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High risk for obstructive sleep apnea and risk of hypertension in military personnel: The CHIEF sleep study

World Journal of Clinical Cases 2023年第30期11卷 7309-7317页

作者： Wei-Nung Liu ko-huan lin Kun-Zhe Tsai Chen-Chih Chu Yun-Chen Chang Younghoon Kwon Gen-Min lin Department of Medicine Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Department of Psychiatry Hualien Tzu Chi HospitalHualien City 970TaiwanChina Department of Stomatology of Periodontology Mackay Memorial HospitalTaipei 104TaiwanChina School of Nursing and Graduate Institute of Nursing China Medical UniversityTaichung 406TaiwanChina Department of Medicine University of WashingtonSeattle98104-2499United States Department of Medicine Hualien Armed Forces General HospitalHualien City 970TaiwanChina

BACKGROUND Epidemiological studies have revealed an association between obstructive sleep apnea(OSA)and hypertension in the general population,while the association in military personnel was rarely *** To examine the association between high risk for OSA and hypertension by phenotypes in military young *** A total of 746 military personnel,aged 27.9 years,were included in the cardiorespiratory fitness and health in armed forces(CHIEF)-sleep study in Taiwan in *** medications were not used by the *** risk for OSA was assessed using the Berlin *** was defined using the 7th Report of the Joint National Committee on Prevention,Detection,Evaluation,and Treatment of High Blood Pressure(JNC 7)and the 2017 American College of Cardiology(ACC)/American Heart Association(AHA)*** cutoff levels of systolic and diastolic blood pressure(SBP and DBP)for the 2017 ACC/AHA-and JNC 7-based guidelines were 130/140 mmHg and 80/90 mmHg,*** phenotypes included isolated systolic and diastolic hypertension(ISH,high SBP only and IDH,high DBP only)and combined hypertension(both high SBP and DBP).Multivariable logistic regression analysis with adjustment for demographics,lifestyle and metabolic *** The prevalence of high risk for OSA,JNC 7-based hypertension and 2017 ACC/AHA-based hypertension were 8.0%,5.2%and 22.0%,*** with a high risk for OSA had a higher probability of JNC 7-based overall and combined hypertension(odds ratios(ORs))and 95%confidence intervals:2.82(1.07-7.42)and 7.54(1.10-51.54),although the probabilities of ISH and IDH were unaffected by a high risk for OSA(ORs:1.96 and 2.35,respectively,both P>0.05).In contrast,no associations for any hypertension phenotypes were found according to the 2017 ACC/AHA *** A high risk for OSA was associated with severe hypertension and combined hypertension among Asian military young adults.

关键词： Asian young adults Berlin questionnaire Hypertension phenotypes Military Sleep apnea

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Nocturnal sentry duty and cardiometabolic characteristics in armed forces personnel

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World Journal of Cardiology 2024年第12期16卷 751-759页

作者： Yen-Po lin Yi-Chiung Hsu ko-huan lin Kun-Zhe Tsai Chen-Chih Chu Yen-Chen lin Gen-Min lin Department of Critical Care Medicine Taipei Tzu Chi General HospitalNew Taipei City 23142TaiwanChina Department of Biomedical Sciences and Engineering National Central UniversityTaoyuan City 320TaiwanChina Department of Psychiatry Hualien Tzu Chi HospitalHualien City 970TaiwanChina Department of Stomatology of Periodontology Mackay Memorial HospitalTaipei 104TaiwanChina Department of Dentistry Tri-Service General HospitalTaipei 114TaiwanChina Department of Medicine Tri-Service General HospitalTaipei 114TaiwanChina Department of Medicine Linkou Chang Gung Memorial HospitalTaoyuan City 333TaiwanChina Department of Medicine Hualien Armed Forces General HospitalHualien City 970TaiwanChina

BACKGROUND Sleep deprivation can lead to increased body weight and blood pressure(BP),but the latent effects of partial sleep deprivation related to required night sentry duties within a short-term period on cardiometabolic characteristic changes in military personnel are *** To investigate the association between night sentry duty frequency in the past 3 months and cardiometabolic characteristics in armed forces *** A total of 867 armed forces personnel who were aged 18-39 years and did not take any antihypertensive medications in Taiwan in 2020 were *** frequency of night sentry duty was self-reported via a questionnaire(average number of night sentry shifts per month for the past 3 months).Hemodynamic status was assessed via the resting BP and pulse rate(PR).Cardiometabolic risk factors were defined according to the International Diabetes Federation *** linear regression analyses of the associations between night sentry duties and PR,BP,and other metabolic syndrome(MetS)marker levels were performed,with adjustments for age,sex,substance use,body mass index and aerobic *** logistic regression analysis was carried out to determine the associations between night sentry duties and the prevalence of each MetS feature.

关键词： Armed forces personnel Cardio-metabolic characteristics Night sentry duty Partial sleep deprivation

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Rationale and design of the cardiorespiratory fitness and hospitalization events in armed forces study in Eastern Taiwan

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World Journal of Cardiology 2016年第8期8卷 464-471页

作者： Gen-Min lin Yi-Hwei Li Chung-Jen Lee Jeng-Chuan Shiang ko-huan lin Kai-Wen Chen Yu-Jung Chen Ching-Fen Wu Been-Sheng lin Yun-Shun Yu Felicia lin Fung-Ying Su Chih-Hung Wang Department of Public Health Tzu-Chi University Department of Medicine Hualien-Armed Forces General Hospital Department of Medicine Tri-Service General Hospital and National Defense Medical Center Department of Nursing Tzu-Chi College of Technology Department of Medicine Mennonite Christian Hospital

AIM To investigate the association between cardiorespiratory fitness and hospitalization events in a cohort of large voluntary arm forces in Taiwan. METHODS The cardiorespiratory fitness and hospitalization events in armed forces(CHIEF) is a retrospective cohort consisting of more than 4000 professional military members aged 18-50 years in Eastern Taiwan. All participants received history taking, physical examination, chest radiography, 12-lead electrocardiography, blood tests for cell counts and fasting glucose, lipid profiles, uric acid, renal function and liver function in the Hualien Armed Forces General Hospital during 2014. In addition, participants were required to undergo two indoor resistant exercise tests including 2-min push-up and 2-min sit-up, both scored by infrared sensing, and one outdoor endurance 3000-m none weight-bearing running test, the main indicator of cardiorespiratory fitness in the Military Physical Training and Testing Center in Eastern Taiwan in 2014. RESULTS Hospitalization events for cardiovascular disease, acute kidney injury, rhabdomyolysis, severe infectious disease, acute psychiatric illness, diabetes, orthopedic surgery and mortality will be identified in the National Insurance Research Database for 10 years. CONCLUSION CHIEF will be among the largest Eastern Asian armed forces cohort, in which physical status was strictly evaluated to follow up the hospitalization events for severe illness.

关键词： Cardiorespiratory fitness Hospitalization Voluntary armed forces

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Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： huan Pei Ren-lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Engineering of Fe d-band center in Fe_(3)O_(4)/CeO_(2)hetero-nanoparticles via orbital coupling for high-efficiency oxygen reduction electrocatalysis

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Nano Research 2025年第1期18卷 129-139页

作者： Jiayi Liu Jingwen Yin Yingzi lin Mingxin Pang huan Pang Songtao Zhang lin Xu Jun Yang Yawen Tang Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023Chin a 2 State Key Laboratory of Multiphase Complex Systems Center of MesoscienceInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009China Testing Center Yangzhou UniversityYangzhou 225009China

The deliberate engineering of the d-band center of metal site represents an effective strategy to boost the intrinsic electrocatalytic performance toward the oxygen reduction reaction(ORR).Herein,following a heterointerfaceinduced orbital coupling rationale,we report a judicious design of an efficient ORR electrocatalyst consisting of Fe_(3)O_(4)/CeO_(2)hetero-nanoparticles in-situ encased into N-doped carbon nanofibers(abbreviated as Fe_(3)O_(4)/CeO_(2)@N-CNFs hereafter).The theoretic calculations uncover that the Fe_(3)O_(4)/CeO_(2)heterointerface-triggered orbital coupling can cause the down shift of the d-band center positions of Fe sites,which leads to the weakened chemisorption of oxygenated groups and lowered energy barrier for the potential-determining step,ultimately dramatically boosting the ORR intrinsic *** a consequence,the well-designed Fe_(3)O_(4)/CeO_(2)@N-CNFs display admirable ORR activity with a half-wave potential of 0.84 V and outstanding structural/electrochemical stability in an alkaline electrolyte,surpassing the commercial Pt/C benchmark and a majority of recently reported Fe_(3)O_(4)-based *** encouragingly,the Fe_(3)O_(4)/CeO_(2)@N-CNFsincorporated Zn-air battery outperforms the Pt/C-assembled counterpart with higher power density,larger energy density,and excellent cycling stability,serving as a competent candidate for ORR-involved renewable energy *** study offers an innovative approach for the rational manipulation of the d-band center and interfacial electron behavior of active sites toward the optimization of electrocatalytic performance.

关键词： hetero-nanoparticles electrospinning interfacial engineering orbital coupling oxygen reduction reaction

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Comprehensive study on the spatial distribution of heavy metals and their environmental risks in high-sulfur coal gangue dumps in China

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Journal of Environmental Sciences 2024年第2期136卷 486-497页

作者： Yingbo Dong huan Lu Hai lin School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory on Resource-oriented Treatment of Industrial Pollutants Beijing 100083China

The accumulation of coal gangue(CG)from coal mining is an important source of heavy metals(HMs)in *** spatial distribution and environment risk assessment are extremely important for the management and remediation of *** soil samples were collected from the high-sulfur CG site in northern China and analyzed for six *** results showed that the soil was heavily contaminated by Mn,Cr and Ni based on the Nemerow index,and posed seriously ecological risk depended on the geo-accumulation index,potential ecological risk index and risk assessment *** semi-variogram model and ordinary kriging interpolation accurately portrayed the spatial distribution of ***,Mn,and Cr were distributed by band diffusion,Ni was distributed by core,the distribution of Cu had obvious patchiness and Zn was more *** spatial autocorrelation indicated that all HMs had strong spatial *** BCR sequential extraction was employed to qualify the geochemical fractions of *** data indicated that Fe and Cr were dominated by residual fraction;Cu,Ni and Zn were dominated by reducible and oxidizable fractions;Mn was dominated by reducible and acid-extractable(25.38%-44.67%)*** correlation analysis showed that pH was the main control factor affecting the non-residue fractions of ***,acid production from high sulfur CG reduced soil pH by 2-3,which indirectly promoted the activity of ***,the conceptual model of HMs contamination at the CG site was proposed,which can be useful for the development of ecological remediation strategies.

关键词： High-sulfur coal gangue Soil contamination Heavy metals Spatial distribution Geochemical fractions Risk assessment

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Investigations on the Interactions between Li-TFSI and Glass Fibers in the Ternary PP/GF/Li-TFSI Composites

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Chinese Journal of Polymer Science 2018年第1期36卷 113-118页

作者： Sen-lin Gu huan-huan Liu huan Cao Claude Mercier Yong-Jin Li College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 310036China Solvay Co.Ltd shanghai 201100China

The polypropylene/glass fiber（PP/GF） composites with excellent antistatic performance and improved mechanical properties have been reported by incorporation of a very small amount of the organic salt, lithium bis（trifluoromethanesulfonyl）imide（Li-TFSI）, into the PP/GF composites. It was considered that GF could play the role as the pathways for the movements of ions in the ternary composites. In this work, the interactions between Li-TFSI and glass fiber and the effects of such interactions on the physical properties of the composites have been systematically investigated. Three types of glass fibers with different ―OH group concentrations have been prepared in order to compare the interactions between GF and Li-TFSI. It was found that the ―OH group concentrations on the surface of glass fiber have significant effects on interactions between glass fibers and Li-TFSI. Such interactions are crucial for both the antistatic and mechanical performances of the final PP/GF/Li-TFSI composites. The investigation indicated that the GF with high ―OH group concentrations confined the movement of TFSI-, which decreased the antistatic properties of PP/GF/Li-TFSI composites. On the other hand, the GF with low ―OH group concentrations inhibited the absorption of Li-TFSI onto the GF, which also hindered the formation of Li-TFSI conductive pathway. The best antistatic performance of the ternary composites can be achieved at the intermediate ―OH concentrations on the GF.

关键词： Polypropylene Glass fiber Li-TFSI Antistatic performance

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Selective N-Methylation of N-Methylaniline with CO_(2) and H_(2) over Cu/In_(2)O_(3) Catalyst

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Chinese Journal of Chemistry 2024年第3期42卷 276-282页

作者： huan Zheng Bo Qian lin He State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouGansu730000 China University of Chinese Academy of Sciences Beijing100049 China

N-Methylation of amines with CO_(2) and H2 is a potential approach for CO_(2) utilization because N-methylated amines can be used as solvents and organic intermediates. In_(2)O_(3)-supported Cu (Cu/In_(2)O_(3)) acts as an effective heterogeneous catalyst for N-methylation reaction of N-methylaniline (MA) with CO_(2) and H_(2),showing higher N,N-dimethylaniline (DMA) selectivity than other supported Cu catalysts. On one hand,the dispersion of Cu can be improved by the defective In_(2)O_(3) support. On the other hand,In_(2)O_(3) support is active in the dissociative adsorption of CO_(2) through C—O bond breaking. In addition,the H_(2) dissociation ability of In_(2)O_(3) can also be enhanced by Cu. The combination of Cu and In_(2)O_(3) is effective in the activation of CO_(2),the adsorption of intermediate N-methylformanilide (MFA),the hydrogenation of MFA to DMA and the prohibition of C—N bond cleavage side reactions,thereby enhancing the reaction rate of MA conversion and the selectivity to DMA.

关键词： N-Methylation CO_(2) Cu/In_(2)O_(3) Supported catalysts Heterogeneous catalysis

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Picoliter droplet array based on bioinspired microholes for in situ single-cell analysis

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Microsystems & Nanoengineering 2020年第1期6卷 951-959页

作者： lin Du huan Liu Jia Zhou State Key Laboratory of ASIC and System School of MicroelectronicsAcademy for Engineering&TechnologyFudan UniversityShanghai 200433China Tian Jin Tuo Rui Med Technology Co. LtdTianjin 200438China

The division of aqueous samples into microdroplet arrays has many applications in biochemical and medical *** by biological features,we propose a method to produce picoliter droplet arrays for single-cell analysis based on physical structure and interface.A 0.9 pL droplet array with an RSD(relative standard deviation)less than 6.3%and a density of 49,000 droplets/cm^(2) was successfully generated on a PDMS chip(polydimethylsiloxane)from a micromachined glass *** droplet generation principle of the wetting behavior in the microholes with splayed sidewalls on the PDMS chip by liquid smearing was *** feasibility of the picoliter droplets for bacterial single-cell analysis was verified by the separation of mixed bacteria into single droplets and isolated in situ bacteria propagation.

关键词： analysis analysis PDMS

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Model Predictive Control Based Real-time Energy Management for Hybrid Energy Storage System

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CSEE Journal of Power and Energy Systems 2021年第4期7卷 862-874页

作者： huan Chen Rui Xiong Cheng lin Weixiang Shen National Engineering Laboratory for Electric Vehicles Department of Vehicle EngineeringSchool of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China Faculty of Science Engineering and TechnologySwinburne University of TechnologyMelbourneVic3122Australia

An accurate driving cycle prediction is a vital function of an onboard energy management strategy(EMS)for a battery/ultracapacitor hybrid energy storage system(HESS)in electric *** this paper,we address the requirements to achieve better EMS performances for a ***,a long short-term niemory・based method is proposed to predict driving cycles under the framework of a model predictive control(MPC)***,the performances of three EMSs based on fuzzy logic,MPC,and dynamic programming are systematically evaluated and *** online implementation,the MPC-based EMS can alleviate the stress on the battery in the HESS and significantly reduce energy dissipation by up to 15.3% in comparison with the fuzzy logic-based ***,the impact of battery aging on EMS performances is explored;it indicates that battery aging consciousness can slightly extend battery ***,a hardware-in-the-loop test platform is established to verify the effectiveness of the MPC-based EMS for the power allocation of a HESS in electric vehicles.

关键词： Energy management hybrid energy storage system long short-term memory model predictive control battery aging consciousness

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