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Fish scale-derived scaffolds with MSCs loading for photothermal therapy of bone defect

Nano Research 2023年第5期16卷 7383-7392页

作者： Siyu Shen Rui Liu Chuanhui Song Tao Shen Yiwen Zhou Junxia Guo bin kong Qing Jiang State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Branch of National Clinical Research Center for Orthopedics Sports Medicine and RehabilitationNanjing 210008China The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing 210008China Department of Orthodontics Nanjing Stomatological HospitalMedical School of Nanjing UniversityNanjing 210008China Department of Sports Medicine and Adult Reconstructive Surgery Nanjing Drum Tower HospitalClinical College of Nanjing Medical UniversityNanjing 210008China Department of Biomedical Engineering School of MedicineShenzhen UniversityShenzhen 518060China

Tissue engineering scaffolds have presented effective value in bone ***,the integration of the diverse components,complex structures,multifunction to impart the scaffolds with improved applicability is still a ***,we propose a novel fish-derived scaffold combined with photothermal therapy and mesenchymal stem cells(MSCs)to promote bone *** fish-derived scaffold is composed of the decellularized fish scale and gelatin methacrylate synthesized from fish gelatin(fGelMA),which can promote the proliferation and osteogenesis of MSCs with no obvious immunological ***,the black phosphorus(BP)nanosheets are incorporated into the fGelMA hydrogel network,which can endow the hydrogel with the capacity of photothermal conversion stimulated by near-infrared(NIR)*** fish-derived scaffold can promote the osteogenesis process of MSCs with higher expression of osteogenic markers and higher mineralization assisted by the NIR light in *** regeneration of mice calvarial defect has also been accelerated by the scaffold with photothermal therapy and *** results suggest that the fish-derived scaffold,photothermal therapy,MSCs-based regenerative therapy is a promising clinical strategy in bone regeneration.

关键词： fish scale GelMA photothermal therapy mesenchymal stem cell bone regeneration

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Natural biopolymers derived hydrogels with injectable,self-healing,and tissue adhesive abilities for wound healing

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Nano Research 2023年第2期16卷 2798-2807页

作者： bin kong Rui Liu Yi Cheng Xiaodong Cai Junying Liu Dagan Zhang Hui Tan Yuanjin Zhao Department of Rheumatology and Immunology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210002China Respiratory department Shenzhen Children's HospitalShenzhen 518038China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001China

Developing a biocompatible and multifunctional adhesive hydrogel with injectability and self-healing ability for promoting wound healing is highly anticipated in various clinical *** this paper,we present a novel natural biopolymer-derived hydrogel based on the aldehyde-modified oxidized guar gum(OGG)and the carboxymethyl chitosan(CMCS)for efficiently improving wound healing with the encapsulation of vascular endothelial growth factor(VEGF).As the hydrogels are synthesized via the dynamically reversible Schiff base linkages,it is imparted with excellent self-healing ability and good shear thinning behavior,which make the hydrogel be easily and conveniently injected through a ***,the physiochemical properties,including porous structure,mechanical strength and swelling ratio of the hydrogel can be well controlled by regulating the concentrations of the ***,the hydrogel can attain strong adhesion to the tissues at physiological temperature based on the Schiff base between the aldehyde group on the hydrogel and the amino group on the *** on these features,we have demonstrated that the VEGF encapsulated hydrogel can adhere tightly to the defect tissue and improve wound repair in the rat model of defected skin by promoting cell proliferation,angiogenesis,and collagen *** results indicate that the multifunctional hydrogel is with great scientific significance and broad clinical application prospects.

关键词： hydrogel self-healing injectability tissue adhesive wound healing

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Synthesis of Co-Ni oxide microflowers as a superior anode for hybrid supercapacitors with ultralong cycle life

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Chinese Chemical Letters 2017年第2期28卷 206-212页

作者： Ling-Yang Liu Xu Zhang Hong-Xia Li Bao Liu Jun-Wei Lang Ling-bin kong Xing-bin Yan State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals Lanzhou University of TechnologyLanzhou 730050China School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou 730050China Laboratory of Clean Energy Chemistry and Materials State Key Laboratory of Solid LubricationLanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

Li-ion hybrid capacitors（LIHCs）,composing of a lithium-ion battery（LIB） type anode and a supercapacitor（SC） type cathode,gained worldwide popularity due to harmonious integrating the virtues of high energy density of LIBs with high power density of ***,nanoflakes composed microflower-like Co-Ni oxide（CoNiO） was successfully synthesized by a simple co-precipitation *** atomic ratio of as-synthesized CoNiO is determined to be 1：3 through XRD and XPS analytical *** a typical battery-type material,CoNiO and capacitor-type activated polyanilinederived carbon（APDC） were used to assemble LIHCs as the anode and cathode materials,*** a result,when an optimized mass ratio of CoNiO and APDC was 1：2,CoNiO//APDC LIHC could deliver a maximum energy density of 143 Wh kg^-1 at a working voltage of 1-4 *** is worth mentioning that the LIHC also exhibits excellent cycle stability with the capacitance retention of -78.2%after 15,000 cycles at a current density of 0.5 A g^-1.

关键词： Li-ion hybrid capacitor Energy storage device Co-precipitation method Cobalt nickel oxide APDC Long cycle life

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Microstructure and High-Temperature Oxidation Behavior of Dy-Doped Nb–Si-Based Alloys

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Acta Metallurgica Sinica(English Letters) 2018年第7期31卷 742-752页

作者： Yue-Ling Guo Li-Na Jia Hua-Rui Zhang bin kong Yong-Lin Huang Hu Zhang School of Materials Science and Engineering Beihang University

Microstructures and oxidation behaviors of four Dy-doped Nb-Si-based alloys at 1250 ℃ were investigated. The nominal compositions of the four alloys are Nb-15Si-24Ti-4Cr-2Al-2Hf-xDy （at.%）, where x = 0, 0.05, 0.10 and 0.15, respectively. Results showed that the four alloys all consisted of Nbss, αNbsSi3 and γNbsSi3, and the addition of Dy produced no obvious effect on the phase constitution and the microstructures of Nb-Si-based alloys. After oxidation at 1250 ℃ for 58 h, it was found that the addition of Dy accelerated the oxidation rate of Nb-Si-based alloys and caused a larger weight gain, accompanied by the formation of a more porous and less protective oxide scale. The oxides of Nb2O5, Ti2Nb10O29, TiNb2O7, Ti0.4Cr0.3Nb0.302 and glassy SiO2 were formed on Dy-doped Nb-Si-based alloys. The high- temperature oxidation mechanism of Dy-doped Nb-Si-based alloys was discussed.

关键词： Nb-Si alloy Intermetallics Directional solidification - Oxidation - Microstructure

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Advances in antioxidative nanozymes for treating ischemic stroke

再生工程(英文)

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再生工程(英文) 2023年第1期4卷 95-102页

作者： Jingyang Shan Xia Liu Xiuping Li Yunru Yu bin kong Lijie Ren Department of Neurology Shenzhen Institute of Translational MedicineThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalGuangdong Key Laboratory for Biomedical Measurements and Ultrasound ImagingNational-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China Pharmaceutical Sciences Laboratory Åbo Akademi UniversityTurku 20520Finland

Ischemic stroke is one of the most common public diseases that increase *** the ischemic brain,blood flow restoration can cause the generation of excess reactive oxygen species(ROS).Endogenous anti-oxidases in the living system,including catalase(CAT)and superoxide dismutase(SOD),can consume the excess ROS by catalysis to regulate ***,these natural enzymes are difficult to be widely used in the treatment of *** advantages of high stability,low cost,and long-term storage,antioxidative nanozymes-mediated treatments have been proven as a promising method against ischemic *** highlight the progress,we summarize the advances in nanozymes with the antioxidative ability for treating ischemic *** is believed that such a promising therapeutic strategy of antioxidative nanozymes will significantly contribute to the field of ischemic *** expect that antioxidative nanozymes will play significant roles in both basic research and clinical applications.

关键词： Nanozymes Reactive oxygen species Antioxidative ability Blood brain barrier Ischemic stroke

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MSCs-laden injectable self-healing hydrogel for systemic sclerosis treatment

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Bioactive Materials 2022年第11期7卷 369-378页

作者： Min Nie bin kong Guopu Chen Ying Xie Yuanjin Zhao Lingyun Sun Department of Rheumatology and Immunology Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing210002China Department of Neurosurgery Health Science CenterThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhen518035China State Key Laboratory of Quality Research in Chinese Medicines Macao University of Science and TechnologyTaipaMacao(SAR)China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China

As a novel cellular therapy, the anti-inflammatory and immunomodulatory virtues of mesenchymal stem cells (MSCs) make them promising candidates for systemic sclerosis (SSc) treatment. However, the clinical efficacy of this stratagem is limited because of the short persistence time, poor survival, and engraftment of MSCs after injection in vivo. Herein, we develop a novel MSCs-laden injectable self-healing hydrogel for SSc treatment. The hydrogel is prepared using N, O-carboxymethyl chitosan (CS-CM) and 4-armed benzaldehyde-terminated poly-ethylene glycol (PEG-BA) as the main components, imparting with self-healing capacity via the reversible Schiff-base connection between the amino and benzaldehyde groups. We demonstrate that the hydrogel laden with MSCs not only promoted the proliferation of MSCs and increased the cellular half-life in vivo, but also improve their immune-modulating functions. The tube formation assay indicates that the MSCs could significantly pro-mote angiopoiesis. Moreover, the MSCs-laden hydrogel could inhibit fibrosis by modulating the synthesis of collagen and ameliorate disease progression in SSc disease model mice after subcutaneous injection of bleo-mycin. All these results highlight this novel MSCs-laden hydrogel and its distinctive functions in treatment of chronic SSc, indicating the additional potential to be used widely in the clinic.

关键词： Mesenchymal Stem cell Injectable Self-healing Hydrogel Systemic sclerosis

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常州市创新国际化的特征及提升路径研究

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全国流通经济 2024年第6期 145-148页

作者：蔡晶豪李夏玲徐思佳孔斌江苏理工学院经济学院江苏常州213000

在以国内大循环为主体、国内国际双循环相互促进的新发展格局中,科技创新扮演着至关重要的角色,其要求充分发挥科技创新在构建和强化国内国际双循环中的关键作用,通过科技创新来推动国内国际产业发展的双向循环。当前国际经济形势严峻,... 详细信息

在以国内大循环为主体、国内国际双循环相互促进的新发展格局中,科技创新扮演着至关重要的角色,其要求充分发挥科技创新在构建和强化国内国际双循环中的关键作用,通过科技创新来推动国内国际产业发展的双向循环。当前国际经济形势严峻,如何在创新国际化难度大幅度提升的背景下,利用创新国际化推动本地区技术进步,是当前摆在常州市面前的极其重要又有待深化的研究课题。本文首先构建了创新国际化衡量指标体系,其次运用指标体系对常州市创新国际化的现状进行了讨论,最后对常州市创新国际化的发展提出了一些可行性的建议。

关键词：创新国际化指标构建经济态势

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A novel polyaniline/mesoporous carbon nano-composite electrode for asymmetric supercapacitor

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Chinese Chemical Letters 2010年第12期21卷 1509-1512页

作者： Jian Jun Cai Ling bin kong Jing Zhang Yong Chun Luo Long Kang State Key Laboratory of Gansu Advanced Non-ferrous Metal Materials Lanzhou University of Technology Lanzhou 730050 China School of Materials Science and Engineering Lanzhou University of Technology Lanzhou 7-30050 China

A novel nano-composite of polyaniline/mesoporous carbon（PANI/CMK-3） was prepared with mesoporous carbon（CMK-3） serving as the *** asymmetric capacitors have been successfully designed by using PANI/CMK-3 composite and CMK-3 as positive and negative electrode,*** results showed that the discharge capacity of the asymmetric capacitor could reach 87.4 F/g under the current density of 5 mA/cm^2 and cell voltage of 1.4 *** energy density of the asymmetric capacitor was up to 23.8 Wh/kg with a power density of 206 W/***,PANI/CMK-3-CMK-3 asymmetric capacitor using this PANI/CMK-3 nano-composite could be activated quickly and possess high charge-discharge efficiency.

关键词： Mesoporous carbon Polyaniline Asymmetric supercapacitor Energy density

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宇航电连接器失效分析及针对性质量保证措施

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机电元件 2024年第4期44卷 34-38页

作者：赵立有邓田葳孔泽斌龚丹丹袁颖上海航天技术基础所上海201109 上海对外经贸大学上海201620

电连接器是宇航元器件的重要组成部分,也是装机后失效数量较多的一类元器件。本文总结了宇航电连接器地面使用过程中常见的失效模式,分析了失效模式产生的原因,包括污染、灌胶气泡、腐蚀、接触件无分离力、虚焊、断裂、插合(分离)力增... 详细信息

电连接器是宇航元器件的重要组成部分,也是装机后失效数量较多的一类元器件。本文总结了宇航电连接器地面使用过程中常见的失效模式,分析了失效模式产生的原因,包括污染、灌胶气泡、腐蚀、接触件无分离力、虚焊、断裂、插合(分离)力增大、零件错位、涂胶缺陷等,探讨了失效产生的机理。在此基础上,从结构设计、工艺与材料、使用三方面提出了针对性质量保证措施。

关键词：电连接器失效分析质量保证

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Plasma amino acid profiling of cancer patients with abnormal Savda based on high-performance liquid chromatography

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Journal of Traditional Chinese Medicine 2014年第5期34卷 560-565页

作者： Batur Mamtimin Kedena bin kong Ayshamgul Hasim Aynur Matsidik Mawlanjan Hizbulla Nazuk Kurbantay Halmurat Upur College of Pharmacy Xinjiang Medical University Department of Radiology Beijing Tiantan HospitalCapital Medical University Basic Medical College Xinjiang Medical University College of Traditional Uyghur Medicine Xinjiang Medical University

OBJECTIVE: To investigate metabolic signatures in plasma of cancer patients with abnormal Savda using plasma-free amino acid profiles, and to evaluate the diagnostic potential of these profiles for the detection and explanation of the mechanisms of different symptoms in traditional Uyghur ***: Plasma samples from cancer patients with abnormal Savda(n=85) or non-abnormal Savda(n=105) and a healthy control group(n=65)were analyzed using high-performance liquid chromatography(HPLC). Orthogonal projection to latent structures with discriminant analysis was used for the classification and prediction of abnormal Savda, and spectral profiles were subjected to Student’s t-tests to assess statistical ***: Compared with the healthy group, the levels of aspartic acid, glutamate, glycine, histidine,arginine, threonine, alanine, proline, methionine,isoleucine, leucine and phenylalanine decreased significantly in plasma of cancer patients with abnormal Savda(all P0.05). Compared with non-abnormal Savda syndrome patients, abnormal Savda syndrome patients showed high concentrations of glutamate, serine, valine, isoleucine, leucine and phenylalanine(all P0.05).CONCLUSION: Plasma-free amino acid profiling has the potential to assist in understanding and determining abnormal Savda. A HPLC-based metabonomic platform could be a powerful tool for the classification of symptoms in traditional medicine.

关键词： Amino acids Medicine,Uyghur traditional Chromatography,High pressure liquid Abnormal Savda

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