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横过青藏高原羌塘地体中央隆起区的深反射地震试验剖面

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地球物理学报 2009年第8期52卷 2008-2014页

作者：卢占武高锐李秋生贺日政匡朝阳侯贺晟熊小松管烨王海燕 klemperer.l.s 中国地质科学院地质研究所北京100037 中国地质科学院深部探测与地球动力学开放实验室北京100037 斯坦福大学地球物理系 ca943052215

跨越中央隆起区的深反射地震探测试验剖面,初步揭露出青藏高原羌塘地体中央隆起区的地壳结构.探测剖面表明,羌塘地体可能具有古老的结晶基底;中央隆起区上地壳变形主要以逆冲、褶皱为主,下地壳出现北倾与南倾"对冲"的反射,揭示出印度和... 详细信息

跨越中央隆起区的深反射地震探测试验剖面,初步揭露出青藏高原羌塘地体中央隆起区的地壳结构.探测剖面表明,羌塘地体可能具有古老的结晶基底;中央隆起区上地壳变形主要以逆冲、褶皱为主,下地壳出现北倾与南倾"对冲"的反射,揭示出印度和欧亚两大板块前缘汇聚的深部过程.

关键词：羌塘地体中央隆起区地壳结构深反射地震试验剖面深部汇聚过程

Crustal structure of seismic velocity in southern Tibet and east-westward escape of the crustal material——An example by wide-angle seismic profile from Peigu Tso to Pumoyong Tso

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science China Earth sciences 2004年第6期47卷 500-506页

作者： s. klemperer Department of Geophysics Stanford University Stanford CA94305-2215 USA

The reflecting events from Moho and other interfaces within the crust are recog-nized from the wavefield characteristics of P- and s-wave for the 480km long wide-angle seismic profile between Peigu Tso and Pumoyong Tso. Then, seismic crustal structures of P- and s-wave velocities and Poisson ratio under the nearly east-west profile in southern Tibet are interpreted by fitting the observed traveltimes with the calculated ones by forward modelling. Our interpreting results demonstrate that the crustal thickness varies remarkably in the east-west direction, showing a pattern that the crust could be divided into three parts bounded by the west of Dingri and the east of Dinggy? respectively, where the depth of Moho is about 71km for the western part, about 76km for the middle and about 74km for the eastern. There is one lower velocity layer (lVl) at the bottom of the upper crust with depth of 20—30 km. One of the distinct features is that the thickness of lVl abruptly thins from 24km on the west to 6km on the east. The other is that the velocity variation in the crust along east-west direction for both P- and s-wave displays a feature as quasi-periodic variation. The lower velocity (compared to the average value for the continent of the globe) in the lower crust and three sets of north-southward active normal faults are probably attributed to the coupling process of material delamination in the lower crust, crustal thicking and east-westward escape of the crustal material accompanied with the continental col-lision between India and Eurasia Plate.

关键词： southern Tibet, crustal structure, lower velocity layer,delamination, east-west escape.

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha R samarasinghe Taniya s Nagpal Michele l Barbeau Charys M Martin Division of General surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MsK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MsK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of MsK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement MsK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy Exercise Online learning

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(Als)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and Als affecting upper and lower motor neurons),these two diseases are complexly *** and Als exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.smith liwen Zhou Cameron l.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared s.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

East-west crustal structure and “down-bowing” Moho under the northern Tibet revealed by wide-angle seismic profile

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science China Earth sciences 2002年第6期45卷 550-558页

作者：张中杰李英康王光杰滕吉文 s.klemperer 李敬卫范进义陈赟 Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100101 China

We recognized 6 sets of reflecting P- and s-wave events from Moho and other interfaces within the crust, respectively, with the wide-angle seismic data acquired from 510 km-long selincuo-Ya'anduo profile in the northern Tibet, fitted the observed events with forward modeling, and interpreted crustal structure of P- and s-wave velocities and Poisson's ratio under the profile. The results demonstrate that the crustal structure between Yarlungzangbo and Bangong-Nujiang sutures changes abruptly, and the crust is the thickest at the middle part of the profile with thickness of 80 km or more. The 'down-bowing' Moho is the striking feature for the crustal variation along the west-east direction. The Moho uplifts with steps, and the uplifting rate westward is greater than that eastward. The heterogeneity of P- and s-wave velocities exists both vertically and horizontally, and one lower velocity layer (lVl) exists with the depth range of 27-34 km and the thickness range of 5-7 km. For the upper crust, Poisson's ratio is the lowest at the middle part of the profile; for the lower crust, the Poisson's ratio at the east segment is lower than that at west segment, which means that the crustal rigidity for the upper crust is different from the lower crust, and the lower crust under the east segment of the profile is more ductile. We infer that the substance in the lower crust endured eastward flow along with the collision between Eurasian and Indian plates, and the 'down-bowing' Moho is attributable to the multi-phase E-W tectonic processes.

关键词： northern Tibet, wide-angle seismic profile, P- and s-wave velocity, Poisson's ratio, 'down-bowing' Moho, eastward flow of materials.

semantic segmentation of lumbar Vertebrae Using Meijering U-Net(MU-Net)on spine Magnetic Resonance Images

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Computer Modeling in Engineering & sciences 2025年第1期142卷 733-757页

作者： lakshmi s V V shiloah Elizabeth Darmanayagam sunil Retmin Raj Cyril Department of Computer science and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people *** to its ability to produce a detailed view of the soft tissues,including the spinal cord,nerves,intervertebral discs,and vertebrae,Magnetic Resonance Imaging is thought to be the most effective method for imaging the *** semantic segmentation of vertebrae plays a major role in the diagnostic process of lumbar *** is difficult to semantically partition the vertebrae in Magnetic Resonance Images from the surrounding variety of tissues,including muscles,ligaments,and intervertebral discs.U-Net is a powerful deep-learning architecture to handle the challenges of medical image analysis tasks and achieves high segmentation *** work proposes a modified U-Net architecture namely MU-Net,consisting of the Meijering convolutional layer that incorporates the Meijering filter to perform the semantic segmentation of lumbar vertebrae l1 to l5 and sacral vertebra ***-colour mask images were generated and used as ground truth for training the *** work has been carried out on 1312 images expanded from T1-weighted mid-sagittal MRI images of 515 patients in the lumbar spine MRI Dataset publicly available from Mendeley *** proposed MU-Net model for the semantic segmentation of the lumbar vertebrae gives better performance with 98.79%of pixel accuracy(PA),98.66%of dice similarity coefficient(DsC),97.36%of Jaccard coefficient,and 92.55%mean Intersection over Union(mean IoU)metrics using the mentioned dataset.

关键词： Computer aided diagnosis(CAD) magnetic resonance imaging(MRI) semantic segmentation lumbar vertebrae deep learning U-Net model

Crustal structure of seismic velocity in southern Tibet and east-westward escape of the crustal material——An example by wide-angle seismic profile from Peigu Tso to Pumoyong Tso

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Crustal structure of seismic velocity in southern Tibet and ...