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Robust topology optimization of multi-material lattice structures under material and load uncertainties

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Frontiers of Mechanical Engineering 2019年第2期14卷 141-152页

作者： Yu-Chin CHAN kohei SHINTANI Wei CHEN Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA

Enabled by advancements in multi-material additive manufacturing,lightweight lattice structures consisting of networks of periodic unit cells have gained popularity due to their extraordinary performance and wide array of *** work proposes a density-based robust topology optimization method for meso-or macroscale multi-material lattice structures under any combination of material and load *** method utilizes a new generalized material interpolation scheme for an arbitrary number of materials,and employs univariate dimension reduction and Gauss-type quadrature to quantify and propagate *** formulating the objective function as a weighted sum of the mean and standard deviation of compliance,the tradeoff between optimality and robustness can be studied and *** of a cantilever beam lattice structure under various material and load uncertainty cases exhibit the efficiency and flexibility of the *** accuracy of univariate dimension reduction is validated by comparing the results to the Monte Carlo approach.

关键词： robust topology optimization lattice structures multi-material material uncertainty load uncertainty univariate dimension reduction

Synthesis of Highly ordered Large Size Mesoporous Silica and Effect of Stabilization as Enzyme Supports in Organic Solvent

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Chemical Research in Chinese Universities 2002年第2期18卷 200-205页

作者： LI Bo Inagaki S miyazaki C Takahashi H Toyota Central R&D Labs. Inc.411YokomichiNagakute choAichi 4801192Japan

FSM 16, MCM 41 and SBA 15 types of hexagonal mesoporous silica with a highly ordered 2 dimensional structure were synthesized by using different silicon sources and surfactants. In the 2 dimensional silicate framework, pore size can be uniformly controlled by the combined use of the surfactants having different alkyl chain lengths and the swelling agents(triisopropyl benzene). The pore diameter of FSM 16 and MCM 41 can be expanded to be 10 nm, SBA 15 to be 15 nm. The crystal regularity was decreased with the increase of the pore diameter. In FSM 16 derived from kanemite(silicon source) and MCM 41 from water glass, their anionic characteristics on the pore wall may be stronger than those of SBA 15 derived from oligomeric tetramethoxysilane(TMOS). We have successfully used FSM 16 and MCM 41 to immobilize the enzyme having cationic residues below isoelectric point. The level of adsorption of enzymes in FSM 16 and MCM 41 was relatively high, but was low in SBA 15 support. The mechanism of enzyme to be adsorbed in mesoporous silica was suggested to be the ionic interactions. In aqueous solutions, horseradish peroxidase(HTP) was immobilized in FSM 16 with 8.9 nm mesopores and the highest loading amount(183 mg/mg FSM) was obtained, but for the FSM 16 of pore diameter 30 nm only an amount of 28 mg/mg FSM was obtained. The catalytic activity in the organic solvent was high when HRP was immobilized in FSM 16 and MCM 41, but it was low in case of SBA 15.

关键词： Mesoporous silica Surfactant Swelling agent Enzyme Activity

肝静脉压力梯度微创时代:基于前臂静脉入路的探索

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中华肝脏病杂志 2024年第1期32卷 35-39页

作者：王继涛李雷牛猛朱清亮赵中伟 kohei Kotani Akira Yamamoto 张海军李双喜徐丹康宁李小果张昆鹏孙骏吴发宗张海龙刘登湘吕沐瀚纪建松 Norifumi Kawada 徐克祁小龙河北省肝硬化门静脉高压重点实验室河北医科大学附属邢台市人民医院邢台054000 兰州大学第一医院介入科兰州730000 中国医科大学附属第一医院介入科沈阳110000 西南医科大学附属医院消化内科泸州646000 丽水市中心医院介入诊疗中心丽水323000 日本大阪市立大学医院肝病科日本大阪日本大阪市立大学医学院放射介入科日本大阪东南大学附属中大医院门静脉高压中心南京210009

目的经颈静脉或经股动脉途径被用作当前实践中肝静脉压力梯度(HVPG)测量的常用方法。该研究旨在证实经前臂静脉途径测量HVPG的安全性和有效性。方法针对2020年9月至2020年12月前瞻性地从中国和日本的6所医院招募了经前臂静脉进行HVPG检... 详细信息

目的经颈静脉或经股动脉途径被用作当前实践中肝静脉压力梯度(HVPG)测量的常用方法。该研究旨在证实经前臂静脉途径测量HVPG的安全性和有效性。方法针对2020年9月至2020年12月前瞻性地从中国和日本的6所医院招募了经前臂静脉进行HVPG检测肝硬化患者,并收集患者的临床基线资料以及HVPG检测数据。入组患者均选择经右侧肘正中静脉或贵要静脉入路,采用HVPG标准化流程进行测压。研究数据采用SPSS 22.0统计学软件进行分析。定量资料采用中位数(四分位数间距)表示,定性资料采用频数和率表示。两组数据之间的相关性分析采用Pearson相关性分析。结果研究共入组43例患者,其中41例(95.3%)患者成功接受了经前臂静脉途径HVPG检测。无患者出现任何严重并发症。经前臂静脉途径HVPG检测中位操作时间为18.0min(12.3~38.8min)。研究证实HVPG与Child-Pugh评分(r=0.47,P=0.002)、白蛋白-胆红素评分(r=0.37,P=0.001)、Lok指数(r=0.36,P=0.02)、肝脏硬度(r=0.58,P=0.01)、脾硬度(r=0.77,P=0.01)呈正相关,且与白蛋白呈负相关(r=-0.42,P=0.006)。结论多中心回顾性研究结果提示经前臂静脉途径HVPG测量是安全可行的。

关键词：肝硬化肝静脉压力梯度前臂静脉

Identification of county-level health factors associated with COVID-19 mortality in the United States

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The Journal of Biomedical Research 2020年第6期34卷 437-445,I0014页

作者： Wei Pan Yasuo miyazaki Hideyo Tsumura Emi miyazaki Wei Yang School of Nursing Duke UniversityDurhamNC 27710USA Department of Population Health Sciences School of MedicineDuke UniversityDurhamNC 27708USA School of Education Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA School of Community Health Sciences University of NevadaRenoNV 89557USA.

Many studies have investigated causes of COVID-19 and explored safety measures for preventing COVID-19 ***,these studies fell short to address disparities in health status and resources among decentralized communities in the United *** this study,we utilized an advanced modeling technique to examine complex associations of county-level health factors with COVID-19 mortality for all 3141 counties in the United *** results indicated that counties with more uninsured people,more housing problems,more urbanized areas,and longer commute are more likely to have higher COVID-19 *** on the nationwide population-based data,this study also echoed prior research that used local data,and confirmed that county-level sociodemographic factors,such as more Black,Hispanic,and older subpopulations,are attributed to high risk of COVID-19 *** hope that these findings will help set up priorities on high risk communities and subpopulations in future for fighting the novel virus.

关键词： COVID-19 mortality health factors health disparity hierarchical generalized linear model

Experimental and Modeling Investigation of Shallow Water Table Fluctuations in Relation to Reverse Wieringermeer Effect

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Open Journal of Soil Science 2011年第2期1卷 17-24页

作者： Ibrahimi Mohamed Khaled miyazaki Tsuyoshi Nishikawa kohei Nishimura Taku Imoto Hiromi 不详

Soil column experiments and modeling investigations were performed to study the behavior of shallow water table in response to various recharge events. Hence, shallow water table fluctuations inside sandy (Toyoura sand) and clayey (Chiba light clay) soil columns in response to surface and sub-surface recharge events were investigated under laboratory conditions. Experimental results showed that small application of water could raise the shallow water table level more than 100 times in depth in the case of Toyoura sand and more than 50 times in the case of Chiba LiC, reflecting a reverse Wieringermeer effect (RWE) response type of groundwater. This rise was associated with a prompt change of pressure head values which exhibited instantaneous fluctuations of centimeters due to the addition of millimeters of water. The recharge volumes leading to such disproportionate water table rise were successfully estimated using a simple analytical model based on the moisture retention curve of the soil and considering the hysteresis effect on soil water dynamics within the capillary fringe zone.

关键词： Groundwater Fluctuation Shallow Water Table Reverse Wieringermeer Effect Capillary Fringe

Flow and geochemical modeling of drainage from Tomitaka mine,miyazaki,Japan

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Journal of Environmental Sciences 2015年第10期27卷 130-143页

作者： kohei Yamaguchi Shingo Tomiyama Hideya Metugi Hiroyuki Ii Akira Ueda Mitsubishi Materials Corporation 1-297 KitabukuroOmiyaSaitama 330-0835Japan Mitsubishi Materials Techno Corporation 1-14-16 KudankitaChiyoda-kuTokyo 102-8205Japan Faculty of Systems Engineering Wakayama University Japan Oil Gas and Metals National Corporation Graduate School Division of Science and Engineering University of Toyama

The chemistry and flow of water in the abandoned Tomitaka mine of miyazaki, western Japan were investigated. This mine is located in a non-ferrous metal deposit and acid mine drainage issues from it. The study was undertaken to estimate the quantities of mine drainage that needs to be treated in order to avoid acidification of local rivers, taking into account seasonal variations in rainfall. Numerical models aimed to reproduce observed water levels and fluxes and chemical variations of groundwater and mine drainage. Rock–water interactions that may explain the observed variations in water chemistry are proposed. The results show that：（1） rain water infiltrates into the deeper bedrock through a highly permeable zone formed largely by stopes that are partially filled with spoil from excavations（ore minerals and host rocks）;（2） the water becomes acidic（p H from 3 to 4） as dissolved oxygen oxidizes pyrite;（3） along the flow path through the rocks, the redox potential of the water becomes reducing, such that pyrite becomes stable and p H of the mine drainage becomes neutral; and（4） upon leaving the mine, the drainage becomes acidic again due to oxidation of pyrite in the rocks. The present numerical model with considering of the geochemical characteristics can simulate the main variations in groundwater flow and water levels in and around the Tomitaka mine, and apply to the future treatment of the mine drainage.

关键词： Mine drainage Hydrogen isotope Oxygen isotope Rock–water interaction Water movement

Fabrication of Co2Fe（Al,Si） and Co2Fe（Al,Si）/MgO on Ge（111） Substrate and Its Magnetic Properties

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Journal of Electronic Science and Technology 2019年第2期17卷 109-115页

作者： kohei Kataoka Nobuki Tezuka Masashi Matsuura Satoshi Sugimoto Graduate School of Engineering Tohoku University

We investigated the interfacial effects on magnetic properties in Co2Fe(Al,Si)/Ge (CFAS/Ge) and CFAS/MgO/Ge systems to demonstrate the effects of the interface structure on magnetic properties. CFAS and CFAS/MgO were deposited on the i-Ge(111) substrate. In-situ reflection high energy electron diffraction (RHEED) patterns showed epitaxially grown CFAS and MgO on Ge(111). According to the X-ray diffraction (XRD)φ-scan of CFAS(220), we determined that the crystallographic orientation relationships were CFAS(111)//Ge(111) and CFAS(111)//MgO(111) Ge(111). The magnetic properties were measured by the vibrating sample magnetometer (VSM) and the saturation magnetization Ms value of CFAS with 2-nm thick MgO reached the value of L21 ordered one. A uniaxial magnetic anisotropy behavior was observed both in CFAS/Ge and CFAS/MgO/Ge structures after annealing. We confirmed the behavior did not only originate from the CFAS/Ge interface but also CFAS/MgO and the ordering structure.

关键词： Co2Fe(Al,Si) full-heusler alloy magnetic anisotropy

A predictive factor for the response to S-1 plus cisplatin in gastric cancer

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World Journal of Gastroenterology 2010年第36期16卷 4575-4582页

作者： Ikuko miyazaki Takashi Kawai Youji Harada Fuminori Moriyasu Department of Gastroenterology and Hepatology Tokyo Medical University Hospital6-7-1 Nishi-ShinjukuShinjuku-kuTokyo 160-0023Japan Endoscope Center Tokyo Medical University Hospital6-7-1 Nishi-ShinjukuShinjuku-kuTokyo 160-0023Japan Department of Gastroenterology Toda Chuo General Hospital1-19-3 HonchoToda-shiSaitama 335-1132Japan

AIM:To prove that the protein expression level of thymidylate synthase is a predictive factor for the response to S-1/cisplatin(CDDP)chemotherapy in gastric ***:We measured the protein expression levels of thymidylate synthase(TS),dihydropyrimidine dehydrogenase(DPD),and orotate phosphoribosyltrans-ferase(OPRT)in advanced gastric *** S-1/CDDP chemotherapy,tumor specimens from primary sites were obtained by endoscopic biopsy and analyzed by enzyme-linked immunosorbent *** chemo-therapeutic effects on the primary sites were evaluated by endoscopic biopsy performed more than once after S-1/CDDP *** effects are a predictive factor for the response to S-1/CDDP chemotherapy inpatients with advanced gastric cancer,as evaluated by endoscopic biopsy over ***:The protein expression level of TS was significantly higher(P40 ng/mg ***:We have confirmed that the protein expression level of TS is a predictive factor for the response to S-1/CDDP chemotherapy in patients with advanced gastric cancer.

关键词： Gastric cancer Thymidylate synthase Dihy-dropyrimidine dehydrogenase Orotate phosphoribosyl-transferase Biopsy

Microstructures of Ti-48%Ni shape memory melt-spun ribbons

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中国有色金属学会会刊：英文版 2006年第B1期16卷 92-95页

作者：邢鸿雁 H.Y.KIM S.miyazaki College of Mechanical Engineering Tianjin University of Science and TechnologyTianjin 300222China Institute of Materials Science University of TsukubaTsukuba 305-8573Japan

The effect of wheel speed on microstructures of Ti-48%Ni (mole fraction) melt-spun ribbons was investigated by X-ray diffractometry, scanning electron microscopy and transmission electron microscopy. When the wheel speed is 26 and 42 m/s, the as-spun ribbons are completely crystallized to the Ti-Ni B2 phase. The Ti-rich plate precipitates lying on {100} planes are observed in the as-spun ribbon fabricated with a wheel speed of 26 m/s. The spherical Ti2Ni precipitates are observed at grain boundaries in the as-spun ribbons fabricated with a wheel speed of 42 m/s. Amorphous and B2 phases coexist in the as-spun ribbon fabricated with a wheel speed of 52 m/s. The uniformity of grain size in heat treated ribbons decreases with increasing wheel speed.

关键词：形状记忆合金钛-镍薄膜显微结构快淬