检索结果-南通市图书馆

Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第47期22卷 10275-10286页

作者： Hannah Ceuleers Hanne Van Spaendonk Nikita Hanning Jelena Heirbaut Anne-Marie Lambeir Jurgen Joossens koen Augustyns Joris G de Man Ingrid de Meester Benedicte Y de Winter Laboratory of Experimental Medicine and Pediatrics Division of Gastroenterology University of Antwerp Laboratory of Medical Biochemistry University of Antwerp Laboratory of Medicinal Chemistry and Antwerp Drug Discovery Network University of Antwerp

Proteases, enzymes catalyzing the hydrolysis of peptide bonds, are present at high concentrations in the gastrointestinal tract. Besides their well-known role in the digestive process, they also function as signaling molecules through the activation of protease-activated receptors(PARs). Based on their chemical mechanism for catalysis, proteases can be classified into several classes: serine, cysteine, aspartic, metallo- and threonine proteases represent the mammalian protease families. In particular, the class of serine proteases will play a significant role in this review. In the last decades, proteases have been suggested to play a key role in the pathogenesis of visceral hypersensitivity, which is a major factor contributing to abdominal pain in patients with inflammatory bowel diseases and/or irritable bowel syndrome. So far, only a few preclinical animal studies have investigated the effect of protease inhibitors specifically on visceral sensitivity while their effect on inflammation is described in more detail. In our accompanying review we describe their effect on gastrointestinal permeability. On account of their promising results in the field of visceral hypersensitivity, further research is warranted. The aim of this review is to give an overview on the concept of visceral hypersensitivity as well as on the physiological and pathophysiological functions of proteases herein.

关键词： Proteases Proteinase-activated receptors Protease inhibitors Visceral hypersensitivity Visceral pain Irritable bowel syndrome Inflammatory bowel diseases

Ecologically-friendly operation scheme for the Jinping cascaded reservoirs in the Yalongjiang River, China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Earth Science 2014年第2期8卷 282-290页

作者： Duan CHEN Qiuwen CHEN Ruonan LI koen BLANCKAERT desuo CAI Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Changjiang River Scientific Research Institute Wuhan 430010 China Nanjing Hydraulics Research Institute Nanjing 210023 China Guangxi Water Conservancy department Nanning 530023 China

Ecologically-friendly reservoir operation pro- cedures aim to conserve key ecosystem properties in the rivers, while minimizing the sacrifice of socioeconomic interests. This study focused on the Jinping cascaded reservoirs as a case study. An optimization model was developed to explore a balance between the ecological flow requirement （EFR） of a target fish species （Schizothorax chongi） in the dewatered natural channel section, and annual power production. The EFR for the channel was determined by the Tennant method and a fish habitat model, respectively. The optimization model was solved by using an adaptive real-coded genetic algorithm. Several operation scenarios corresponding to the ecological flow series were evaluated using the optimization model. Through comparisons, an optimal operational scheme, which combines relatively low power production loss with a preferred ecological flow regime in the dewatered channel, is proposed for the cascaded reservoirs. Under the recommended scheme, the discharge into the Dahewan river reach in the dry season ranges from 36 to 50 m3/s. This will enable at least 50% of the target fish habitats in the channel to be conserved, at a cost of only 2.5% annual power production loss. The study demonstrates that the use of EFRs is an efficient approach to the optimization of reservoir operation in an ecologically friendly way. Similar modeling, for other important fish species and ecosystem functions, supplemented by field validation of results, is needed in order to secure the long-term conservation of the affected river ecosystem.

关键词： ecologically-friendly operation optimizationmodel ecological flow Jinping cascaded reservoirs,Schizothorax chongi

The physical and physiological effects of vacuum massage on the different skin layers: a current status of the literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Burns & Trauma 2016年第3期4卷 180-191页

作者： Peter Moortgat Mieke Anthonissen Jill Meirte Ulrike Van Daele koen Maertens OSCARE Organisation for BurnsScar After-care and ResearchVan Roiestraat 18B-2170 AntwerpBelgium OSCARE Organisation for BurnsScar After-care and ResearchVan Roiestraat 18B-2170 AntwerpBelgium department of Rehabilitation Sciences KU LeuvenTervuursevest 101box 15003001 HeverleeBelgium OSCARE Organisation for BurnsScar After-care and ResearchVan Roiestraat 18B-2170 AntwerpBelgium department of Rehabilitation Sciences and Physiotherapy University of AntwerpUniversiteitsplein 12610 AntwerpBelgium department of Rehabilitation Sciences and Physiotherapy University of AntwerpUniversiteitsplein 12610 AntwerpBelgium OSCARE Organisation for BurnsScar After-care and ResearchVan Roiestraat 18B-2170 AntwerpBelgium department of Clinical and Lifespan Psychology Vrije Universiteit BrusselPleinlaan 21050 BrusselsBelgium

Vacuum massage is a non-invasive mechanical massage technique performed with a mechanical device that lifts the skin by means of suction,creates a skin fold and mobilises that skin *** the late 1970s,this therapy was introduced to treat traumatic or burn *** vacuum massage was invented to treat burns and scars,one can find very little literature on the effects of this ***,the aim of this review is to present an overview of the available literature on the physical and physiological effects of vacuum massage on epidermal and dermal skin structures in order to find the underlying working mechanisms that could benefit the healing of burns and *** discussion contains translational analysis of the results and provides recommendations for future research on the *** extended search for publications was performed using PubMed,Web of Science and Google *** authors independently identified and checked each study against the inclusion *** articles were included in the qualitative *** two most reported physical effects of vacuum massage were improvement of the tissue hardness and the elasticity of the *** physical effects,a variety of physiological effects are reported in literature,for example,an increased number of fibroblasts and collagen fibres accompanied by an alteration of fibroblast phenotype and collagen *** information was found on the decrease of pain and itch due to vacuum *** vacuum massage initially had been developed for the treatment of burn scars,this literature review found little evidence for the efficacy of this *** in duration,amplitude or frequency of the treatment have a substantial influence on collagen restructuring and reorientation,thus implying possible beneficial influences on the healing potential by mechanotransduction *** massage may release the mechanical tension associated with scar retraction and thus in

关键词： Vacuum massage Endermology Vacuotherapy depressomassage Scars Hypertrophic Physical Physiological Intervention

Comparison of FDA safety and efficacy data for KAMRA and Raindrop corneal inlays

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2017年第9期10卷 1446-1451页

作者： Majid Moshirfar Jordan D desautels Ryan T Wallace Nicholas koen Phillip C.Hoopes HDR Research Center Hoopes VisionDraperUtah 84020United States john A.Moran Eye Center Department of Ophthalmology and Visual SciencesUniversity of Utah School of MedicineSalt Lake CityUtah 84132United States Tufts University School of Medicine BostonMassachusetts 02111United States Brigham Young University ProvoUtah 84602United States Brown University Alpert School of Medicine ProvidenceRhode Island 02906United States

aim：To provide a side-by-side analysis of the summary of safety and effectiveness data（SSED）submitted to the FDA for the KAMRA and Raindrop corneal inlays for the correction of ***：SSED reports submitted to the FDA for KAMRA and Raindrop were compared with respect to loss of corrected distance visual acuity（CDVA）,adverse event rates,induction of astigmatism,retention of contrast sensitivity,stability of manifest refractive spherical equivalent（MRSE）,and achieved monocular uncorrected near visual acuity（UNVA）at ***：Totally 442/508 of KAMRA patients and344/373 Raindrop patients remained enrolled in the clinical trials at *** proportion of KAMRA and Raindrop patients who lost≥2 lines of CDVA at 24mo was 3.4%and1%,*** adverse event rate was comparable between the *** significant inductions of astigmatism were *** technologies induced a transient myopic shift in MRSE followed by a hyperopic shift and subsequent *** 87%of KAMRA and 98%of Raindrop patients attained a monocular UNVA of J5（20/40）or better at 24mo,28%of KAMRA and 67%of Raindrop patients attained a monocular UNVA of J1（20/20）or better at ***：Both devices can be considered safe and effective,however,the results of corneal inlay implantation are mixed,and long-term patient satisfaction will likely depend on subjective expectations about the capabilities of the *** in surgical technique and postoperative care within and between the two clinical trials diminishes the comparative power of this article.

关键词： KAMRA Raindrop presbyopia comeal inlay

Effect of introducing an online system on the follow-up of elbow arthroplasty

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2016年第12期7卷 826-831页

作者： Jetske Viveen Ante Prkic Bertram The koen LM koenraadt denise Eygendaal Upper Limb Unit Department of Orthopaedic SurgeryAmphia Hospital Foundation for Orthopedic Research Care & EducationAmphia Hospital department of Orthopaedic Surgery University of Amsterdam

aim To evaluate the effect of introducing a structured online follow-up system on the response *** Since June 2015 we have set up an electronic followup system for prosthesis in orthopedic patients. This system allows prospective data gathering using both online and paper questionnaires. In the past all patients received questionnaires on paper. This study includes only patients who received elbow arthroplasty. Response rates before and after introduction of the online database were compared. After the implementation,completeness of the questionnaires was compared between paper and digital versions. For both comparisons Fisher's Exact tests were *** A total of 233 patients were included in the study. With the introduction of this online follow-up system,the overall response rate increased from 49.8% to 91.6%(P 0.05).Paper questionnaires had a completeness of 54.4%,which was lower compared to the online questionnaires where we reached full completeness(P ders proved to be younger with a mean age of 52 years compared to a mean age 62 years of responders(P < 0.05).CONCLUSION The use of a structured online follow-up system increased the response rate. Moreover,online questionnaires are more complete than paper questionnaires.

关键词： Patient reported outcome measures Elbow Follow-up Arthroplasty Online Database

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

用于纺织品整理的可再生抗菌剂

国际纺织导报 2015年第9期43卷 38-40页

作者： D.de smet M.Vanneste K.Leppchen-Frohlich M.Meyer 程党党张文宇 Centexbel 比利时 FILK 德国

介绍了纺织品整理方面的新型可持续材料,以及工业应用和规模扩大所需的一些小的优化。整理的目标是获得功能化纺织品,故需采用生物添加剂。由于新的抗菌剂法规的出现,抗菌纺织品得到更多重视。概述了适用于纺织品的可再生抗菌剂的应用。

关键词：可再生抗菌剂纺织品整理

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

聚酯表面的生物技术改性

国际纺织导报 2011年第2期39卷 22-23,27页

作者： V. A. Nierstrasz L．V．Langenhove P．Kiekens I．Donelli G．Freddi P．smet D．Poelman 喻盈捷（译）行兰（校） Ghent大学纺织系比利时丝绸研究所意大利根特大学LumiLab比利时不详

合成纤维是纺织工业的重要组成部分。合成纤维的缺点是其亲水度低,PET纤维特别疏水,这影响纤维的加工性和功能性。比较新颖、有前途、可供选择的方法是酶用于合成纤维的表面改性。已经报道,用酶水解酯键,从而提高聚酯的亲水度。这一促... 详细信息

合成纤维是纺织工业的重要组成部分。合成纤维的缺点是其亲水度低,PET纤维特别疏水,这影响纤维的加工性和功能性。比较新颖、有前途、可供选择的方法是酶用于合成纤维的表面改性。已经报道,用酶水解酯键,从而提高聚酯的亲水度。这一促进功能化的过程,目标是用现代的生物技术使PET纺织材料功能化。结果将形成新的特定知识和技术,产生用生物技术改性的纺织材料,从而有助于向生物型经济转变。

关键词：聚酯表面酶生物技术改性功能化