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Cardiac Structure and Function in Men with Prostate Cancer Receiving Androgen-Deprivation Therapy and the Effects of Recreational Small-Sided Football Training:A Randomized Controlled Trial

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World Journal of Cardiovascular Diseases 2017年第9期7卷 308-322页

作者： Jakob Friis Schmidt Lars Juel Andersen Jacob Uth Therese Hornstrup Jesper Christensen Julie Midtgaard klaus Brasso peter Krustrup Mikael Rorth peter Riis Hansen Department of Cardiology Copenhagen University HospitalGentofteDenmark Department of Nutrition Exercise and SportsCentre for Team Sport and HealthUniversity of CopenhagenCopenhagenDenmark Department of Cardiology Roskilde HospitalRoskildeDenmark The University Hospitals Centre for Health Care Research(UCSF) Copenhagen University HospitalRigshospitaletDenmark Department of Public Health University of CopenhagenCopenhagenDenmark Copenhagen Prostate Cancer Center Department of UrologyCopenhagen University HospitalRigshospitaletDenmark Sport and Health Sciences University of ExeterExeterGreat Britain Department of Sports Science and Clinical Biomechanics SDU Sport and Health Sciences Cluster(SHSC)University of Southern DenmarkOdenseDenmark Department of Oncology Copenhagen University HospitalRigshospitaletDenmark

Purpose: Androgen deprivation therapy (ADT) is a cornerstone in prostate cancer (PCa) management that prolongs PCa-free and overall survival, but effects of ADT on human cardiac function have not been investigated. We used echocardiography to examine cardiac structure and function in patients with prostate cancer receiving ADT and to determine whether an exercise intervention can elicit cardiac adaptations in these subjects. Methods: Forty-three patients with prostate cancer receiving ADT were randomized to 12 weeks football training (ST group;n = 20) or usual care (control [CO] group;n = 23). Cardiac function was assessed at baseline and after 12 weeks by comprehensive echocardiography. Peak oxygen consumption, blood pressure and peripheral microvascular function was also measured. Results: At baseline, no considerable echocardiographic abnormalities were observed. In the ST group, increases in left ventricular diastolic function variables including E/A ratio (P = 0.03), E’ (P = 0.016), E’TDIcolor (P = 0.040) and in left atrial diameter (P = 0.001) were observed after 12 weeks. In addition, diastolic blood pressure (P = 0.027) and resting heart rate (P 0.001) were reduced after ST. In the CO group, no significant changes were observed in the examined variables after 12 weeks. Despite within group changes in the ST group, no significant differences were observed after 12 weeks between groups in echocardiographic variables, peak oxygen consumption, blood pressure and peripheral microvascular function. Conclusion: In men with prostate cancer receiving ADT, echocardiography showed no abnormalities in cardiac structure and function. Twelve weeks of ST failed to elicit significant cardiovascular adaptations and ADT may blunt cardiovascular adaptations to short-term exercise training.

关键词： Prostate Cancer Exercise Rehabilitation Cardiovascular

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超光谱成像差分吸收光谱技术研究

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物理学报 2008年第9期57卷 6018-6023页

作者：司福祺谢品华 klaus-peter Heue 刘诚彭夫敏刘文清中国科学院环境光学与技术重点实验室中国科学院安徽光学精密机械研究所合肥230031 环境物理研究所德国海德堡大学德国海德堡卫星研究小组马普化学所德国美因茨

基于散射光的被动差分吸收(DOAS)技术利用气体的特性吸收谱线可实现对不同大气污染气体的定量测量,介绍了一种基于成像光谱仪的光学遥感系统,该系统运用被动DOAS原理实现了对大气污染气体的二维成像测量,并报道了该系统对实验室样品池... 详细信息

基于散射光的被动差分吸收(DOAS)技术利用气体的特性吸收谱线可实现对不同大气污染气体的定量测量,介绍了一种基于成像光谱仪的光学遥感系统,该系统运用被动DOAS原理实现了对大气污染气体的二维成像测量,并报道了该系统对实验室样品池一维测量与城市道路上方NO2组分的成像测量实验.基于成像光谱仪的被动DOAS系统利用太阳散射光可获取垂直方向一维的光谱信息,结合扫描装置,便可实现对污染气体的二维成像解析.

关键词：被动差分吸收光谱成像光谱仪污染气体二维成像

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Exploiting moderate hypoxia to benefit patients with brain disease: Molecular mechanisms and translational research in progress

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Neuroprotection 2023年第1期1卷 9-19页

作者： Hannelore Ehrenreich Max Gassmann Luise Poustka Martin Burtscher peter Hammermann PhD Anna-Leena Sirén klaus-Armin Nave Kamilla Miskowiak Clinical Neuroscience Max Planck Institute for Multidisciplinary SciencesGöttingenGermany Institute of Veterinary Physiology and Zürich Center for Integrative Human Physiology University of ZürichZürichSwitzerland Department of Child and Adolescent Psychiatry and Psychotherapy University Medical Center GöttingenGöttingenGermany Faculty of Sports Science University of InnsbruckInnsbruckAustria HBL Investmentpartners GmbH München‐FrankfurtGermany Departments of Neurophysiology and Neurosurgery University of WürzburgWürzburgGermany Department of Neurogenetics Max Planck Institute for Multidisciplinary SciencesGöttingenGermany Psychiatric Centre Copenhagen University HospitalRigshospitaletCopenhagenDenmark Department of Psychology University of CopenhagenCopenhagenDenmark

Hypoxia is increasingly recognized as an important physiological driving force.A specific transcriptional program,induced by a decrease in oxygen(O2)availability,for example,inspiratory hypoxia at high altitude,allows cells to adapt to lower O2 and limited energy *** transcriptional program is partly controlled by and partly independent of hypoxia-inducible ***,this same transcriptional program is stimulated in the brain by extensive motor-cognitive exercise,leading to a relative decrease in O2 supply,compared to the acutely augmented O2 *** have coined the term“functional hypoxia”for this important demand-responsive,relative reduction in O2 *** hypoxia seems to be critical for enduring adaptation to higher physiological challenge that includes substantial“brain hardware upgrade,”underlying advanced ***-induced erythropoietin expression in the brain likely plays a decisive role in these processes,which can be imitated by recombinant human erythropoietin *** article review presents hints of how inspiratory O2 manipulations can potentially contribute to enhanced brain *** thereby provides the ground for exploiting moderate inspiratory plus functional hypoxia to treat individuals with brain ***,it sketches a planned multistep pilot study in healthy volunteers and first patients,about to start,aiming at improved performance upon motor-cognitive training under inspiratory hypoxia.

关键词： brain EPO circle erythropoietin functional hypoxia HIF human pilot study hyperoxia inspiratory oxygen manipulations motor-cognitive performance PBMC translation

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庚型肝炎

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德国医学 1997年第1期14卷 8-10页

作者： klaus-peter Maier 郝连杰 Stadtlyische Krankenanstalten Esslingen am NeckarGermany 同济医科大学附属同济医院

庚型肝炎为一种RNA病毒(庚型肝炎病毒,Hepatitis G Virus,HGV)引起的急性病毒性肝炎(非甲-非戊型)。为散发性,并常见于高危人群(毒瘾者、多次输血者),常与其它病毒,特别是丙型肝炎病毒(HCV)和丁型肝炎病毒(HDV)同时存在。其对疾病严重... 详细信息

庚型肝炎为一种RNA病毒(庚型肝炎病毒,Hepatitis G Virus,HGV)引起的急性病毒性肝炎(非甲-非戊型)。为散发性,并常见于高危人群(毒瘾者、多次输血者),常与其它病毒,特别是丙型肝炎病毒(HCV)和丁型肝炎病毒(HDV)同时存在。其对疾病严重性、临床经过以及发展成慢性化等的致病意义尚不清楚。

关键词：庚型肝炎病毒学流行病学临床表现治疗

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HCV感染的自然经过

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德国医学 1996年第3期13卷 127-129页

作者： klaus-peter Maier 郝连杰 Department of Medicine City Hospital Esslingen Academic Department University of TübingenGermany 同济医科大学附属同济医院

HCV 感染的自然史可以视为病毒和宿主抵抗力相互作用所形成的不同临床后果。病毒绝大多数病人急性感染后,病毒持续存在于体内。慢性化的原因还不太清楚,免疫压力下,病毒迅速变异可能是最重要的因素。在感染的急性阶段。

关键词：丙型肝炎病毒感染自然过程

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喷膜制膜代替压铸制膜

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流程工业 2013年第1期 42-43页

作者： Jens-peter Kraus klaus peter Mont Kumpugdee Vollrath 柏林Beuth枝术学院柏林Libel工程技术公司

在某一合作项目中，Beuth技术学院研发设计了一台新型的、利用喷雾技术生产较大面积薄膜的实验室设备。这一设备使得在实验室辊涂机外，通过重复生产对保护膜的形成和性能进行检验成为可能。本文介绍了这一设备的结构设计和首次测试的... 详细信息

在某一合作项目中，Beuth技术学院研发设计了一台新型的、利用喷雾技术生产较大面积薄膜的实验室设备。这一设备使得在实验室辊涂机外，通过重复生产对保护膜的形成和性能进行检验成为可能。本文介绍了这一设备的结构设计和首次测试的结果。

关键词：实验室设备制膜压铸喷膜喷雾技术结构设计合作项目辊涂机

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Project Adtyre:Towards Dynamic Tyre Inflation Control

Project Adtyre:Towards Dynamic Tyre Inflation Control

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FISITA 2012 World Automotive Congress--Volume 10：Chassis Systems and Integration Technology

作者： klaus Augsburg Valentin Ivanov Katja Kruchkova Kristian Hopping Sebastian Gramstat Marijonas Bogdevicius peter Kiss TU Ilmenau HmcnauGermany Vilnius Gediminas Technical University VilniusLithuania Szent Istvan University GodolloHungary

The paper presents the results of the research project ADTYRE that is concentrated on the development of dynamic tyre pressure control systems（TPCS）with the aim to reduce rolling resistance and to improve driving *** project is coordinated by the Ilmenau University of Technology（Germany） in cooperation with Gumpert Sportwagenmanufaktur GmbH（Germany）,senTec Elektronik GmbH（Germany）.Vilnius Gediminas Technical University（Lithuania）,and Szent Istvan University（Hungary）.The paper covers the following content:（1） State-ofthe-art of tyre pressure monitoring and control systems;（2） Simulation study to estimate the potential of high-dynamic tyre pressure adaptation to the actual driving situation and operational state of the tyres;（3） TPCS design procedure using complex simulation tool（AMESim,IPG CarMaker）;（4） Design of a data acquisition system with high sampling rate to monitor the tyre pressure and temperature;（5） Functional validation of the TPCS approach with experiments on the test rig and real *** of the laboratory and vehicle testing point out that the developed dynamic tyre pressure control system has an evident potential in increasing the vehicle safety and performance.

关键词： Tyre pressure control system Vehicle dynamics Rolling resistance Vehicle safety

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锌、镉表面酸性三价铬钝化溶液

锌、镉表面酸性三价铬钝化溶液

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2004年北京推动电镀与精饰清洁生产技术论坛

作者：高媛 Klos klaus-peter 北京电镀协会

一种用于锌、锌合金、镉表面的含氟酸性三价铬钝化液,含有一种或多种如方程式中所示的化和物:[Cr(HO)F](3-x)+)A;其中x是从1到3的整数,A是NO、SO、PO、Cl、Br、F以及I中的任何一种阴离子。特别是溶液中含有一种可溶性硝酸盐,其含量较三... 详细信息

一种用于锌、锌合金、镉表面的含氟酸性三价铬钝化液,含有一种或多种如方程式中所示的化和物:[Cr(HO)F](3-x)+)A;其中x是从1到3的整数,A是NO、SO、PO、Cl、Br、F以及I中的任何一种阴离子。特别是溶液中含有一种可溶性硝酸盐,其含量较三价铬稍多,并且在使用该溶液之前要先加热至60℃或在15℃以上用催化剂处理。

关键词：锌锌合金镉三价铬钝化

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低成本无铅倒装钎焊工艺链(布局配置-工艺-可靠性)

低成本无铅倒装钎焊工艺链(布局配置-工艺-可靠性)

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2004中国电子制造技术论坛

作者： peter Wolflick klaus Feldmann Institute for Manufacturing Automation and Production Systems University of Erlangen-Nuremberg

现代电子工业的最大驱动力在于客户对小型化,高集成,多功能设备的需求。这些设备必须具备比传统产品更好的价格优势,而且应采用无铅化更好的钎料比便更好适应市场。论文研究的主要目的就是开发无铅化低成本产品制造的革新技术。小型化...

现代电子工业的最大驱动力在于客户对小型化,高集成,多功能设备的需求。这些设备必须具备比传统产品更好的价格优势,而且应采用无铅化更好的钎料比便更好适应市场。论文研究的主要目的就是开发无铅化低成本产品制造的革新技术。小型化的最根本方法就是采用倒装部件。采用标准FR-4基件代替高成本的陶瓷基PCB,可以减少成本,具有广阔前景。结合模板印刷形成一低成本化的产品生产链。利用标准材料和工艺,倒装片能集成于现有的SMT生产线。由于环境问题,无铅铅料的研究发展被提到日程上来。因而工艺及连接可靠性仍需分析。本文主要表述了无铅化,低成本倒装焊接工艺流程,从基板装配,到基片、模板阻润湿性。同时对工艺参数对铅料润湿性的影响进行了研究,并对倒装装配的难点进行了讨论。实施了可行的回流钎焊,同时考虑采用氮气气氛保护。此外本文解释了未焊满工艺的重要性,给出了检测倒装件的可行性方法。并检测了倒装接头长期使用性能的可靠性论证,并给出了选择倒装钎焊工艺的基本方法。

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Behavioral features of mice fed with a cholesterol-enriched diet: Deficient novelty exploration and unaltered aggressive behavior

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Translational Neuroscience and Clinics 2016年第2期2卷 87-95页

作者： Ekaterina Veniaminova Raymond Cespuglio Nataliia Markova Niall Mortimer Chi Wai Cheung Harry W.Steinbusch klaus-peter Lesch Tatyana Strekalova Department of Neuroscience School for Mental Health and Neuroscience Maastricht University Institute of General Pathology and Pathophysiology Russian Academy of Medical Sciences Faculty of Medicine Neuroscience research Center of Lyon C. Bernard University Department of Anatomy Guangzhou Medical University Laboratory of Biomolecular Screening Institute of Physiologically Active Compounds Russian Academy of Sciences Division of Molecular Psychiatry Laboratory of Translational Neuroscience Department of Psychiatry Psychosomatics and PsychotherapyUniversity of Wuerzburg Department of Anaesthesiology the University of Hong Kong Queen Mary Hospital

Objectives: Previous studies involving mice have demonstrated that a cholesterolenriched diet evokes liver steatosis, dystrophy, inflammation, and aspects of nonalcoholic fatty liver disease(NAFLD). These changes are accompanied by the activation of pro-inflammatory brain and liver molecular pathways, as well as anxiety and depressive-like behaviors. Given previously reported evidence for the neurobiological relationship between the above-mentioned molecular changes and abnormalities in coping with environmental stimuli, such as interactions with other individuals and new environmental contexts, we hypothesized that novelty exploration and aggressive behavior are affected in a mouse NAFLD model. Methods: To test this hypothesis, young female C57BL/6J mice were fed with a regular chow or a diet containing 0.2% cholesterol for 3 weeks. The mice were then assessed for new object and novel cage exploration, and social interaction in a food competition test. Results: We found reduced object exploration in mice on the cholesterol-enriched diet. This reduction was not related to whether the new object was placed in an anxiogenic or non-anxiogenic environment. These changes were accompanied by diminished exploration of the new environment in a novel cage, and delayed approach to food after a period of food deprivation. Mice on the regular chow or cholesterolenriched diet showed no differences in aggressive behavior towards a counter-partner in a food competition test. Food intake and body weight did not differ between the groups, thus, excluding their potential as confounders in the measured behaviors. Conclusions: We conclude that a diet enriched with cholesterol reduces novelty exploration irrespective of the anxiogenic level of the environment and does not induce aggressive behavior in female mice.

关键词： Western diet cholesterol novelty exploration aggression mouse

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