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Gender Differences in Comorbidities and Sleep Patterns of Obese Patients with Obstructive Sleep Apnea

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World Journal of Neuroscience 2015年第1期5卷 49-57页

作者： Ricardo José Benício Valadares klayton galante sousa Marília Nascimento Espindola Carlos Eduardo Ventura Gaio dos Santos Carlos Alberto Assis Viegas Postgraduate School of Medicine at the University of Brasilia (UNB) Brasilia Brazil

Objective: The aim of the study was to compare the comorbidities and sleep patterns most commonly associated with each gender in obstructive sleep apnea (OSA). Methods: This was a cross-sectional study of obese individuals with OSA.?The polysomnographies were carried out in a sleep laboratory environment, using a 15-channel polysomnography setup. Airflow was measured using a nasal pressure cannula/thermistor combination. A standard handbook was used for interpretation of PSG findings. Results: A total of 284 subjects were included in the study, (147 females). The mean age, body mass index and neck circumference were similar between females and males (p?= 0.9579,?p??p?< 0.0001, respectively). On polysomnography, females exhibited longer latency to REM sleep (146.50 ± 85.93 vs. 122.3 ± 68.28,?p?= 0.0210) and a higher percentage of?delta sleep (10.09 ± 7.48 vs. 7.55 ± 6.57,?p?= 0.0037);males had more frequent microarousals (38.37?± 27.44 vs. 28.07 ± 21.23,?p?= 0.0017) and a higher AHI score (30.56 ± 27.52 vs. 17.31 ± 21.23,?p?< 0.0001). The comorbidities most commonly associated with female gender were diabetes (29% vs. 9.49%,?p?= 0.0132), hypothyroidism (20% vs. 2.19%,?p?< 0.0001), and depression (81.63% vs. 51.22%,?p?< 0.0001). Male gender was associated with myocardial infarction (6.57% vs. 1.38%,?p?= 0.0245) and alcohol intake (33.88% vs. 11.34%,?p?< 0.0001). Obese males with OSA have a larger?neck circumference and higher AHI and arousal indices than females. Conclusions: There are genderdifferences both in the sleep patterns and in the comorbidities of patients with OSA. Men had a larger neck circumference, higher apnea and sleep fragmentation scores, were more likely to consume alcohol, and were more likely to have a history of myocardial infarction than women.

关键词： Obstructive Sleep Apnea Obesity Gender Comorbidity

Mechanically durable,super-repellent 3D printed microcell/nanoparticle surfaces

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Nano Research 2022年第6期15卷 5678-5686页

作者： Sajad Haghanifar Anthony J galante Mehdi Zarei Jun Chen Susheng Tan Paul W Leu Department of Industrial Engineering University of PittsburghPittsburghPA 15261USA Department of Mechanical Engineering and Materials Science University of PittsburghPittsburghPA 15261USA Department of Electrical and Computer Engineering and Peterson Institute of NanoScience and Engineering University of PittsburghPittsburghPA 15261USA Department of Chemical Engineering University of PittsburghPittsburghPA 15261USA

Three-dimensional(3D)printed re-entrant micropillars have demonstrated high static contact angles for an unprecedented variety of liquids,but have yet to achieve this with low contact angle hysteresis and excellent abrasion *** report on the demonstration of 3D printed microcell/nanoparticle structures that exhibit high static contact angle,low contact angle hysteresis,and high mechanical *** and microcells both exhibit high static contact angles with water and ethylene glycol(EG),but suffer from high contact angle hysteresis,indicative of rose petal *** modeling results indicate that micropillars are able to achieve higher static contact angle and breakthrough pressure simultaneously compared with ***,simulations also indicate that micropillars have higher maximum equivalent stress at their bases,so that they are more prone to mechanical *** address contact angle hysteresis and mechanical durability issues by the creation of 3D printed microcell/nanoparticle arrays that demonstrate super-repellency and retain their super-repellency after 100 cycles of mechanical abrasion with a Scotch-Brite abrasive pad under a pressure of 1.2 *** use of interconnected microcell structures as opposed to micropillars addresses mechanical durability *** contact angle hysteresis is realized by coating 3D printed structures with low surface energy nanoparticles,which lowers the solid–liquid contact area *** results demonstrate new 3D printed structures with mechanical durability and super-repellency through the use of microcell structures integrated with fluorinated nanoparticles.

关键词： superomniphobicity three-dimensional(3D)printing surface evolver mechanical durability microcell re-entrant micropillar

Anomalous behaviour detection using one-class support vector machine and remote sensing images: a case study of algal bloom occurrence in inland waters

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International Journal of Digital Earth 2021年第7期14卷 921-942页

作者： Pedro Henrique Moraes Ananias Rogério galante Negri Graduate Program in Natural Disasters UNESP/CEMADENSão Josédos CamposSão PauloBrazil Sciences Technology Institute São Paulo State University(UNESP)São Josédos CamposSão PauloBrazil

Algal blooms are a frequent subject in scientific discussions and are the focus of many recent studies,mainly due to their adverse effect on *** the lack of ground truth data and the need to develop tools for their detection and monitoring,this research proposes a novel method to automate *** derived from multi-temporal image series processing,spectral indices and classification with Oneclass Support Vector Machine(OC-SVM)are used in this *** from multi-spectral sensors on Landsat-8 and MODIS were acquired through the Google Earth Engine API(GEE API).In order to evaluate our method,two bloom detection case studies(Lake Erie(USA)and Lake Taihu(China))were *** were made with methods based on spectral index ***,to demonstrate the performance of the OC-SVM classifier compared to other machine learning methods,the proposal was adapted to be used with a Random Forest(RF)classifier,having its results added to the *** situ measurements show that the proposed method delivers highly accurate results compared to spectral index thresholding ***,a drawback of the proposal refers to its higher computational *** application of the new method to a real-world bloom case is demonstrated.

关键词： Remote sensing spectral indices unsupervised classification anomalies algal bloom detection

A Review on Clustering Methods for Climatology Analysis and Its Application over South America

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International Journal of Geosciences 2023年第9期14卷 877-894页

作者： Luana Albertani Pampuch Rogério galante Negri Paul C. Loikith Cassiano Antonio Bortolozo Environmental Engineering Department Institute of Science and Technology S&#227o Paulo State University S&#227o José dos Campos Brazil Department of Geography Portland State University Portland Oregon Cemaden-National Center for Monitoring and Early Warning of Natural Disasters General Coordination of Research and Development S&#227o José dos Campos Brazil

South America’s climatic diversity is a product of its vast geographical expanse, encompassing tropical to subtropical latitudes. The variations in precipitation and temperature across the region stem from the influence of distinct atmospheric systems. While some studies have characterized the prevailing systems over South America, they often lacked the utilization of statistical techniques for homogenization. On the other hand, other research has employed multivariate statistical methods to identify homogeneous regions regarding temperature and precipitation, but their focus has been limited to specific areas, such as the south, southeast, and northeast. Surprisingly, there is a lack of work that compares various multivariate statistical techniques to determine homogeneous regions across the entirety of South America concerning temperature and precipitation. This paper aims to address this gap by comparing three such techniques: Cluster Analysis (K-means and Ward) and Self Organizing Maps, using data from different sources for temperature (ERA5, ERA5-Land, and CRU) and precipitation (ERA5, ERA5-Land, and CPC). Spatial patterns and time series were generated for each region over the period 1981-2010. The results from this analysis of spatially homogeneous regions concerning temperature and precipitation have the potential to significantly benefit climate analysis and forecasts. Moreover, they can offer valuable insights for various climatological studies, guiding decision-making processes in diverse fields that rely on climate information, such as agriculture, disaster management, and water resources planning.

关键词： Climatology Clustering Methods Clustering Regionalization Reanalysis Data South America

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大型砂箱的自动化造型——大型风电铸件生产

大型砂箱的自动化造型——大型风电铸件生产

Genetic variation in foundation species governs the dynamics of trophic interactions

调整创新迈向铸造强国——第九届中国铸造协会年会

作者： galante 意大利IMF公司

"风电场"正以惊人的发展速度在各工业国中铺开。就是塞万提斯动用了堂吉珂德的全部军队也难以阻挡这个发展的势头。虽然我们对风电场对环境的影响仍然有些困惑,但无论从哪个方面来看,没有人可以否定我们对发展清洁能源的基本需求。

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Current Zoology 2018年第1期64卷 13-22页

作者： Leticia VALENCIA-CUEVAS Patricia MUSSALI-galante Zenon CANO-SANTANA Juli PUJADE-VILLAR Armando EQUIHUA-MARTINEZ Efrain TOVAR-SANCHEZ Laboratorio de Marcadores Moleculares Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de Morelos Av. Universidad 1001 Col. Chamilpa Cuernavaca Morelos CP 62209 Mexico Laboratorio de Investigaciones Ambientales Centro de Investigacion en Biotecnologia Universidad Autonoma del Estado de Morelos Av. Universidad 1001 Col. Chamilpa Cuernavaca Morelos CP 62209 Moxico Departamento de Ecologia y Recursos Naturales Facultad de Ciencias Universidad Nacional Autonoma de Mexico Delegacion Coyoacan DF 04510 Mexico Departamento de Biologia Animal Universitat de Barcelona Facultat de Biologla Av. Diagonal 645 Barcelona 08028 Espana Instituto de Fitosanidad Colegio de Postgraduados Montecillo Texcoco 56230 Estado de Mexico

Various studies have demonstrated that the foundation species genetic diversity can have direct effects that extend beyond the individual or population level, affecting the dependent communities. Additionally, these effects may be indirectly extended to higher trophic levels throughout the entire community. is an oak species with characteristics of foundation species beyond presenting a wide geographical distribution and being a dominant element of Mexican temperate forests. In this study, we analyzed the influence of population () and individual () genetic diversity of on its canopy endophagous insect community and associated parasitoids. Specifically, we studied the composition, richness () and density of leaf-mining moths (Lepidoptera: Tischeridae, Citheraniidae), gall-forming wasps (Hymenoptera: Cynipidae), and canopy parasitoids of . We sampled 120 trees belonging to six populations (20/site) through the previously recognized gradient of genetic diversity. In total, 22 endophagous insect species belonging to three orders (Hymenoptera, Lepidoptera, and Diptera) and 20 parasitoid species belonging to 13 families were identified. In general, we observed that the individual genetic diversity of the host plant () has a significant positive effect on the and density of the canopy endophagous insect communities. In contrast, has a significant negative effect on the of endophagous insects. Additionally, indirect effects of were observed, affecting the and density of parasitoid insects. Our results suggest that genetic variation in foundation species can be one of the most important factors governing the dynamics of tritrophic interactions that involve oaks, herbivores, and parasitoids.

关键词：昆虫种类基因差异相互作用动力学化管理基础营养地理分布

Trypanosoma rangeli:growth in mammalian cells in vitro and action of a repositioned drug(17-AAG)and a natural extract(Artemisia *** oil)

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BIOCELL 2019年第1期43卷 13-19页

作者： Ana Laura CIMADOR Emeli Luciana galante Lucila Ibel MUNOZ Patricia Silvia ROMANO Antonella Denisse LOSINNO Maria Cristina VANRELL Facultad de Farmacia y Bioquimica Universidad Juan Agustin Maza.MendozaArgentina Facultad de Ciencias Medicas Universidad Nacional de Cuyo.MendozaArgentina Laboratorio de Biologia de Trypanosoma cruzi y la celula hospedadora-Instituto de Histologia y Embriologia“Dr.Mario H.Burgos”IHEM-CONICET-Universidad Nacional de Cuyo.Mendoza Argentina

Trypanosoma rangeli and *** are both parasitic unicellular species that infect *** ***,the causative agent of Chagas disease,*** is an infective and non-pathogenic parasite for humans,but pathogenic for vectors from the Rhodnius *** both species can coexist in different hosts and overlap their infective cycles but very little is known about the infection of *** in mammalian cells,we decided to characterize both the development of this parasite in cell culture and the effect of therapeutic agents with potential trypanocidal action on *** found that *** exhibits a cycle of infection in Vero cells similar to that for *** and that the repurposed drug,17-AAG,and the natural extract Artemisia *** oil produce a toxic effect on epimastigotes showing a trypanocidal action from the fifth day of *** treatments also affected the infection of trypomastigotes and reduced the capacity of replication of amastigotes of *** ***/*** coinfection cases have been reported,the finding of drugs with potential activity against both species could be significant in the ***,studies of susceptibility of both species to drugs could also help to know the different mechanisms of pathogenicity in humans displayed by *** that are absent in ***.

关键词： Life-cycle Treatment Trypanosoma rangeli

Intelligent Agent Technologies: The Work Horse of ERP E-Commerce

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International Journal of Intelligence Science 2015年第4期5卷 173-176页

作者： Anne T. galante Department of Computing Systems SUNY Farmingdale State College Farmingdale USA

Agents are the new defacto standard for inclusion in modules of today’s software systems such as ERP systems, mobile applications and operating systems. Agents are an integral part of today’s software design. The question is how do intelligent agents work in the specific area of ERP credit card processing e-commerce models? To answer this question, a specific area of ERP systems will be analyzed: credit card processing for merchants. One specific merchant credit card processor will be specifically investigated: EVO Merchants. This paper will research how exactly does ERP systems interact using Application Programing Interface or “API” specified by a credit card clearing house. Secure Socket Layers or SSL, and XML are discussed and elaborated on specifically how intelligent agents play such a pivotal role in ERP e-commerce systems for credit card processing.

关键词： Intelligent Agents Agent Technologies ERP E-Commerce API Artificial Intelligence Decision Making Enterprise Resource Planning Application Programing Interface EVO Credit Cards XML SSL AIM W3C SGML

Epigenetic and Transcriptional Modulator Potential of Epigallocatechin-3-gallate and Genistein on Fetal Hemoglobin Reactivators Genes

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Clinical Complementary Medicine and Pharmacology 2022年第2期2卷 39-49页

作者： Edna Ribeiro Mariana Delgadinho Elisabete Matos Raquel Santos Daniela sousa Heloísa galante Miguel Britoa H&TRC-Health and Technology Research Center ESTeSL-Escola Superior de Tecnologia da SaúdeInstituto Politécnico de LisboaAv.D.João IILote 4.69.01Parque das NaçõesLisboa 1990-096Portugal Faculty of Sciences of the University of Lisbon Universidade de LisboaCampo Grande 016Lisboa 1749-016Portugal

Background:𝛽-hemoglobinopathies are one of the most common recessive genetic diseases worldwide,with limited treatments available,particularly in developed countries where the prevalence is *** reactivation of Fetal Hemoglobin(HbF)is a promising therapeutic ***,approximately 25%of the patients do not respond to Hydroxyurea(HU),the first and most commonly used HbF inducing agent approved by the ***:Here,we performed an in vitro assessment of transcriptional effects induced by natural bioactive compounds,namely Epigallocatechin-3-gallate(EGCG)and genistein(GN)in globin genes(HBA1,HBB,HBG1 and HBG2)in HbF regulators/silencer genes(KLF1,BCL11A,MYB and BGLT3)and in epigenetic regulator genes(DNMT1,DNMT3A,DNMT3B,HDAC1,HDAC2,HDAC3 and HDAC8).Moreover,we evaluated EGCG’s in vivo effects in hematological parameters of healthy ***:K562 cells were exposed for 72 and 96 h to GN and EGCG at 100,250 and 500 ng/*** proliferation and viability were measured,and transcriptional levels were evaluated by *** in vivo assay,complete blood count was determined by flow cytometry and HbF level was determined through HPLC in 30 healthy individuals before and after 225 mg EGCG ingestion per day during a 90-day ***:Both compounds impact cellular metabolism and proliferation with no cytotoxic *** GN and EGCG effects in globin and BGLT3 expression levels suggest the involvement of divergent signaling *** for the epigenetic potential,EGCG particularly affects HDAC2 and HDAC8 transcription,whereas GN signifi-cantly affects expression patterns of methylation and acetylation *** appears to have time divergent effects,with greater impact in methylation at 72 h(overregulates DNTM3A)while affecting acetylation mostly at 96 h(downregulates HDAC1 and HDAC8).Additionally,in vivo,EGCG demonstrated a modulator effect in hematopoiesis and HbF ***:Our results advocate EGCG and GN

关键词： Epigenetic modulators Fetal hemoglobin Genistein Epigallocatechin-3-gallate In vitro transcriptional effects In vivo hematologic effects