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Weighted gene co-expression network analysis reveals similarities and differences of molecular features between dilated and ischemic cardiomyopathies

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Journal of Electronic Science and Technology 2023年第2期21卷 14-29页

作者： felix K.Biwott Ni-Ni Rao Chang-Long Dong Guang-Bin Wang School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu610054China

Cardiomyopathies represent the most common clinical and genetic heterogeneous group of diseases that affect the heart *** progress has been made to elucidate the process,molecular mechanisms of different classes of cardiomyopathies remain *** paper aims to describe the similarities and differences in molecular features of dilated cardiomyopathy(DCM)and ischemic cardiomyopathy(ICM).We firstly detected the co-expressed modules using the weighted gene co-expression network analysis(WGCNA).Significant modules associated with DCM/ICM were identified by the Pearson correlation coefficient(PCC)between the modules and the phenotype of DCM/*** differentially expressed genes in the modules were selected to perform functional *** potential transcription factors(TFs)prediction was conducted for transcription regulation of hub *** and cardiac conduction were perturbed in DCM and ICM,*** demonstrated that the biomarkers and the transcription regulations in DCM and ICM were different,which helps make more accurate discrimination between them at molecular *** conclusion,comprehensive analyses of the molecular features may advance our understanding of DCM and ICM causes and ***,this understanding may promote the development of innovative diagnoses and treatments.

关键词： Dilated cardiomyopathy(DCM) Hub genes Ischemic cardiomyopathy(ICM) Transcription factors(TFs) Weighted gene co-expression network analysis(WGCNA)

Mineralogical and Chemical Characteristics of Clays Consumed in the District of Abidjan(Cote D’Ivoire)

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Materials Sciences and Applications 2014年第14期5卷 1048-1059页

作者： Vamoussa Coulibaly Joseph Sei Leon konan koffi Samuel Oyetola El-Aid Jdid Fabien Thomas Laboratoire de Chimie des Materiaux Inorganiques UFR SSMTUniversite Felix Houphouet-Boigny de Cocody-AbidjanAbidjanCote d’Ivoire Universite de Lorraine Laboratoire Georessources—UMR 7359Rue du Doyen RoubaultVandoeuvreFrance CNRS Laboratoire Georessources—UMR 7359Rue du Doyen RoubaultVandoeuvreFrance Universite de Lorraine Laboratoire Interdisciplinaire des Environnements Continentaux—UMR 736015 rue du CharmoisVandoeuvreFrance CNRS Laboratoire Interdisciplinaire des Environnements Continentaux—UMR 736015 rue du CharmoisVandoeuvreFrance

Clay materials of the quarry of Bingerville (district of Abidjan) have been characterized by chemical analysis, X-rays diffraction, infrared spectroscopy and thermal analysis. These materials contain kaolinite (41% - 84%), illite (4% - 10%), quartz (14% - 27%), goethite (2% - 5%) and small amount of rutile (1%) that are not toxic minerals. They also contain some heavy metals which are beneficial to human biological activity (cobalt, copper, molybdenum, zinc) in tiny quantities. Some other heavy metals (lead, cadmium) which are considered as poisonous for human are present in very low content. The samples characterized by relatively fine grains are moderately crystallized. Their specific surface area varied from 26 to 43 m2·g—1. The mineralogical and physicochemical characteristics of these samples are like ones known for their healing properties. The consumption by internal way of studied materials, although it may be beneficial, requires a sifting to remove coarse grains (Φ > 2 μm) and a previous microbiological control.

关键词： Mineralogy Physicochemical Analysis Kaolinite Illite Edibility

Dimensioning of an Anaerobic Digester for the Treatment of Chicken Manure and for the Production of Biogas: The Case Study of a Chicken Farm in Yaokokoroko (Côte d’Ivoire)

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Green and Sustainable Chemistry 2022年第4期12卷 91-103页

作者： Kouakou Adjoumani Rodrigue Ehouman Ahissan Donatien konan Affoué Tindo Sylvie Teki Adjoba Marie-Emmanuelle Kouadio Marc Cyril Adou Kouakou Eric konan Gbangbo Remis Laboratoire de Thermodynamique et de Physico-Chimie du Milieu (LTPCM) UFR Sciences Fondamentales Appliquées Université Nangui Abrogoua Abidjan C&#244 te d’Ivoire Département de Formation et de Recherche des Sciences de la Terre et des Ressources Minières Ressources en Eaux et Risques Hydrologiques Institut National Polytechnique Felix Houphou&#235 t-Boigny Yamoussoukro C&#244 te d’Ivoire Institut de Recherche sur les Energies Nouvelles Université Nangui Abrogoua Abidjan C&#244 te d’Ivoire Laboratoire des Procédés Industriels de Synthèse de l’Environnement et des énergies Nouvelles (LAPISEN) Institut National Polytechnique Houphou&#235 t-Boigny Yamoussoukro C&#244 te d’Ivoire

This study allowed us to highlight the level of pollution of a BAYA River water near several poultry farms and the sizing of an anaerobic digester that will be able to treat chicken manure from a poultry farm (BRIN FOUNDATION). To evaluate this pollution, the parameters such as ammonium (NH4+), Phosphate (PO43-), Biochemical Oxygen Demand (DBO5) and Nitrate (NO3-) were determined. For sampling point P1, the concentrations in mg/L of these parameters are (25.00 ± 4.25), (0.40 ± 0.20), (98.00 ± 6.35) and (96.00 ± 5.35), respectively. On the other hand, for sampling point P2, the concentrations in mg/L of these parameters are respectively (33.00 ± 9.05), (0.70 ± 0.12), (123 ± 7.13) and (93 ± 7.10). These values indicate a strong organic pollution of the BAYA River. The determination of the different concentrations of the organic pollution parameters allowed us to evaluate the degradation and the quality of the water of the BAYA River water, by the poultry activity. However, considering the physicochemical properties of the waste (chicken manure), which is the main source of organic pollution, we have considered an energy recovery through the production of biogas. This requires the design, sizing, and implementation of an anaerobic digester in a poultry farm. Therefore, the project would require the construction of an adapted masonry type anaerobic digester with a capacity of 10 m3.

关键词： Biogas Organic Pollution Surface Water Biodigester Chicken Manure Anaerobic Digestion

Structural and Thermomechanical Study of Plastic Films Made from Cassava-Starch Reinforced with Kaolin and Metakaolin

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Materials Sciences and Applications 2018年第1期9卷 41-54页

作者： Namory Meite Léon koffi konan Drissa Bamba Bi Irié Hervé Goure-Doubi Samuel Oyetola Laboratory of Materials Chemistry Felix Houphouet Boigny University Cocody-Abidjan Ivory Coast Laboratory of Water Chemistry Training School of Abidjan (ENS) Abidjan Ivory Coast Laboratory of Biological Sciences Péléforo Gon Coulibaly University of Korhogo Korhogo Ivory Coast

The structural and thermomechanical properties of starch-based plastic films reinforced with kaolin and metakaolin have been studied by various techniques (X-ray diffraction, IR-TF spectroscopy, scanning electron microscopy, tensile tests, and thermal resistance). The results obtained showed that kaolin, an inert material, prevents the starch from losing its granular structure and to solubilize during the heating, generating plastic films of low Young’s modulus (7 MPa). On the other hand, metakaolin, an amorphous and dehydroxylated material obtained after heating of kaolin at 700°C for 1 hour, substantially improves the thermomechanical properties of the plastic films. The Young’s modulus increases from 19 MPa to 25 MPa while the thermal resistance increases from 90°C to 120°C. This was attributed to good dispersion of the metakaolin in the polymer matrix after the loss of the granular structure of the starch during heating.

关键词： Cassava Starch Plastic Films Kaolin Metakaolin Stress at Break Young’s Modulus

Study of Photocatalytic Activity of a Nanostructured Composite of ZnS and Carbon Dots

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Advances in Nanoparticles 2022年第4期11卷 111-128页

作者： Irié Bi Irié Williams Essy Kouadio Fodjo Pomi Bi Boussou Narcisse Aka Alla Martin koffi koffi Kra Sylvestre Trokourey Albert Zhen Gu Laboratory of Constitution and Reaction of Matter UFR SSMT Université Felix Houphouet Boigny Abidjan Cote d’Ivoire Key Laboratory of Advanced Control and Optimization for Chemical Processes Ministry of Education East China University of Science and Technology Shanghai China

Environmental pollution jeopardizes our existence. For this purpose, research is moving more and more towards the search for economic means and green chemistry to curb this phenomenon. In this context, the photocatalytic activity of zinc sulfide nanoparticles (ZnS NPs) and nanostructured composite ZnS/carbon dots (ZnS/CDs) was evaluated after their synthesis. The results of X-ray diffraction (XRD) analysis indicate that the crystal structure of ZnS/CDs is identical to that of the cubic phase structure of ZnS, revealing that the cubic phase structure of ZnS was not altered in the presence of CDs. Indeed, there is no additional peak in the crystal structure of ZnS/CDs, revealing that the crystalline structure of ZnS is not responsible for the difference in photocatalytic activity between ZnS/CDs and ZnS NPs. Moreover, analysis performed by transmission electron microscopy (TEM) shows aggregation of the synthesized ZnS and ZnS/CDs nanoparticles with an average size estimated around 10 nm and 12 nm, respectively. In addition, the reflectance study in the visible range shows a reduction in the sunlight reflection intensity using ZnS/CDs compared to the capability of ZnS NPs. Photocatalytic degradation tests reveal that ZnS/CDs have the best methylene blue (MB) degradation rate. Indeed, under the optimal conditions, the photocatalytic activity can reach 100% efficiency within 100 min and 240 min of sunlight exposure for the degradation of 7.5 mg/L MB using ZnS/CDs and ZnS, respectively. This improvement in photocatalytic activity of ZnS/CDs may be due to the presence of CDs which can permit to undergo a reduction of reflection properties of ZnS NPs in the visible range. These results show that CDs can play a key role in enhancing the photocatalytic activity of ZnS, and suggest that ZnS/CDs could be used as eco-friendly composite materials for the degradation of organic pollutants of similar structures in the aquatic environment under solar irradiation.

关键词： Fluorescent Carbon Dots (CDs) Photocatalytic Degradation of Methylene Blue Sunlight Reflectance Property Synthesis of ZnS Nanoparticles

Implementing uterine balloon tamponade(UBT)device for immediate postpartum hemorrhage management:Leveraging resource allocation and highlighting noteworthy experiences

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Gynecology and Obstetrics Clinical Medicine 2023年第3期3卷 175-180页

作者： Mian Dehi Boston Guie Privat Apollinaire Horo Aka Edele Kouakou konan Virginie Aholoupke Bruno KonéSeydou Rochon Sarah Boni Serge Burke Thomas F felix Houphouet Boigny University Cote d’Ivoire Division of Global Health and Human Rights Department of Emergency MedicineCote d’Ivoire National Mother and Child Health Program Côte d'Ivoire Cote d’Ivoire Massachusetts General Hospital Division of Global Health and Human Rights BostonMAUSA Harvard T.H.Chan School of Public Health BostonMAUSA Harvard Medical School BostonMAUSA

Background The use of uterine balloon tamponade(UBT)devices for intrauterine packing and management of vaginal bleeding by uterine atony has shown promising results in improving the quality of care and reducing maternal *** This report aims to provide an overview of progress made in implementing UBT devices in northern Cote d'*** and methods A four-year retrospective study was conducted in the North-East(163,645),North-Center(351,909),and North-West(57,983).In 2017,UBT was adopted by members of the healthcare ***,5 national and 32 regional trainers have been *** training session was a theoretical and practical program with a low *** is a male condom tied to a urinary catheter,filled with *** outcomes included stopping bleeding,avoiding the need for surgery,and preventing maternal deaths(MD).In 2018,3,515 UBT devices were *** 2019,monitoring tools and transmission circuits of the data were *** 2020,the collection of data and local manufacturing was *** During the process,978 health workers,mainly midwife(52.0%)and nurses(32.2%)out of the 1,295 assigned were *** number of trained individuals decreased from 209 in 2019 to 160 in 2020.A total of 1,715 UBT devices were locally manufactured,adding to the existing gift of 5,080 devices,with total availability of 6,*** distribution of devices increased from 2017 to 2019 but decreased in *** rates increased from 87.3%in 2017(365/418)to 95.0%in 2019(556/585)and slightly decreased in 2020 to 98.0%(681/695).Adverse outcomes(144/2,193),included MD(35/2,193)and medical evacuation to the surgical center(109/2,193).Conclusion The implementation of UBT in northern Cote d'Ivoire successfully reduced maternal death rates caused by immediate post-partum hemorrhage(IPPH).However,to ensure sustainability,further improvements are needed,including increased monitoring,ongoing training,and device availability.

关键词： Implementation Uterine balloon tamponade Post-partum hemorrhage Health providers Health regions

Effect of surface damage induced by cavitation erosion on pitting and passive behaviors of 304L stainless steel

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International Journal of Minerals,Metallurgy and Materials 2023年第7期30卷 1338-1352页

作者： Liang Li Yanxin Qiao Lianmin Zhang Aili Ma Enobong felix Daniel Rongyao Ma Jian Chen Yugui Zheng School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Shenyang National Research Center for Materials Science Institute of MetalsChinese Academy of SciencesShenyang 110016China

The corrosion behavior of 304L stainless steel(SS)in 3.5wt%NaCl solution after different cavitation erosion(CE)times was mainly evaluated using electrochemical noise and potentiostatic polarization *** was found that the antagonism effect resulting in the passivation and depassivation of 304L SS had significant distinctions at different CE *** passive behavior was predominant during the incubation period of CE where the metastable pitting initiated at the surface of 304L *** the rising period of CE,the 304L SS experienced a transition from passivation to depassivation,leading to the massive growth of metastable pitting and stable *** depassivation of304L SS was found to be dominant at the stable period of CE where serious localized corrosion occurred.

关键词： cavitation erosion pitting stainless steel electrochemical noise

Active anticorrosion and self-healing coatings:A review with focus on multi-action smart coating strategies

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Journal of Materials Science & Technology 2022年第21期116卷 224-237页

作者： Inime Ime Udoh Hongwei Shi Enobong felix Daniel Jianyang Li Songhua Gu Fuchun Liu En-Hou Han CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Environmental and Chemical Engineering Shenyang Ligong UniversityShenyang 110159China University of Science and Technology of China Hefei 230026China

The development of smart coatings with potential for active anticorrosion and self-healing protection of metals is essential for long-term performance of metallic structures in aggressive chemical ***,emphasis has been placed on the development of advanced smart coatings for corrosion protection in different *** multifunctional coatings with fascinating stimuliresponsive functionalities are considered“smart”.The stimuli-responsive functionalities of these smart coatings when properly harnessed result in a class of coatings with inherent autonomous control of ***,when metals are exposed to aggressive environments,occurrences at the metalsolution interface cause environmental *** changes can be controlled when triggers from external environment set off active components of smart coating,thereby enhancing coating’s life and *** triggers include the availability of moisture,concentration of chloride ion,p H gradient,mechanical damage,impact,fatigue,light,redox activity and *** this review,recent technological trends in active anticorrosion and self-healing coatings as functional routes for metal protection are summarized,stimuli responsiveness and mechanisms of inhibition are discussed,and recent multi-action protective systems are particularly focused on.

关键词： Smart coating Active anticorrosion protection Self-healing Multi-action Protection mechanism

Radical Hysterectomy in Cervical Cancer: Patients’ Epidemiological and Clinical Profiles and Perioperative Outcome in Two Referral Hospitals in Cameroon

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Open Journal of Obstetrics and Gynecology 2024年第3期14卷 466-479页

作者： Théophile Njamen Nana Robert Tchounzou Fulbert Nkwele Mangala Alphonse Ngalame Henri Essome Sedrick Tiokeng Sidonie Noa Ananga Andrew Tassang Humphry Tatah Neng Isaac Mboh Eyong Gaetan Andre Wambo Simo felix Adolphe Elong Fidelia Kobenge Mbi Junior Cédric Nana Njamen Charlotte Tchente Nguefack Thomas Obinchemti Egbe Gregory Ekane Halle Emile Telesphore Mboudou Marcellin Ngowe Ngowe Department of Obstetrics and Gynaecology Douala General Hospital Douala Cameroon Department of Obstetrics and Gynaecology Faculty of Health Sciences University of Buea Buea Cameroon Department of Obstetrics and Gynaecology Douala Gynaeco-Obstetric and Pediatric Hospital Douala Cameroon Department of Surgery and Specialties Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Pathology Douala General Hospital Douala Cameroon Faculté Des Sciences De La Santé Université Joseph Kizerbo Ouagadougou Burkina Faso

Background: Cervical cancer (CC) is one of the most frequent cancers and the leading cause of death from gynecological cancer in Low and middle income countries, Cameroon inclusive. Surgery is the primary treatment modality when the disease is diagnosed at early stage. Radical hysterectomy in cervical cancer has not been evaluated in recent years in Cameroon. The purpose of this study is thus to evaluate the epidemiological and clinical features and short term outcomes of patients who underwent surgery. Patients and methods: This retrospective study was conducted at the Douala Gynaeco-obstetric and Pediatric Hospital and the Douala General Hospital. Cervical cancer patients who underwent Radical hysterectomy between January 2015 and December 2020 were included. A pre-established data collection tool was used to record socio-demographic, clinical and outcomes information from patients’ files;additional outcome information was obtained from phone calls. Descriptive analysis was done using the SPSS version 26. Bivariate analysis was used to determine associations between disease and patients characteristics and occurrence of adverse postoperative outcome. P value of 0.05 was considered. Results: Sixty one patients were enrolled. Their ages ranged from 33 to 74 years with a mean age of 51.95 ± 10.29 years. Over 85% of women were married, 65.57% were unemployed and 86.88% were multiparous. Only 28% had never done cervical cancer screening. Most patients had stage IB1 to IB2 stage disease (57.1%). Less than 9% underwent radical hysterectomy and 8 of those (13.11%) suffered intraoperative complications. Twenty-five patients (40.98%) presented immediate and short term complications. There was no significant association between the disease or patients’ characteristics and adverse outcomes. Conclusion: Cervical cancer patients are relatively young in our settings and only 9% of them reach the hospital at early stage. Postoperative adverse outcomes rate is higher than that rep

关键词： Cervical Cancer Radical Hysterectomy Epidemiological and Clinical Profiles Outcomes Cameroon