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Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker

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World Journal of Gastroenterology 2015年第1期21卷 333-341页

作者： Susen Burock Pia Herrmann Ina Wendler Markus Niederstrasser klaus-dieter wernecke Ulrike Stein Charité Comprehensive Cancer Center Invali-denstra?e 8010117 BerlinGermany Experimental and Clinical Research Center Charité University Medicine Berlin and Max- Delbrück-Center for Molecular MedicineRobert-R?ssle-Stra?e 1013125 BerlinGermany Charité University Medicine Berlin Lindenberger Weg 8013125 BerlinGermany Institute of Medical Biometry Charité University Medicine BerlinLuisenstra?e 6510117 BerlinGermany

AIM: To evaluate the diagnostic and prognostic value of circulating Metastasis Associated in Colon Cancer 1(MACC1) transcripts in plasma of gastric cancer ***: We provide for the first time a blood-based assay for transcript quantification of the metastasis inducer MACC1 in a prospective study of gastric cancer patient ***1 is a strong prognostic biomarker for tumor progression and metastasis in a variety of solid *** conducted a study to define the diagnostic and prognostic power of MACC1 transcripts using 76 plasma samples from gastric cancer patients,either newly diagnosed with gastric cancer,newly diagnosed with metachronous metastasis of gastric cancer,as well as follow-up *** were controlled by using plasma samples from 54 tumor-free *** was separated,RNA was isolated,and levels of MACC1 as well as S100A4 transcripts were determined by quantitative ***: Based on the levels of circulating MACC1 transcripts in plasma we significantly discriminated tumorfree volunteers and gastric cancer patients(P < 0.001).Levels of circulating MACC1 transcripts were increased in gastric cancer patients of each disease stage,compared to tumor-free volunteers: patients with tumors without metastasis(P = 0.005),with synchronous metastasis(P = 0.002),with metachronous metastasis(P = 0.005),and patients during follow-up(P = 0.021).Sensitivity was 0.68(95%CI: 0.45-0.85) and specificity was 0.89(95%CI: 0.77-0.95),***,gastric cancer patients with high circulating MACC1 transcript levels in plasma demonstrated significantly shorter survival whencompared with patients demonstrating low MACC1 levels(P = 0.0015).Furthermore,gastric cancer patients with high circulating transcript levels of MACC1 as well as of S100A4 in plasma demonstrated significantly shorter survival when compared with patients demonstrating low levels of both biomarkers or with only one biomarker elevated(P = 0.001).CONCLUSION: Level

关键词： Gastric cancer Plasma Circulating transcripts MACC

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Natural water purification and water management by artificial groundwater recharge

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第3期9卷 221-226页

作者： klaus-dieter BALKE Institute for Geosciences University of TübingenSigwartstr.10D-72076 TübingenGermany

Worldwide,several regions suffer from water scarcity and *** infiltration and subsurface storage of rain and river water can reduce water *** groundwater recharge,possibly combined with bank filtration,plant purification and/or the use of subsurface dams and artificial aquifers,is especially advantageous in areas where layers of gravel and sand exist below the earth's *** infiltration of surface water into the uppermost aquifer has qualitative and quantitative *** contamination of infiltrated river water will be reduced by natural *** minerals,iron hydroxide and humic matter as well as microorganisms located in the subsurface have high decontamination *** this,a final water treatment,if necessary,becomes much easier and *** quantitative effect concerns the seasonally changing river discharge that influences the possibility of water extraction for drinking water *** changes can be equalised by seasonally adapted infiltration/extraction of water in/out of the aquifer according to the river discharge and the water *** method enables a continuous water supply over the whole ***,artificially recharged groundwater is better protected against pollution than surface water,and the delimitation of water protection zones makes it even more save.

关键词： Artificial groundwater recharge Natural attenuation Water management

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Groundwater protection:What can we learn from Germany?

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第3期9卷 227-231页

作者： klaus-dieter BALKE Institute for Geosciences University of TübingenSigwartstr.10D-72076 TübingenGermany

For drinking water security the German waterworks proceed on a comprehensive concept,i.e.,the protection of all the regions from the recharge area to the *** includes the protection of the recharge area by a precautionary management,a safe water treatment,a strict maintenance of the water distribution network,continuous control and an intensive training of *** protection zones together with effective regulations and control play a very important *** protection zones with different restrictions in land-use are *** in reservoirs and lakes is also protected by Surface Water Protection *** the surrounding area the land-use is controlled,*** treatment is necessary if acidification happens caused by acid rain,or eutrophication caused by the inflow of *** important is the collaboration between waterworks and the farmers cultivating land in the recharge area in order to execute water-protecting ecological farming with the aim to reduce the application of fertilizers and plant protection *** financial losses have to be compensated by the waterworks.

关键词： Drinking water security Germany Groundwater protection zone Water protection

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On the Identity and Taxonomic Status of Coluber nuthalli Theobald, 1868, with Redescription of the Type Specimens of Coluber nuthalli and Elaphis yunnanensis Anderson, 1879(Reptilia, Squamata, Colubridae)

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Asian Herpetological Research 2015年第1期6卷 1-10页

作者： klaus dieter SCHULZ Frank TILLACK Abhijit DAS Notker HELFENBERGER An Kuckum5a 52146 Würselen Germany Museum für Naturkunde Leibniz Institute for Evolution and Biodiversity Science Invalidenstrαβe 43 D-10115 Berlin Germany Wildlife Institute of India Chandrabani Dehradun India Kasereistrasse4 9305 Berg SG Switzerland

The taxaColuber nuthalli Theobald, 1868 andElaphis yunnanensis Anderson, 1879 are compared and re-described, based on the examination of their type material. The morphological similarities of these two taxa revealed them as *** yunnanensis Anderson is thus declared as a protected name （nomen conservandum） with priority overC. nuthalli Theobald （nomen oblitum）. A lectotype forElaphis yunnanensis is designated and described. The validity ofyunnanensis as subspecies name in combination withOrthriophis taeniurus （Cope） will be discussed. A key to the subspecies ofO. taeniurus is provided.

关键词： Reptilia Serpentes Colubridae Elaphisyunnanensis Anderson (nomen protectum) Coluber nuthalli Theobald (nomen oblitum) Elapheauct. Orthriophis taeniurus yunnanensis taxonomy morphology China Myanmar

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The virtual lover： variable and easily guided 3D fish animations as an innovative tool inmate-choice experiments with sailfinmollies-II. Validation

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Current Zoology 2017年第1期63卷 65-74页

作者： Stefanie GIERSZEWSKI klaus MuLLER levgen SMIELIK Jan-Marco HUTWOHL klaus-dieter KUHNERT Klaudia WITTE Research Group of Ecology and Behavioral Biology Institute of Biology University of Siegen Adolf-Reichwein- StraBe 2 Siegen 57068 Germany Institute of Real-Time Learning Systems Department of ElectricalEngineering & Computer Science University of Siegen HSIderlinstraBe 3 Siegen 57076 Germany

The use of computer animation in behavioral research is a state-of-the-art method for designing andpresenting animated animals to live test animals. The major advantages of computer animations are：（1） the creation of animated animal stimuli with high variability of morphology and even behavior; （2）animated stimuli provide highly standardized, controlled and repeatable testing procedures; and （3）they allow a reduction in the number of live test animals regarding the 3Rs principle. But the use of ani-mated animals should be attended by a thorough validation for each test species to verify that behaviormeasured with live animals toward virtual animals can also be expected with natural stimuli. Here wepresent results on the validation of a custom-made simulation for animated 3D sailfin mollies Poecilialatipinna and show that responses of live test females were as strong to an animated fish as to a videoor a live male fish. Movement of an animated stimulus was important but female response was stron-ger toward a swimming 3D fish stimulus than to a ＂swimming＂ box. Moreover, male test fish wereable to discriminate between animated male and female stimuli; hence, rendering the animated 3D fisha useful tool in mate-choice experiments with sailfin mollies.

关键词： computer animation, fish behavior, mate-choice experiment, validation, virtual fish model.

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The virtual lover： variable and easily guided 3D fish animations as an innovative tool inmate-choice experiments with sailfin mollies-I,Design and implementation

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Current Zoology 2017年第1期63卷 55-64页

作者： klaus MuLLER Jevgen SMIELIK Jan-Marco HOTWOHL Stefanie GIERSZEWSKI Klaudia WITTE klaus-dieter KUHNERT Department of Electrical Engineering & Computer Science Institute of Real-Time Learning Systems University of Siegen HSIderlinstraBe 3 Siegen 57076 Germany Research Group of Ecology and Behavioral Biology Institute of Biology University of Siegen Adolf-Reichwein-Stral~e 2 Siegen 57068 Germany

Animal behavior researchers often face problems regarding standardization and reproducibility oftheir experiments. This has led to the partial substitution of live animals with artificial virtual stim-uli. In addition to standardization and reproducibility, virtual stimuli open new options for re-searchers since they are easily changeable in morphology and appearance, and their behavior canbe defined. In this article, a novel toolchain to conduct behavior experiments with fish is presentedby a case study in sailfin mollies Poecilia latipinna. As the toolchain holds many different and novelfeatures, it offers new possibilities for studies in behavioral animal research and promotes thestandardization of experiments. The presented method includes options to design, animate, andpresent virtual stimuli to live fish. The designing tool offers an easy and user-friendly way to definesize, coloration, and morphology of stimuli and moreover it is able to configure virtual stimuli ran-domly without any user influence. Furthermore, the toolchain brings a novel method to animatestimuli in a semiautomatic way with the help of a game controller. These created swimming pathscan be applied to different stimuli in real time. A presentation tool combines models and swim-ming paths regarding formerly defined playlists, and presents the stimuli onto 2 *** with live sailfin mollies validated the usage of the created virtual 3D fish models inmate-choice experiments.

关键词： computer animation, fish behavior, mate-choice experiment, research tool, virtual fish model.

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Porous FeAl alloys via powder sintering:Phase transformation,microstructure and aqueous corrosion behavior

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Journal of Materials Science & Technology 2021年第27期86卷 64-69页

作者： Gang Chen klaus-dieter Liss Chao Chen Yuehui He Xuanhui Qu Peng Cao Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing100083PR China Materials and Engineering Science Program Guangdong Technion-Israel Institute of TechnologyShantouGuangdong515063PR China Technion-Israel Institute of Technology Haifa32000Israel School of Mechanical MaterialsMechatronic and Biomedical EngineeringFaculty of Engineering&Information SciencesUniversity of WollongongWollongongNSW2522Australia State Key Laboratory for Powder Metallurgy Central South UniversityChangsha410083PR China Department of Chemical and Materials Engineering The University of AucklandPrivate Bag 92019Auckland1142New Zealand MacDiarmid Institute of Advanced Materials and Nanotechnology Victoria University of WellingtonPO Box 600Wellington6140New Zealand

This study investigates the phase transformation and microstructure of porous Fe Al parts sintered from elemental powder mixtures using in-situ neutron diffraction and in-situ thermal dilatometry.A single B2 structured Fe Al phase was determined in the sintered Fe Al *** combined effects of the Kirkendall porosity,transient liquid phase,and phase transformations associated with powder sintering all contribute to the swelling phenomenon of the final sintered *** aqueous corrosion test indicates that the corrosion products include iron oxides in the porous Fe Al *** accumulation of corrosion products blocks the pore channel and decreases pore size and permeability over the soaking time.

关键词： Powder sintering Intermetallic Porous Corrosion Neutron diffraction

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Problems of drinking water treatment along Ismailia Canal Province, Egypt

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第3期9卷 232-242页

作者： Mohamed H.GERIESH klaus-dieter BALKE Ahmed E.EL-RAYES Geology Department Faculty of ScienceSuez Canal UniversityP.C.41522IsmailiaEgypt Institute of Geosciences Teubingen University72076 TeubingenGermany

The present drinking water purification system in Egypt uses surface water as a raw water supply without a preliminary filtration *** the other hand,chlorine gas is added as a disinfectant agent in two steps,pre-and *** to these reasons most of water treatment plants suffer low filtering effectiveness and produce the trihalomethane(THM) species as a chlorination *** Ismailia Canal represents the most distal downstream of the main Nile *** its water contains all the proceeded pollutants discharged into the *** addition,the downstream reaches of the canal act as an agricultural drain during the closing period of the High Dam gates in January and February every ***,the wide industrial zone along the upstream course of the canal enriches the canal water with high concentrations of heavy *** obtained results indicate that the canal gains up to 24.06×106 m3 of water from the surrounding shallow aquifer during the closing period of the High Dam gates,while during the rest of the year,the canal acts as an influent stream losing about 99.6×106 m3 of its water *** reduction of total organic carbon(TOC) and suspended particulate matters(SPMs) should be one of the central goals of any treatment plan to avoid the disinfectants *** combination of sedimentation basins,gravel pre-filtration and slow sand filtration,and underground passage with microbiological oxidation-reduction and adsorption criteria showed good removal of parasites and bacteria and complete elimination of TOC,SPM and heavy ***,it reduces the use of disinfectants chemicals and lowers the treatment ***,this purification system under the arid climate prevailing in Egypt should be tested and modified prior to application.

关键词： Drinking water treatment Hazardous by-products Natural attenuation Ismailia Canal Egypt

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Role of fast-setting cements in arthroplasty: A comparative analysis of characteristics

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World Journal of Orthopedics 2017年第12期8卷 881-890页

作者： Neil Ayron Caraan Reinhard Windhager Jason Webb Nadine Zentgraf klaus-dieter Kuehn Department of Orthopaedics and Orthopaedic Surgery Medical University of Vienna Avon Orthopaedic Centre North Bristol NHS TrustSouthmead Hospital Heraeus Medical GmbH

AIM To evaluate the behaviour of two fast-setting polymethylmethacrylate(PMMA) cements CMW~? 2 G and Palacos~? fast R + G, as reference: Standard-setting Palacos~? R + *** The fast-setting cements CMW~? 2 G and Palacos~? fast R + G were studied, using standard-setting high viscosity Palacos~? R + G as a reference. Eleven units(of two batch numbers) of each cement were tested. All cements were mixed as specified by the manufacturer and analysed on the following parameters: Handling properties(mixing, waiting, working and hardening phase) according to Kuehn, Mechanical properties according to ISO 5833 and DIN 53435, Fatigue strength according to ISO 16402, Benzoyl Peroxide(BPO)-Content by titration, powder/liquid-ratio by weighing, antibiotic elution profile by High Performance Liquid Chromatography. All tests were done in an acclimatised laboratory with temperatures set at 23.5 ℃± 0.5 ℃ and a humidity of > 40%. RESULTS Palacos~? fast R + G showed slightly shorter handling properties(doughing, hardening phase, n = 12) than CMW~? 2 G, allowing to reduce operative time and to optimise cemented cup implantation. Data of the quasistatic properties of ISO 5833 and DIN 53435 of both cements tested was comparable. The ISO compressive strength(MPa) of Palacos~? fast R + G was significantly higher than CMW~? 2 G, resulting in ANOVA(P < 0.01) and two sample t-test(P < 0.01) at 0.05 level of significance(n = 20). Palacos~? fast R + G showed a higher fatigue strength of about 18% mean(ISO 16402) of 15.3 MPa instead of 13.0 MPa for CMW~? 2 G(n = 5 × 10~6 cycles). Palacos~? fast R + G and CMW~? 2 G differed only by 0.11%(n = 6) with the former having the higher content. The BPO-content of both cements were therefore comparable. CMW~? 2 G had a powder/liquid ratio of 2:1, Palacos~? fast R + G of 2.550:1 due to a higher powder content. Despite its higher gentamicin content, CMW~? 2 G showed a significantly lower antibiotic elution over time than Palacos~? fast R + G(n = 3). CON

关键词： Polymethylmethacrylate Elution Fastsetting Viscosity Antibiotic Fatigue Arthroplasty

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PA6 Obtained by Polymerization with Trifunctional Regulators and Its DSC Results

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Journal of China Textile University(English Edition) 2000年第4期17卷 16-19页

作者：戴礼兴王朝生李力锋黄南薰唐志廉 klaus-dieter Hungenberg BASF Coll. of Materials Eng. Soochow Univ. Suzhou 215021 China

Hydrolytic polymerization of 8 - caprolactam is carried out by the use of trimesinic acid as molecular weight controlling agent, and polyamide 6 with three branched chains is obtained. The initial concentrations of regulators almost have no effect on the conversion of caprolactam , while relative viscosity of the polymer is affected by the concentrations. DSC investigation shows that DSC curve changes from single peak for regular polyamide 6 to one peak with one shoulder or one small peak for polyamide 6 with three branched chains and the melting point decreases with the increase of the amount of trimesinic acid. In addition, the concentration of trimesinic acid being the same, DSC curves change from almost sharp single peak to double peak with increasing reaction time.

关键词： polymerization polyamide 6 trifunctional regulator

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