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Acta Oceanologica Sinica 2003年第1期22卷 111-122页

作者：曲宪成 Massaki Nagae Sinji Adachi kohei yamauchi Fisheries College Shanghai Fisheries University334 Jungong RoadShanghai 200090China Faculty of Environmental Studies Course of Environmental Conservation and PlanningNagasaki University1-14 Bunkyo-machiNagasaki 852-8521Japan Department of Biology Faculty of FisheriesHokkaido University3-1-1 Minato-choHakodate 041-0821Japan

In order to evaluate the involvement of the thyroid gland in reproduction, thyroid functioning was described in female cultivated Japanese eel (Anguilla japonica) in progressive stages of sexual maturation induced by chum salmon pituitary homogenate (SPH) treatment. Serum thyroid hormones, thyroxine (T4) and triiodothyronine (T3) were also measured in each stage. Thyroid gland activity (epithelial cell height) was high before SPH injection (previtellogenic stage), further increasing at the early vitellogenic stage, thereafter decreasing to late vitellogenic and migratory nucleus stages. The profiles of both T3 and T4 changed during vitellogenesis, being high during previtellogenic and early vitellogenic stages, and subsequently declining, thus mimicking thyroid gland activity. These results suggest that the thyroid has relation with eel ovarian development during artificial maturation.

关键词： Thyroid activity thyroxine (T4) triiodothyronine (T3) Japanese eel artificial maturation

Effect of estradiol-17β on pituitary-thyroidal axis of Japanese eel (Anguilla japonica)

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Acta Oceanologica Sinica 2001年第4期20卷 585-596页

作者：曲宪成 Fisheries College Shanghai Fisheries University 334 Jungong Road Shanghai 200090 China Department of Environmental Biology Faculty of Environmental Studies Nagasaki University Nagasaki 852-8521 Japan Department of Biology Faculty of Fisheries Hokkaido University 3-1-1 Minato-cho Hakodate 041-0821 Japan

The effect of estradiol-17β (E2)treatment on the pituitary-thyroidal axis has been investi- gated in female Japanese eels in seawater. The eels were injected with 1 mg/kg body weight (BW) weekly for two to eight weeks; another group was treated with 5 mg/kg BW weekly for eight weeks and sacrificed three days after the last injection. In the pituitary, using RT-PCR systern, the thyroid stim- ulating hormone 3 subunit mRNA (TSHβ MRNA) level is slowly increased in the low-dose E2 treatment group. A significant increase in values occurred after eight weeks E2 injections. The histological structure of the thyroid follicles suggests a hypo-activity as shown by a reduced epithelial cell height in eels injected with E2 after six and eight times, and eventually reached a minimum level after eight weeks. Using ra- dioimmunoassay of thyroxine (T4),triiodothyronine (T3) in the serum, a slowly decrease of both hor- mones is demonstrated. On the other hand, the TSHβ mRNA level is significantly increased from initial in the high-dose E2 treatment group. The histological structure of the thyroid follicles suggests a hypo- activity, and a sharp decrease of the both hormones is also indicated. These data suggest that the expres- sion of TSHβ mRNA level is increased and thyroid hormone release is depressed by E2, the effects de- pend upon E2 inection period and dose. Furthermore, E2 could not directly influence the TSHβ mRNA expression and, TSH transcription might be controlled by a negative feedback of thyroid hormone.

关键词： Thyroid activity thyroxine (T4) triiodothyronine (T3) Japanese eel RT-PCR

Effects of the 23-Valent Pneumococcal Polysaccharide Vaccine on the Mortality of Pneumonia among Elderly over 70 Years Old after the Great East Japan Earthquake—PPV Vaccination Program in Iwate Prefecture, Japan

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Advances in Infectious Diseases 2023年第2期13卷 216-226页

作者： Hiromi Nagashima Kozo Tanno Kiyomi Sakata Masachica Akiyama Yu Utsumi kohei yamauchi Department of Internal Medicine Iwate Medical University Yahaba Japan Department of Hygiene and Preventive Medicine Iwate Medical University Yahaba Japan Takizawa Central Hospital Takizawa Japan

Objective: To estimate the efficacy of 23-valent pneumococcal polysaccharide vaccine (PPSV23) among the elderly, we analyzed the relationship between the mortality of the elderly for pneumonia and the vaccination rate of PPSV23 from 2008 to 2016 in Iwate Prefecture, Japan. Study Design: The present study was a retrospective, observational, database study adopting an ecological design. The mortality for pneumonia among the elderly over 70 years old from 2006 to 2016 in Iwate Prefecture was calculated based on the data from the Japanese Vital Statistics. We compared the mortality rate (MR) of pneumonia among the elderly over 70 years old between the low-vaccinated period (LVP) (2006-2010) and high-vaccinated period (HVP) (2012-2016) using a Poisson regression model. Results: While the vaccination rate of PPSV23 among the elderly over 65 years old was 3.3% in 2010, it increased rapidly up to 40.7% in 2012 and reached 66.4% in 2016. The MR ratio of the total population during HVP to the average MR during LVP was 0.749. The MR of the total population during HVP was significantly lower than that during LVP (p Conclusion: The increase in vaccination rate of PPSV23 during HVP (2012-2016) may contribute to the decrease in mortality for pneumonia among the elderly over 70 years old in Iwate Prefecture.

关键词： PPSV23 Mortality of the Elderly for Pneumonia

Pyrin重组蛋白对支气管哮喘小鼠气道炎症的影响

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中华微生物学和免疫学杂志 2012年第2期32卷 102-107页

作者：延光海朴红梅安昌善山内广平延边大学医学部解剖学教研部延吉133002 延边大学附属医院呼吸内科延吉133002 日本岩手医科大学

目的探讨Pydn重组蛋白对支气管哮喘小鼠气道炎症的抑制作用及机制的研究。方法40只雄性清洁级BALB／c小鼠，随机分为4组，每组10只。分别为生理盐水对照组、卵蛋白（OVA）哮喘组、Pyrin重组蛋白治疗3d组和Pyrin重组蛋白治疗7d组。在末... 详细信息

目的探讨Pydn重组蛋白对支气管哮喘小鼠气道炎症的抑制作用及机制的研究。方法40只雄性清洁级BALB／c小鼠，随机分为4组，每组10只。分别为生理盐水对照组、卵蛋白（OVA）哮喘组、Pyrin重组蛋白治疗3d组和Pyrin重组蛋白治疗7d组。在末次激发24h后所有小鼠取左肺组织行苏木精．伊红（HE）染色，Masson三色染色；用图像分析软件测定支气管壁厚度（WAt／Pbm）、支气管平滑肌厚度（WAm／Pbm）及胶原纤维面积；用酶联免疫吸附法（ELISA）检测支气管肺泡灌洗液（bronchoalveolarlavage：fluid，BALF）中IL-4、IL-5、TNF—α及IFN-1含量；用RT—PCR检测肺组织中结缔组织生长因子（connectivetissuegrowthfactor，CTGF）和转化生长因子-β1（transforminggrowthfactor-61，TGF—β1）的mRNA表达；用Westernblot方法检测核转录因子（nuclearfactorkappaB，NF-KB）的表达。结果哮喘模型组小鼠BALF中细胞总数、IL4、IL-5、TNF-仪水平增高和IFN-1水平降低；肺组织支气管管壁厚度、气道平滑肌厚度、胶原纤维面积，CTGF、TGF-β1的转录和表达水平以及NF—κB表达水平均显著高于生理盐水对照组（P〈O．05）。Pyfin重组蛋白3d和7d干预组小鼠BALF中细胞总数、IL-4、IL-5、TNF-α水平和肺组织支气管管壁厚度、气道平滑肌厚度、胶原纤维面积、NF—κB表达水平显著降低，与哮喘模型组比较差异均具有统计学意义（P〈0．05），而BALF中IFN-γ水平明显上升，与哮喘模型组比较，差异均具有统计学意义（P〈O．05）；P州n重组蛋白7d干预组CTGF、TGF-β1的转录和表达水平显著低于哮喘组（P〈0．05）。结论我们推测Pyrin重组蛋白可能部分是通过抑制NF-κB信号途径来阻断TGF-β1和CTGF的过度表达而实现抑制气道炎症，进而抑制气道重构的发生。

关键词：支气管哮喘气道重构小鼠 Pyrin重组蛋白

Superconducting joints using reacted multifilament MgB_(2)wires:A technology toward cryogen-free MRI magnets

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Journal of Magnesium and Alloys 2024年第1期12卷 159-170页

作者： Dipak Patel Akiyoshi Matsumoto Hiroaki Kumakura Yuka Hara Toru Hara Minoru Maeda Hao Liang Yusuke yamauchi Seyong Choi Jung Ho Kim Md Shahriar A.Hossain School of Mechanical and Mining Engineering The University of QueenslandSt LuciaQueensland 4072Australia National Institute for Materials Science(NIMS) 1-2-1 SengenTsukubaIbaraki 305-0047Japan Department of Electrical Engineering and Kangwon High Magnetic Field Center Institute of Quantum Convergence TechnologyKangwon National UniversityGangwon 24341Republic of Korea Australian Institute for Bioengineering and Nanotechnology(AIBN) The University of QueenslandSt LuciaQueensland 4072Australia Department of Materials Process Engineering Graduate School of EngineeringNagoya UniversityNagoyaAichi 464-8603Japan Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongNorth WollongongNew South Wales 2500Australia

The development of superconducting joining technology for reacted magnesium diboride(MgB_(2))conductors remains a critical challenge for the advancement of cryogen-free MgB_(2)-based magnets for magnetic resonance imaging(MRI).Herein,the fabrication of superconducting joints using reacted carbon-doped multifilament MgB_(2)wires for MRI magnets is *** achieve successful superconducting joints,the powder-in-mold method was employed,which involved tuning the filament protection mechanism,the powder compaction pressure,and the heat treatment *** fabricated joints demonstrated clear superconducting-to-normal transitions in self-field,with effective magnetic field screening up to 0.5 T at 20 *** evaluate the interface between one of the MgB_(2)filaments and the MgB_(2)bulk within the joint,serial sectioning was conducted for the first time in this type of superconducting *** serial sectioning revealed space formation at the interface,potentially caused by the volume shrinkage associated with the MgB_(2)formation or the combined effect of the volume shrinkage and the different thermal expansion coefficients of the MgB_(2)bulk,the filament,the mold,and the sealing *** findings are expected to be pivotal in developing MgB_(2)superconducting joining technology for MRI magnet applications through interface engineering.

关键词： Mg B2 superconducting joint MgB_(2)conductor MRI applications Cryogen-free magnet Persistent-mode operation

Ageing Society and Assistive Products

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稀有金属材料与工程 2006年第A3期35卷 67-70页

作者： Shigeru yamauchi Department of Health Science and Social Welfare Faculty of Human Sciences Waseda UniversityMikajima 2-579-15TokorozawaSaitama 359-1192Japan

North East Asian countries are facing to rapid increase in aged population *** most recent values of aged population ratios are 19.5%,8.7%,and 6.9%,for Japan,Korea and China,*** of the welfare services in the aged society is provision of assistive *** control systems are commonly adopted in modern assistive products and sensors are indispensable for control *** systems,such as fire alarm,smoke detectors,and gas leak detectors,have been regarded as indispensable to safety of elderly persons and persons with *** application of chemical sensors in home care of elderly persons is in the field of personal care and personal medical *** for personal medical treatment include that for medical treatment in home care and that to keep elderly persons *** market is expected in the latter one.

关键词： population ageing assistive products long term care personal mental treatment

Species-dependent effects of the phenolic herbicide ioxynil with potential thyroid hormone disrupting activity: modulation of its cellular uptake and activity by interaction with serum thyroid hormone-binding proteins

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Journal of Environmental Sciences 2012年第5期24卷 949-955页

作者： Sakura Akiyoshi Gobun Sai Kiyoshi yamauchi Department of Biological Science Faculty of Science Shizuoka University

Ioxynil, a phenolic herbicide, is known to exert thyroid hormone （TH） disrupting activity by interfering with TH-binding to plasma proteins and a step of the cellular TH-signaling pathway in restricted animal species. However, comparative studies are still lacking on the TH disruption. We investigated the interaction of [125I] ioxynil with serum proteins from rainbow trout, bullfrog, chicken, pig, rat, and mouse, using native polyacrylamide gel electrophoresis. Candidate ioxynil-binding proteins, which included lipoproteins, albumin and transthyretin （TTR）, differed among the vertebrates tested. Rainbow trout and bullfrog tadpole serum had the lowest binding activity for ioxynil, whereas the eutherian serum had the highest binding activity. The cellular uptake of, and response to, ioxynil were suppressed by rat serum greater than by tadpole serum. The cellular uptake of [125I]ioxynil competed strongly with phenols with a single ring, but not with THs. Our results suggested that ioxynil interferes with TH homeostasis in plasma and with a step of cellular TH-signaling pathway other than TH-uptake system, in a species-specific manner.

关键词： endocrine disruption ioxynil thyroid hormone serum transthyretin uptake

Bin-scanning:Segmentation of X-ray CT volume of binned parts using Morse skeleton graph of distance transform

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Computational Visual Media 2023年第2期9卷 319-333页

作者： Yuta yamauchi Tatsuya Yatagawa Yutaka Ohtake Hiromasa Suzuki School of Engineering The University of Tokyo7–3–1HongoBunkyo-kuTokyoJapan

X-ray CT scanners,due to the transmissive nature of X-rays,have enabled the non-destructive evaluation of industrial products,even inside their *** light of its effectiveness,this study introduces a new approach to accelerate the inspection of many mechanical parts with the same shape in a *** input to this problem is a volumetric image(i.e.,CT volume)of many parts obtained by a single CT *** need to segment the parts in the volume to inspect each of them;however,random postures and dense contacts of the parts prohibit part segmentation using traditional template *** address this problem,we convert both the scanned volumetric images of the template and the binned parts to simpler graph structures and solve a subgraph matching problem to segment the *** perform a distance transform to convert the CT volume into a distance ***,we construct a graph based on Morse theory,in which graph nodes are located at the extremum points of the distance *** experimental evaluation demonstrates that our fully automatic approach can detect target parts appropriately,even for a heap of 50 ***,the overall computation can be performed in approximately 30 min for a large CT volume of approximately 2000×2000×1000 voxels.

关键词： X-ray computed tomography(CT) volume segmentation graph matching non-destructive inspection

Gas6-Tyro3 signaling is required for Schwann cell myelination and possible remyelination

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Neural Regeneration Research 2016年第2期11卷 215-216页

作者： Tomohiro Torii Junji yamauchi apan Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Bunkyo Tokyo lapan

Myelin plays important roles in vertebrates,ensuring the rapid propagation of action potentials and the long-term integrity of axons,but the molecular mechanisms of myelin formation remain poorly *** studies have demo... 详细信息

关键词： cell Gas6-Tyro3 signaling is required for Schwann cell myelination and possible remyelination LINGO

Study of Optical Fibers Strain-Temperature Sensitivities Using Hybrid Brillouin-Rayleigh System

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Photonic Sensors 2014年第1期4卷 1-11页

作者： Kinzo Kishida Yoshiaki yamauchi Artur Guzik Neubrex Co.Ltd. Sakaemachi-dori 1-1-24Chuo-kuKobeHyogo650-0023Japan

In this paper, the most recent progress as well as challenges of distributed optical fiber sensing （DOFS） in industrial applications is discussed. Compared to the vast market of sensors used to measure strain or temperature, the success of distributed optical fiber sensing （DOFS） at the industrial level is very limited, at best. One of the reasons for this lack of the wider acceptance is the mismatch between the commercially available systems and actual industrial requirements, especially for the spatial resolution and precision. These requirements are organized and clarified in the paper. It also describes the hybrid Brillouin-Rayleigh system, which exhibits capabilities surpassing those of strain gauges. The principles of the system are illustrated considering the fiber calibration methodology. Formulas required for determining strain, temperature, and hydro-pressure are derived and discussed. Finally, the examples of applications are presented.

关键词： Hybrid Brillouin/Rayleigh system cross-sensitivity material dependence