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Harnessing a T1 Phage-Derived Spanin for Developing Phage-Based Antimicrobial Development

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BioDesign Research 2024年第1期6卷 28-38页

作者： Wakana Yamashita Shinjiro Ojima Azumi Tamura Aa Haeruman Azam kohei Kondo Zhang Yuancheng Longzhu Cui Masaki shintani Masato Suzuki Yoshimasa Takahashi Koichi Watashi Satoshi Tsuneda Kotaro Kiga Research Center for Drug and Vaccine Development National Institute of Infectious DiseasesTokyo 162-8640Japan Department of Life Science and Medical Bioscience Waseda University2-2 Wakamatsu-choShinjuku-kuTokyo 162-8480Japan Division of Infectious Diseases Advanced Clinical Research CenterThe Institute of Medical ScienceThe University of TokyoTokyo 108-8639Japan Antimicrobial Resistance Research Center National Institute of Infectious DiseasesTokyoJapan Division of Bacteriology Department of Infection and ImmunitySchool of MedicineJichi Medical UniversityShimotsuke-shiTochigi 329-0498Japan Department of Engineering Graduate School of Integrated Science and TechnologyShizuoka University3-5-1 JohokuNaka-kuHamamatsuShizuoka432-8561Japan Phage Therapy Institute Comprehensive Research OrganizationWaseda University2-2 Wakamatsu-choShinjuku-kuTokyo 162-8480Japan

The global increase in the prevalence of drug-resistant bacteria has necessitated the development of alternative treatments that do not rely on conventional antimicrobial *** bacteriophage-derived lytic enzymes in antibacterial therapy shows promise;however,a thorough comparison and evaluation of their bactericidal efficacy are *** study aimed to compare and investigate the bactericidal activity and spectrum of such lytic enzymes,with the goal of harnessing them for antibacterial ***,we examined the bactericidal activity of spanins,endolysins,and holins derived from 2 Escherichia coli model phages,T1 and *** these,T1-spanin exhibited the highest bactericidal activity against ***,we expressed T1-spanin within bacterial cells and assessed its bactericidal activity.T1-spanin showed potent bactericidal activity against all clinical isolates tested,including bacterial strains of 111 ***,2 Acinetobacter spp.,3 Klebsiella spp.,and 3 Pseudomonas *** contrast,T1 phage-derived endolysin showed bactericidal activity against *** and ***,yet its efficacy against other bacteria was inferior to that of ***,we developed a phage-based technology to introduce the T1-spanin gene into target *** synthesized non-proliferative phage exhibited strong antibacterial activity against the targeted *** potent bactericidal activity exhibited by spanins,combined with the novel phage synthetic technology,holds promise for the development of innovative antimicrobial agents.

关键词： development antimicrobial developing harnessing phage-based phage-derived spanin

DOING META-ANALYSIS IN SLA:PRACTICES,CHOICES,AND STANDARDS

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当代外语研究 2012年第12期384卷 1-17页

作者： SHAOFENG LI NATSUKO shintani ROD ELLIS University of Auckland Nanyang Technological University

Meta-analysis is a statistical method used to synthesize the cumulative effect of an interventional treatment or a certain relationship that has been subjected to empirical *** the increasing popularity of meta-analysis in second language acquisition(SLA)research,there is considerable methodological inconsistency in the 22SLA meta-analyses published to ***,given the highly technical nature of some aspects of this statistical procedure and the specialized knowledge associated with it,it is a daunting task to conduct a meta-analysis and understand or interpret meta-analytic *** paper seeks to solve the conundrum surrounding metaanalysis by explicating its basic procedure and technical aspects in an accessible *** SLA meta-analyses as examples,it discusses the methodological options of each stage of a meta-analysis,makes recommendations about how to handle some key issues,and points out the pitfalls that might undermine the robustness and credibility of meta-analytic findings.

关键词：英语教学教学方法课堂教学阅读教学

Web Block Extraction System Based on Client-Side Imaging for Clickable Image Map

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通讯和计算机（中英文版） 2013年第6期10卷 815-822页

作者： Hiroyuki Sano Shun Shiramatsu Tadachika Ozono Toramatsu shintani Department of Computer Science and Engineering Graduate School of Engineering Nagoya Institute of Technology Aichi466-8555 Japan

Anti-Inflammatory and Immunostimulatory Effects of Extract from Culture of Effective Microorganisms (ECEM) Revealed by Functional Genomics and Metabolome Analyses

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Food and Nutrition Sciences 2015年第12期6卷 1115-1125页

作者： Masaki shintani Fusako Mitsunaga Shun Shimabukuro Shin Nakamura EM Research Organization Inc. Kitanakagusuku Japan Intelligence and Technology Lab Inc. Kaizu Japan Biomedical Institute NPO Primate Agora Inuyama Japan

The extract from culture of effective microorganisms (ECEM) is a secondary metabolite produced in symbiotic culture of a mixture of yeasts and lactic bacteria followed by photosynthetic bacteria. Metabolomics studies have demonstrated that ECEM contained several active ingredients associated with anti-inflammation through interactions with nuclear factor-κB. Functional genomics using DNA microarrays revealed that ECEM had distinctive anti-inflammatory and immunostimulatory actions in RAW264.7 cells. ECEM inhibited the LPS-upregulated expression of one group of pro-inflammatory genes (iNos, Il6 and Cox2) but not another group genes (Tnf, Ccl7 and Dusp2);it also upregulated the expression of Cd1d1, which participates in antigen presentation on lipids, resulting in activation of natural killer T (NKT) cells related to infection defense and cancer. Bacterial glycosylated lipid and other related complex lipids in ECEM are thought to trigger this upregulation of Cd1d1 expression. These results suggest that ECEM functions in the immune response in both inflammation and antigen presentation and that it contains components important for these functions. These novel effects of ECEM could be invaluable for developing functional drinks or health beverages.

关键词： DNA Microarray Secondary Metabolites iNos Il6 Cd1d1

Electrochemical Behavior of Stainless Steel under High-Temperature and High-Pressure Methanol Solution Containing Oxygen and Chloride Ions

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材料科学与工程（中英文B版） 2011年第7期1卷 861-870页

作者： Daisuke shintani Toshio Ishida Yoshiaki Matsuo Yosohiro Sugie Kimura Chemical Plant Co. Ltd 2-1-2 Terashima Kuise Amagasaki Hyogo 660-8567 Japan School of Engineering Department of Materials Science and Engineering University of Hyodo 2167 Shosha Himeji Hyogo 671-2280 Japan

Review of literature: Role of 5-aminolevulinic acid and sleep

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World Journal of Neuroscience 2013年第4期3卷 307-312页

作者： Michael H. Perez Beatriz L. Rodriguez Terry T. shintani Terry T. shintani Rosanne C. Harrigan Department of Complementary and Alternative Medicine John A. Burns School of Medicine University of Hawaii Manoa USA

Objective: To determine if current peer-reviewed literature supports the existence of a relationship between the administration of dietary supplements containing 5-Aminolevulinic Acid (5-ALA) and sleep. Methods: Conceptual analysis of a systematically defined group of data is based on publications in referred journals. Constant comparative analyses were used to analyze the data. Detailed analyses were used to identify trends that led to qualifying relationships between the use of 5-ALA and heme. In addition, the relationship among heme, melatonin, and sleep were explored. Since there were no published data related to 5-ALA and sleep, an analysis of what is known about 5-ALA and heme was undertaken. Results: Currently, within the scope of this review, no literature available directly connecting 5-ALA and sleep was found. Research indicates that 5-ALA has an indirect relationship with intra-cellular energy production, which could result in a wide range of effects fromcellular to endocrine to neurologic to behavioral. In addition, there is evidence that 5-ALA may influence tryptophan and serotonin levels. Conclusion: While there are no studies on 5-ALA and sleep were found, current research suggests several potential mechanisms by which 5-ALA could influence sleep. The mechanisms suggest the potential for 5-ALA to assist in the adjustment of a person’s circadian cycle, endocrine function, or neurologic function in order to allow for better sleep in a natural way. In doing so, it may provide for a safer alternative to currently available sleep medication. Further research is needed to explore this possibility.

关键词： Insomnia Heme Melatonin Energy Metabolism 5-Aminolevulinic Acid Sleep

Linked Data-based Slide Repository： The Episodic Slide Retrieval Using the Episodic Keyword Networks

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Journal of Control Science and Engineering 2016年第1期4卷 36-49页

作者： Tomohiro Iwasa Yudai Kato Shun Shiramatsu Tadaehika Ozono Toramatsu shintani Department of Computer Science and Engineering Graduate School of Engineering Nagoya Institute of Technology Gokiso-choShowa-ku Nagoya Aichi 466-8555 Japan

This paper focuses on developing a system that allows presentation authors to effectively retrieve presentation slides for reuse from a large volume of existing presentation materials. We assume episodic memories of the authors can be used as contextual keywords in query expressions to efficiently dig out the expected slides for reuse rather than using only the part-of-slide-descriptions-based keyword queries. As a system, a new slide repository is proposed, composed of slide material collections, slide content data and pieces of information from authors＇ episodic memories related to each slide and presentation together with a slide retrieval application enabling authors to use the episodic memories as part of queries. The result of our experiment shows that the episodic memory-used queries can give more discoverability than the keyword-based queries. Additionally, an improvement model is discussed on the slide retrieval for further slide-finding efficiency by expanding the episodic memories model in the repository taking in the links with the author-and-slide-related data and events having been post on the private and social media sites.

关键词： Slide Retrieval Linked Data-based Slide Repository Episodic Keyword Networks Linked Data episodic memories social media life event.

Computational Study for the Aromatic Nucleophilic Substitution Reaction on 1-Dimethylamino-2,4-bis(trifluoroacetyl)-naphthalene with Amines

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International Journal of Organic Chemistry 2018年第3期8卷 273-281页

作者： Norio Ota Tomohiro Nakada Takumi shintani Yasuhiro Kamitori Etsuji Okada Department of Chemical Science and Engineering Graduate School of Engineering Kobe University Kobe Japan

Our previous research showed that aliphatic amines were put in order of high reactivity as “ethylamine > ammonia > t-butylamine > diethylamine” on the aromatic nucleophilic substitution of 1-dimetylamino-2,4-bis(trifluoroacetyl)-naphthalene 1 in acetonitrile. The DFT calculation study (B3LYP/6-31G* with solvation model) for the reactions of 1 with above four amines rationally explained the difference of each amines reactivity based on the energies of their Meisenheimer complexes 3 which are assumed to formed as the reaction intermediates in the course of the reaction giving the corresponding N-N exchange products 2. Intramolecular hydrogen bond between amino proton in 1-amino group and carbonyl oxygen in 2-trifluoroacetyl group stabilizes Meisenheimer complexes 3 effectively, and accelerates the substitution reaction from 1 to 2. Our calculation results also predicted that the above order of amines is also true if less polar toluene is used as a solvent instead of acetonitrile even though more enhanced conditions are required.

关键词： 1-Amino-2 4-bis(trifluoroacetyl)naphthalenes Aliphatic Amines Meisenheimer Complexes Aromatic Nucleophilic Substitution DFT Calculation

Saliva protein profiles to identify oral cancer patients

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中国口腔颌面外科杂志 2008年第B5期6卷 80-81页

作者： Satoru shintani Hiroshi Hatori Takahiko Toyoshima Yoshiya Ueyama Hiroyuki Hamakawa Department of Oral & Maxillofacial Surgery Showa Univ. School of Dentistrt Tokyo JAPAN Department of Oral & Maxillofacial Surgery Yamaguchi Univ. School of Medicine Yarnaguchi Japan Department of Oral & Maxillofacial Surgery Showa Univ. School of Medicine Ehime Japan