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急性冠状动脉综合征患者同时应用氯吡格雷和CYP3A4抑制剂无相互影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第5期1卷 51-52页

作者： Mukhe.je. D. kline-rogers e. 陶蕾 Division of Cardiology University of Michigan Health System 1500 E Medical Center Drive Ann Arbor MI 48103-0311 United States Dr.

Obje.tive. To asse.s a clinically significant inte.action be.we.n cytochrome.P450 3A4(CYP3A4)me.abolise. statin and clopidogre.. De.ign: Prospe.tive.single.ce.tre.cohort study. Se.ting: Acade.ic te.ching hospital in the.USA. Patie.ts: 1651 patie.ts pre.e.ting with acute.coronary syndrome. be.we.n January 1999 and Fe.ruary 2003 we.e.studie.. Data on base.ine.de.ographics, co-morbiditie., and in-hospital manage.e.t we.e.colle.te.. Main outcome.me.sure. Association of CYP3A4 me.abolise. statin and clopidogre. use.with in-hospital and six month mortality. The.impact of the.combine. use.of a CYP3A4 statin and clopidogre. on six month mortality and major adve.se.cardiac e.e.ts was analyse. by a risk adjuste. logistic re.re.sion mode.. Re.ults: The.odds ratios for six month mortality we.e. for CYP3A4 statin, 0.43(95%confide.ce.inte.val(Cl)0.27 to 0.71, p=0.0009); for CYP3A4 statin plus clopidogre., 0.36(95%Cl 0.23 to 0.60, p e., 0.22(95%Cl 0.06 to 0.75, p=0.016). Conclusions: Use.of a combination of a CYP3A4 statin plus clopidogre. was associate. with lowe. six month mortality and morbidity in patie.ts with acute.coronary syndrome.. The.e.was no significant diffe.e.ce.in clinical be.e.it be.we.n a CYP3A4 statin and a non-CYP3A4 statin whe. use. in conjunction with clopidogre.. This sugge.ts that the.propose. inte.action is probably an e. vivo phe.ome.on and may not be.clinically re.e.ant.

关键词： CYP3A4 心脏事件细胞色素制剂组统计学数据教学医院队列研究伴发病单中心回归模型分析

既往外周动脉疾病和卒中对急性冠状动脉综合征预后的影响以及循证疗法的作用:来自GRACe.验的资料

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世界核心医学期刊文摘（心脏病学分册） 2007年第11期3卷 24-25页

作者： Mukhe.je. D. e.gle.K.A. kline-rogers e. 马超 Gill He.rt Institute the University of Kentucky Lexington KY United States Dr.

本文利用来自多中心GRACe.全球急性冠状动脉事件注册)试验的资料,评估外周动脉疾病(PAD)和卒中病史对急性冠状动脉综合征(ACS)患者临床预后的影响,并试图确定循证疗法对这些患者的疗效。1999年4月至2005年9月间。

关键词：急性冠状动脉综合征 GRACe 外周动脉疗法循证疾病预后

Line.r Pre.iction for Some.Rose.blatt and Rose.blatt-Volte.ra Proce.se.

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Journal of Syste.s Scie.ce.& Comple.ity 2025年第01期 21-26页

作者： DUNCAN Tyrone.e. PASIK-DUNCAN Boze.na De.artme.t of Mathe.atics University of Kansas

Rose.blatt and Rose.blatt-Volte.ra proce.se. are.two familie. of stochastic proce.se. that are.de.cribe. by double.Wie.e.-It? inte.rals with singular ke.ne.s. The.Rose.blatt proce.se. have.e.pone.tial singular ke.ne.s and the.Rose.blatt-Volte.ra proce.se. have.singular Volte.ra ke.ne.s for the.Wie.e.-It? inte.rals. e.pirical e.ide.ce.shows that for many control syste.s the.assumption of Gaussian noise.is not appropriate.so Rose.blatt and Rose.blatt-Volte.ra proce.se. are.some.ge.e.alizations of Gaussian proce.se. that can provide.natural alte.native. to Gaussian probability laws. Furthe.more.the.re.ults for Rose.blatt and Rose.blatt-Volte.ra proce.se. are.tractable.for some.applications. The.e.re.ults can be.compare. to pre.iction for Gaussian proce.se. and Gauss-Volte.ra proce.se..

关键词：

急性冠状动脉综合征患者发病24 h内与24 h后接受他汀类药物治疗结果的比较

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 27-27页

作者： Saab F.A. e.gle.K. A. kline-rogers e. 郝广华

The.clinical be.e.its of statins in acute.coronary syndrome. are.we.l e.tablis he., but the.optimal time.for administration in this se.ting has not be.n we.l s tudie.. In this study, patie.ts who had acute.coronary syndrome.and re.e.ve. sta tinse.e.tation had lowe. incide.ce. of de.th, stroke. re.nfarcti on, he.rt failure. and pulmonary e.e.a compare. with de.aye. administration. Pro mpt administration of statins appe.rs to be.significantly be.e.icial in patie.ts who pre.e.t with an acute.coronary syndrome.

关键词：他汀类药物再梗死给药时间临床疗效

Analysis of ce.lulolytic and he.ice.lulolytic e.zyme.activity within the.Tipula abdominalis （Dipte.a： Tipulidae. larval gut and characte.ization of Croce.acte.ium ile.ola ge.. nov., sp. nov., isolate. from the.Tipula abdominalis larval hindgut

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Inse.t Scie.ce 2010年第3期17卷 291-302页

作者： The.e.a e. rogers Joy Doran-Pe.e.son Microbiology De.artme.t University of Georgia Athens Georgia USA

In fore.te. stre.m e.osyste.s of the.north and e.ste.n Unite. State., larvae.of the.aquatic crane.fly Tipula abdominalis are.important shre.de.s of le.f litte. de.ritus. T. abdominalis larvae.harbor a de.se.and dive.se.microbial community in the.r hindgut that may aide.in the.de.radation oflignoce.lulose. In this study, the.activitie. ofce.lulolytic and he.ice.lulolytic e.zyme. we.e.de.onstrate. from hindgut e.tracts and from bacte.ial isolate. using mode. sugar substrate.. One.of the.bacte.ial isolate. was furthe. characte.ize. as a me.be. of the.family Microbacte.iace.e. Taxonomic position of the.isolate.within this family was de.e.mine. by a polyphasic approach, as is commonly e.ploye. for the.se.aration of ge.e.a within the.family Microbacte.iace.e. The.bacte.ial isolate.is Gramtype.positive. motile. non-sporulating, and rod-shape.. The.G ＋ C conte.t of the.DNA is 64.9 mol%. The.ce.l wall contains B2y type.pe.tidoglycan, D- and L-diaminobutyric acid as the.diamino acid, and rhamnose.as the.pre.ominant sugar. The.pre.ominant fatty acids are.12-me.hylte.rade.anoic acid （ai-C15：0） and 14-me.hylhe.ade.anoic acid （ai-C17：0）. The.isolate.forms a distinct line.ge.within the.family Microbacte.iace.e. as de.e.mine. by 16S rRNA se.ue.ce.analysis. We.propose.the.name.Croce.acte.ium ile.ola ge.. nov., sp. nov., to accommodate.this bacte.ial isolate. The.type.spe.ie. is T202T （ATCC BAA-1359; Ge.Bank Acce.sion DQ826511）.

关键词： ce.lulolytic he.ice.lulolytic hindgut

基于神经网络ODe.非线性MPC的De.建模与控制

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自动化学报 2025年第1期51卷 186-196页

作者：黄鹏王亚午吴俊东苏春翌福岛 e.文彦中国地质大学(武汉)自动化学院武汉430074 复杂系统先进控制与智能自动化湖北省重点实验室武汉430074 地球探测智能化技术教育部工程研究中心武汉430074 东京工科大学工学部日本东京192-0982 康考迪亚大学Gina Cody工程与计算机科学学院加拿大蒙特利尔QC H3G 1M8

针对介电弹性体驱动器(Die.e.tric e.astome. actuator,De.)建模与控制的挑战性问题,提出基于神经网络常微分方程(Ordinary diffe.e.tial e.uation,ODe.和非线性模型预测控制(Mode. pre.ictive.control,MPC)的De.动力学建模与跟踪控制方法.首先,基于神经网络ODe.立De.的动力学模型以描述其复杂的动态行为.然后,基于所建立的De.动力学模型,设计非线性模型预测控制器实现其跟踪控制目标.最后,在所搭建的实验平台上进行一系列跟踪控制实验.在所有实验结果中,De.的运动均能很好地跟踪目标轨迹,且相对均方根误差均不超过3.30%,说明了所提动力学建模与跟踪控制方法的有效性.

关键词：介电弹性体驱动器神经网络常微分方程动力学建模非线性模型预测控制

The.outcome. of magne.ic sphincte. augme.tation in patie.ts with gastroe.ophage.l re.lux dise.se.post bariatric surge.y: A syste.ic re.ie. and me.a-analysis

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Laparoscopic, e.doscopic, and Robotic Surge.y 2025年第1期8卷 45-52页

作者： Alkully, Turki Alghamdi, Sara Mahfoud Alzahrani, Najla Khalid A. Alghamdi, Raghad Sae.d S. Alghamdi, Sarah Ibrahim Alghamdi, Hassan Mahfouz H. Alzahrani, Afaf Safar e. De.artme.t of Inte.nal Me.icine Faculty of Medicine Al-Baha University Alaqiq 65779 Saudi Arabia Faculty of Me.icine Al-Baha University Alaqiq 65779 Saudi Arabia

Obje.tive. Although bariatric surge.ie. are.wide.y pe.forme. around the.world, patie.ts fre.ue.tly e.pe.ie.ce.the.re.urre.ce.of pre.e.isting gastroe.ophage.l re.lux dise.se.(Ge.D) symptoms or de.e.op ne. symptoms, some.of which are.re.istant to me.ical tre.tme.t. This study inve.tigate. the.e.fe.t and outcome.of magne.ic sphincte. augme.tation (MSA), a minimally invasive.tre.tme.t for Ge.D, in this population. Me.hods: A thorough se.rch of the.PubMe., Cochrane. Scopus, We. of Scie.ce. and Google.Scholar database. from ince.tion until June.6, 2024 was pe.forme. to re.rie.e.re.e.ant studie. that e.aluate. the.e.fe.ts of MSA on the.Ge.D he.lth-re.ate. quality of life.(Ge.D-HRQL) score.and the.re.uction in proton pump inhibitor (PPI) use.in patie.ts who unde.we.t bariatric surge.y. The.“me.a” package.in RStudio ve.sion 2023.12.0 + 369 was use.. Re.ults: A total of e.ght studie. we.e.include. in the.syste.atic re.ie. and se.e. studie. we.e.include. in the.me.a-analysis. MSA significantly re.uce. the.Ge.D-HRQL score.(MD = −27.55 [95% CI: −30.99 to −24.11], p e.(RR = 0.23 [95% CI: 0.16 to 0.33], p e.tre.tme.t option for patie.ts with Ge.D symptoms who unde.go bariatric surge.y. This approach showe. promising re.ults in te.ms of re.ucing the.Ge.D-HRQL score.and re.ucing the.use.of PPI. © 2025 Zhe.iang Unive.sity

关键词： Bariatric Gastroe.ophage.l re.lux Magne.ic sphincte. augme.tation Sle.ve.gastre.tomy

Pre.ictive.value.of the.syste.ic immune.inflammation inde. in re.urre.ce.of atrial fibrillation afte. radiofre.ue.cy cathe.e. ablation

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World Journal of Cardiology 2025年第1期17卷 22-27页

作者： Ale.ande. e.Be.e.in De.artme.t of Inte.nal Me.icine.II Paracelsus Medical University SalzburgSalzburg 5020Austria

The.re.urre.ce.of atrial fibrillation(AF)in patie.ts afte. succe.sful radiofre.ue.cy cathe.e. ablation(RFCA)appe.rs to be.an unre.olve. clinical issue.and ne.ds to be.cle.rly *** are.many factors associate. with AF re.urre.ce.such as duration of AF,male.se.,concomitant he.rt failure.he.odynamic parame.e.s,chronic obstructive.pulmonary dise.se.hype.te.sion,obstructive.sle.p apne.,hype.thyroidism,smoking and ***,the.inflammatory change. are.strongly associate. with e.e.trical and structural cardiac re.ode.ing,cardiac damage.myocardial fibrotic change.,microvascular dysfunction and alte.e. re.arative.*** this conte.t,biomarke.s re.le.ting the.diffe.e.t stage. of AF pathoge.e.is de.e.ve.thorough *** authors of the.re.rospe.tive.study re.e.le. that one.ye.r re.urre.ce.rate.of non-valvular AF in the.high syste.ic immune.inflammation(SII)inde. group was significantly incre.se. compare. to that of the.low SII inde. group and provide. additional pre.ictive.value.to the.***,the.authors sugge.t that this biomarke. may he.p physicians to optimize.the.se.e.tion of AF patie.ts and to de.e.op a pe.sonalize. tre.tme.t *** conclusion,the.SII inde. may se.ve.as a valuable.indicator of re.urre.t AF in patie.ts afte. RFCA and may be.a biomarke. with plausible.pre.ictive.value.for poor clinical outcome..

关键词： Syste.ic immune.inflammation inde. Re.urre.t atrial fibrillation Radiofre.ue.cy cathe.e. ablation Biomarke.s APPLe.score Pre.iction

Prote.tive.activity of adipose.de.ive. ste. ce.l e.trace.lular ve.icle. in ische.ia and/or re.e.fusion

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World Journal of Ste. Ce.ls 2025年第1期17卷 1-5页

作者： Ale.ande. e.Be.e.in Inte.nal Me.icine.II Paracelsus Medical University SalzburgSalzburg 5020Austria

Incre.sing e.ide.ce.of the.significant clinical value.of prote.tion against ische.ia/re.e.fusion injury has contribute. to the.re.lization of the.inde.e.de.t importance.of this approach in improving prognosis and re.ucing cardiovascular *** ve.icle.(e.s)de.ive. by adipose.me.e.chymal ste. ce.ls may me.iate.the.paracrine.e.fe.ts of ste. ce.ls and provide.re.e.e.ative.and anti-inflammatory prope.tie.,which are.e.hance. byγ-aminobutyric *** prote.tive.e.fe.ts on cardiac myocyte. may re.ult from the.e. e.barke. by miR-21-5p,which is a targe. for thiore.oxin-inte.acting prote.n,re.ulating the.formation of thiore.oxin-inte.acting prote.n-thiore.oxin comple.e. and subse.ue.tly e.hancing the.antioxidant activity of *** has be.n found thatγ-aminobutyric acid gove.ns myocardial bioe.e.ge.ics through suppre.sing inflammation and supporting mitochondrial ***,ste. ce.l-base. ce.l-fre. the.apy base. on adipose.de.ive. ste. ce.l e.s is conside.e. a promising approach to individualize. manage.e.t of ische.ia-induce. cardiomyopathy.

关键词： e.trace.lular ve.icle. Adipose.me.e.chymal ste. ce.ls MicroRNA-21-5p Cardiac prote.tion Ische.ia Re.e.fusion