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Spleen Function and Anxiety in Chinese Medicine: A Western Medicine Perspective

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Chinese Medicine 2016年第3期7卷 110-123页

作者： Yin Kwan Chung Jihang Chen kam Ming ko Division of Life Science Hong Kong University of Science & Technology Clear Water Bay Hong Kong China

This article aims to illustrate the function of the Spleen in Traditional Chinese Medicine (TCM) in the context of modern medicine. TCM has been practiced since ancient times in China for the prevention and/or treatment of diseases. Yet, the complete understanding of its theoretical basis in relation to clinical practice from the modern medicine perspective is still lacking. According to TCM theory, the Spleen, as one of the five Zang (i.e., visceral organs), plays an important role in various physiological functions, including digestion and absorption of nutrients, regulation of water retention and excretion, facilitation of blood perfusion to skeletal muscle and on the optimal functioning of the immune system. Clinical applications of herbal formulations for the treatment of Spleen dysfunction (i.e., Spleen deficiency—a decline in Spleen function) and their pharmacological activities are described. The view point of TCM on how emotions (or Qing Zhi) can influence the body function is introduced. The relationship between anxiety and Spleen function has been analyzed by reviewing relevant research studies in modern medicine. These findings suggest that the cause/consequence relationship between anxiety and Spleen function may be bi-directional.

关键词： TCM Theory Spleen Function Anxiety

Meeting the communicative demands in academic and professional training curricula: An overview of ELT in tertiary institutions in Singapore

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外语教学与研究 2001年第4期33卷 258-267页

作者： Ho Wah kam TheSingaporeTeachers'Union

This paper focuses on the upper end of the formal Singapore educational spectrum,providing an overview of ELT in polytechnics and universities. It is in four *** order to show continuity between ELT in schools and tertiary institutions,Part 1 explains briefly the nation’s language policy in *** Part 2,an attempt is made to delineate the main trends in ELT in universities and polytechnics and the approaches to ELT generally adopted for mature learners. Part 3 draws attention to the changing emphases in tertiary education in Singapore and to how students are being prepared in innovative ways in ELT for a globalised world and a knowledge based economy. Part 4 provides a summary of the paper.

关键词：英语教学高等院校教学方法语言交际能力

Uniform Asymptotics for Finite-time Ruin Probability in a Dependent Risk Model with General Stochastic Investment Return Process

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Acta Mathematicae Applicatae Sinica 2021年第4期37卷 847-857页

作者： Yang YANG kam Chuen YUEN Jun-feng LIU School of Statistics and Data Science Nanjing Audit UniversityNanjing211815China Department of Statistics and Actuarial Science The University of Hong KongPokfulam RoadHong KongChina

In this paper,we consider a non-standard renewal risk model with dependent claim sizes,where an insurance company is allowed to invest his/her wealth in financial assets,leading to some stochastic investment log-returns described as a general adapted càdlàg *** the assumptions that the claim sizes are heavy-tailed and the stochastic log-return process on investments is bounded from below almost surely,we derive some asymptotic formulas for the finite-time ruin probability holding uniformly in any finite time horizon.

关键词： finite-time ruin probability stochastic log-return process on investments upper tail asymptotic independence dominated variation uniformity

Joint timing and frequency synchronization in coherent optical OFDM systems

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Frontiers of Optoelectronics 2019年第1期12卷 4-14页

作者： Xinwei DU Pooi-Yuen kam Changyuan YU Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore National University of Singapore(Suzhou)Research Institute Suzhou 21512China Department of Electrical and Information Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

In this paper,we review our joint timing and frequency synchronization algorithms in coherent optical orthogonal frequency division multiplexing(CO-OFDM)*** first present a timing estimation method by designing the pattern of the training symbol,whose timing metric has a sharp and clear peak,to ensure accurate timing offset(TO)estimation *** we provide both data-aided(DA)and blind(BL)approaches to estimate the carrier frequency offset(CFO).For the DA algorithm,we utilize the same training symbol structure as the timing estimation does,while for the BL algorithm,we utilize the zero-subcarrier power(ZSP)to achieve full-range CFO *** that our joint timing and frequency synchronization approaches require only one OFDM symbol,which ensure not only the data transmission efficiency,but also the TO and CFO estimation performance.A modified BL ZSP algorithm is proposed to further improve the CFO estimation performance by taking the power average over a series of OFDM *** effectiveness of the TO estimation algorithm,and both the DA and BL CFO estimation algorithms are verified and demonstrated in both simulations and experiments.

关键词： timing offset (TO) carrier frequency offset (CFO) coherent optical orthogonal frequency division multiplexing (CO-OFDM) zero-subcarrier power (ZSP)

Enriched reproducing kernel particle method for fractional advection–diffusion equation

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Acta Mechanica Sinica 2018年第3期34卷 515-527页

作者： Yuping Ying Yanping Lian Shaoqiang Tang Wing kam Liu Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics College of Engineering Peking University Department of Mechanical Engineering Northwestern University HEDPS CAPT and LTCS Peking University

The reproducing kernel particle method （RKPM） has been efficiently applied to problems with large deformations, high gradients and high modal density. In this paper, it is extended to solve a nonlocal problem modeled by a fractional advectiondiffusion equation （FADE）, which exhibits a boundary layer with low regularity. We formulate this method on a moving least-square approach. Via the enrichment of fractional-order power functions to the traditional integer-order basis for RKPM, leading terms of the solution to the FADE can be exactly reproduced, which guarantees a good approximation to the boundary layer. Numerical tests are performed to verify the proposed approach.

关键词： Meshfree method Fractional calulus Enriched reproducing kernel Advection-diffusion equation Fractional-order basis

Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis

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World Journal of Gastroenterology 2019年第33期25卷 4933-4944页

作者： Marianne Anastasia De Roza Lim Kai Jia wen kam Yiong Huak Chan Andrew Kwek Tiing Leong Ang John Chen Hsiang Department of Gastroenterology and Hepatology Changi General HospitalSinghealth 529889Singapore Clinical Trials and Research Unit Changi General HospitalSinghealth 529889Singapore Biostatistics Unit Yong Loo Lin School of MedicineNational University of SingaporeSingapore 160608Singapore

BACKGROUND Proton pump inhibitors(PPIs)are widely prescribed,often without clear *** are conflicting data on its association with mortality risk and hepatic decompensation in cirrhotic ***,PPI users and PPI exposure in some studies have been poorly defined with many confounding *** To examine if PPI use increases mortality and hepatic decompensation and the impact of cumulative PPI dose *** Data from patients with decompensated liver cirrhosis were extracted from a hospital database between 2013 to *** users were defined as cumulative defined daily dose(cDDD)≥28 within a landmark period,after hospitalisation for hepatic *** regression analysis for comparison was done after propensity score *** risk of hepatic decompensation was analysed by Poisson *** Among 295 decompensated cirrhosis patients,238 were PPI users and 57 were *** users had higher mortality compared to non-users[adjusted HR=2.10,(1.20-3.67);P=0.009].Longer PPI use with cDDD>90 was associated with higher mortality,compared to non-users[aHR=2.27,(1.10-5.14);P=0.038].PPI users had a higher incidence of hospitalization for hepatic decompensation[aRR=1.61,(1.30-2.11);P90 increases the risk of mortality.

关键词： Proton pump inhibitor Liver cirrhosis Mortality Hospitalisation Complications Portal hypertension Variceal bleeding Ascites Spontaneous bacterial peritonitis Hepatic encephalopathy

Aurone derivatives as Vps34 inhibitors that modulate autophagy

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Acta Pharmaceutica Sinica B 2019年第3期9卷 537-544页

作者： Guodong Li Joshua William Boyle Chung-Nga ko Wu Zeng Vincent kam Wai Wong Jian-Bo Wan Philip Wai Hong Chan Dik-Lung Ma Chung-Hang Leung State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao999078China School of Chemistry Monash UniversityClayton3800Australia Department of Chemistry Hong Kong Baptist UniversityHong Kong999077China State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao999078China Department of Chemistry University of WarwickCoventry CV47ALUK

We report in this study the identification of a natural product-like antagonist(1a) of Vps34 as a potent autophagy modulator via structure-based virtual screening. Aurone derivative 1a strongly inhibited Vps34 activity in cell-free and cell-based assays. Significantly, 1a prevents autophagy in human cells induced either by starvation or by an mT OR inhibitor. In silico modeling and kinetic data revealed that 1a could function as an ATP-competitive inhibitor of Vps34. Moreover, it suppressed autophagy in vivo and without inducing heart or liver damage in mice. 1a could be utilized as a new motif for more selective and efficacious antagonists of Vps34 for the potential treatment of autophagy-related human diseases.

关键词： Autophagy Natural products Vps34 Inhibitor Structure-based virtual screening Vesicle trafficking Heart or liver damage Aurone derivative

TRANSFECTION AND CELL FUSION BY FEMTOSECOND LASERS

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Journal of Innovative Optical Health Sciences 2011年第2期4卷 113-125页

作者： HAO HE SIU KAI koNG kam TAI CHAN Department of Electronic Engineering The Chinese University of Hong kong ShatinN.T.Hong Kong Department of Biochemistry The Chinese University of Hong kong ShatinN.T.Hong Kong

Biophotonics is an exciting and fast-expanding frontier which involves the fusion of advanced photonics and *** has not only created many novel methodologies for biomedical research,but also achieved many significant results as an *** to femtosecond(fs)laser technologies,important progresses have been made regarding the manipulation,imaging,and engineering of biological samples ranging from single molecules to tissues in the last 20 *** ultrashort pulses at near-infrared band provide many advantages:high nonlinear efficiency,low absorption by biological samples,high spatial and temporal resolution and confinement,and low *** are noninvasive and easy to *** the mechanism of how fs laser pulses interact with cells remains unclear,experimental results have shown that they could open up the cell membrane and hence made optical transfection and optical cell fusion *** this review,some of the seminal works on transfection and cell fusion by fs lasers are *** ideas behind and the experimental details will be described together with a highlight on their ***,the thermal effect is analyzed based on multiphoton excitation and plasma formation in an aqueous environment to explain the nontoxic characteristic of fs laser ***,some applications of fs laser induced transfection and cellcell fusion with potential major impact in biomedical sciences are proposed.

关键词： Biophotonics transfection cell fusion femtosecond laser

Alternative Approach to the Optimality of the Threshold Strategy for Spectrally Negative Lvy Processes

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Acta Mathematicae Applicatae Sinica 2013年第4期29卷 705-716页

作者： Ying SHEN Chuan-cun YIN kam Chuen YUEN School of Mathematical Sciences Qufu Normal UniversityChina Department of Statistics and Actuarial Science The University of Hong Kong

Consider the optimal dividend problem for an insurance company whose uncontrolled surplus precess evolves as a spectrally negative Levy process. We assume that dividends are paid to the shareholders according to admissible strategies whose dividend rate is bounded by a constant. The objective is to find a dividend policy so as to maximize the expected discounted value of dividends which are paid to the shareholders until the company is ruined. In this paper, we show that a threshold strategy （also called refraction strategy） forms an optimal strategy under the condition that the Levy measure has a completely monotone density.

关键词： Spectrally negative Levy process optimal dividend problem scale function complete monotonic-ity threshold strategy