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Effects of Elevated Ozone Concentration on Starch and Starch Synthesis Enzymes of Yangmai 16 Under Fully Open-Air Field Conditions

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Journal of Integrative Agriculture 2013年第12期12卷 2157-2163页

作者： ZHANG Ru-biao HU Hai-juan ZHAO Zheng YANG Dan-dan ZHU Xin-kai GUO Wen-shan ZHU Jian-guo Kazuhiko kobayashi Key Lab of Crop Genetics and Physiology Jiangsu Province/Wheat Research InstituteYangzhou University State Key Laboratory of Soil and Sustainable Agriculture Ministry of Science and Technology/Institute of Soil SciencesChinese Academy of Sciences Graduate School of Agricultural and Life Sciences The University of Tokyo

O3 is not only greenhouse gas but also a primary gaseous contaminant in the *** has long-lasting effects on crop growth,yield and quality,and brings a series of ecological and environmental problems.A free-air controlled enrichment（FACE） system was applied to study the effect of elevated ozone concentration on activities of key enzymes of starch synthesis of Yangmai 16 in *** main-plot treatment had two levels of O 3 ：ambient level（A-O 3） and 50% higher than ambient level（E-O 3）.the main results were that accumulation rate of amylose,amylopectin and starch were represented in a single peak curve,and their content and accumulation amount rose *** O 3 elevation decreased the accumulation rate of amylose,amylopectin and starch amylase,reduced the accumulation amount of amylopectin and starch,and decreased the content of amylopectin and starch,but increased the content of *** the increase of O 3 concentration,the enzyme activity of grain granule-bound starch synthase（GBSS）,soluble starch synthase（SSS） and starch branching enzyme（SBE） decreased after *** activities of GBSS and SSS had highly significant correlations with amylose,amylopectin and starch accumulation rate,and the activity of SBE had significant correlations with these *** the O 3 elevation decreased the activity of key enzymes of starch synthesis,which led to the variation of starch synthesis.

关键词： O3 FACE wheat starch activity of enzymes

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Simultaneous formation of sorbitol and gluconic acid from cellobiose using carbon-supported ruthenium catalysts

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Journal of Energy Chemistry 2013年第2期22卷 290-295页

作者： tasuku Komanoya Hirokazu kobayashi Kenji Hara Wang-Jae Chun Atsushi Fukuoka Catalysis Research Center Hokkaido University Kita 21 Nishi 10 Kita-ku Sapporo Hokkaido 001-0021 Japan Division of Chemical Sciences and Engineering Graduate School of Chemical Sciences and Engineering Hokkaido University Kita 13 Nishi 8 Kita-ku Sapporo Hokkaido 060-8628 Japan Division of Arts and Sciences International Christian University 3-10-2 Osawa Mitaka Tokyo 181-8585 Japan

A carbon-supported Ru catalyst, Ru/BP2000, is able to simultaneously convert cellobiose into sorbitol and gluconic acid. this reaction occurs as the result of hydrolytic disproportionation in water at 393 K under an Ar atmosphere, without bases or sacrificial reagents. In-situ XANES measurements suggest that the active Ru species involved is composed of partially oxidized Ru metal.

关键词： cellobiose supported ruthenium catalyst hydrolysis disproportionation

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Observation of New Isotope^(131)Ag via the two-Step Fragmentation technique

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Chinese Physics Letters 2013年第4期30卷 51-54页

作者： WANG He N.Aoi S.takeuchi M.Matsushita P.Doornenbal t.Motobayashi D.Steppenbeck K.Yoneda K.kobayashi J.Lee LIU Hong-Na Y.Kondo R.Yokoyama H.Sakurai YE Yan-Lin School of Physics and State Key Laboratory of Nuclear Physics and technology Peking UniversityBeijing 100871 RIKEN Nishina Center 2-1 HirosawaWakoSaitama 351-0198Japan Research Center for Nuclear Physics Osaka UniversityIbarakiOsaka 567-0047Japan Center for Nuclear Study University of TokyoRIKEN campusWakoSaitama 351-0198Japan Department of Physics Rikkyo University3-34-1 Nishi-IkebukuroToshimaTokyo 172-8501Japan Department of Physics Tokyo Institute of Technology2-12-1 OokayamaMeguroTokyo 152-8551Japan

We report on the first observation of the neutron-rich nucleus^(131)*** isotope was produced via fragmentation reactions of intense secondary radioactive ion beams,including 134,*** secondary beams were produced from induced fission reactions from a stable 238U beam at 345 MeV/*** reaction residues were selected by the ZeroDegree spectrometer and identified by measuring their magnetic rigidity,time of flight,energy loss,and total kinetic energy.

关键词： rigidity intense

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Liver-targeted hydrodynamic gene therapy: Recent advances in the technique

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World Journal of Gastroenterology 2016年第40期22卷 8862-8868页

作者： takeshi Yokoo Kenya Kamimura Hiroyuki Abe Yuji kobayashi tsutomu Kanefuji Kohei Ogawa Ryo Goto Masafumi Oda takeshi Suda Shuji terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University Institute for Research Collaboration and Promotion Niigata University

One of the major research focuses in the field of gene therapy is the development of clinically applicable, safe, and effective gene-delivery methods. Since the first case of human gene therapy was performed in 1990, a number of gene-delivery methods have been developed, evaluated for efficacy and safety, and modified for human application. to date, viral-vectormediated deliveries have shown effective therapeutic results. However, the risk of lethal immune response and carcinogenesis have been reported, and it is still controversial to be applied as a standard therapeutic option. On the other hand, delivery methods for nonviral vector systems have been developed, extensively studied, and utilized in in vivo gene-transfer studies. Compared to viral-vector mediated gene transfer, nonviral systems have less risk of biological reactions. However, the lower gene-transfer efficiency was a critical hurdle for applying them to human gene therapy. Among a number of nonviral vector systems, our studies focus on hydrodynamic gene delivery to utilize physical force to deliver naked DNA into the cells in the living animals. this method achieves a high gene-transfer level by DNA solution injections into the tail vein of rodents, especially in the liver. With the development of genome editing methods, in vivo gene-transfer therapy using this method is currently the focus in this research field. this review explains the method principle, efficiency, safety, and procedural modifications to achieve a high level of reproducibility in large-animal models.

关键词： Gene therapy liver Hydrodynamic gene delivery Non-viral image-guided

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Early gastric cancer frequently has high expression of KKLC-1, a cancer-testis antigen

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World Journal of Gastroenterology 2017年第46期23卷 8200-8206页

作者： Nobue Futawatari takashi Fukuyama Rui Yamamura Akiko Shida Yoshihito takahashi Yatsushi Nishi Yoshinobu Ichiki Noritada kobayashi Hitoshi Yamazaki Masahiko Watanabe Department of Surgery Sagamihara National Hospital Division of Biomedical Research Kitasato University Medical Center Department of Surgery School of MedicineKitasato University Department of Surgery Kitasato University Medical Center Second Department of Surgery School of MedicineUniversity of Occupational and Environmental Health Department of Pathology Kitasato University Medical Center

AIM to assess cancer-testis antigens(CtAs) expression in gastric cancer patients and examined their associations with clinicopathological *** Eighty-three gastric cancer patients were evaluated in this study. Gastric cancer specimens were evaluated for the gene expression of CtAs, Kitakyushu lung cancer antigen-1(KK-LC-1), melanoma antigen(MAGE)-A1, MAGE-A3 and New York esophageal cancer-1(NYESO-1), by reverse transcription PCR. Clinicopathological background information, such as gender, age, tumor size, macroscopic type, tumor histology, depth of invasion, lymph node metastasis, lymphatic invasion, venous invasion, and pathological stage, was obtained. Statistical comparisons between the expression of each CtA and each clinicopathological background were performed using the χ2 test. RESULtS the expression rates of KK-LC-1, MAGE-A1, MAGE-A3, and NY-ESO-1 were 79.5%, 32.5%, 39.8%, and 15.7%, respectively. In early stage gastric cancer specimens, the expression of KK-LC-1 was 79.4%, which is comparable to the 79.6% observed in advanced stage specimens. the expression of KK-LC-1 was not significantly associated with clinicopathological factors, while there were considerable differences in the expression rates of MAGE-A1 and MAGE-A3 with vs without lymphatic invasion(MAGE-A1, 39.3% vs 13.6%, P = 0.034; MAGE-A3, 47.5% vs 18.2%, P = 0.022) and/or vascular invasion(MAGE-A1, 41.5% vs 16.7%, P = 0.028; MAGE-A3, 49.1% vs 23.3%, P = 0.035) and, particularly, MAGE-A3, in patients with early vs advanced stage(36.5% vs 49.0%, P = 0.044), respectively. Patients expressing MAGE-A3 and NYESO-1 were older than those not expressing MAGE-A3 and NY-ESO-1(MAGE-A3, 73.7 ± 7.1 vs 67.4 ± 12.3, P = 0.009; NY-ESO-1, 75.5 ± 7.2 vs 68.8 ± 11.2, P = 0.042). CONCLUSION the KK-LC-1 expression rate was high even in patients with stage I cancer, suggesting that KK-LC-1 is a useful biomarker for early diagnosis of gastric cancer.

关键词： Cancer-testis antigen Kitakyushu lung cancer antigen-1 Melanoma antigen-A1 Melanoma antigen-A3 Gastric cancer New York esophageal cancer-1 Clinicopathological factor early stage

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Metal Ion Production with RIKEN 18GHz-ECRIS

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Chinese Physics C 2007年第S1期31卷 97-100页

作者： M.Kidera t.Nakagawa t.Kageyama Y.Higurashi H.Haba t.Aihara t.Ohki K.kobayashi A.Goto Y.Yano Nishina Center for Accelerator Based Science RIKENHirosawa2-1WakoSaitama 351-0198Japan SHI Acclcrator Service Ltd. Kitashinagawa5-9-11ShinagawaTokyo 141-8686Japan

At RIKEN,three ECR ion sources(10GHz ECRIS,18GHz ECRIS and liquid He-free SC-ECRIS) are operated as external ion sources of heavy ion *** the last year,multi-charged uranium ion beam was produced from 18GHz ECRIS by using UF_6 and the ^(238)U ion was successfully accelerated by the accelerator complex which consists of the RFQ linear accelerator,RIKEN heavy ion linear accelerator(RILAC)and RIKEN ring cyclotron accelerator(RRC).the typical beam intensity of^(238)U^(14+) was about 2pμA on faraday cup after analysing magnet.^(70)Zn beam was still supplied for the new super-heavy element search experiment with insertion *** beam of^(70)Zn^(16+) was produced for long term(～43 days)without vacuum break and remarkably low material consumption rate(～100μgr/h).We already supplied Zn beam longer than 200 days for this experiment.^(48)Ca ion was also produced by insertion method using^(48)CaO rod for the nuclear physics *** this contribution,we will present ion source parameter and techniques for production of each of the metal ions.

关键词： ECRIS metal ion ^(238)Su ^(70)Zn ^(48)Ca

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Recent evidence for subcutaneous drains to prevent surgical site infections after abdominal surgery:A systematic review and metaanalysis

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2879-2889页

作者： tomohiro Ishinuki Hiroji Shinkawa Keita Kouzu Seiichi Shinji Erika Goda toshio Ohyanagi Masahiro kobayashi Motomu kobayashi Katsunori Suzuki Yuichi Kitagawa Chizuru Yamashita Yasuhiko Mohri Junzo Shimizu Motoi Uchino Seiji Haji Masahiro Yoshida Hiroki Ohge toshihiko Mayumi toru Mizuguchi Department of Nursing Surgical SciencesSapporo Medical UniversitySapporo 060-8556HokkaidoJapan Department of Hepatobiliary-Pancreatic Surgery Osaka Metropolitan University Graduate School of MedicineAbeno-Ku 545-0051Japan Department of Surgery National Defense Medical CollegeTokorozawa 359-8513Japan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical SchoolTokyo 113-8602Japan Department of Nursing Japan Health Care UniversitySapporo 062-0053Japan Department of Liberal Arts and Sciences Center for Medical EducationSapporo Medical UniversitySapporo 060-8556Japan Department of Clinical Pharmacokinetics Research and Education Center for Clinical PharmacyKitasato UniversityTokyo 108-8641Japan Department of Anesthesiology Hokushinkai Megumino HospitalEniwa 061-1395Japan Department of Infectious Disease Medicine School of MedicineUniversity of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Gastrointestinal Surgery National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Anesthesiology and Critical Care Medicine Fujita Health UniversityToyoake 470-1192Japan Department of Gastrointestinal Surgery Mie Prefectural General Medical CenterYokkaich 510-8561Japan Department of Surgery Toyonaka Municipal HospitalToyonaka 560-8565Japan Department of Gastroenterological Surgery Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Surgery Soseikai General HospitalKyoto 612-8473Japan Department of Hepato-Biliary-Pancreatic&Gastrointestinal Surgery International University of Health and WelfareIchikawa 272-0827Japan Department of Infectious Disease Hiroshima University HospitalHiroshima 734-8551Japan Department of Intensive Care Unit Chukyo HospitalJapan Community Health Care OrganizationNagoya 457-8510Japan

BACKGROUND Surgical site infections(SSIs)increase mortality,hospital stays,additional medical treatment,and medical *** drains prevent SSIs in gynecological and breast surgeries;however,their clinical impact in abdominal surgery remains *** to investigate whether subcutaneous drains were beneficial in abdominal surgery using a systematic review and *** the database search used PubMed,MEDLINE,and the Cochrane *** following inclusion criteria were set for the systematic review:(1)Randomized controlled trial studies comparing SSIs after abdominal surgery with or without subcutaneous drains;and(2)Studies that described clinical outcomes,such as SSIs,seroma formation,the length of hospital stays,and *** Eight studies were included in this *** rate of total SSIs was significantly lower in the drained group(54/771,7.0%)than in the control group(89/759,11.7%),particularly in gastrointestinal ***,the rate of superficial SSIs was slightly lower in the drained group(31/517,6.0%)than in the control group(49/521,9.4%).No significant differences were observed in seroma formation between the *** stays were shorter in the drained group than in the control *** Subcutaneous drains after abdominal surgery prevented SSIs and reduced hospital stays but did not significantly affect seroma *** timing of drain removal needs to be reconsidered in future studies.

关键词： Abdominal surgery Mortality Seroma formation Subcutaneous drain Surgical site infections

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Extraction of Lignin from Lignocellulosic Biomass Residue with Atmospheric Acetic Acid Pulping and Estimation of Chemical Nature of the Lignin

Extraction of Lignin from Lignocellulosic Biomass Residue wi...

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the 19th European Biomass Conference and Exhibition

作者： Ito,K. Yagisawa,Y. Ito,A. takahashi,t. kobayashi,J.

One of the important issues in bio-ethanol production from lignocellulosic biomass is the effective usage of sacchararification *** sacchararification residue includes lignin,which is contained a variety of functional *** is possible to apply the lignin as raw martial for chemical agents and plastics,thus there is a need for an effective extraction technique of lignin from the sacchararification *** this study,enzymatic sacchararification residue was applied to the extraction technique that was reported in previous *** results,the method could extract acetic acid lignin from the sacchararification *** addition,the yield of acetic acid lignin increased with extraction time was *** extraction of acetic acid lignin,chemical natures of the lignin were estimated with fourier transform infrared spectroscopy *** results indicated the hydroxylation of the acetic acid lignin with extraction *** generally,many types of polymer are produced by polymerization of hydroxyl containing ***,it is possible that the acetic acid lignin extracted from sacchararification residue is used as plastics material.

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Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

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Cellular & Molecular Immunology 2018年第11期15卷 953-962页

作者： tomonori Yaguchi Asuka kobayashi takashi Inozume Kenji Morii Haruna Nagumo Hiroshi Nishio takashi Iwata Yuyo Ka Ikumi Katano Ryoji Ito Mamoru Ito Yutaka Kawakami Division of Cellular Signaling Institute for Advanced Medical ResearchKeio University School of MedicineTokyo 160-8582Japan Department of Dermatology Yamanashi University School of MedicineYamanashi 409-3898Japan Department of Obstetrics and Gynecology Keio University School of MedicineTokyo 160-8582Japan Central Institute for Experimental Animals Kanagawa 210-0821Japan

Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune ***,when human peripheral blood mononuclear cells(PBMCs)are transferred into NOG(NOD/Shi-scid,IL-2rg null)mice,severe graft versus host disease(GVHD)hinders long term detailed *** of human PBMCs into newly developed murine MHC class I-and class II-deficient NOG(NOG-dKO;NOG-Iab,B2m-double-knockout)mice showed sufficient engraftment of human immune cells with little sign of *** with influenza vaccine resulted in an increase in influenza-specific human IgG Ab,indicating induction of antigen-specific B cells in the NOG-dKO *** with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic t cells,indicating the induction of antigen-specific t cells in the NOG-dKO *** cell therapies(ACts)using melanoma antigen recognized by t cells(MARt-1)-specific tCR-transduced activated t cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MARt-1-specific t *** using cultured human melanoma infiltrating t cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice,in which changes in human cancer phenotypes by immune intervention,such as increased CD271 expression,could be ***,NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of t-cell and B-cell responses for a longer period than regular NOG mice.

关键词： adoptive cell therapy humanized mouse vaccine

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Behavior of Impurity Elements in Electrolytic Copper in Copper Recycling by Using Ammoniacal Alkaline Solution Containing Cu（I）

Behavior of Impurity Elements in Electrolytic Copper in Copp...

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第八届东亚资源再生技术国际会议

作者： K.KOYAMA M.tANAKA M.kobayashi t.SEKINE J.LEE National Institute of Advanced Industrial Science and technology（AISt） 16-1 Onogawa Tsukuba Ibaraki 305-8569 Japan National Institute of Advanced Industrial Science and technology（AISt） 16-1 Onogawa Tsukuba Ibaraki 305-8569 Japan National Institute of Advanced Industrial Science and technology（AISt） 16-1 Onogawa Tsukuba Ibaraki 305-8569 Japan Department of Metallurgical Engineering Chiba Institute of Technology 2-17-1 TsudanumaNarashino Chiba 275-858 Japan Korea Institute of Geoscience ＆ Mineral Resources（KIGAM） 30 Gajeong-dong Yuseong Daejeon 305-350 Korea

＜正＞Behaviors of nickel and silver in the electrolytic copper were investigated in order to obtain high purity copper in the recycling system from metallic wastes by using ammoniacal alkaline solution containing Cu（I）. Both nickel and silver were found to be stable in Cu（I）-ammine solution from potential-pH diagrams. the nickel concentration in the electrolytic copper was reduced with a decrease in the nickel concentration in the aqueous solution. It was less than *** when the nickel concentration in the solution was less than 0.01 kmol m-3 and the current density was less than 500 A m-2. the cathode potential for the deposition of silver was around -0.1 V vs SHE which was higher than that of copper. the silver concentration in the electrolytic copper was less than 25ppm when the silver concentration in the solution was less than 7.4×10-5 kmol m-3 and the current density was less than 500 A m-2.

关键词： Cu recycling electrowinning impurity Cuprous ion

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