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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 56-57页

作者： Spaide R.F. klancnik jr. j.m. 吴琼 Vitreous Retina Macula Consult. N. 460 Park Avenue New York NY 10022 United States Dr.

Purpose: To investigate the autofluorescence characteristics in patients with central serous chorioretinopathy. Design: Observational case series. Participants: Thirty consecutive patients examined in a private referral practice. methods: Patients were imaged with autofluorescence photography, fundus photography, fluorescein angiography, and optical coherence tomography (OCT). The mean and standard deviation (SD) of the grayscale values from a 100-pixel-diameter circle centered on the fovea were obtained and normalized with the level of autofluorescence of the posterior pole. Results: There were 30 patients, 23 male (76.7%) and 7 female (23.3%), with a median visual acuity (VA) of 20/25 and a range of 20/15 to 20/400. Stepwise linear regression that included individual fixed effects found that normalized central macular autofluorescence (P ment mottling in the fovea (P=0.045), subfoveal fluid detected by OCT (P=0.033), and the SD of the central macular autofluorescence (P=0.025) produced a highly significant model (R2=0.92, Pmulation of material on the outer surface of the retina as seen by OCT. Decreased central macular autofluorescence, particularly in those eyes with central geographic retinal pigment epithelial atrophy, was associated with poor VA. Conclusions: This study established that autofluorescence changes occurring in central serous chorioretinopathy with explicit patterns can be measured in a noninvasive manner, and this information can be used to estimate the damage induced by central serous chorioretinopathywith a high degree of statistical significance. We hypothesize that the material on the outer surface of the elevated retina may represent accumulation of photoreceptor outer segments secondary to the lack of direct apposition and phagocytosis by the retinal pigment epithelium.

关键词：自发荧光视网膜色素上皮中心凹眼底照相平均视力荧光造影视网膜外层光感受器后极部外节

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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

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ERROR ESTImATES FOR THE TImE DISCRETIZATION FOR NONLINEAR mAXWELL'S EQUATIONS

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journal of Computational mathematics 2008年第5期26卷 677-688页

作者： mavián Slodika ján Bua jr. Department of mathematical Analysis Ghent University

This paper is devoted to the study of a nonlinear evolution eddy current model of the type δtB（H）＋ △↓× （ △↓ × H） =0 subject to homogeneous Dirichlet boundary conditions H × v = 0 and a given initial datum. Here, the magnetic properties of a soft ferromagnet are linked by a nonlinear material law described by B（H）. We apply the backward Euler method for the time discretization and we derive the error estimates in suitable function spaces. The results depend on the nonlinearity of B（H）.

关键词： Electromagnetic field Nonlinear eddy current problem Time discretization,Error estimate.

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Alternative expressions for stand diameter in complex forests

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Forest Ecosystems 2023年第3期10卷 328-336页

作者： mark j.Ducey john A.Kershaw jr. Department of Natural Resources and the Environment University of New HampshireDurhamNHUSA Faculty of Forestry and Environmental management University of New BrunswickFrederictonNBCanada

Quadratic mean diameter is the most frequently reported descriptor of the diameter distribution of *** such,it is often used as an indicator of forest stand structure,developmental stage,and ecological and economic ***,quadratic mean diameter can be heavily influenced by the presence or absence of large numbers of small stems in lower canopy strata,and it is also sensitive to left-truncation of the diameter distribution,making its interpretation across inventories with different protocols ***,we examine three alternative expressions of stand diameter:the arithmetic and quadratic mean diameter of the thickest 100 trees per hectare,and the basal area-weighted mean *** data from the United States Forest Inventory and Analysis program for New York and New England,these alternative expressions showed closer correlation with multiple stand structural variables than did quadratic mean diameter,including merchantable cubic and board foot volume per hectare,aboveground live tree carbon per hectare,and total number of live and dead standing trees greater than 40 cm diameter at breast height per hectare(previously proposed as an index of old-growth structure).Arithmetic and quadratic mean diameter of the thickest 100 trees per hectare showed nearly identical performance,and the strongest correlations across the *** develop closed-form expressions for these variables when the diameter distribution is a Weibull,and illustrate their behavior relative to quadratic mean diameter for that *** the reasons for prevalence of quadratic mean diameter as an indicator remain valid,we suggest that these alternative measures should be more widely reported and analyzed to give a more informative depiction of stand structure and development in complex forests.

关键词： Forest structure Diameter at breast height Weibull distribution

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Development of a 3D model for particle-wall collision and induced rotation and its influence on particle trajectories

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Particuology 2024年第11期94卷 211-228页

作者： Cairen miranda john Palmore jr. Department of mechanical Engineering Virginia TechBlacksburg24060VAUSA Department of mechanical Engineering University of WashingtonSeattle98195WAUSA

The present research focuses on improving the prediction of rotating particle *** particle-surface collision models do not accurately predict the particle rebound when taking rotation into *** data,such as the studies by Gorham and Kharaz(2000),Buck,Tang,Heinrich,Deen and Kuipers(2017),and Dong and moys(2006)show that the Tsuji,Oshima and morikawa(1985)model is inaccurate due to the incorrect tangential coefficient of restitution ***,Kuipers,mohd Salleh,Stein,and Seville(2001)introduced a similar model to the work by Tsuji et al.(1985)which includes a tangential coefficient of restitution but is only in two dimensions and does not consider out of plane *** work re-derives the particle collision model from the impulse equations for binary collisions in 3D while considering rotating *** derived equations in this work compares well to experimental particle-surface impact *** implications of this model are seen by investigating erosion due to particle collision in a simple pipe *** is shown that Tsuji et al.(1985)over predicts the *** small differences in particle trajectories between the present model and the Tsuji et al.(1985)model will grow in complex flows with multiple close range particle impacts leading to inaccurate erosion predictions which will negatively impact the design of turbomachinery and pneumatic pipes.

关键词： Particle collisions CFD Rotation Three dimensional

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Fourier Analysis with Respect to Bilinear maps

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Acta mathematica Sinica,English Series 2009年第4期25卷 519-530页

作者： O. BLASCO j.m. CALABUIG Department of mathematics Universitat de Valencia Burjassot 46100 Valencia Spain Department of Applied mathematics Universidad Politdcnica de Valencia 46022 Valencia Spain

Several results about convolution and about Fourier coefficients for X-valued functions defined on t he torus satisfying the condition sup ｜｜y｜｜=1∫-π^π｜｜ B （f （e^iθ）, y）｜｜dθ/2π〈 ∞ for a bounded bil... 详细信息

关键词： vector-valued functions Pettis integral Bochner integrals Fourier type

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Dietary free fatty acids complex with amylose creating another form of resistant starch: Gastrointestinal formation with fowl and swine

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Animal Nutrition 2021年第4期7卷 1124-1132页

作者： Edwin T.moran jr. Poultry Science Department Auburn UniversityAL36849-5416USA

Fat added to poultry and swine feeds often contains abundant free fatty acids(FFA)that can impair digestible energy(DE).Placement of the fatty acid(FA)hydrocarbon chain in the helix core reformed from amylose creates a complex of both *** modifications create a new structure termed the V-helix that becomes resistant toα-*** in grain naturally contain minimal amounts of these complexes with more being generated during food manufacturing when moisture and heat release amylose in the presence of FFA.A paucity of FFA usually exists in complete feeds without sources of poorquality *** fats and by-product meals from rendering are prominent in their saturated FFA content which favorably complex within the helix.V-helix-FA complexes may arise during their concurrent encounter of FFA together with amylose during feed manufacture,particularly *** in the gastrointestinal tract(GIT)are speculated to further form complexes when present together with *** amylose may be dissolved in the gastric and small intestinal milieu,FFA separately coalesce into hydrophobic fat droplets along with other dietary *** of complexes is likely restricted until FFA are released into the aqueous phase during fat ***α-amylase may be prominent,V-helix-FA complexes being resistant to enzymic attack pass into the large *** microbial catabolism of V-helices may generate volatile fatty acids that are absorbed by the mucosa;however,an inability to use FFA once released leads to their excretion and basis for decreased *** microbial populations with young animals usually lack the capacity to fully catabolize the V-helix,further extending the loss in DE.

关键词： Amylose Digestible energy Free fatty acid Feed manufacture

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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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Detection of Arterial Occlusions Using Viscoelastic Wave Propagation

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Advances in Applied mathematics and mechanics 2009年第1期1卷 1-28页

作者： H.T.Banks j.R.Samuels,jr. Center for Research in Scientific Computation North Carolina State UniversityCampus Box 8212RaleighNC 27695-8212USA

We consider the problem of detecting cardiac artery occlusions using stenosis driven viscoelastic(VE)waves propagated through biotissue to body surface *** investigate possible statistical model formulations(ordinary least squares(OLS),generalized least squares(GLS))and post analysis techniques(residual plots)to ascertain uncertainty in estimates as well as validity of the statistical models as part of a methodology for stenosis detection using viscoelastic waves.

关键词： Inverse problems viscoelastic models wave propagation in biotissue statistical models

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Recrystallization and Grain Growth in Austenitic Stainless Steels: a Statistical Approach

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journal of materials Science & Technology 2003年第z1期19卷 119-121页

作者： A.Di Schino G.Abbruzzese j.m. Kenny materials Engineering Center University of Perugia Loc. Pentima Bassa TERNI Italy Centro Sviluppo Materiali Italy Materials Engineering Center University of Perugia Loc. Pentima Bassa TERNI Italy

A mathematical model, able to describe the recrystallization and grain growth in metals, has been developed. Taking into account the classical constitutive equations of the Taylor′s theory, the model involves only two free parameters (the dislocation density and the initial number of nuclei). Results from the model are here discussed in comparison with measurements performed on an AISI 304 stainless steel. The predictions of the model are in good agreement with experimental results. As cross check of the model prediction, the independent parameter "dislocation density"was found to properly correlate to the mechanical properties of the steel and to X-ray diffraction measurements,according to Taylor′s and Debye′s relations respectively.

关键词： Recrystallization, Grain growth, Stainless steels

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