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Donor's site evaluation after restoration with autografts or synthetic plugs in rabbits

World Journal of Orthopedics 2014年第4期5卷 550-556页

作者： Konstantinos S Intzoglou Dimitrios S Mastrokalos Dimitrios S Korres kleo papaparaskeva Dimitrios Koulalis George C Babis Laboratory for Research of the Musculoskeletal System University of Athens Maroussi 14561 Greece 3rd Ortopaedic University Department "K.A.T." Hospital Maroussi Athens 14561 Greece 1st Orthopaedic University Department "ATTIKON" Hospital Haidari Athens 12462 Greece Pathology department Konstantinopouleion Hospital Nea Ionia Athens 14233 Greece

AIM: To investigate donor site's area histological and immunohistochemical knee cartilage appearances after resurfacing iatrogenic defects with biosynthetic plugs orautografts. METHODS: Thirty New Zealand White rabbits were used in this study. A full-thickness cylindrical defect of 4.5 mm(diameter) × 7 mm(depth) was created with a hand drill in the femoral groove of every animal. In Group A(n = 10) the defect of the donor site was re-paired with a biosynthetic osteochondral plug, in Group B(n = 10) with an osteochondral autograft, while in Group C(control group of 10) rabbits were left untreated. RESULTS: Twenty-four weeks postoperatively, smooth articular cartilage was found macroscopically in some trocleas' surfaces; in all others, an articular surface with discontinuities was observed. Twenty-eight out of 30 animals were found with predominantly viable chondrocytes leaving the remaining two-which were found only in the control group- with partially viable chondrocytes. However, histology revealed many statistical differences between the groups as far as the International Cartilage Repair Society(ICRS) categories are concerned. Immunofluoresence also revealed the presence of collagen Ⅱ in all specimens of Group B, whereas in Group A collagen Ⅱ was found in less specimens. In Group C collagen Ⅱwas not found. CONCLUSION: The matrix, cell distribution, subchondral bone and cartilage mineralization ICRS categories showed statistically differences between the three groups. Group A was second, while group B received the best scores; the control group got the worst ICRS scores in these categories. So, the donor site area, when repairing osteochondral lesions with autografting systems, is better amended with osteochondral autograft rather than bone graft substitute implant.

关键词： Autografts Synthetic plug Osteochondral defects Rabbit model animal study Donor site Immunofluoresence Histological evaluation International Cartilage Repair Society score

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