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Preoperative blood circulation modification prior to pancreaticoduodenectomy in patients with celiac trunk occlusion:Two case reports

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World Journal of Gastrointestinal Surgery 2022年第11期14卷 1310-1319页

作者： Marco Colella kohei mishima Taiga Wakabayashi Yoshiki Fujiyama Malek A Al-Omari Go Wakabayashi Center for Advanced Treatment of HBP Diseases Ageo Central General HospitalAgeo 362-8588SaitamaJapan

BACKGROUND Celiac trunk stenosis or occlusion is a common condition observed in patients undergoing pancreaticoduodenectomy(PD).The risk of upper abdominal organ ischemia or failure increases if the blood circulation in the celiac arterial system is not maintained after the surgery.CASE SUMMARY We present two cases of elderly patients with distal cholangiocarcinoma and celiac trunk occlusion who underwent PD.We performed blood circulation modification preoperatively with transcatheter coil embolization of the arterial arcades of the pancreatic head via the superior mesenteric artery to develop collateral communication between the superior mesenteric artery and the common hepatic or splenic arteries to ensure arterial blood flow to the upper abdominal organs.The postoperative course was marked by delayed gastric emptying,but no major surgical complications,such as biliary or pancreatic fistula,or clinical,biochemical,or radiological evidence of ischemic disease,was observed.CONCLUSION Preoperative blood circulation modification may be a valid alternative procedure for elderly patients with celiac trunk occlusion who are ineligible for interventional or surgical revascularization.

关键词： Preoperative blood circulation modification Cholangiocarcinoma Pancreaticoduodenectomy Whipple procedure Celiac trunk occlusion Atherosclerosis Transcatheter coil embolization Case report

Helicobacter cinaedi bacteremia with cellulitis after ABO-incompatible living-donor liver transplantation: Case report

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World Journal of Gastroenterology 2015年第25期21卷 7911-7915页

作者： kohei mishima Hideaki Obara Kayoko Sugita Masahiro Shinoda Minoru Kitago Yuta Abe Taizo Hibi Hiroshi Yagi Kentaro Matsubara Takehiko Mori Yaoko Takano Hiroshi Fujiwara Osamu Itano Naoki Hasegawa Satoshi Iwata Yuko Kitagawa Department of Surgery Keio University School of Medicine Center for Infectious Diseases and Infection Control Keio University School of Medicine Division of Hematology the Department of Medicine Keio University School of Medicine Department of Infectious Diseases Keio University School of Medicine

Helicobacter cinaedi(H. cinaedi), a Gram-negative spiral-shaped bacterium, is an enterohepatic nonHelicobacter pylori Helicobacter species. We report the first case of H. cinaedi bacteremia with cellulitis after liver transplantation. A 48-year-old male, who had been a dog breeder for 15 years, underwent ABO-incompatible living-donor liver transplantation for hepatitis C virus-induced decompensated cirrhosis using an anti-hepatitis B core antibody-positive graft. The patient was preoperatively administered rituximab and underwent plasma exchange twice to overcome blood type incompatibility. After discharge, he had been doing well with immunosuppression therapy comprising cyclosporine, mycophenolate mofetil, and steroid according to the ABO-incompatible protocol of our institution. However, 7 mo after transplantation, he was admitted to our hospital with a diagnosis of recurrent cellulitis on the left lower extremity, and H. cinaedi was detected by both blood culture and polymerase chain reaction analysis. Antibiotics improved his symptoms, and he was discharged at day 30 after admission. Clinicians should be more aware of H. cinaedi in immunocompromised patients, such as ABO-incompatible transplant recipients.

关键词： Helicobacter cinaedi Bacteremia Cellulitis Liver transplantation Hepatitis C Living-donor ABOincompatible HBc-Ab-positive donor

Current perspectives of viral

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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： Daisuke Usuda Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami EriNakajima Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki ShintaroShimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro mishima Akihiko Kondo KeikoMizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of death.The five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral therapies.There remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver disease.Furthermore,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’complications.In 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral hepatitis.Today,treatment is sufficiently able to prevent the disease from reaching advanced phases.However,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral hepatitis.This review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives

Identifying visual sensitive areas:an evaluation of view corridors to support nature-culture heritage conservation in Chiang Mai historic city

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Built Heritage 2022年第4期6卷 15-34页

作者： Janjira Sukwai Nobuo mishima Nattasit Srinurak Graduate School of Science and Engineering Saga University1 Honjo-machiSaga 840-8502Japan. Urban Design and Environmental Studies Center SRIChiang Mai University239 SuthepChiang Mai 50230Thailand.

The visual integrity of mountains contributing to cultural landscapes as nature-culture attributes is often obscured by the vertical intrusive built environment,especially in bufer areas of protected heritage zones.Therefore,this study argued that even low/medium-rise buildings that inappropriately appear in the horizontal visual plane could be a factor increasing sensitivity to this panoramic view.An integrative tool–visual sensitivity assessment–consists of Viewshed and Skyline analysis considering the pedestrian’s visual limitation in identifying the sensitive areas of the mountain view corridor in the historic city of Chiang Mai.The visible mountain areas(VMAs)were determined as a baseline,and their relationship with the visible building areas(VBAs)was then examined using statistical correlation to defne a strong negative relationship as the visual sensitive areas in fve zones.The results showed that the bufer zone was found to have more areas with visual sensitivity values,but this varies depending on the characteristics of buildings and the assessment from the view corridor.Meanwhile,in height-restricted areas,such as historic area zone 5,there are some concerns about the visual intrusion,which necessitates continuous monitoring using the assessment result as a guideline.Incorporating the results into implementation could support cultural landscape conservation in Chiang Mai city.The method is applicable in historic cities with similar settings to produce the baseline for the built environment that is harmonious with the cultural and historical characteristics of the city and with respect to its broader setting.

关键词： Nature-culture heritage conservation Mountain view corridor Visual sensitivity assessment Intrusive built environment Visual integrity

Precipitation of Icosahedral Quasicrystalline Phase, R-phase and Laves Phase in Ferritic Alloys

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材料热处理学报 2004年第5期25卷 229-233页

作者： Keisuke Yamamoto Yoshisato Kimura Yoshinao mishima Department of Materials Science and Engineering Tokyo Institute of Technology Yokohama JapanDepartment of Materials Science and Engineering Tokyo Institute of Technology Yokohama JapanDepartment of Materials Science and Engineering Tokyo Institute of Technology Yokohama Japan

Ferritic heat resistant steels involving precipitation of intermetallic phases have drawn a growing interest for the enhancement of creep strength, while the brittleness of the intermetallic phases may lower the toughness of the alloy. Therefore, it is necessary to optimize the dispersion characteristics of the intermetallics phase through microstructural control to minimize the trade-off between the strength and toughness. The effects of -Fe matrix substructures on the precipitation sequence, morphology, dispersion characteristics, and the stability of the intermetallic phases are investigated in Fe-Cr-W-Co-Si system. The precipitates of the Si-free Fe-10Cr-l.4W-4.5Co (at%) alloy aged at 873K are the R-phase but those of the Si-added Fe-10Cr-l.4W-4.5Co-0.3Si (at%) alloy are the icosahedral quasicrystalline phase. The precipitates in both the Si-free and Si-added alloys aged at 973K are the Laves phase. Matrix of the alloys is controlled by heat treatments as to provide three types of matrix substructures; ferrite, ferrite/martensite mixture and martensite. The hardening behavior of the alloys depends on the matrix substructures and is independent of the kinds of precipitates. In the alloys with ferrite matrix, the peak of hardness during aging at 873K shifts to longer aging time in comparison with that in the alloys with lath martensite matrix which contain numbers of nucleation sites.

关键词：过渡电子扫描仪准晶体 R相拉夫斯相铁素体钢

Numerical Analysis on Temperature Distribution in a Single Cell of PEFC Operated at Higher Temperature by1D Heat Transfer Model and 3D Multi-Physics Simulation Model

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Energy and Power Engineering 2023年第5期15卷 205-227页

作者： Akira Nishimura Kyohei Toyoda Daiki mishima Eric Hu Division of Mechanical Engineering Graduate School of Engineering Mie University Tsu Japan

This study is to understand the impact of operating conditions, especially initial operation temperature (Tini) which is set in a high temperature range, on the temperature profile of the interface between the polymer electrolyte membrane (PEM) and the catalyst layer at the cathode (i.e., the reaction surface) in a single cell of polymer electrolyte fuel cell (PEFC). A 1D multi-plate heat transfer model based on the temperature data of the separator measured using the thermograph in a power generation experiment was developed to evaluate the reaction surface temperature (Treact). In addition, to validate the proposed heat transfer model, Treact obtained from the model was compared with that from the 3D numerical simulation using CFD software COMSOL Multiphysics which solves the continuity equation, Brinkman equation, Maxwell-Stefan equation, Butler-Volmer equation as well as heat transfer equation. As a result, the temperature gap between the results obtained by 1D heat transfer model and those obtained by 3D numerical simulation is below approximately 0.5 K. The simulation results show the change in the molar concentration of O2 and H2O from the inlet to the outlet is more even with the increase in Tini due to the lower performance of O2 reduction reaction. The change in the current density from the inlet to the outlet is more even with the increase in Tini and the value of current density is smaller with the increase in Tini due to the increase in ohmic over-potential and concentration over-potential. It is revealed that the change in Treact from the inlet to the outlet is more even with the increase in Tini irrespective of heat transfer model. This is because the generated heat from the power generation is lower with the increase in Tini due to the lower performance of O2 reduction reaction.

关键词： PEFC Heat Transfer Model Temperature Distribution Numerical Simulation High Temperature Operation

Impact of Separator Thickness on Temperature Distribution in Single Polymer Electrolyte Fuel Cell Based on 1D Heat Transfer

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Energy and Power Engineering 2022年第7期14卷 248-273页

作者： Akira Nishimura Daiki mishima Nozomu Kono Kyohei Toyoda Mohan Lal Kolhe Mie University Tsu Japan

It is known from the New Energy and Industry Technology Development Organization (NEDO) roam map Japan, 2017 that the polymer electrolyte fuel cell (PEFC) power generation system is required to operate at 100°C for application of mobility usage from 2020 to 2025. This study aims to clarify the effect of separator thickness on the distribution of the temperature of reaction surface (Treact) at the initial temperature of cell (Tini) with flow rate, relative humidity (RH) of supply gases as well as RH of air surrounding cell of PEFC. The distribution of Treact is estimated by means of the heat transfer model considering the H2O vapor transfer proposed by the authors. The relationship between the standard deviation of Treact-Tini and total voltage obtained in the experiment is also investigated. We can know the effect of the flow rate of supply gas as well as RH of air surrounding cell of PEFC on the distribution of Treact-Tini is not significant. It is observed the wider distribution of Treact-Tini provides the reduction in power generation performance irrespective of separator thickness. In the case of separator thickness of 1.0 mm, the standard deviation of Treact-Tini has smaller distribution range and the total voltage shows a larger variation compared to the other cases.

关键词： Polymer Electrolyte Fuel Cell Heat Transfer Modeling H2O Vapor Transfer Temperature Distribution High Temperature

Obligate aerobic, gram-positive, weak acid-fast, nonmotile bacilli, Tsukamurella tyrosinosolvens: Minireview of a rare opportunistic pathogen

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World Journal of Clinical Cases 2022年第24期10卷 8443-8449页

作者： Daisuke Usuda Risa Tanaka Makoto Suzuki Shintaro Shimozawa Hayabusa Takano Yuta Hotchi Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima-ku 177-8521TokyoJapan Department of Medicine Juntendo UniversityBunkyo-ku 113-8421TokyoJapan

Tsukamurella species are obligate aerobic,gram-positive,weak acid-fast,nonmotile bacilli.They are found in various environments,such as soil,water,sludge,and petroleum reservoir wastewater,and belong to the order Actinomycetales.In 2016,there was a reclassification of species within the genus Tsukamurella,merging the species Tsukamurella tyrosinosolvens(T.tyrosinosolvens)and Tsukamurella carboxydivorans.Tsukamurella species are clinically considered to be a rare opportunistic pathogen,because most reported cases have been related to bacteremia and intravascular prosthetic devices and immunosuppression.To date,it has been isolated only from human specimens,and has always been associated with clinical disease;human infections are very rare.Reported infections have included pneumonia,brain abscesses,catheter-related bloodstream infections,ocular infections,bacteremia,and sepsis presenting with septic pulmonary emboli in patients who are immunocompromised.To date,there is no commercially available test for identification.On the other hand,sequence-based identification,including matrix-assisted laser desorption ionization time-of-flight mass spectrometry,is an alternative method for identifying clinical isolates that are either slow growers or difficult to identify through biochemical profiling.The golden standards for diagnosis and optimal management still remain to be determined.However,newer molecular biological techniques can provide accurate identification,and contribute to the appropriate selection of definitive therapy for infections caused by this organism.Combinations of several antimicrobial agents have been proposed for treatment,though the length of treatment for infections has yet to be determined,and should be individualized according to clinical response.Immunocompromised patients often experience severe cases due to infection,and life-threatening T.tyrosinosolvens events associated with dissemination and/or failure of source control have occurred.Favorable prognoses can be achieved through earlier iden

关键词： Tsukamurella tyrosinosolvens Gram-positive bacilli Opportunistic infection Sequence-based identification Matrix-assisted laser desorption ionization time-of-flight mass spectrometry Combination antibiotic therapy

Effects of binder strength and aggregate size on the compressive strength and void ratio of porous concrete

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International Journal of Minerals,Metallurgy and Materials 2009年第6期16卷 714-719页

作者： P. Chindaprasirt S. Hatanaka N. mishima Y. Yuasa T. Chareerat Department of Civil Engineering Faculty of Engineering Khon Kaen University Department of Architecture Faculty of Engineering Mie University Industrial Research Division Mie Prefecture Science and Technology Promotion Center Department of Civil and Environmental Engineering Faculty of Science and Engineering Kasetsart University

To test the influence of binder strength, porous concretes with 4 binder strengths between 30.0-135.0 MPa and 5 void ratios between 15%-35% were tested. The results indicated that for the same aggregate, the rates of strength reduction due to the increases in void ratio were the same for binders with different strengths. To study the influence of aggregate size, 3 single size aggregates with nominal sizes of 5.0, 13.0 and 20.0 mm （Nos. 7, 6 and 5 according to JIS A 5001） were used to make porous concrete. The strengths of porous concrete are found to be dependent on aggregate size. The rate of strength reduction of porous concrete with small aggregate size is found to be higher than that with larger aggregate size. At the same void ratio, the strength of porous concrete with large aggregate is larger than that with small aggregate. The general equations for porous concrete are related to compressive strength and void ratio for different binder strengths and aggregate sizes.

关键词： cement paste porous concrete compressive strength void ratio