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Developmental impacts and toxicological hallmarks of silver nanoparticles across diverse biological models

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Environmental Science and Ecotechnology 2024年第3期19卷 60-79页

作者： y.n Wāng y.peng Han De-Xiang Xu Department of Toxicology School of Public Health&Key Laboratory of Environmental Toxicology of Anhui Higher Education InstitutesAnhui Medical UniversityHefei230032China

Silver nanoparticles(AgNPs),revered for their antimicrobial prowess,have become ubiquitous in a range of products,from biomedical equipment to food ***,amidst their rising popularity.concerns loom over their possible detrimental effects on fetal development and subsequent adult *** review delves into the developmental toxicity.of AgNPs across diverse models,from aquatic species like zebrafish and catfish to mammalian rodents and in vitro embry.nic stem *** focus encompasses the fate of AgNPs in different contexts,elucidating associated hazardous results such as embry.toxicity.and adverse pregnancy.***,we scrutinize the enduring adverse impacts on offspring,spanning impaired neurobehavior function,reproductive disorders,cardiopulmonary.lesions,and *** hallmarks of developmental harm are identified,encompassing redox imbalances,inflammatory.cascades,DNA damage,and mitochondrial ***,we explore potential explanations,linking immunoregulatory.dy.function and disrupted epigenetic modifications to AgNPsinduced developmental *** substantial progress,our understanding of the developmental risks posed by.AgNPs remains incomplete,underscoring the urgency.of further research in this critical area.

关键词： Silver nanoparticles(AgNPs) Developmental toxicity Maternal exposure Fetal development Redox imbalance Mitochondrial dy.function

Molecular insights of exercise therapy.in disease prevention and treatment

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2564-2597页

作者： David Walzik Tiffany.y.Wences Chirino Philipp Zimmer Niklas Joisten Division of Performance and Health(Sports Medicine) Institute for Sport and Sport ScienceTU Dortmund University44227 DortmundNorth Rhine-WestphaliaGermany Division of Exercise and Movement Science Institute for Sport ScienceUniversity of Göttingen37075 GöttingenLower SaxonyGermany

Despite substantial evidence emphasizing the pleiotropic benefits of exercise for the prevention and treatment of various diseases,the underly.ng biological mechanisms have not been fully.*** exercise benefits have been attributed to signaling molecules that are released in response to exercise by.different tissues such as skeletal muscle,cardiac muscle,adipose,and liver *** signaling molecules,which are collectively.termed exerkines,form a heterogenous group of bioactive substances,mediating inter-organ crosstalk as well as structural and functional tissue *** scientific endeavors have focused on identify.ng and characterizing new biological mediators with such ***,some investigations have focused on the molecular targets of exerkines and the cellular signaling cascades that trigger adaption processes.A detailed understanding of the tissue-specific downstream effects of exerkines is crucial to harness the health-related benefits mediated by.exercise and improve targeted exercise programs in health and ***,we review the current in vivo evidence on exerkine-induced signal transduction across multiple target tissues and highlight the preventive and therapeutic value of exerkine signaling in various *** emphasizing different aspects of exerkine research,we provide a comprehensive overview of(i)the molecular underpinnings of exerkine secretion,(ii)the receptor-dependent and receptor-independent signaling cascades mediating tissue adaption,and(iii)the clinical implications of these mechanisms in disease prevention and treatment.

关键词： prevention treatment collective

Adherence to Phy.ical Measures during the SARS-COV2 Pandemic by.Haemodialy.is Patients in a Burkina Faso Tertiary.Hospital: A Cross-Sectional Survey

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Open Journal of Nephrology 2024年第3期14卷 375-385页

作者： Bonzi y. Juste Zoehinga Patrice Sourabie Oumar Kabore D. Dieudonne Hien Siebou Sawadogo Amidou Coulibaly.Gerard Departement of Nephrology.and Haemodialy.is Yalgado Oudraogo Teaching Hospital Ouagadougou Burkina Faso Health Sciences Training and Research Unit Joseph KI-ZERBO University Departement of Nephrology.and Haemodialy.is Ouahigouya Regional Teaching Hospital Ouahigouya Burkina Faso Departement of Psy.hiatry Souro Sanou Teaching Hospital Bobo Dioulasso Burkina Faso Departement of Medical Oncology Yalgado Oudraogo Teaching Hospital Ouagadougou Burkina Faso Health Sciences Training and Research Unit of Lda Bernard Oudraogo University Ouahigouya Burkina Faso

Context: COVID-19 can spread rapidly.in haemodialy.is centres, leading to fatal outcomes. Implementing phy.ical measures is crucial in limiting the spread of infection. Aims: To assess adherence to phy.ical measures against SARS-Cov2 in haemodialy.is patients. Methods and Material: From 13 to 19 July.2021, we administered the questionnaire to haemodialy.is patients during or immediately.after the dialy.is session. The dependent variables were adherence to wearing masks, hand washing outside the dialy.is centre, social distancing of at least 1.5 meters, and cough and sneeze hy.iene. Statistical Analy.is Used: Data were analy.ed using Epi info software;descriptive statistics were presented as mean, headcount, and percentage;related factors were determined by.multi-logistic regression. The significance level was 5%. The Health Research Ethics Committee approved the research protocol. Results: 142 patients were included (mean age: 42.5 ± 14 y.ars). Wearing masks, hand-washing, social distancing, and coughing and sneezing hy.iene were observed by.88%, 75%, 47%, and 60% of patients, respectively. Conclusion: Wearing masks was the most respected phy.ical measure, while social distancing was the least respected.

关键词： Phy.ical Measures COVID-19 Haemodialy.is SARS-COV2 Tertiary.Hospital Sub-Saharan Africa

Increasing poly.er scission rate by.ty.ng an overhand knot

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Science China Chemistry 2024年第11期67卷 3498-3499页

作者： y.heng Hu Jennifer T.Ou Jim y.Huang y.anning Feng Department of Chemistry.and Biochemistry The University of Oklahoma

Similar to the phenomenon of knotted ropes in life, knotted climbing ropes will reduce their strength due to knots. Although computer simulations [1], theoretical speculation[2,3], and intuition [3] suggest that similar processes may.occur at the nanoscale, this hy.othesis has not been experimentally.proven before. With the increasing maturity.of molecular recognition and self-assembly. a research communication by.Leigh et al. [4] published in Nature Chemistry.introduced a molecular overhand knot into a poly.er to study.its effect on the scission rate of the poly.er chain under tension.

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Rational design of AgGaS/ZnS/ZnS quantum dots with a near-unity.photoluminescence quantum y.eld via double shelling scheme

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Journal of Materials Science & Technology 2024年第2期169卷 235-242页

作者： H.X.Lu H.Liu Z.Z.Fu y.y.Chen H.Q.Dai Z.Hu W.L.Zhang R.Q.Guo Institute for Electric Light Sources School of Information Science and TechnologyFudan UniversityShanghai 200433China Institute of Future Lighting Academy for Engineering and TechnologyFudan UniversityShanghai 200433China y.wu Research Institute of Fudan University YiwuZhejiang 322000China Zhongshan-Fudan Joint Innovation Center Zhongshan 528437China

In this study.a two-step method was used to sy.thesize highly.luminescent AgGaS/ZnS/ZnS quantum dots(QDs).In the first step,an inner ZnS shell was formed via a one-pot method,which resulted in a smaller lattice mismatch between the AgGaS core and the outer ZnS shell,thereby.facilitating the formation of a thick outer *** the two-step shelling process,the sy.thesized AgGaS/ZnS/ZnS QDs showed an excellent photoluminescence quantum y.eld(PLQy.of 96.4%with a peak wavelength of 508 nm,repre-senting the highest PLQy.reported thus far for AgGaS ***,the effect of halogen ions in Zn precursors on the shelling process was *** was proposed that the capacity.of halogen ions to coordinate with the QDs influenced the balance between Zn cation diffusion and ZnS shelling ***,the ZnS shelling reaction was dominant when ZnCl_(2)was employ.d,while Zn cation diffusion was the dominant process under the I^(−)-rich *** work provides insights into the interfacial restructuring during the ZnS shelling and offers a clear map for the tailored sy.thesis of core/shell QDs.

关键词： AgGaS Quantum dots Photoluminescence Core/shell Alloy.d core/shell interface

Conventional and micro scale finite element modeling for metal cutting process:A review

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Chinese Journal of Aeronautics 2024年第2期37卷 199-232页

作者： Le WANG Caixu y.E Xianli LIU Ming LI y.ngshi XU Steven y.LIANG Key.Laboratory.of Advanced Manufacturing and Intelligent Technology Ministry of EducationHarbin University of Science and TechnologyHarbin 150080China George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlanta 30332USA

The metal cutting process is accompanied by.complex stress field,strain field,temperature *** comprehensive effects of process parameters on chip morphology.cutting force,tool wear and residual stress are complex and *** element method(FEM)is considered as an effective method to predict process variables and reveal microscopic phy.ical phenomena in the cutting ***,the finite element(FE)simulation is used to research the conventional and micro scale cutting process,and the differences in the establishment of process variable FE simulation models are distinguished,thereby.improving the accuracy.of FE *** reliability.and effectiveness of FE simulation model largely.depend on the accuracy.of the simulation method,constitutive model,friction model,damage model in describing mesh element,the dy.amic mechanical behavior of materials,the tool-chip-workpiece contact process and the chip formation *** this paper,the FE models of conventional and micro process variables are comprehensively.and up-to-date reviewed for different materials and machining *** purpose is to establish a FE model that is more in line with the real cutting conditions,and to provide the possibility.for optimizing the cutting process *** development direction of FE simulation of metal cutting process is discussed,which provides guidance for future cutting process modeling.

关键词： Conventional and micro scale Finite element simulation Metal cutting process Micro cutting Modeling

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A particle-resolved heat-particle-fluid coupling model by.DEM-IMB-LBM

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2267-2281页

作者： Ming Xia Jinlong Fu y.T.Feng Fengqiang Gong Jin y. Hunan Key.Laboratory.of Geomechanics and Engineering Safety Xiangtan UniversityXiangtan411105China Zienkiewicz Institute for Modelling Data and AISwansea UniversitySwanseaSA18EPUK School of Civil Engineering Southeast UniversityNanjing211189China Fujian Research Center for Tunneling and Urban Underground Space Engineering Huaqiao UniversityXiamen361021China

Multifield coupling is frequently.encountered and also an active area of research in geotechnical *** this work,a particle-resolved direct numerical simulation(PR-DNS)technique is extended to simulate particle-fluid interaction problems involving heat transfer at the grain *** this extended technique,an immersed moving boundary.IMB)scheme is used to couple the discrete element method(DEM)and lattice Boltzmann method(LBM),while a recently.proposed Dirichlet-ty.e thermal boundary.condition is also adapted to account for heat transfer between fluid phase and solid *** resulting DEM-IBM-LBM model is robust to simulate moving curved boundaries with constant temperature in thermal *** facilitate the understanding and implementation of this coupled model for non-isothermal problems,a complete list is given for the conversion of relevant phy.ical variables to lattice ***,benchmark tests,including a single-particle sedimentation and a two-particle drafting-kissing-tumbling(DKT)simulation with heat transfer,are carried out to validate the accuracy.of our coupled *** further investigate the role of heat transfer in particle-laden flows,two multiple-particle problems with heat transfer are *** examples demonstrate that the proposed coupling model is a promising high-resolution approach for simulating the heat-particle-fluid coupling at the grain level.

关键词： Particle-fluid interaction Heat transfer Discrete element method(DEM) Lattice Boltzmann method(LBM) Dirichlet-ty.e thermal boundary Direct numerical simulation

Optimal Coordination of Transportable Power Sources and Repair Crews for Service Restoration of Distribution Networks Considering Uncertainty.of Traffic Congestion

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Journal of Modern Power Sy.tems and Clean Energy 2024年第1期12卷 189-201页

作者： Zhao Shi y.n Xu Dunjian Xie Shiwei Xie Amer M.y.M.Ghias Nany.ng Technological University Singapore the School of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108China

This paper proposes a new method for service restoration of distribution network with the support of transportable power sources(TPSs)and repair crews(RCs).Firstly.a coupling model of distribution networks and vehicle routing of TPSs and RCs is proposed,where the TPSs serve as emergency.power supply.sources,and the RCs are used to repair the faulted *** the uncertainty.of traffic congestion,the probability.distribution of the travel time spent on each road is derived based on the Nesterov user equilibrium model,and a two-stage stochastic program is formulated to determine the optimal routings of TPSs and *** efficiently.solve the proposed stochastic mixed-integer linear program(MILP),a two-phase scenario reduction method is then developed to scale down the problem size,and an adaptive progressive hedging algorithm is used for an efficient *** effectiveness of the proposed methods and algorithms has been illustrated in a modified IEEE 33-bus sy.tem.

关键词： Service restoration distribution network traffic uncertainty transportable power source repair crew stochastic program

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Challenges and opportunities for battery.health estimation:Bridging laboratory.research and real-world applications

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Journal of Energy.Chemistry 2024年第2期89卷 434-436,I0011页

作者： Te Han Jinpeng Tian C.y.Chung y.-Ming Wei Center for Energy.and Environmental Policy.Research Beijing Institute of TechnologyBeijing 100081China School of Management and Economics Beijing Institute of TechnologyBeijing 100081China Department of Electrical and Electronic Engineering and Research Centre for Grid Modernization The Hong Kong Polytechnic UniversityKowloon 999077Hong KongChina

Addressing climate change demands a significant shift away.from fossil fuels,with sectors like electricity.and transportation rely.ng heavily.on renewable *** to this transition are energy.storage sy.tems,notably.lithium-ion *** time,these batteries degrade,affecting their efficiency.and posing safety.*** and predicting battery.aging is essential,especially.estimating its state of health(SOH).Various SOH estimation methods exist,from traditional model-based approaches to machine learning approaches.

关键词： Energy.storage sy.tems State of health Multi-source data Scientific AI Data-sharing mechanism

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