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Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats

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World Journal of Gastroenterology 2008年第30期14卷 4784-4790页

作者： Koyuki Tajima kiyoto Kageyama Takashi Kyoi Department of Pharmacology Discovery Research LaboratoriesNippon Shinyaku Co. Ltd.

AIM： To investigate the mucosal protective effect and the mechanisms of action of the anti-ulcer drug irsogladine maleate in gastric injury induced by indomethacin in rats. METHODS： Gastric mucosal injury was induced in male Hos：Donryu rats by oral administration of indomethacin at a dose of 48 mg/kg. One hour before indomethacin treatment, animals were orally pretreated with irsogladine maleate at doses of 1 mg/kg, 3 mg/kg or 10 mg/kg. Four hours after indomethacin administration, the animals were sacrificed and their stomachs were rapidly removed and processed for the evaluation of gastric mucosal damage and the determination of the concentrations of tumor necrosis factor-α （TNF-α）, interleukin-1β （IL-1β）, IL-8 and myeloperoxidase （MPO） in mucosal tissues. RESULTS： Linear hemorrhagic mucosal lesions were observed primarily in the glandular stomach 4 h alter oral administration of indomethacin. Pretreatment with irsogladine maleate markedly reduced the number and severity of these lesions in a dose-dependent manner. The mucosal concentrations of proinflammatory cytokines （TNF-α, IL-1β, and IL-8） and MPO, which indicates the degree of mucosal infiltration by neutrophils, increased concomitantly with the occurrence of gastric injury in the indomethacintreated rats. Pretreatment with irsogladine maleate significantly decreased the levels of these inflammatory factors in gastric tissue elicited by ***： The mucosal protective effects afforded by irsogladine maleate on gastric injury induced by indomethacin are mediated by inhibition of mucosal proinflammatory cytokine production and neutrophil infiltration, leading to suppression of mucosal inflammation and subsequent tissue destruction.

关键词： Irsogladine Gastric injury Indomethacin Cytokine Myeloperoxidase

Current Ramp-up by Microwave Power in the LATE Device

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Plasma Science and Technology 2009年第4期11卷 394-396页

作者： Takashi maekawa Hitoshi TANAKA Masaki UCHIDA Graduate School of Energy Science Kyoto University

In the low aspect ratio torus experiment （LATE） device, plasma current is initiated and ramped up to 20 kA solely by microwave power at the electron cyclotron （EC） range of frequency with a ramp of the external vertical field By for the radial equilibrium of plasma torus at larger currents. Measurements suggest that an energetic electron tail in the energy range of about 200 keV carries the current. The line averaged electron density is higher than the plasma cutoff density, suggesting that tail electrons might be driven by electron Bernstein waves modeconverted from the launched electromagnetic waves.

关键词： current ramp-up microwave electron cyclotron range of frequency

Energy Variable Slow Positron Beam Study of Li^＋-Implantation-Induced Defects in ZnO

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Chinese Physics Letters 2006年第3期23卷 675-677页

作者：陈志权 M. maekawa A. Kawasuso Department of Physics Wuhan University Wuhan 430072 Advanced Science Research Center Japan Atomic Energy Research Institute 1233 Watanuki Takasaki Gunma 370-1292 Japan

ZnO films grown on sapphire substrates are implanted with lO0-keV Li ions up to a total dose of 1 × 10^16 cm^-2. Vacancy-type defects, mostly vacancy dusters, are observed by positron annihilation measurements after implantation. Upon annealing, they first have an agglomeration process which leads to the growth in the vacancy size. After anneling at about 500℃, vacancy clusters grow into microvoids, which is indicated by the positronium formation. With annealing temperature increases to above 500℃, the microvoids begin to recover, and finMly M1 the implantation-induced vacancy defects are removed at 1000℃. No Li nanoclusters can be observed after Li^＋ implantation.

关键词： ROOM-TEMPERATURE THIN-FILMS

Formation of Low Aspect Ratio Torus Equilibria by ECH in the LATE Device

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Plasma Science and Technology 2006年第1期8卷 95-98页

作者： Takashi maekawa Hitoshi TANAKA Masaki UCHIDA Tomokazu YOSHINAGA Graduate School of Energy Science Kyoto UniversityKyoto 606-8502Japan

By ECH under a steady By field, a closed field equilibrium of a low aspect ratio as low as R/a = 1.4 is spontaneously formed in the LATE device. After the spontaneous formation, the plasma current has increased further up to Ip = 7.2 kA by 2.45 GHz, 30 kW and Ip = 11 kA by 5 GHz, 120 kW, by increasing the microwave power with a slow ramp of By for the equilibrium of the plasma loop at larger currents. Both amount to 12% of the total toroidai coil current. ECH/ECCD at 2nd harmonic resonance of EBW supports the plasma. An outline of the theoretical considerations for the formation process is presented.

关键词： ECH spherical tokamaks non-inductive start-up

The sequestrate genus Rosbeeva ***&Orihara ***.(Boletaceae)from Australasia and Japan:new species and new combinations

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Fungal Diversity 2012年第1期52卷 49-71页

作者： Teresa Lebel Takamichi Orihara Nitaro maekawa National Herbarium of Victoria Royal Botanic Gardens MelbournePrivate Bag 2000Birdwood AveSouth YarraVIC 3141Australia The United Graduate School of Agriculture Sciences Tottori University4–101 Koyama-cho-minamiTottori 680–8553Japan Fungus/Mushroom Resource and Research Center Faculty of AgricultureTottori University4–101 Koyama-cho-minamiTottori 680–8553Japan Kanagawa Prefectural Museum of Natural History 499 IriudaOdawara-shiKanagawa 250–0031Japan

The sequestrate genus Chamonixia has been shown to have affinities to the Boletales,in particular the genus *** and Japanese species of Chamonixia were examined using morphological and molecular(ITS and nLSU rDNA)data and found to also have affinities with Leccinum and Leccinellum,however they form a distinct clade separate from the European type species *** Rolland and North American species.A new genus,Rosbeeva ***&Orihara ***.,is proposed for the Australasian,Japanese and Chinese *** species ***(Petri)*** *** restricted in distribution to Singapore and Borneo,and ***(Zeller&***)*** *** New Zealand,with Australian collections considered to belong to a revised ***(***,Pegler&***)*** *** a new species *** *** *** Chinese species ***(***&***)***&Orihara *** is transferred to the new genus based upon morphological *** new species from Japan,Rosbeeva eucyanea Orihara and *** Orihara,are also described and illustrated.A key to all species of Rosbeeva is *** to the highly modified gastroid sporocarp forms of both Chamonixia and Rosbeeva,many macroscopic characters of use in agaricoid taxonomy are difficult to ***,color change and texture of sporocarps are of some use to distinguish genera and *** characters such as spore shape,dimensions,and ornamentation,and pileipellis and hymenophoral trama structure,are essential for determining genera and species.

关键词： Chamonixia Sequestrate fungi Leccinum Systematics Octaviania

Primary hepatic leiomyosarcoma with liver metastasis of rectal cancer

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World Journal of Gastroenterology 2012年第38期18卷 5479-5484页

作者： kiyoto Takehara Hideki Aoki Yuko Takehara Rie Yamasaki Kohji Tanakaya Hitoshi Takeuchi Department of Gastroenterological Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan Department of Surgery National Hospital Organization Iwakuni Clinical Center Yamaguchi 740-8510 Japan Department of Clinical Examination National Hospital Organization Iwakuni Clinical Center Yamaguchi 740-8510 Japan

Primary hepatic leiomyosarcoma is a particularly rare tumor with a poor prognosis. Curative resection is currently the only effective treatment, and the efficacy of chemotherapy is unclear. This represents the first case report of a patient with primary hepatic leiomyosarcoma co-existing with metastatic liver carcinoma. We present a 59-year-old man who was diagnosed preoperatively with rectal cancer with multiple liver metastases. He underwent a curative hepatectomy after a series of chemotherapy regimens with modified FOLFOX6 consisting of 5-fluorouracil, leucovorin and oxaliplatin plus bevacizumab, FOLFIRI consisting of 5-fluorouracil, leucovorin and irinotecan plus bevacizumab, and irinotecan plus cetuximab. One of the liver tumors showed a different response to chemotherapy and was diag-nosed as a leiomyosarcoma following histopathological examination. This case suggests that irinotecan has the potential to inhibit the growth of hepatic leiomyosarcomas. The possibility of comorbid different histological types of tumors should be suspected when considering the treatment of multiple liver tumors.

关键词： Leiomyosarcoma Rectal cancer Metastasis Chemotherapy Surgery

Ultra-fast microwave aided synthesis of gold nanocages and structural maneuver studies

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Nano Research 2017年第3期10卷 1078-1091页

作者： Sreejith Raveendran Anindito Sen Toru maekawa D. Sakthi Kumar Bio-Nano Electronics Research Centre Graduate School of Interdisciplinary New Science Toyo University 2100 Kujirai Kawagoe Saitama 350-8585 Japan JEOL Ltd. 13F Ohtemachi Nomura Building 2-1-10htemachi Chiyoda-Ku. Tokyo 100-0004 Japan

Gold nanocages （AuNcgs） are well-studied, hollow, metallic nanostructures that have fascinated researchers in the fields of nanotechnology, materials science, photoelectronics, biotechnology, and medical science for the last decade. However, the time-consuming synthesis of AuNcgs has limited their widespread use in materials science and nano-biotechnology. A novel, ultra-fast, simple, and highly convenient method for the production of AuNcgs using microwave heating is demonstrated herein. This quick method of AuNcg synthesis requires mild laboratory conditions for large-scale production of AuNcgs. The microwave heating technique offers the advantage of precise mechanical control over the temperature and heating power, even for the shortest reaction period （i.e., seconds）. Microwave-synthesized AuNcgs were compared with conventionally synthesized AuNcgs. Structural maneuver studies employing the conventionally produced AuNcgs revealed the formation of screw dislocations and a shift in the lattice plane. Detailed characterization of the microwave-generated AuNcgs was performed using high resolution transmission electron microscopy （HRTEM）, scanning electron microscopy （SEM）, X-ray powder diffraction （XRD）, and spectroscopic techniques.

关键词： gold nanocages nanocages nanoboxes microwave technology ultra-fast screw dislocation

The Pre-rRNA Processing Complex in Arabidopsis Includes Two WD40-Domain-Containing Proteins Encoded by Glucose-Inducible Genes and Plant-Specific Proteins

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Molecular Plant 2016年第2期9卷 312-315页

作者： Tetsuya Ishida Shugo maekawa Shuichi Yanagisawa Laboratory of Plant Functional Biotechnology Biotechnology Research Center The University of Tokyo Yayoi 1-1-1 Bunkyo-ku Tokyo 113-8657 Japan

Dear Editor,In plants, sugars not only serve as energy and metabolic resources but they also exhibit hormone-like activity. Sugars modulate several fundamental processes throughout a plant＇s life cycle, including embryogenesis, germination, vegetative growth, development, reproduction, and senescence （Eveland and Jackson, 2012; Lastdrager et al., 2014; Ruan, 2014）. Previous studies have revealed that various pathways and molecular mechanisms are involved in plant sugar responses,

关键词： glucose component embryo

Study of Electron Orbits for Formation of Toroidal Closed Flux Surface by ECH

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Plasma Science and Technology 2011年第3期13卷 342-346页

作者： Tak,ushi maekawa Tomokazu YOSHINAGA Hitoshi TANAKA Masaki UCHIDA Fumitake WATANABE Graduate School of Energy Science Kyoto University Kyoto 606-8502 Japan National Institute for Fusion Science Toki 509-5292 Japan

Electron orbits under the external vertical field （Bv） and the self poloidal field of the toroidal plasma current in a toroidal geometry are investigated by using analytic model fields in order to search for the conditions of occurence of appropriate confinement asymmetry of fast electrons along the field lines. This asymmetry efficiently and quickly generates a toroidal current, which may close the field lines in ECH-started plasmas. It is analytically shown that the characteristics of confinement asymmetry depend on the product of the major radius and the strength of the external vertical field. The results suggest that in large devices By should be lowered and also some artificial means to speed up the pitch angle scattering for the fast electrons at a higher energy range are beneficial to generate the toroidal current in order to close the filed

关键词： ECH closed flux surface electron orbit