metastatic liver carcinoma. We present a 59-year-old man who was diagnosed preoperatively with rectal cancer with multiple liver metastases. He underwent a curative hepatectomy after a series of chemotherapy regimens with modified FOLFOX6 consisting of 5-fluorouracil, leucovorin and oxaliplatin plus bevacizumab, FOLFIRI consisting of 5-fluorouracil, leucovorin and irinotecan plus bevacizumab, and irinotecan plus cetuximab. One of the liver tumors showed a different response to chemotherapy and was diag-nosed as a leiomyosarcoma following histopathological examination. This case suggests that irinotecan has the potential to inhibit the growth of hepatic leiomyosarcomas. The possibility of comorbid different histological types of tumors should be suspected when considering the treatment of multiple liver tumors.

关键词： Leiomyosarcoma Rectal cancer Metastasis Chemotherapy Surgery