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Observations and modeling of the ice-ocean conditions in the coastal Chukchi and Beaufort Seas

Acta Oceanologica Sinica 2008年第3期27卷 79-87页

作者： JIN Meibing WANG Jia MIZOBATA kohei HU Haoguo SHIMADA Koji International Arctic Research Center University of Alaska Fairbanks AK 99775-7340 USA NOAA Great Lakes Environmental Research Laboratory Ann Arbor MI 48105 USA Tokyo University of Marine Science and Technology 4-5-7 Kounan Minato-ku Tokyo 108-8477 Japan Cooperative Institute for Limnology and Ecosystems Research School of Natural Resources and Environment University of MichiganAnn Arbor MI USA

The Chukchi and Beaufort Seas include several important hydrological features： inflow of the Pacific water, Alaska coast current （ ACC ）, the seasonal to perennial sea ice cover, and landfast ice ＇along the Alaskan coast. The dynamics of this coupled ice-ocean system is important for both regional scale oceanography and large-scale global climate change research. A mumber of moorings were deployed in the area by JAMSTEC since 1992, and the data revealed highly variable characteristics of the hydrological environment. A regional high-resolution coupled ice-ocean model of the Chukchi and Beaufort Seas was established to simulate the ice-ocean environment and unique seasonal landfast ice in the coastal Beaufort Sea. The model results reproduced the Beaufort gyre and the ACC. The depthaveraged annual mean ocean currents along the Beaufort Sea coast and shelf hreak compared well with data from four moored ADCPs, but the simulated velocity had smaller standard deviations, which indicate small-scale eddies were frequent in the region. The model resuits captured the sea,real variations of sea ice area as compared with remote sensing data, and the simulated sea ice velocity showed an ahnost stationary area along the Beaufort Sea coast that was similar to the observed landfast ice extent. It is the combined effects of the weak oceanic current near the coast, a prevailing wind with an onshore component, the opposite direction of the ocean current, and the blocking hy the coastline that make the Beaufort Sea coastal areas prone to the formation of landfast ice.

关键词： circulation sea ice fast ice Beaufort Sea coupled ice-ocean model

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A patient presenting painful chest wall swelling: Tietze syndrome

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World Journal of Emergency Medicine 2019年第2期10卷 122-124页

作者： kohei Sawada Hiromi Ihoriya Taihei Yamada Tetsuya Yumoto kohei Tsukahara Takaaki Osako Hiromichi Naito Atsunori Nakao Department of Emergency Critical Care and Disaster Medicine Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Dear editor,Patients frequently visit the emergency room with acute chest *** some potentially life-threatening disorders may cause the pain,in approximately 80%of cases,the chest pain source is benign,and musculoskeletal chest pain accounts for nearly 20%– 50%of those cases.^[1–6]Thus,pain caused by benign and pathological conditions of the chest wall encountered in the emergency department is sometimes incorrectly attributed to angina pectoris or pleuritic and other serious cardiopulmonary diseases.

关键词： Patients frequently emergency room life-threatening

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Intracellular and extracellular TGF-β signaling in cancer： some recent topics

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Frontiers of Medicine 2018年第4期12卷 387-411页

作者： kohei Miyazono Yoko Katsuno Daizo Koinuma Shogo Ehata Masato Morikawa Department of Molecular Pathology Graduate School of Medicine The University of Tokyo Bunkyo-ku Tokyo 113-0033 Japan

Transforming growth factor （TGF）-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively studied and well-characterized in many cancers, especially at early stages, accumulating evidence has revealed the critical roles of TGF-β as a pro-tumorigenic factor in various types of cancer. This review will focus on recent findings regarding epithelial-mesenchymal transition （EMT） induced by TGF-β, in relation to crosstalk with some other signaling pathways, and the roles of TGF-[~ in lung and pancreatic cancers, in which TGF-β has been shown to be involved in cancer progression. Recent findings also strongly suggested that targeting TGF-β signaling using specific inhibitors may be useful for the treatment of some cancers. TGF-β plays a pivotal role in the differentiation and function of regulatory T cells （Tregs）. TGF-β is produced as latent high molecular weight complexes, and the latent TGF-β complex expressed on the surface of Tregs contains glycoprotein A repetitions predominant （GARP, also known as leucine-rich repeat containing 32 or LRRC32）. Inhibition of the TGF-β activities through regulation of the latent TGF-β complex activation will be discussed.

关键词： TGF-β EMT lung cancer pancreatic cancer latent form immune function GARP

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Identification of sources of lead in the atmosphere by chemical speciation using X-ray absorption near-edge structure(XANES) spectroscopy

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Journal of Environmental Sciences 2014年第2期26卷 343-352页

作者： kohei Sakata Aya Sakaguchi Masaharu Tanimizu Yuichi Takaku Yuka Yokoyama Yoshio Takahashi Department of Earth and Planetary Systems Science Hiroshima University Kochi Institute for Core Sample Research Japan Agency for Marine-Earth Science and Technology Institute for Environmental Sciences

Sources of Pb pollution in the local atmosphere together with Pb species, major ions, and heavy metal concentrations in a size-fractionated aerosol sample from Higashi-Hiroshima （Japan） have been determined by X-ray absorption near-edge structure （XANES） spectroscopy, ion chromatography, and ICP-MS/AES, respectively. About 80% of total Pb was concentrated in fine aerosol particles. Lead species in the coarse aerosol particles were PbC204, 2PbCO3-Pb（OH）2, and Pb（NO3）2, whereas Pb species in the fine aerosol particles were PbC204, PbSO4, and Pb（NO3）2. Chemical speciation and abundance data suggested that the source of Pb in the fine aerosol particles was different from that of the coarse ones. The dominant sources of Pb in the fine aerosol particles were judged to be fly ash from a municipal solid waste incinerator and heavy oil combustion. For the coarse aerosol particles, road dust was considered to be the main Pb source. In addition to Pb species, elemental concentrations in the aerosols were also determined. The results suggested that Pb species in size-fractionated aerosols can be used to identify the origin of aerosol particles in the atmosphere as an alternative to Pb isotope ratio measurement.

关键词： lead lead speciation XAFS spectroscopy size-fractionated aerosol sample

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Feasibility of drug delivery to the eye’s posterior segment by topical instillation of PLGA nanoparticles

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Asian Journal of Pharmaceutical Sciences 2017年第4期12卷 394-399页

作者： kohei Tahara Keiichi Karasawa Risako Onodera Hirofumi Takeuchi Laboratory of Pharmaceutical Engineering Gifu Pharmaceutical University

We investigated the delivery of drugs to the posterior segment of the eye by non-invasive topical instillation using submicron-sized poly(D,L-lactide-co-glycolide)(PLGA) nanoparticles(NPs). Surface-modified PLGA NPs were developed to improve the drug delivery efficiency to the retina and were administered as topical eye drops to mice. Chitosan(CS) and glycol chitosan(GCS), which are mucoadhesive polymers, and polysorbate 80(P80) were used as surface modifiers, and have been reported to increase the association of NPs with ***-6 was used as a model drug and fluorescent marker, and after ocular administration of PLGA NP eye drops, the fluorescence intensity of coumarin-6 was observed in the retina. The fluorescence image analysis indicated that there are several possible routes to the retina and fates of PLGA NPs in ocular tissue, and that these pathways involved the corneal,non-corneal, or uveal routes. Delivery to the mouse retina segments after topical administration was increased by surface modification with CS, GCS, or P80. Surface-modified PLGA NPs are a promising method for retinal drug delivery via topical instillation.

关键词： PLGA Nanoparticles Topical instillation Retina Surface modification

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蒙古牧场植物群落的组成、分布和环境驱动因素

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Journal of Plant Ecology 2023年第3期16卷 108-118页

作者： kohei Suzuki Radnaakhand Tungalag Amartuvshin Narantsetseg Tsagaanbandi Tsendeekhuu Masato Shinoda Norikazu Yamanaka Takashi Kamijo Faculty of Life and Environmental Sciences University of TsukubaTsukubaJapan Department of Biology School of Arts and SciencesNational University of MongoliaUlaanbaatarMongolia Botanic Garden and Research Institute Mongolian Academy of ScienceUlaanbaatarMongolia Graduate School of Environmental Studies Nagoya UniversityNagoyaJapan Arid Land Research Center Tottori UniversityTottoriJapan

在蒙古,过度放牧和由此导致的牧场退化仍是比较严重的问题。为解决牧场退化问题,我们试图以区域特征对蒙古牧场群落进行广泛的植被分类;此外,我们试图阐明群落的空间分布和分布的环境驱动因素。在2012-2016年,我们调查了蒙古不同地区的... 详细信息

在蒙古,过度放牧和由此导致的牧场退化仍是比较严重的问题。为解决牧场退化问题,我们试图以区域特征对蒙古牧场群落进行广泛的植被分类;此外,我们试图阐明群落的空间分布和分布的环境驱动因素。在2012-2016年,我们调查了蒙古不同地区的278个地块(10 m×10 m)的植被,这些地块的放牧压力相对于邻近地区较低。使用改进的双向指示物种分析方法(TWINSPAN),将数据分组为植被单元。然后,我们探讨了物种组成和群落分布的区域特征,以及分布与气候变量之间的关系。改进的TWINSPAN将植被数据分为3个集群,每个集群对应一种特定类型的带状植被(即森林草原、草原和沙漠草原)。干旱指数被确定为所有集群分布的重要驱动因素,而经度和海拔是集群组内集群分布的重要决定因素。与东部地区相比,西部地区具有更高的海拔和大陆性特征,在最潮湿的季度平均气温和降水量较低,导致集群组内的物种组成存在差异。物种组成的区域差异反映了植物地理起源的差异。因此,蒙古牧场群落的物种组成和分布模式框架与气候和地理因素相关。

关键词：旱地草原改良的TWINSPAN 植被

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Current standard values of health utility scores for evaluating costeffectiveness in liver disease:A meta-analysis

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World Journal of Gastroenterology 2022年第31期28卷 4442-4455页

作者： Tomohiro Ishinuki Shigenori Ota kohei Harada Masaki Kawamoto Makoto Meguro Goro Kutomi Hiroomi Tatsumi Keisuke Harada Koji Miyanishi Toru Kato Toshio Ohyanagi Thomas T Hui Toru Mizuguchi Department of Nursing Surgical SciencesSapporo Medical UniversitySapporo 0608556Japan Departments of Surgery Surgical Science and OncologySapporo Medical UniversitySapporo 0608543Japan Department of Radiology Sapporo Medical UniversitySapporo 0608543Japan Departments of Surgery Nemuro City HospitalNemuro 0870008Japan Departments of Surgery Sapporo Satozuka HospitalSapporo 0040811Japan Department of Intensive Care Medicine Sapporo Medical UniversitySapporo 0608543Japan Department of Emergency Medicine Sapporo Medical UniversitySapporo 0608543Japan Department of Medical Oncology Sapporo Medical UniversitySapporo 0608543Japan Department of Liberal Arts and Sciences Center for Medical EducationSapporo Medical UniversitySapporo 0608556Japan Departments of Surgery Stanford University School of MedicineStanford94598United States

BACKGROUND Health utility assessments have been developed for various conditions,including chronic liver *** utility scores are required for socio-economic evaluations,which can aid the distribution of national ***,the standard health utility assessment scores for specific health conditions are largely *** To summarize the health utility scores,including the EuroQOL 5-dimensions 5-levels(EQ-5D-5L),EuroQol-visual analogue scale,short from-36(SF-36),RAND-36,and Health Utilities Index(HUI)-Mark2/Mark3 scores,for the normal population and chronic liver disease *** A systematic literature search of PubMed and MEDLINE,including the Cochrane Library,was ***-analysis was performed using the RevMan *** means and standard deviations were combined using the StatsToDo online web *** The EQ-5D-5L and SF-36 can be used for health utility evaluations during antiviral therapy for hepatitis ***-Mark2/Mark3 indicated that the health utility scores of hepatitis B patients are roughly 30% better than those of hepatitis C *** The EQ-5D-5L is the most popular questionnaire for health utility *** assessments that allow free registration would be useful for evaluating health utility in patients with liver disease.

关键词： Quality of life EuroQOL 5-dimensions 5-levels Short from-36 RAND-36 Health Utilities Index-Mark

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Millimeter-Wave Concurrent Beamforming:A Multi-Player Multi-Armed Bandit Approach

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Computers, Materials & Continua 2020年第12期65卷 1987-2007页

作者： Ehab Mahmoud Mohamed Sherief Hashima kohei Hatano Hani Kasban Mohamed Rihan Electrical Engineering Department College of EngineeringPrince Sattam Bin Abdulaziz UniversityWadi Addwasir11991Saudi Arabia Electrical Engineering Department Faculty of EngineeringAswan UniversityAswan81542Egypt Computational Learning Theory Team RIKEN-Advanced Intelligent ProjectFukuoka819-0395Japan Engineering Department Nuclear Research CenterEgyptian Atomic Energy AuthorityCairo13759Egypt Faculty of Arts and Science Kyushu UniversityFukuok819-0395Japan Electronics and Electrical Communication Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt

The communication in the Millimeter-wave(mmWave)band,i.e.,30~300 GHz,is characterized by short-range transmissions and the use of antenna beamforming(BF).Thus,multiple mmWave access points(APs)should be installed to fully cover a target environment with gigabits per second(Gbps)***,inter-beam interference prevents maximizing the sum rates of the established concurrent *** this paper,a reinforcement learning(RL)approach is proposed for enabling mmWave concurrent transmissions by finding out beam directions that maximize the long-term average sum rates of the concurrent ***,the problem is formulated as a multiplayer multiarmed bandit(MAB),where mmWave APs act as the players aiming to maximize their achievable rewards,i.e.,data rates,and the arms to play are the available beam *** this setup,a selfish concurrent multiplayer MAB strategy is *** different MAB algorithms,namely,ϵ-greedy,upper confidence bound(UCB),Thompson sampling(TS),and exponential weight algorithm for exploration and exploitation(EXP3)are examined by employing them in each AP to selfishly enhance its beam selection based only on its previous *** a few rounds of interactions,mmWave APs learn how to select concurrent beams that enhance the overall system *** proposed MAB based mmWave concurrent BF shows comparable performance to the optimal solution.

关键词： Millimeter wave(mmWave) concurrent transmissions reinforcement learning multiarmed bandit(MAB)

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Characterization of termetallic Pt-Ir-Au catalysts for NO decomposition

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Rare Metals 2011年第1期30卷 53-57页

作者： Akira Morikawa kohei Okumura Masaru Ishii Koichi Kikuta Akihiko Suda Hirofumi Shinjo Catalyst Lab. Toyota Central R&D Labs.Inc.41-1 YokomichiNagakuteNagakute-ChoAichi-GunAichi 480-1192Japan Vehicle Engineering Group Material Engineering Division ⅡToyota Motor Corporation1 Toyota-choToyotaAichi 471-8572Japan Department of Crystalline Materials Science School of EngineeringNagoya UniversityFuro-ChoChikusa-KuNagoyaAichi 464-8603Japan

A termetallic catalyst of Pt-Ir-Au/Al2O3 for NOx decomposition was prepared by loading the metallic colloids in C2H5OH-H2O solution and a surfactant of polyvinyl *** with an impregnated Pt/Al2O3 catalyst,the termetallic catalyst of PtIrAu811/Al2O3,with a Pt：Ir：Au atomic ratio of 8：1：1,exhibited higher NO decomposition and selectivity to *** electron microscopy and X-ray diffraction were conducted to clarify the state of the supported metals and indicate three precious metals alloyed on the *** the study of NO-temperature programmed desorption,oxygen desorption on the PtIrAu811 catalyst shifted to the low temperature side compared to that on Pt/Al2O3,which correlated well with its higher catalytic performance in NO decomposition.

关键词： catalysts iridium gold platinum decomposition nitrogen oxides

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Long-term health-related quality of life of living liver donors:what should the transplant team know?

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 394-396页

作者： kohei Ogawa Katsunori Sakamoto Yasutsugu Takada Department of Hepatobiliary Pancreatic and Breast Surgery Ehime UniversityShitsukawaToonEhimeJapan

Living-donor liver transplantation(LDLT)has been established as an alternative to deceased donor liver transplantation as a treatment option for patients with end-stage liver *** in Japan,where the number of deceased donor liver transplants is extremely small compared to Western countries,LDLT still accounts for the majority of liver transplants.

关键词： liver donor patients

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