检索结果-南通市图书馆

Cowpea NAC1/NAC2 transcription factors improve growth and tolerance to drought and heat in transgenic cowpea through combined activation of photosynthetic and antioxidant mechanisms

引用

Journal of Integrative Plant Biology 2023年第1期65卷 25-44页

作者： Richa Srivastava Yuriko kobayashi Hiroyuki Koyama Lingaraj Sahoo Department of Biosciences and Bioengineering Indian Institute of Technology Guwahati Guwahati Assam 781039 India Faculty of Applied Biological Sciences Gifu University 1-1 YanagidoGifu 501-1193Japan

NAC(NAM/ATAF1/2/CUC2)transcription factors are central switches of growth and stress responses in ***,unpredictable interspecies conservation of function and regulatory targets makes the well-studied NAC orthologs inapt for pulse *** knowledge of suitable NAC candidates in hardy pulses like cowpea(Vigna unguiculata(L.)Walp.)is still in infancy,hence warrants immediate biotechnological ***,we showed that overexpression of two native NAC genes(VuNAC1and VuNAC2)promoted germinative,vegetative,and reproductive growth and conferred multiple abiotic stress tolerance in a commercial cowpea *** transgenic lines displayed increased leaf area,thicker stem,nodule-rich denser root system,early flowering,higher pod production(~3.2-fold and~2.1-fold),and greater seed weight(10.3%and 6.0%).In contrast,transient suppression of VuNAC1/2 caused severe growth retardation and flower *** overexpressor lines showed remarkable tolerance to major yielddeclining terminal stresses,such as drought,salinity,heat,and cold,and recovered growth and seed production by boosting photosynthetic activity,water use efficiency,membrane integrity,Na^(+)/K^(+)homeostasis,and antioxidant *** comparative transcriptome study indicated consolidated activation of genes involved in chloroplast development,photosynthetic complexes,cell division and expansion,cell wall biogenesis,nutrient uptake and metabolism,stress response,abscisic acid,and auxin *** their orthologs,VuNAC1/2 direct synergistic transcriptional tuning of stress and developmental signaling to avoid unwanted *** overexpression governs the favorable interplay of photosynthesis and reactive oxygen species regulation to improve stress recovery,nutritional sufficiency,biomass,and *** unconventional balance of strong stress tolerance and agronomic quality is useful for translational crop research and molecular breeding of pulses.

关键词： cowpea enhanced photosynthetic activity improved growth improved yield legume genetic engineering multiple stress tolerance NAC transcription factor VuNAC

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Occurrence factors of large vacant lots in central districts and their utilization by local governments in Japan

引用

Frontiers of Architectural Research 2016年第4期5卷 393-402页

作者： Takeshi kobayashi Shinji Ikaruga Graduate School of Science and Technology for Innovation Yamaguchi University Yamaguchi 753-8511Japan

In Japan, focal cities experience a number of probtems retated to deterioration of residentiat environment, quality of public service, and vitalization of commercial rand. SpecificaLLy, the presence of Large vacant tots behind sizable stores, office buildings, hospitals, and factories devitatize urban activity and its Landscape. Many local cities are seeking to actuatize a sustainable compact city with an integrated poputation, commerce, traffic and other pubLic services in ways that promote a tow carbon and energy-conserving society. Against the backdrop of these issues, this study examines the occurrence of large vacant lots and their utilization by tocat governments in Japan based on a questionnaire and fietd survey. It highlights severat cases in which a Large vacant tot is used to forward the development of a compact city by a tocat government.

关键词： Large vacant tot Centra| district Urban regeneration Land use conversion Compact city

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in therapeutics for liver metastasis from colorectal cancer

引用

World Journal of Gastrointestinal Oncology 2010年第10期2卷 380-389页

作者： Akira kobayashi Shinichi Miyagawa First Department of Surgery Shinshu University School of Medicine

The evolution of chemotherapeutic regimens that include targeted molecular agents has resulted in a breakthrough in the management of advanced colorectal liver metastasis (CLM), improving the progression-free survival after liver resection, and rendering initially unresectable liver tumors resectable, with reported resection rates ranging from 13% to 51%. In addition, the criteria used for selecting patients for hepatectomy have been expanding because of advances in surgical techniques and improvements in chemotherapy. However, the increasing use of chemotherapy has raised concern about potential hepatotoxicities such as steatosis, chemotherapy-associated steatohepatitis, and sinusoidal obstruction syndrome, and their deleterious effects on postoperative outcome. The present review focuses on the advantages and disadvantages of chemotherapy, strategies for the prevention and diagnosis of chemotherapy-associated liver injury, and the adoption of more aggressive surgical approaches, which have changed the traditional paradigm for CLM.

关键词： Colorectal liver metastasis Chemotherapy Hapatotoxicity Multimodal therapy Targeted biological agent

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pneumonia and seizures due to hypereosinophilic syndrome—organ damage and eosinophilia without synchronisation:A case report

引用

World Journal of Clinical Cases 2022年第18期10卷 6325-6332页

作者： Tetsuro Ishida Tomonori Murayama Seiju kobayashi Department of Psychiatry Hokujinkai Ishibashi HospitalOtaru 047-8585Japan Department of Psychiatry Kushiro Red Cross HospitalKushiro 085-8512Japan Department of Psychiatry Shinyukai Nakae HospitalSapporo 001-0022Japan

BACKGROUND Hypereosinophilic syndrome(HES)is a condition characterized by increased eosinophil proliferation in the bone marrow,as well as tissue eosinophilia,often causing organ *** cause of the disease is *** symptoms include fatigue,cough,shortness of breath,myalgia,angioedema,fever,and *** addition to the respiratory symptoms,damage to the central nervous system can lead to severe ***,we report a case with pneumonia and complex partial seizures secondary to *** SUMMARY A 94-year-old woman was admitted to our hospital for heart failure and bloody *** admission,she also showed symptoms of ***-contrast computed tomography of the chest showed pleural effusion and infiltrative *** gastrointestinal endoscopy showed multiple ulcers in the sigmoid *** analyses showed marked eosinophilia(eosinophils 1760/mm3,total leukocytes 6850/mm3).Initial treatment with furosemide 20 mg/d and prednisolone 25 mg/d relieved these ***,the patient subsequently experienced localised epileptic seizures characterized by bilateral eyelid twitching and eyes rolling upwards,without generalized convulsions,and respiratory arrest *** showed spikes and ***-contrast magnetic resonance imaging of the brain showed extensive periventricular *** administration of levetiracetam 1000 mg/d the epileptic seizures ***,the patient’s consciousness remained impaired,and her pneumonia worsened *** weeks later,she died of *** HES symptoms are variable and atypical,and the level and timing of eosinophilia and organ damage are often discordant.

关键词： Case report Hypereosinophilic syndrome Pneumonia Seizures Prednisolone Levetiracetam

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hemodynamic Profiling Using a Cardiac Index–Systemic Vascular Resistance Plot in Patients with Fontan Circulation

引用

Congenital Heart Disease 2023年第4期18卷 431-445页

作者： Yuki Kawasaki Takeshi Sasaki Daisuke kobayashi Division of Pediatric Cardiology Osaka City General Hospital Pediatric Medical CenterOsaka5340021Japan Division of Cardiology St.Louis Children’s HospitalDepartment of PediatricsWashington University in St.LouisSt.LouisMO 63130USA

Background: Elevated Fontan pressure (FP) alone cannot fully predict clinical outcomes. We hypothesized thathemodynamic profiling using a cardiac index (CI)-systemic vascular resistance (SVR) plot could characterize clinicalfeatures and predict the prognosis of post-Fontan patients. Methods: We included post-Fontan patients whounderwent cardiac catheterization at age < 10 years. Patients were classified into four categories: A, CI ≥ 3, SVRindex (SVRI) ≥ 20;B, CI < 3, SVRI ≥ 20;C, CI ≥ 3, SVRI < 20;and D, CI < 3, SVRI < 20. The primary outcome wasfreedom from the combined endpoint: new onset of protein-losing enteropathy or plastic bronchitis, heart transplant,and death. Clinical and hemodynamic variables and freedom from the endpoint were compared betweenthe hemodynamic categories and outcome predictors were evaluated. Results: Eighty-three patients wereincluded. Median follow-up was 5.3 years. Category A/B/C/D consisted of 4/15/53/11 patients, respectively. Allthe patients in category A were New York Heart Association I/II and had a significantly lower pulmonary vascularresistance index (PVRI). Patients in category C had lower pulmonary/systemic blood flow. Patients in category Dhad a higher PVRI and had the poorest freedom from the endpoint (44% at 5 years). Elevated FP and category Dwere outcome predictors. Conclusions: CI-SVR plots was a novel adjunctive method for Fontan hemodynamicprofiling.

关键词： Cardiac index systemic vascular resistance perfusion pressure hemodynamic category fontan circulation prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Endoscopic surveillance of gastric cancers after Helicobacter pylori eradication

引用

World Journal of Gastroenterology 2015年第37期21卷 10553-10562页

作者： Masaaki kobayashi Yuichi Sato Shuji Terai Department of Gastroenterology and Hepatology Uonuma Institute of Community Medicine Niigata University Medical and Dental Hospital Division of Gastroenterology and Hepatology Niigata University Graduate School of Medical and Dental Sciences

The incidence and mortality of gastric cancer remains high in East Asian countries. Current data suggest that Helicobacter pylori(H. pylori) eradication might be more effective for preventing gastric cancer in young people before they develop atrophic gastritis and intestinal metaplasia. However, the long-term effect of H. pylori eradication on metachronous cancer prevention after endoscopic resection(ER) of early gastric cancer remains controversial, with some discordance between results published for Japanese and Korean *** detection ability of synchronous lesions before ER and eradication of H. pylori directly influences these results. After eradication, some gastric cancers are more difficult to diagnose by endoscopy because of morphologic changes that lead to a flat or depressed appearance. Narrow-band imaging with magnifying endoscopy(NBI-ME) is expected to be useful for identifying metachronous cancers. However, some gastric cancers after eradication show a "gastritislike"appearance under NBI-ME. The gastritis-like appearance correlates with the histological surface differentiation of the cancer tubules and superficial non-neoplastic epithelium atop or interspersed with the cancer. Till date, it remains unclear whether *** eradication could prevent progression of gastric cancer. Until we can establish more useful endoscopic examination methodologies, regular endoscopic surveillance of high-risk groups is expected to be the most beneficial approach for detection.

关键词： Gastric cancer Helicobacter pylori Atrophic gastri

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pulsed actuation avoids failure in dielectric elastomer artificial muscles

引用

International Journal of Smart and Nano Materials 2014年第4期5卷 217-226页

作者： Toma kobayashi Stoyan K.Smoukov Department of Materials Science and Metallurgy University of CambridgeCambridgeUK

Dielectric elastomer actuators(DEAs)are a class of artificial muscles capable of large linear strains(well over 100%),and with high energy density,and low cost and *** of the most prominent failure modes of a DEA is electrical breakdown,which can damage the device permanently,limiting its deformation *** is also common,since to maximize energy output,devices often operate near the breakdown *** breakdown mechanisms,as well as finding ways to prevent it,are of intense research *** show that by applying short electrical pulses,one could minimize the exposure of the DEAs to high leakage current,which is one of the main mechanisms for electrical *** allows one to operate at significantly higher potentials than the DC breakdown *** applying pulses,we demonstrate up to 81.7%area strain repeatedly,at voltages more than twice the DC breakdown limit,without the risk of *** pulsed operation mode of DEAs accommodating higher voltages than possible with DC represents an opportunity for potential applications,safer and simpler device designs,and a technique for further study of DEA breakdown mechanisms.

关键词： dielectric elastomer electrical breakdown pulsed operation leakage current high voltage design safety

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation and treatment of malignant ascites secondary to gastric cancer

引用

World Journal of Gastroenterology 2015年第39期21卷 10936-10947页

作者： Hiromichi Maeda Michiya kobayashi Junichi Sakamoto Cancer Treatment Center Kochi Medical School Tokai Central Hospital Sohara Higashijimacho

Malignant ascites affects approximately 10% of patients with gastric cancer(gC), and poses significant difficulties for both patients and clinicians. In addition to the dismal general condition of affected patients and the diversity of associated complications such as jaundice and ileus, problems in assessing scattered tumors have hampered the expansion of clinical trials for this condition. However, the accumulation of reported studies is starting to indicate that the weak response to treatment in g C patients with malignant ascites is more relevant to their poor prognosis rather than to the ascites volume at diagnosis. Therefore, precise assessment of initial state of ascites, repetitive evaluation of treatment efficacy, selection of suitable treatment, and swift transition to other treatment options as needed are paramount to maximizing patient benefit. Accurately determining ascites volume is the crucial first step in clinically treating a patient with malignant ascites. Ultrasonography is commonly used to identify the existence of ascites, and several methods have been proposed to estimate ascites volume. Reportedly, the sum of the depth of ascites at five points(named "five-point method") on three panels of computed tomography images is well correlated to the actual ascites volume and/or abdominal girth. This method is already suited to repetitive assessment due to its convenience compared to the conventional volume rendering method. Meanwhile, a new concept, "Clinical Benefit Response in g C(CBR-GC)", was recently introduced to measure the efficacy of chemotherapy for malignant ascites of g C. CBR-GC is a simple and reliable patient-oriented evaluation system based on changes in performance status and ascites, and is expected to become an important clinical endpoint in future clinical trials. The principal of treatment for g C patients with ascites is palliation and prevention of ascites-related symptoms. The treatment options are various, including a standar

关键词： Ascites Clinical benefit Gastric cancer Peritoneal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of dielectric and piezoelectric behavior of unpoled and poled barium titanate polycrystals with oxygen vacancies using phase field method

引用

International Journal of Smart and Nano Materials 2016年第4期7卷 265-275页

作者： Fumio Narita Takuya kobayashi Yasuhide Shindo Department of Materials Processing Graduate School of EngineeringTohoku UniversityAoba-yama 6-6-02SendaiJapan

This article studies the dielectric and piezoelectric behavior of unpoled and poled barium titanate(BaTiO_(3))polycrystals with oxygen vacancies.A phase field model is employed for BaTiO_(3) polycrystals,coupled with the time-dependent Ginzburg–Landau theory and the oxygen vacancies diffusion,to demonstrate the interaction between oxygen vacancies and domain *** generate grain structures,the phase field model for grain growth is also *** hysteresis loop and butterfly curve are predicted at room and high *** permittivity,and longitudinal and transverse piezoelectric constants of the BaTiO_(3) polycrystals are then examined for various grain sizes and oxygen vacancy densities.

关键词： Mesomechanics phase field method ferroelectric ceramics piezoelectric property smart materials and structures

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Use of Asian selected agricultural byproducts to modulate rumen microbes and fermentation

引用

Journal of Animal Science and Biotechnology 2017年第2期8卷 317-326页

作者： Yasuo kobayashi Seongjin Oh Htun Myint Satoshi Koike Lab of Animal Function and Nutrition Research Faculty of AgricultureHokkaido UniversitySapporo 060-8589 Japan

In the last five decades, attempts have been made to improve rumen fermentation and host animal nutrition through modulation of rumen microbiota. The goals have been decreasing methane production, partially inhibiting protein degradation to avoid excess release of ammonia, and activation of fiber digestion. The main approach has been the use of dietary supplements. Since growth-promoting antibiotics were banned in European countries in2006, safer alternatives including plant-derived materials have been explored. Plant oils, their component fatty acids,plant secondary metabolites and other compounds have been studied, and many originate or are abundantly available in Asia as agricultural byproducts. In this review, the potency of selected byproducts in inhibition of methane production and protein degradation, and in stimulation of fiber degradation was described in relation to their modes of action. In particular, cashew and ginkgo byproducts containing alkylphenols to mitigate methane emission and bean husks as a source of functional fiber to boost the number of fiber-degrading bacteria were highlighted. Other byproducts influencing rumen microbiota and fermentation profile were also described. Future application of these feed and additive candidates is very dependent on a sufficient, cost-effective supply and optimal usage in feeding practice.

关键词： Agricultural byproduct Fermentation Fiber degradation Methane mitigation Microbiota Plant secondary metabolites Rumen

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：