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Iatrogenic giant pseudomeningocele of the cervical spine:A case report

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World Journal of Clinical Cases 2021年第31期9卷 9686-9690页

作者： koh-woon kim Jae-Heung Cho Department of Korean Medicine Rehabilitation College of Korean MedicineKyung Hee UniversitySeoul 02447South Korea

BACKGROUND Only a few cases of giant pseudomeningoceles have been reported in the ***,we report a giant pseudomeningocele of the cervical spine that was found after cervical laminectomy for an epidural hematoma following epidural *** SUMMARY A 47-year-old man presented with recurrent neck pain and posterior neck swelling after spinal *** resonance imaging of the cervical spine revealed fluid collection(5.6 cm×6.6 cm×11.2 cm)at the C3-6 level;this proved to be a *** related to the pseudomeningocele resolved following dural repair and fat graft *** Although rare,pseudomeningocele is a possibility in patients with recurrent back pain,radicular pain,or a persistent headache following spinal *** attention should be paid throughout the spinal procedure,whether conservative or non-conservative.

关键词： Iatrogenic spinal pseudomeningocele Giant pseudomeningocele Cervical spine C3-6 level Cervical laminectomy Case report

Effect of modified fasting therapy on body weight, fat and muscle mass, and blood chemistry in patients with obesity

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Journal of Traditional Chinese Medicine 2016年第1期36卷 57-62页

作者： koh-woon kim Mi-Yeon Song Seok-Hee Chung Won-Seok Chung Department of Korean Rehabilitation Medicine College of Korean Medicine Kyung Hee University

OBJECTIVE: The aim of this study was to investigate the effects and safety of modified fasting therapy using fermented medicinal herbs and exercise on body weight, fat and muscle mass, and blood chemistry in obese ***: Twenty-six patients participated in a14-day fast, during which they ingested a supplement made from fermented medicinal herbs and carbohydrates(intake: 400-600 kcal/d). The schedule included 7 prefasting relief days and 14 days of stepwise reintroduction of food. The patients also took part in an exercise program that incorporated Qigong, weight training, and walking exercises. The efficacy of treatments was observed by assessing body fat mass and muscle mass, and alanine aminotransferase(ALT), aspartate aminotransferase(AST),cholesterol, and triglycerides in each study *** symptoms or side effects were ***: Body weight and body fat mass both decreased significantly by(5.16 ± 0.95) and(3.89 ±0.79) kg(both P < 0.05), while muscle mass decreased by an average of(0.26 ± 0.22) kg, without statistical significance. ALT levels were significantly decreased(P < 0.05), while AST levels decreased without statistical significance(P = 0.052). The levels of total cholesterol and triglycerides were also significantly decreased(both P < 0.05). There were few adverse events except for mild dizziness, which did not affect everyday ***: These results suggest that modified fasting therapy using fermented medicinal herbs and exercise could be effective and safe on obese patients.

关键词： Obesity Fasting Houttuynia Cordata Saururus Chinensis Exercise Blood chemicalanalysis Medicine, Korean traditional

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum Jun kim Seungyon koh Hyo Jin Cho Xuelian Jin Byung Gon kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Translocator protein 18 kDa(TSPO): old dogma, new mice, new structure, and new questions for neuroprotection

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Neural Regeneration Research 2015年第6期10卷 878-880页

作者： Eun-Jung kim Seong-woon Yu Department of Brain and Cognitive Science Daegu Gyeongbuk Institute of Science and Technology (DGIST)

The normal development and optimal functioning of the brain requires a vigilant immune surveillance system to detect and remove potential risk factors and prevent infection and tissue damage. Microglia are the resident immune cells and the frontline defenders responsible for the immune response of the brain. Resting microglia possess a ramified morphology with numerous thin processes that continuously sample the environment. In response to inflammatory signals, microglia become activated and transform their morphology into a thick, amoeboid-like shape. Activated microglia proliferate, tolerate to sites of iniurv,

关键词： TSPO old dogma Translocator protein 18 kDa new mice new structure

Seroprevalence of anti-HAV among patients with chronic viral liver disease

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World Journal of Gastroenterology 2011年第2期17卷 236-241页

作者： Hyun Chin Cho Seung woon Paik Yu Jin kim Moon Seok Choi Joon Hyeok Lee Kwang Cheol koh Byung Chul Yoo Hee Jung Son Seon Woo kim Division of Gastroenterology Samsung Medical CenterSungkyunkwan University School of Medicine Division of Gastroenterology Center for Health PromotionSamsung Medical CenterSungkyunkwan University School of Medicine Biostatics Team Samsung Medical CenterSungkyunkwan University School of Medicine

AIM:To investigate the current seroprevalence of hepatitis A virus(HAV) antibodies in patients with chronic viral liver disease in *** also tried to identify the factors affecting the prevalence of HAV antibodies. METHODS:We performed an analysis of the clinical records of 986 patients(mean age:49±9 years,714 males/272 females) with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection who had undergone HAV antibody testing between January 2008 and December ***:The overall prevalence of IgG anti-HAV was 86.61%(854/986) in patients with chronic liver disease and was 88.13%(869/986) in age-and gendermatched patients from the Center for Health *** anti-HAV prevalence was 80.04%(405/506) in patients with chronic hepatitis B,86.96%(20/23) in patients with chronic hepatitis C,93.78%(422/450) in patients with HBV related liver cirrhosis,and 100%(7/7) in patients with HCV related liver *** anti-HAV prevalence according to the decade of age was as follows:20s(6.67%) ,30s(50.86%) ,40s(92.29%) ,50s(97.77%) ,and 60s(100%) .The antiHAV prevalence was significantly higher in patients older than 40 years compared with that in patients younger than 40 years of *** analysis showed that age≥40 years,female gender and metropolitan cities as the place of residence were independent risk factors for IgG anti-HAV seropositivity. CONCLUSION:Most Korean patients with chronic liver disease and who are above 40 years of age have already been exposed to hepatitis A virus.

关键词： Chronic hepatitis B Chronic hepatitis C Hepatitis A virus Korea Seroprevalence

Image enhancement with intensity transformation on embedding space

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 101-115页

作者： Hanul kim Yeji Jeon Yeong Jun koh Department of Applied Artificial Intelligence Seoul National University of Science and TechnologySeoulSouth Korea Department of Computer Science and Engineering Chungnam National UniversityDaejeonSouth Korea

In recent times,an image enhancement approach,which learns the global transformation function using deep neural networks,has gained ***,many existing methods based on this approach have a limitation:their transformation functions are too simple to imitate complex colour transformations between low-quality images and manually retouched high-quality *** order to address this limitation,a simple yet effective approach for image enhancement is *** proposed algorithm based on the channel-wise intensity transformation is ***,this transformation is applied to the learnt embedding space instead of specific colour spaces and then return enhanced features to *** this end,the authors define the continuous intensity transformation(CIT)to describe the mapping between input and output intensities on the embedding ***,the enhancement network is developed,which produces multi-scale feature maps from input images,derives the set of transformation functions,and performs the CIT to obtain enhanced *** experiments on the MIT-Adobe 5K dataset demonstrate that the authors’approach improves the performance of conventional intensity transforms on colour space ***,the authors achieved a 3.8%improvement in peak signal-to-noise ratio,a 1.8%improvement in structual similarity index measure,and a 27.5%improvement in learned perceptual image patch ***,the authors’algorithm outperforms state-of-the-art alternatives on three image enhancement datasets:MIT-Adobe 5K,Low-Light,and Google HDRþ.

关键词： computer vision deep learning image enhancement image processing

Fatigue strength evaluation of self-piercing riveted joints of AZ31 Mg alloy and cold-rolled steel sheets

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Journal of Magnesium and Alloys 2020年第1期8卷 241-251页

作者： Se-Hyung Kang Dong-woon Han Ho-Kyung kim Graduate School Seoul National University of Science and TechnologySeoul01811South Korea Department of Mechanical and Automotive Engineering Seoul National University of Science and TechnologySeoul01811 South Korea

The application of magnesium alloys to automobiles is increasing due to their superior specific strength and specific *** this study,an upper sheet of AZ31 magnesium alloy and a lower sheet of cold-rolled steel were joined by self-piercing riveting(SPR),a method commonly used to join automotive panels.A cross-shaped specimen was fabricated with a punching force of 35 kN,which exhibited the best joint strength for the SPR joint specimen *** and fatigue strengths were evaluated using cross-shaped specimens at loading angles of 0°,45°,and 90°.The load amplitude corresponding to the fatigue endurance limit was assumed to be at 106 cycles,and the fatigue ratios(=fatigue endurance limit/static strength)at the loading angles of 0°,45°,and 90°are 22%,13%,and 9%,*** all three loading angle specimens,fatigue cracks initiated at the triple point where the rivet shank,the upper sheet and the lower sheet are in contact with each other,with the cracks propagating through the thickness of the upper sheet and ultimately leading to *** fatigue lifetimes were evaluated through the von-Mises stress,maximum principal stress,and equivalent stress intensity *** was found that the fatigue lifetimes could be evaluated most appropriately through the maximum principal stress.

关键词： Self-piercing riveting Magnesium alloy Fatigue strength Maximum principal stress Fatigue lifetime

Tenofovir rescue therapy for chronic hepatitis B patients after multiple treatment failures

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World Journal of Gastroenterology 2012年第47期18卷 6996-7002页

作者： Yu Jin kim Dong Hyun Sinn Geum-Youn Gwak Moon Seok Choi Kwang Cheol koh Seung woon Paik Byung Chul Yoo Joon Hyeok Lee Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135-710South Korea

AIM:To evaluate the efficacy and safety of tenofovir disoproxil fumarate(TDF) for chronic hepatitis B(CHB) patients after multiple ***:A total of 29 CHB patients who had a suboptimal response or developed resistance to two or more previous nucleoside/nucleotide analogue(NA) treatments were *** subjects were treated with TDF alone(n = 13) or in combination with lamivudine(LAM,n = 12) or entecavir(ETV,n = 4) for ≥ 6 *** virologic response(CVR) was defined as an achievement of serum hepatitis B virus(HBV) DNA level ≤ 60 IU/mL by real-time polymerase chain reaction method during *** assessment was based on serum creatinine and phosphorus *** patients had histories of LAM and adefovir dipivoxil(ADV) treatment and 18 patients were exposed to LAM,ADV,and ***-seven patients(93.1%) were hepatitis B e antigen(HBeAg) positive and the mean value of the baseline serum HBV DNA level was 5.5 log IU/mL ± 1.7 log IU/*** median treatment duration was 16 mo(range 7 to 29 mo).RESULTS:All the patients had been treated with LAM and developed genotypic and phenotypic resistance to *** to ADV was present in 7 patients and 10 subjects had a resistance to *** patient had a resistance to both ADV and *** cumulative probabilities of CVR at 12 and 24 mo of TDF containing treatment regimen calculated by the Kaplan Meier method were 86.2% and 96.6%,*** one patient failed to achieve CVR,serum HBV DNA level decreased by 3.9 log IU/mL from the baseline and the last serum HBV DNA level during treatment was 85 IU/mL,achieving near *** patients in this study showed viral breakthrough or primary non-response during the follow-up *** cumulative probability of HBeAg clearance in the 27 HBeAg positive patients was 7.4%,12%,and 27% at 6,12,and 18 mo of treatment,*** efficacy of TDF containing regimen was not statistically different according to the presence of specific HBV mutatio

关键词： Tenofovir Chronic hepatitis B Treatment failure

Discovery of Zr-based metal-organic polygon:Unveiling new design opportunities in reticular chemistry

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Nano Research 2021年第2期14卷 392-397页

作者： Jiyeon kim Dongsik Nam Hiroshi Kitagawa Dae-woon Lim Wonyoung Choe Department of Chemistry Ulsan National Institute of Science and Technology50 UNIST-gilUlsan 44919Republic of Korea Department of Chemistry Graduate School of ScienceKyoto UniversityKitashirakawa Oiwake-choSakyo-kuKyoto 606-8502Japan Department of Chemistry and Medical Chemistry College of Science and TechnologyYonsei University1 Yonseidae-gilWonjuGangwon-do 26493Republic of Korea

Metal-based secondary building unit and the shape of organic ligands are the two crucial factors for determining the final topology of metal-organic materials.A careful choice of organic and inorganic structural building units occasionally produces unexpected structures,facilitating deeper fundamental understanding of coordination-driven self-assembly behind metal-organic ***,we have synthesized a triangular metal-organic polygon(MOT-1),assembled from bulky tetramethyl terephthalate and Zr-based secondary building ***,the Zr-based secondary building unit serves as an unusual ditopic Zr-connector,toform metal-organic polygon MOT-1,proven to be a good candidate for water adsorption with *** study highlights the interplay of the geometrically frustrated ligand and secondary building unit in controlling the connectivity of metal-organic *** a strategy can be further used to unveil a new class of metal-organic materials.

关键词： reticular chem istry Zr-based metal-organic polygon geometrical frustration ditopic secondary building unit