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Prevalence of fever of unidentifed aetiology in East African adolescents and adults: a systematic review and meta-analysis

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Infectious Diseases of Poverty 2023年第3期12卷 88-88页

作者： Faisal Nooh Afona Chernet klaus.reither James Okuma Norbert W.Brattig Jürg Utzinger Nicole Probst-Hensch Daniel H.Paris Anou Dreyfus Swiss Tropical and Public Health Institute Kreuzstrasse 24123 AllschwilSwitzerland University of Basel BaselSwitzerland College of Medicine and Health Sciences Jigjiga UniversityJigjigaEthiopia College of Medicine and Health Sciences University of HargeisaHargeisaSomaliland Depart-ment Infectious Disease Epidemiology Bernhard Nocht Institute for Tropical MedicineHamburgGermany Section of Epidemiology University of ZürichZurichSwitzerland

Background Primary health care settings and hospitals of low-and middle-income countries have few accessible diagnostic tools and limited laboratory and human resources capacity to identify multiple pathogens with high accu‑*** addition,there is a paucity of information on fever and its underlying aetiology in the adolescent and adult population in East *** purpose of this study was to estimate the pooled prevalence of fever of unidentifed aetiology among adolescent and adult febrile patients seeking health care in East *** We pursued a systematic review using readily available electronic databases(***,Cumulative Index to Nursing&Allied Health Literature,Scopus,Cochrane Library and Web of Science)without language restric‑tion from inception date of the respective databases to October 31,*** adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** studies were screened for *** analyses based on pre-set eligibility criteria were carried out for fnal *** reviewers independently screened and extracted *** of study bias was ***-analysis of the prevalence of fever of unidentifed aetiology was *** We identifed 14,029 articles of which 25 were eligible for inclusion,reporting data from 8538 *** pooled prevalence of febrile cases with unidentifed aetiology was 64%[95%confdence interval(CI):51–77%,I 2=99.6%]among febrile adolescents and adults in East *** the proportion of patients with identifed aetiol‑ogy,the studies documented bacterial pathogens(human bloodstream infections),bacterial zoonotic pathogens and arboviruses as the main non-malarial causative agents in East *** Our study provides evidence that almost two-thirds of adolescent and adult febrile patients attending health care facilities in East Africa might receive inappropriate treatments due to unidentifed potential life-threat‑ening fever aetiolo

关键词： Aetiology East Africa Febrile illness Fever Meta-analysis Prevalence Systematic review

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The impact of pastoralist mobility on tuberculosis control in Ethiopia:a systematic review and meta-synthesis

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Infectious Diseases of Poverty 2019年第5期8卷 91-91页

作者： Faisal Nooh Lisa Crump Abdiwahab Hashi Rea Tschopp Esther Schelling klaus.reither Jan Hattendorf Seid M.Ali Brigit Obrist Jurg Utzinger Jakob Zinsstag Swiss Tropical and Public Health Institute P.O.BoxCH-4002BaselSwitzerland University of Basel P.O.BoxCH-4003BaselSwitzerland 不详

Background:Directly observed treatment,short-course(DOTS)is the current mainstay to control tuberculosis(TB)***-specific adaptations of DOTS have impending implications in the fight against *** Ethiopia,there is a national TB control programme with the goal to eliminate TB,but uneven distribution across lifestyle gradients remains a ***,the mobile pastoralist communities in the country are disproportionately left *** aim of this study was to summarize the evidence base from published literature to guide TB control strategy for mobile pastoralist communities in *** text:We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines and systematically reviewed articles in seven electronic databases:Excerptra Medical Database,African Journal Online,PubMed,Google Scholar,Centre for Agriculture and Bioscience International Direct,Cochrane Library and Web of *** databases were searched from inception to December 31,2018,with no language *** screened 692 items of which 19 met our inclusion *** a meta-ethnographic method,we identified six themes:(i)pastoralism in Ethiopia;(ii)pastoralists’livelihood profile;(iii)pastoralists’service utilisation;(iv)pastoralists’knowledge and awareness on TB control services;(v)challenges of TB control in pastoral settings;and(vi)equity disparities affecting *** interpretation triangulates the results across all included studies and shows that TB control activities observed in pastoralist regions of Ethiopia are far fewer than elsewhere in the ***:This systematic review and meta-synthesis shows that TB control in Ethiopia does not align well with the pastoralist *** and lack of acceptability of TB care are the key bottlenecks to pastoralist TB service *** these two parameters holds promise to enhance effectiveness of an intervention.

关键词： Directly observed treatment short-course(DOTS) Effectiveness Equity Ethiopia,Meta-ethnographic method Pastoralist Systematic review Tuberculosis

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Distinct clinical characteristics and helminth co-infections in adult tuberculosis patients from urban compared to rural Tanzania

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Infectious Diseases of Poverty 2018年第1期7卷 243-254页

作者： George Sikalengo Jerry Hella Francis Mhimbira Liliana K.Rutaihwa Farida Bani Robert Ndege Mohamed Sasamalo Lujeko Kamwela Khadija Said Grace Mhalu Yeromin Mlacha Christoph Hatz Stefanie Knopp Sebastien Gagneux klaus.reither Jurg Utzinger Marcel Tanner Emilio Letang Maja Weisser Lukas Fenner Ifakara Health Institute Dar es SalaamTanzania Swiss Tropical and Public Health Institute BaselSwitzerland' University of Basel BaselSwitzerland Institute of Social and Preventive Medicine University of BernBernSwitzerland

Background:Differences in rural and urban settings could account for distinct characteristics in the epidemiology of tuberculosis(TB).We comparatively studied epidemiological features of TB and helminth co-infections in adult patients from rural and urban settings of ***:Adult patients(≥18 years)with microbiologically confirmed pulmonary TB were consecutively enrolled into two cohorts in Dar es Salaam,with~4.4 million inhabitants(urban),and Ifakara in the sparsely populated Kilombero District with~400000 inhabitants(rural).Clinical data were obtained at *** and urine samples were subjected to diagnose helminthiases using Kato-Katz,Baermann,urine filtration,and circulating cathodic antigen *** between groups were assessed byχ2,Fisher’s exact,and Wilcoxon rank sum *** regression models were used to determine ***:Between August 2015 and February 2017,668 patients were enrolled,460(68.9%)at the urban and 208(31.1%)at the rural *** patient age was 35 years(interquartile range[IQR]:27-41.5 years),and 454(68%)were *** from the rural setting were older(median age 37 years vs.34 years,P=0.003),had a lower median body mass index(17.5 kg/m2 vs.18.5 kg/m2,P<0.001),a higher proportion of recurrent TB cases(9%vs.1%,P<0.001),and in HIV/TB co-infected patients a lower median CD4 cell counts(147 cells/μl vs.249 cells/μl,P=0.02)compared to those from urban *** was no significant difference in frequencies of HIV infection,diabetes mellitus,and haemoglobin concentration levels between the two *** overall prevalence of helminth co-infections was 22.9%(95%confidence interval[CI]:20.4-27.0%).The significantly higher prevalence of helminth infections at the urban site(25.7%vs.17.3%,P=0.018)was predominantly driven by Strongyloides stercoralis(17.0%vs.4.8%,P<0.001)and Schistosoma mansoni infection(4.1%vs.16.4%,P<0.001).Recurrent TB was associated with living in a rural setting(adjuste

关键词： Co-infection Helminth infection Recurrent tuberculosis Schistosomiasis Tanzania Tubercu

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