检索结果-南通市图书馆

Mitigating Iron Toxicity by Using Rock Phosphate to Improve Rice Productivity

在线全文

学校读者我要写书评

暂无评论

Pollen-inferred vegetation and environmental changes in the central Tibetan Plateau since 8200 yr BP

Agricultural Sciences（农业科学） 2024年第4期 423页

作者： Adama Bagayogo Honorékam Jacques Sawadogo Moumouni konate Moussa Sie Satoshi Nakamura Fujio Nagumo Mahamadou Sawadogo

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Science China Earth Sciences 2009年第8期52卷 1104-1114页

作者： LIU kam-Biu Carrie MORRILL Jonathan T. OVERPECK Julia E. COLE Department of Oceanography and Coastal Sciences School of the Coast and Environment Louisiana State University NOAA Paleoclimatology Program and Cooperative Institute for Research in Environmental Sciences (CIRES) Institute for the Study of Planet Earth and Department of Geosciences University of Arizona

The ecotone between alpine steppe and meadow in the central Tibetan Plateau is sensitive to climate changes. Here we used the pollen records from three lakes in this region to reconstruct the evolution of local vegetation and climate since 8200 cal. yr BP. The history of temperature and precipitation was reconstructed quantitatively with multi-bioclimatic indexes and a transfer function from pollen records. Results show that the steppe/meadow dominated during the period of 8200―6500 cal. yr BP, especially 8200―7200 cal. yr BP, indicating the central Tibetan Plateau was controlled by strong monsoon. The steppe dominated during the periods of 6000―4900, 4400―3900, and 2800―2400 cal. yr BP. The steppe decreased gradually and the meadow expanded during the period of 4900―4400 cal. yr BP. Three century-scale drought events occurred during 5800―4900, 4400―3900 and 2800 cal. yr BP, respectively. The first time when the regional climate shifted to the present level was at 6500 cal. yr BP in the central Plateau. Since 3000 cal. yr BP, the temperature and precipitation have decreased gradually to the present level. However, the cold climate between 700―300 cal. yr BP likely corresponds to the Little Ice Age.

关键词： the meadow-steppe ecotone (MSE) pollen record bioclimatic index central Tibetan Plateau

Mechanistic data-driven prediction of as-built mechanical properties in metal additive manufacturing

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2021年第1期7卷 767-778页

作者： Xiaoyu Xie Jennifer Bennett Sourav Saha Ye Lu Jian Cao Wing kam Liu Zhengtao Gan Department of Mechanical Engineering Northwestern UniversityEvanstonILUSA DMG MORI Hoffman EstatesILUSA Theoretical and Applied Mechanics Northwestern UniversityEvanstonILUSA

Metal additive manufacturing provides remarkable flexibility in geometry and component design,but localized heating/cooling heterogeneity leads to spatial variations of as-built mechanical properties,significantly complicating the materials design *** this end,we develop a mechanistic data-driven framework integrating wavelet transforms and convolutional neural networks to predict location-dependent mechanical properties over fabricated parts based on process-induced temperature sequences,i.e.,thermal *** framework enables multiresolution analysis and importance analysis to reveal dominant mechanistic features underlying the additive manufacturing process,such as critical temperature ranges and fundamental thermal *** systematically compare the developed approach with other machine learning *** results demonstrate that the developed approach achieves reasonably good predictive capability using a small amount of noisy experimental *** provides a concrete foundation for a revolutionary methodology that predicts spatial and temporal evolution of mechanical properties leveraging domain-specific knowledge and cutting-edge machine and deep learning technologies.

关键词： additive properties prediction

Effects of Motivation and Demography on the Quantitative Plausibility of the Trojan Horse Defence Against Possession of Child Pornography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Harbin Institute of Technology(New Series) 2014年第6期21卷 9-15页

作者： Richard E Overill Jantje A M Silomon kam-Pui Chow Hayson Tse Dept.of Informatics King's College LondonLondon WC2R 2LSUnited Kingdom Dept.of Computer Science University of Hong Kong

The Enhanced Complexity Model( ECM) developed previously has been further extended to produce a Motivationally Enhanced Complexity Model( MECM) which enables the degree of motivation,capability and opportunity of a hypothetical Trojan Horse author to be included in quantifying the relative plausibility of competing explanations for the existence of uncontested digital *** new model has been applied to the case of the Trojan Horse defence( THD) against the possession of child *** results demonstrate that the THD in this case cannot be plausibly sustained unless it can be shown that an ‘off-theshelf'( OTS) Trojan Horse for this task is available and it is not detectable by the target computer,at the material time.

关键词： Trojan Horse defence child pornography digital forensic evidence complexity quantitative plausibility metrics posterior odds

A Cardiomyopeptin Preparation Protects against Isoproterenol-Induced Chronic Heart Failure in Rats

在线全文

学校读者我要写书评

暂无评论

Chinese Medicine 2023年第4期14卷 242-254页

作者： Zumeng Xia Hoi Yan Leung Hoi Ling Siu Chung Wai Chan kam Ming ko R&D Center Infinitus China Limited Guangzhou China Division of Life Science Hong Kong University of Science & Technology Hong Kong China

The present study investigated the effect of an herbal extract-supplemented cardiomyopeptin preparation (HECP), in the rat model of chronic heart failure. HECP pre-/co-treatment at a daily dose of 0.072 to 0.124 g/kg for 30 days protected against isoproterenol (ISO)-induced chronic myocardial damage in rats in a dose-dependent manner, with the extent of protection, as assessed by plasma cardiac troponin I level, being up to 76%. The cardioprotection afforded by HECP was associated with the enhancement of myocardial mitochondrial antioxidant status, amelioration of plasma parameters on cardiac dysfunction and hypertrophy, as well as an increase in myocardial endothelial nitric oxide synthase activity. Myocardial apoptotic and anti-apoptotic parameters were suppressed and stimulated, respectively. The cardioprotection afforded by HECP was accompanied by an increase in exercise capacity, an indirect functional index of the myocardium, in ISO-challenged rats. In conclusion, HECP may offer a promising prospect in preventing chronic heart failure in human subjects.

关键词： Cardiomyopeptin Herbal Extract Chronic Heart Failure Isoproterenol

“Qi-Invigorating” Chinese Tonic Herbs (Shens) Stimulate Mitochondrial ATP Generation Capacity in H9c2 Cardiomyocytes in Situand Rat Hearts ex Vivo

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medicine 2012年第2期3卷 101-105页

作者： Hoi Shan Wong weng Fat Cheung Wai Ling Tang kam Ming ko Division of Life Science Hong Kong University of Science & Technology Hong Kong China

In the study, using ethanol extracts of Renshen (Panax ginseng C A Meyer), Xiyangshen (Panax quinquefolius L.) and Dangshen (Codonopsis pilosulae), we investigated the effect of these “Qi-invigorating” Chinese tonic herbs on mitochondrial ATP generation capacity (ATP-GC) in H9c2 cardiomyocytes in situ and rat hearts ex vivo. All three types of “Shens” stimulated mitochondrial ATP-GC, with Renshen being most potent. While a parallel enhancement in mitochondrial ATP-GC was observed in Renshen- and Xiyangshen-pretreated rats, Dangshen treatment did not produce detectable effect ex vivo. The discrepancy between in situ and ex vivo assays for Dangshen may be attributed by its limited oral-bioavailability to the heart. The tissue specific activity of Shens on mitochondrial ATP-GC may be explained by the “Meridian Theory” in traditional Chinese medicine.

关键词： Qi Chinese Medicine ATP Mitochondria Cardiomyocytes

Acute Kidney Injury:Global Health Alert

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肾脏病与透析肾移植杂志 2013年第1期22卷 3-9页

作者： Philip kam Tao Li Emmanuel A Burdmann Ravindra L Mehta Department of Medicine & Therapeutics Prince of Wales HospitalChinese University of Hong KongHong Kong Department of Medicine University of Sao Paulo Medical SchoolSao PauloSPBrazil Department of Medicine University of California San DiegoSan DiegoCAUSA

Acute kidney injury(AKI) is increasingly prevalent in developing and developed countries and is associated with severe morbidity and *** etiologies of AKI can be prevented by interventions at the individual,community,regional and in-hospital *** measures must include community-wide efforts to increase an awareness of the devastating effects of AKI and provide guidance on preventive strategies,as well as early recognition and *** should be focused on minimizing causes of AKI,increasing awareness of the importance of serial measurements of serum creatinine in high risk patients,and documenting urine volume in acutely ill people to achieve early diagnosis;there is as yet no definitive role for alternative *** need to be developed to systematically manage prerenal conditions and specific *** accurate data about the true incidence and clinical impact of AKI will help to raise the importance of the disease in the community,increase awareness of AKI by governments,the public,general and family physicians and other health care professionals to help prevent the *** is the key to avoid the heavy burden of mortality and morbidity associated with AKI.

关键词：肾脏病临床治疗移植手术

Development of a dual targeting scaffold of SET7/MLL inhibitor for castration-resistant prostate cancer treatment

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第6期10卷 2260-2262页

作者： Guodong Li Qi Huang Vincent kam Wai Wong Wanhe Wang Chung-Hang Leung Institute of Chinese Medical Sciences and State Key Laboratory of Quality Research in Chinese Medicine University of MacaoMacao SAR 999078China Dr.Neher's Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao SAR 999078China Institute of Medical Research Northwestern Polytechnical UniversityXi'anShaanxi 710072China Macao Centre for Research and Development in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China Department of Biomedical Sciences Faculty of Health SciencesUniversity of MacaoMacao SAR 999078China Zhuhai UM Science and Technology Research Institute ZhuhaiGuangdong 519000China

Histone methyltransferase enzyme SET7 and mixed-lineage leukemia protein(MLL)complex are crucial co-activators of androgen receptor(AR)and have recently emerged as potential therapeutic targets for advanced castration-resistant prostate cancer(CRPC).In this study,we described the identification of a rhodium-based hybrid complex(SM_1)as a potent blocker of AR activity via simultaneously inhibiting SET7 and MLL complex activity,which makes it a potential lead scaffold for CPRC drug development.

关键词： cancer inhibiting treatment

Schisandrae Fructus oil-induced elevation in serum triglyceride and lipoprotein concentrations associated with physiologic hepatomegaly in mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2022年第2期12卷 59-68页

作者： Si-Yuan Pan Xue-Lan Song Zhao-Heng Lin Qing Yu Yi Zhang Hai-Chuan Tai Gan Luo Xiao-Yan Wang Pei-Li Zhu Nan Sun Zhu-Sheng Chu Zhi-Ling Yu Yi Zhang kam-Ming ko School of Traditional Dai-Thai Medicine West Yunnan University of Applied SciencesJinghongYunnanChina School of Chinese Materia Medica Beijing University of Chinese MedicineBeijingChina Department of Biology Hong Kong Baptist UniversityHong KongChina School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina Division of Life Science Hong Kong University of Science&TechnologyHong KongChina

Objective:To investigate hypertriglyceridemia and hepatomegaly caused by Schisandrae Sphenantherae Fructus(FSS)and Schisandra chinensis Fructus(FSC)oils in ***:Mice were orally administered a single dose of ***(TG),triglyceridetransferprotein(TTP),apolipoproteinB48(Apo B48),very-low-densitylipoprotein(VLDL),hepatocytegrowth factor(HGF),alanine aminotransfease(ALT)and liver index were measured at 6-120 h ***:FSS and FSC oil caused time and dose-dependent increases in serum and hepatic TG levels,with maximum increases in the liver(by 297%and 340%)at 12 h post-dosing and serum(244%and 439%)at 24-h post-dosing,*** Fructus oil treatments also elevated the levels of serum TTP by 51%and63%,Apo B48 by 152%and 425%,and VLDL by 67%and 38%in mice,*** and FSC oil treatments also increased liver mass by 53%and 55%and HGF by 106%and 174%,but lowered serum ALT activity by 38%and 22%,*** pre/co-treatment attenuated the FSS and FSC oil-induced elevation in serum TG levels by 41%and 49%at 48 h post-dosing,respectively,but increased hepatic TG contents(by 38%and 33%,respectively)at 12 h ***:Our findings provide evidence to support the establishment of a novel mouse model of hypertriglyceridemia by oral administration of FSS oil(mainly increasing endogenous TG)and FSC oil(mainly elevating exogenous TG).

关键词： Schisandrae Fructus oils Triglyceride Alanine aminotransferase Hepatomegaly Mouse model Hypertriglyceridemia