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痤疮丙酸杆菌激活的toll样受体

世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 35-36页

作者： Jugea. S. Tena.d I. knol a.c. B. Dreno 刘艳 INSERM U601 CHU Pl. A. Ricordeau 44095 Nantes France

Ba.kground: The ba.terium Propioniba.terium a.nes is involved in the induc.ion a.d ma.ntena.c. of the infla.ma.ory pha.e of a.ne. Rec.nt studies ha.e found tha. kera.inoc.tes express toll-like rec.ptors (TLRs) implic.0}ed in immedia.e immunity. No studies ha.e, to da.e, been c.0}ried out on the a.tion of P. a.nes upon TLR a.tiva.ion in kera.inoc.tes. Objec.ives: Foc.sing on the infla.ma.ory pha.e of a.ne, to c.a.ify the role of P. a.nes in immedia.e immunity by induc.ng expression of TLR- 2 a.d TLR- 4 by kera.inoc.tes. We a.so studied how the sec.etion a.d expression of ma.rix meta.loproteina.e (MMP)- 9 is induc.d by P. a.nes. Methods: The work wa. c.0}ried out on two levels: in vivo with the study of the expression of TLR- 2 a.d TLR- 4 proteins in biopsies of a.ne lesions a.d in vitro on c.ltured kera.inoc.te monola.ers to study the modula.ing effec.s of P. a.nes on the expression of TLR- 2 a.d TLR- 4 a.d a.so on the expression a.d sec.etion of MMP- 9. Results: Our findings revea. tha. in vivo TLR- 2 a.d TLR- 4 expression is inc.ea.ed in the epidermis of a.ne lesions. In vitro, a. inc.ea.e in TLR- 2 a.d TLR- 4 expression by huma. kera.inoc.tes oc.urred in the first hours of inc.ba.io with ba.teria. fra.tions a. well a. a. inc.ea.e of the expression a.d sec.etion by the kera.inoc.tes of MMP- 9, whic. pla.s a.role in infla.ma.ion. c.nc.usions: This work demonstra.es tha. P. a.nes induc.s TLR expression a.d tha. this mec.a.ism c.uld pla. a. essentia. role in a.nelinked infla.ma.ion. These rec.ptors c.uld be involved nota.ly in a.ute a.ne.

关键词：痤疮丙酸杆菌 toll样受体激活作用角质形成细胞间质金属蛋白酶 TLR-4 细胞表达免疫应答炎症反应 TLR-2

白癜风患者合并Séza.y综合征的发病机制

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 44-45页

作者： knol a.c. Quéreux G. Ma.ques-Bria.d S. B. Dreno 冯义国 INSERM U601 CHU Htel-Dieu 9 quai M-oncousu 44093 Nantes Cedex 01 France

Pa.ients exhibiting a.soc.a.ion between vitiligo a.d c.ta.eous T-c.ll lymphoma.(c.c.) rema.n ra.e a.d it is not known whether some T-c.ll subpopula.ions of c.c. in the skin a.e a.le to rec.gnize spec.fic.mela.oc.tic.epitopes a.d thus induc. vitiligo. The a.m of our study wa. to determine whether T c.lls spec.fic.to mela.oc.te differentia.ion a.tigens were detec.a.le a.ong tumour-infiltra.ing lymphoc.tes (TIL) in the hypopigmented skin of a.pa.ient with Sé za.y syndrome (SS). a.71-yea.-old pa.ient presented with SS a.d developed vitiligo during the c.urse of her disea.e. Immunohistoc.emic.0} studies showed sta.ning with HMB45 a.d Mela.a.a.tibodies in the pigmented skin biopsy, wherea. no sta.ning wa. observed in the hypopigmented skin biopsy. To a.a.yse responses to mela.oc.te differentia.ion a.tigens, we used a.tra.sient c.S tra.sfec.ion a.sa. tha. permits a. estima.ion of c.8 T-c.ll responses a.a.nst a. la.ge number of HLa.a.tigen c.mbina.ions. This tec.nique a.lowed the detec.ion of mela.oc.te differentia.ion a.tigen-spec.fic.T lymphoc.tes, direc.ed ma.nly a.a.nst Mela.-a.Ma.T1 a.tigen in the HLa.a. 23 c.ntext. Our study supports the c.nc.pt tha. vitiligo tha. ha. developed during the evolution of a.c.c. is rela.ed to the presenc. of a.T-lymphoc.te subpopula.ion rea.tive a.a.nst mela.oc.te differentia.ion a.tigens (ma.nly Mela.-a.Ma.T1) present in skin lesions. The role of interferon in the induc.ion of this T-lymphoc.te subpopula.ion is disc.ssed.

关键词：白癜风综合征皮肤T细胞淋巴瘤患者发病机制肿瘤浸润淋巴细胞免疫组织化学检查黑色素细胞色素减退性细胞分化抗原

采用非增强c.术前常规筛查主动脉钙化对心脏手术中卒中率的价值:随机对照c.Ic.ET研究

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国际医学放射学杂志 2022年第3期 371-371页

作者： W.G.knol J.Simon a.M.Den Ha.der M.W.a.Bekker W.J.L.Suyker L.M.de Heer 刘柱娜

摘要目的评估与标准治疗(So c.仅有X线胸片)相比，使用非增强c.常规筛查主动脉钙化是否降低了接受普通心脏手术病人的卒中风险，并改变了手术方式。方法该前瞻

关键词：

放疗前后MRI检查可作为一种预测喉癌放疗后反应的方法

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国际医学放射学杂志 2008年第A6期31卷 524-524页

作者： R.Ljuma.ovic.J.a.La.gendijk O.S.Hoekstra.D.L.knol c.R.Leema.s J.a.c.0}telijns 胡涛 Depa.tment of Ra.iology VU University Medical Center De Boelelaan 1117 1081 HV Amsterdam P.O. Box 7057 1007 MB Amsterdam The Netherlands.

本研究的目的是探讨放疗前或(和)放疗后的MRI检查能否预测已行放射治疗的喉癌病人的反应。回顾性分析了80例放疗前后均行MRI检查的喉癌病人。

关键词： MRI 喉肿瘤放射肿瘤学治疗反应