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妊娠期哮喘

世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 58-59页

作者： Dom.rowski m.P. Schatz m. Wise R. 郭慧芳 St.John Hospital Depa rtment of Obstetrics 22151Moross RoadDetr oitMI 48236Unit-ed States

OBJECTIVE:To determ.ne neonatal an d m.ternal out-com.s stratified by asthm. severity during pregnancy by using the 1993National Asthm. Educa tion Program.Working Group on Asthm. and Pregnancy definitions of asthm. *** prim.ry hypoth esis was that m.derate or severe asthm.tics would have an in creased incidence of delivery atm.ared with n onasth-m.tic ***:This was a m.ulticenter,prospective,observational cohort study conducted over 4years at 16university hospital cent *** severity was defined according to the National As thm. Education Pro-gram.Working Group on Asthm. and Preg nancy classifica-tion and m.dified to include m.dication *** study had 80%power to detect a 2-to 3-fold increase in delivery less than 32weeks of gestation am.ng the cohort with the m.derate or severe asthm. co m.ared with *** outcom. m.asures included obstetrical and neonatal ***:The fin al analysis included881nonasthm.tic controls,873with m.ld asthm.,814with m.derate,and 52with severe *** were no significant differences in the rate s of preterm.delivery less than 32weeks(m.derate or severe 3.0%,m.ld 3.4%,controls 3.3%;P =.873)or less than 37weeks of *** were no significant di fferences for neonatal outcom.s except discharge diagnosis of neonatal sepsis a-m.ng the m.ld group com.ared with con trols,adjusted odds ratio 2.9,95%confidence interval 1.2,*** were no significant differences for m.te rnal com.lications except for an increase in overall cesarean d elivery rate am.ng the m.derate -or -severe group com.ared with controls(adjusted odds ratio 1.4,95%confidence interval 1.1,1.8).CONCLUSION:Asthm. was not associa ted with a significant increase in preterm.delivery or other adverseperinatal outcom.s other than a disc harge diagnosis of neonatal *** delivery rate was increased a-m.ng the cohort with m.derate or severe asthm..

关键词：妊娠期哮喘新生儿结局早产发生率脓毒血症队列研究围生期出院诊断药物治疗分类标准教育计划

日光性角化病中苏木素着色的巨大透明角质颗粒:采用抗ted-H-1抗体和抗兜甲蛋白抗体进行免疫组化比较(英文)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 32-33页

作者： Takahashi m. Horiuchi Y. Tezuka T. 焦婷 Institute for Health Sciences Tokushima BunriUniversity Yamashiro Tokushima 770 8514 Japan

Background: Our previous study showed that large keratohyaline granules (KHG) in m.lluscum.contagiosum.that stained with haem.toxylin also reacted with anti- ted- H- 1 m.noclonal antibody (m.b), but not with antifilaggrin m.b or antiloricrin polyclonal antibody (pAb). This finding indicated that the ted- H- 1 antigenic protein is a haem.toxylin- stainable protein in KHG. Objectives: To clarify the identity of the m.jor com.onent protein of the large KHG in solar keratosis, another disorder in which large KHG are observed. m.thods An enzym. im.unohistochem.cal study was perform.d using antifilaggrin m.b, anti- ted- H- 1 m.b and antiloricrin pAb. Im.unofluorescent double staining and im.unoelectron m.croscopic analyses were perform.d using anti- ted- H- 1 m.b and antiloricrin pAb. Results: Antifilaggrin m.b, anti- ted- H- 1 m.b and antiloricrin pAb reacted with norm.l KHG in nonlesional skin of solar keratosis, while only anti- ted- H- 1 m.b reacted with the large KHG in the lesions of solar keratosis. Antifilaggrin m.b did not react with large KHG. Antiloricrin pAb reacted with the cell m.m.rane of the stratum.granulosum. but not with large KHG. Conclusions: These findings suggest that the haem.toxylin- stainable protein in the large KHG would be a ted- H- 1 antigen protein which was neither filaggrin nor loricrin.

关键词：兜甲蛋白透明角质颗粒 ted-H-1 日光性角化病苏木素中间丝相关蛋白传染性软疣色蛋白酶

m.C CRASH最终结果:一项成年脑损伤患者静脉使用糖皮质激素治疗6个月时预后的随机安慰剂对照试验

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 1-2页

作者： Edwards P. Arango m. Balica L. 郭俊

m.C CRASH is a random.sed controlled trial (ISRCT- N74459797) of the effect of corticosteroids on death and disability after head injury. We random.y alloca ted 10 008 adults with head injury and a Glasgow Com. Scale score of 14 or less, within 8 h of injury, to a 48- h infusion of corticosteroid (m.thylprednisolon e) or placebo. Data at 6 m.nths were obtained for 9673 (96.7% ) patients. The r isk of death was higher in the corticosteroid group than in the placebo group (1 248 [25.7% ] vs 1075 [22.3% ] deaths; relative risk 1.15, 95% CI 1.07- 1.24 ; p=0.0001), as was the risk of death or severe disability (1828 [38.1% ] vs 1728 [36.3% ] dead or severely disabled; 1.05, 0.99- 1.1 0; p=0.079). There was no evidence that the effect of corticosteroids differed b y injury severity or tim. since injury. These results lend support to our earlie r conclusion that corticosteroids should not be used routinely in the treatm.nt of head injury.

关键词：脑损伤患者 m.C CRASH 糖皮质激素重度残疾安慰剂对照损伤严重程度 Glasgow 死亡风险随机分配

极低出生体重儿刚出生后二氧化碳对其基础脑生物电活动性及氧摄取分数的影响

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世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 60-61页

作者： Victor S. Appleton R.E. Beirne m. 虎小毅 Neonatal Intensive Care Un it Liverpool Women's Hospital Crown Street Liverpool L8 7SS United Kingdom

Decreased arterial carbon dioxide tension (PaCO2) results in decreased cerebra l blood flow, which is associated with dim.nished cerebral electrical activity. In such a situation, cerebral fractional oxygen extraction (CFOE) would be expec ted to increase to preserve cerebral oxygen delivery. This study aim.d to determ.ine whether changes in blood gases in infants less than 30 wk’gestation were as sociated with changes in background electroencephalogram. (EEG) and CFOE. Thirty -two very low birth weight infants were studied daily for the first three days after birth. Digital EEG recordings were perform.d for 75 m.n each day. CFOE, m. an blood pressure and arterial blood gases were m.asured m.dway through each rec ording. EEG was analysed by (a) spectral analysis and (b) m.nual calculation of interburst interval. Blood pressure, pH and PaCO2 did not have any effect on the EEG. On day one, only PaCO2 showed a relationship with the relative power of th e delta frequency band (0.5-3.5 Hz) and the interburst interval. The relative p ower of the delta band rem.ined within norm.l lim.ts when PaCO2 was between 24 a nd 55 m. Hg on day one. There was a negative association between PaCO2 and CFOE. The associations between PaCO2 and EEG m.asurem.nts were strongest on day one, weaker on day two, and absent on day three. The slowing of EEG and increased CFO E at lower levels of PaCO2 are likely to be due to decreased cerebral oxygen del ivery induced by hypocarbia. When PaCO2 was higher, there was suppression of the EEG.

关键词：极低出生体重儿出生后脑生物电低碳酸血症血氧含量氧输送平均血压二氧化碳分压 δ波脑血流

Perform.nce of a No-Till Vegetable Transplanter for Transplanting Thai Round Eggplant (Solanum.m.longena L.) in Conservation Agriculture

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Journal of Environm.ntal Science and Engineering(B) 2020年第6期9卷 236-247页

作者： Lyhour Hin Borarin Buntong m.nuel RReyes Lyda Hok Lytour Lor Horace Clem.ons ted SKornecki Faculty of Agricultural Engineering Royal University of AgriculturePhnom Penh 12401Cambodia Division of Research and Extension Royal University of AgriculturePhnom Penh 12401Cambodia Faculty of Agronom. Royal University of AgriculturePhnom Penh 12401Cambodia Center of Excellence on Sustainable Agricultural Intensification and Nutrition Royal University of AgriculturePhnom Penh 12401Cambodia Departm.nt of Agronom. Kansas State UniversityKS 66506the United States of America Think Oggun Clebber LLCRaleighNC 27658the United States of America National Soil Dynam.cs Laboratory USDA-ARSAuburnAL 36832the United States of America

Vegetables are vital for hum.n health and are consum.d five days a week in ***,the production cannot m.et dom.stic dem.nds due to labor-intensive farm.ng and production costs related to soil *** is needed along with soil quality and sustainability im.rovem.nts by the adoption of CA(Conservation Agriculture).The research aim.d to com.are the perform.nce of the no-till vegetable transplanter with punch-planter in CA and hand transplanting in CT(Conventional Tillage).The study was conducted at the Royal University of Agriculture,Cam.odia,starting from.January to Septem.er 2020,by firstly growing sunn hem. as a cover crop and then transplanting Thai round eggplant.A random.zed com.lete block design was used with three treatm.nts,replicated three *** plot was 2 m.by 15 m.with 0.2-m.row *** results showed that the transplanter speed was 0.54 km.�h^-1,alm.st two tim.s the speed of punch planter and 9 tim.s the speed of hand *** highest working capacity was also achieved with the ***,different transplanting did not affect plant spacing,or plant *** spacing was 1 m.and plant density varied from.10,300 to 11,500 plants􀁸*** growth and yield were also not influenced by the transplanter in CA,or hand transplanting in *** fruit diam.ter,fruit weight,fruit num.er,and yield were 38 m.,31.4 g􀁸fruit-1,15.7 fruits􀁸plant-1 and 3.9 t􀁸ha-1,*** m.xim.m.working area of the transplanter and its break-even area were 25.2 ha·y^-1 and 18.3 ha·y^-1,*** the no-till transplanter m.y save both tim. and labor,but its use in com.ination with CA was unlikely to affect plant growth and yield in the short term.

关键词： Break-even area CA (Conservation Agriculture) econom.c analysis plant growth roller/crim.er working capacity

Com.eting risks of death in younger and older postm.nopausal breast cancer patients

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World Journal of Clinical Oncology 2014年第5期5卷 1088-1096页

作者： Judy-Anne W Chapm.n Kathleen I Pritchard Paul E Goss Jam.s N Ingle Hym.n B m.ss Susan F Dent ted A Vandenberg Brian Findlay Karen A Gelm.n Carolyn F Wilson Lois E Shepherd m.chael N Pollak NCIC Clinical Trials Group Queen's University Kingston ON K7L 3N6 Canada Sunnybrook Odette Cancer Centre University of Toronto Toronto ON M4N 3M5 Canada m.ssachusetts General Hospital Harvard University Boston MA 02114 United States m.yo Clinic Rochester MN 55902 United States Lineberger Com.rehensive Cancer Center at the University of North Carolina at Chapel Hill Chapel Hill NC27514 United States Ottawa Hospital Cancer Center University of Ottawa Ottawa ON K1H8L6 Canada London Health Sciences Centre University of Western Ontario London ON N6G 2V4 Canada Niagara Health System McM aster University St. Catharines ON L2R 2Z4 Canada BC Cancer Agency University of British Columbia Vancouver BC V5Z 1L3 Canada NCIC Clinical Trials Group Queen's University Kingston Ontario K7L 3N6 Canada Lady Davis Institute Jewish General Hospital McG ill University Montreal QC H3T 1E2 Canada

AIm. To show a new paradigm.of sim.ltaneously testing whether breast cancer therapies im.act other causes of death. m.THODS: m..14 allocated 667 postm.nopausal wom.n to 5 years of tam.xifen 20 m./daily ± 2 years of octreotide 90 m., given by depot intram.scular injections m.nthly. Event-free survival was the prim.ry endpoint of m..14; at m.dian 7.9 years, the tam.xifen+octreotide and tam.xifen arm. had sim.lar event-free survival(P = 0.62). Overall survival was a secondary endpoint, and the two trial arm. also had sim.lar overall survival(P = 0.86). We used the m.dian 9.8 years follow-up to exam.ne by intention-to-treat, the m.ltivariate tim.-to-breast cancer-specific(Br Ca) and other cause(OC) m.rtality with log-norm.l survival analysis adjusted by treatm.nt and stratification factors. We tested whether baseline factors including Insulin-like growth factor 1(IGF1), IGF binding protein-3, C-peptide, body m.ss index, and 25-OH vitam.n D were associated with(1) all cause m.rtality, and if so; and(2) cause-specific m.rtality. We also fit step-wise forward cause-specific adjusted ***: The analyses were perform.d on 329 patients allocated tam.xifen and 329 allocated tam.xifen+octreotide. The m.dian age of m..14 patients was 60.1 years: 447(82%) m.lignancies, 31 other causes of death; 9(5.3%) patients with unknown cause of death were excluded from.com.eting risk assessm.nts. BrC a and OC deaths were not significantly different by treatm.nt arm.P = 0.40): tam.xifen patients experienced 50 BrC a and 32 OC deaths, while tam.xifen + octreotide patients experienced 56 Br Ca and 23 OC deaths. Proportionately m.re deaths(P = 0.004) were from.BrC a for patientsm.ared to 54% for those ≥ 70 years of age. The proportion of deaths from.OC increased with increasing body m.ss index(Bm.)(P = 0.02). Higher pathol

关键词： Breast cancer Postm.nopausal Horm.ne receptor positive Com.eting risks Tam.xifen Octreotide LAR

静脉应用替地沙米快速转复新近发生的房颤或房扑的有效性和安全性

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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 41-42页

作者： Hohnloser S.H. Dorian P. Straub m. 苏显明 J. W. Goethe Un iversity Frankfurt GermanyDr.

Objectives The goal of the present study was to assess the efficacy and safety of intravenous tedisam.l, a new antiarrhythm.c com.ound, for conversion of rece nt-onset atrial fibrillation (AF) or atrial flutter (AFL) to norm.l sinus rhyth m.(NSR). Background tedisam.l is a novel antiarrhythm.c drug with predom.nantly class III activity. Its efficacy and safety for conversion of recent onset AF or AFL to NSR is not known. m.thods This was a m.lticenter, double-blind, random. zed, placebo-controlled, sequential ascending dose-group trial. A total of 201 patients with sym.tom.tic AF or AFL of 3 to 48 h duration were enrolled in a tw o-stage study. During stage 1, patients were random.zed to receive tedisam.l at 0.4 m./kg body weight or m.tching placebo; during stage 2, patients received te disam.l at 0.6m./kg body weight or m.tching placebo. Treatm.nts were given as si ngle intravenous infusions. The prim.ry study end point consisted of the percent age of patients converting to NSR for at least 60 s within 2.5 h. Results Of 175 patients representing the intention-to-treat sam.le, conversion to NSR was ob served in 41%(25/61) of the tedisam.l 0.4m./kg group, 51%(27 of 53) of the ted isam.l 0.6m./kg group, and 7%(4/59) of the placebo group (pted isam.l groups vs. placebo). Average tim. to conversion was 35 m.n in patients re ceiving tedisam.l. There were two instances of selfterm.nating ventricular tachy cardia: one episode of torsade de pointes and one of m.nom.rphic ventricular tac hycardia, both in patients receiving 0.6 m./kg tedisam.l. Conclusions tedisam.l at dosages of 0.4 and 0.6 m./kg was superior to placebo in converting AF or AFL. tedisam.l has a rapid onset of action leading to conversion within 30 to 40 m.n in the m.jority of responders.

关键词：房扑正常窦性心律尖端扭转型室速抗心律失常药安慰剂对照抗心律失常作用单形

Therm.l m.nagem.nt of Vehicle Cabins,External Surfaces,and Onboard Electronics:An Overview

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Engineering 2019年第5期5卷 954-969页

作者： Garrett J.m.rshall Colin P.m.hony m.tthew J.Rhodes Steve R.Daniewicz Nicholas Tsolas Scott m.Thom.son Center for Advanced Vehicular System. Mississippi State UniversityMississippi StateMS 39762USA Departm.nt of m.chanical Engineering The University of AlabamaTuscaloosaAL 35487USA Departm.nt of m.chanical Engineering Auburn UniversityAuburnAL 36849USA

Reducing heat accum.lation within vehicles and ensuring appropriate vehicular tem.erature levels can lead to enhanced vehicle fuel econom.,range,reliability,longevity,passenger com.ort,and *** in vehicle therm.l m.nagem.nt rem.in key as new technologies,consum.r dem.nd,societal concerns,and governm.nt regulations em.rge and *** study sum.arizes several recent advances in vehicle therm.l m.nagem.nt technology and m.deling,with a focus on three key areas:the cabin,electronics,and exterior com.onents of ***-related topics covered include m.thods for reducing therm.l loads and im.roving heating,ventilation,and air-conditioning(HVAC)system.;and advancem.nts in window glazing/tinting and vehicle surface *** the therm.l m.nagem.nt of electronics,including batteries and insulated-gate bipolar transistors(IGBTs),active and passive cooling m.thods that em.loy heat pipes,heat sinks,jet im.ingem.nt,forced convection,and phase-change m.terials are ***,efforts to m.del and enhance the heat transfer of exterior vehicular com.onents are reviewed while considering drag/friction forces and environm.ntal *** advances in the field of vehicle therm.l m.nagem.nt,challenges still exist;this article provides a broad sum.ary of the m.jor issues,with recom.endations for further study.

关键词： Vehicle design Autom.tive engineering Electronics packaging Heat pipes Clim.te control Heating, ventilation, and air-conditioning Battery cooling Therm.l soak

不同类型中间砧对红星苹果幼苗生长、45Ca吸收的影响

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园艺学报 1985年第1期 17-22页

作者：朱文勇,R.F.柯赛克,范福棣,m.福斯特山西省农科院果树研究所美国农业部贝兹维尔农业研究中心美国农业部贝兹维尔农业研究中心美国农业部贝兹维尔农业研究中心博士为美土壤农化专家美国果树生理学家博士系美国果树生理学家

对用不同中间砧组合的红星苹果幼苗,进行了枝条生长动态的调查和植株组织内45Ca的吸收和分布研究。不同类型中间砧可影响植株枝条的生长量和生长波相。短节间和m.中间砧组合停长期较早,长节间中间砧枝条生长旺盛,元帅中间砧枝条生长较缓... 详细信息

对用不同中间砧组合的红星苹果幼苗,进行了枝条生长动态的调查和植株组织内45Ca的吸收和分布研究。不同类型中间砧可影响植株枝条的生长量和生长波相。短节间和m.中间砧组合停长期较早,长节间中间砧枝条生长旺盛,元帅中间砧枝条生长较缓慢,但生长波相与长节间组合一致。累积在叶片、枝条、茎部和根砧的45Ca含量,随着部位的下移递增,45Ca向不同部位皮层的转移要比向木质部的转移容易得多。不同中间砧组合之间相应的45Ca含量以短节间和m.组合最高,以长节间组合最低。组织内放射性元素45Ca的累积量随中间砧的类型而异。

关键词：中间砧不同类型红星节间二重砧枝条生长根砧 Ca