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Surgical Science 2012年第10期3卷 463-468页

作者： kiyosumi shibata Hiroaki Kajiyama Mik Mizuno Eiko Yamamoto Fumitaka Kikkawa Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya Japan

Objective: To identify prognostic factors in patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy (CCRT). Methods and Materials: We analyzed 76 patients with FIGO stage IB2 - IVb cervical cancer treated with CCRT between 2001 and 2006 at the Nagoya University Hospital. Patients with an advanced cervical cancer treated with CCRT. Overall survival (OS) and Progression-free survival (PFS) rates were estimated using the Kaplan-Meier method. The log-rank test was used to test differences in survival. Fisher's exact test was employed for univariate analysis. The Cox proportional hazard model was used for multivariate analysis. Results: The median age was 52, and the median follow-up period was 36 months. The 5 - year OS and PFS rates of all patients were 88.2% and 72.4%, respectively. Twenty-one of the 76 patients were diagnosed with recurrence. A higher serum CEA before CCRT was an independent predictive factor for a poor prognosis on multivariate analysis. Conclusions: A high level of serum CEA was a predictive factor for a poor prognosis. New strategies should be considered to control disease in this group of patients.

关键词： Cervical Cancer Chemoradiotherapy Recurrence Prognostic Factor Carcinoembryonic Angtigen (CEA)

Postrecurrence Clinical Outcome of Patients with Stage I Epithelial Ovarian Cancer Who Underwent Fertility-Sparing Surgery Compared to Those with Radical Surgery

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Surgical Science 2013年第1期4卷 118-124页

作者： Hiroaki Kajiyama kiyosumi shibata Mika Mizuno Eiko Yamamoto Michiyasu Kawai Tetsuro Nagasaka Fumitaka Kikkawa Department of Medical Laboratory Sciences School of Health Science Nagoya University Graduate School of Medicine Nagoya Japan Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya Japan Department of Obstetrics and Gynecology Toyohashi Municipal Hospital Toyohashi Japan

Background: To examine the difference in the survival of patients with recurrent ovarian cancer who received fertility-sparing surgery (FSS) and those receiving radical surgery. Methods: Clinicopathologic data on a total of 90 patients with stage I recurrent ovarian cancer collected under the central pathological review system were subjected to survival analyses. Patients were divided into 2 groups: 1) FSS (N = 11), 2) Radical (N = 79). Results: Five-year overall survival rates of patients in the two groups were as follows: 40.8% (FSS)/44.2% (Radical), respectively. There was no significant difference in overall survival among the groups (P = 0.887). Additionally, three-year postrecurrence survival rates of patients in the two groups were 24.8% (FSS) and 25.3% (Radical) (P = 0.730). Furthermore, we accumulated 137 patients {FSS (N = 58), Radical group (N = 79)} with stage I recurrent ovarian cancer from the current study and six representative reports in the literature. Patients who experienced recurrence in the remaining ovary alone (FSS) showed a more favorable prognosis than those who had extra-ovarian site recurrence (overall survival: P = 0.021, postrecurrence survival: P = 0.069). Conclusions: Although our retrospective analysis was very preliminary, we could propose the hypothesis that patients with stage I recurrent ovarian cancer who undergo FSS may not show poorer survival rates than patients who receive radical surgery.

关键词： Recurrent Ovarian Cancer Fertility-Sparing Surgery Overall Survival Postrecurrence Survival

Patterns of Recurrence and Their Significance in Patients with Endometrial Carcinoma<br>—For Improved Follow-Up after Initial Treatment<br>

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Surgical Science 2013年第2期4卷 154-159页

作者： Fumi Utsumi Hiroaki Kajiyama kiyosumi shibata Hiroko Mitsui Ryuichiro Sekiya Mika Mizuno Shiro Suzuki Tomokazu Umezu Eiko Yamamoto Fumitaka Kikkawa Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya Japan

Objectives: The aim of this study was to identify the patterns of recurrence and their significance in patients with endometrial carcinoma (EMCA). Patients and Methods: After a search of the medical records from single institutions, a total of 49 patients with relapsed endometrial carcinoma were retrospectively evaluated. Various clinical information was examined, including the site of recurrence, detection procedure, and presence or absence of any symptom at the time of recurrence. Furthermore, the postrecurrence survival analysis was based on the Kaplan-Meier method. Results: The median follow-up period of all patients was 39.4 months (5.8 - 293.1). In all, twenty-five (51.0%) patients experienced recurrence within 12 months after the final treatment. At the time of recurrence, 15 (30.6%) and 34 (69.4%) patients were symptomatic and asymptomatic, respectively. Among the 34 asymptomatic patients, recurrence was detected by CT scan in 14 (28.6%), tumor markers alone in 14 (28.6%), and pelvic examination/ultrasound scan in 5 (10.2%). There was no relapsed case detected by vaginal vault cytology alone. The 5-year postrecurrence survival rates in symptomatic and asymptomatic patients were 57.5 and 36.6 months, respectively (P = 0.2973). After recurrence, 12 patients underwent debulking surgery, and 37 received salvage chemotherapy or radiotherapy. The postrecurrence survival of patients receiving surgery did not differ from that of those with chemotherapy/radiotherapy (P = 0.9198). Conclusion: Although imaging studies and tumor marker measurement contributed to the early detection of recurrence, they did not necessarily improve the prognosis postrecurrence.

关键词： Endometrial Carcinoma Recurrence Site Postrecurrence Survival Symptomatic Vaginal Vault Cytology

Thermal simulation and analysis of the STF cryomodule

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Chinese Physics C 2009年第3期33卷 236-239页

作者：徐庆金 Ohuchi Norihito kiyosumi Tsuchiya Tsai Ming-Hsun 宗占国翟纪元高杰 Institute of High Energy Physics Chinese Academy of Sciences High Energy Accelerator Research Organization Synchrotron Radiation Research Center Technical Institute of Physics and Chemistry Chinese Academy of Sciences

STF is a superconducting RF test facility constructed at the high energy accelerator research Organization of Japan （KEK）, as a main part of a R＆D project for the proposed International Linear Collider （ILC） in Asia. Thermal study of the STF 1.3 GHz 9-cell cavity cryomodule was carried out within a collaboration between China and Japan. Static and dynamic thermal behaviors of the STF cryomodule were simulated and analyzed with the FEM method, and some simulation results were compared with the available experimental data. This paper presents the details.

关键词： STF cryomodule thermal simulation ILC

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钙质石灰岩中桩基轴向承载特性的有限元分析

岩土力学 2009年第9期30卷 2792-2798页

作者：彭芳乐高伟清住真大内正敏同济大学地下建筑与工程系上海200092 同济大学岩土及地下工程教育部重点试验室上海200092 日本白石(建设)公司技术本部东京116024

为了研究钙质石灰岩中桩基的合理设计理论及开发相关的变形破坏数值分析方法,利用弹塑性有限元方法对以硫球石灰岩作为持力层的桩基现场轴向载荷试验进行了数值分析。有限元分析中钙质石灰岩被假定为理想弹塑性材料。结果表明,如果能在... 详细信息

为了研究钙质石灰岩中桩基的合理设计理论及开发相关的变形破坏数值分析方法,利用弹塑性有限元方法对以硫球石灰岩作为持力层的桩基现场轴向载荷试验进行了数值分析。有限元分析中钙质石灰岩被假定为理想弹塑性材料。结果表明,如果能在有限元解析中合理地考虑桩侧摩阻力的低减效果,弹塑性有限元计算可以较好地模拟与分析钙质砂土中桩基的轴向承载力特性。最后还对开口钢管桩基的土塞效应的发生机制进行了分析。

关键词：岩土力学钙质砂土桩基础承载力数值分析土塞效应

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空洞的存在对浅基础承载力与沉降的影响分析

岩石力学与工程学报 2007年第6期26卷 1123-1131页

作者：彭芳乐清住真高伟大内正敏同济大学岩土及地下工程教育部重点实验室日本白石(建设)公司技术本部日本东京116024

空洞的位置、形状、大小以及地基土的类型等诸因素都会对浅基础的承载力和沉降产生影响。利用一系列的二维弹塑性有限元方法分析一个空洞存在时其位置对浅基础承载力与沉降的影响,并对其发生机制进行研究。研究结果表明:空洞对浅基础承... 详细信息

空洞的位置、形状、大小以及地基土的类型等诸因素都会对浅基础的承载力和沉降产生影响。利用一系列的二维弹塑性有限元方法分析一个空洞存在时其位置对浅基础承载力与沉降的影响,并对其发生机制进行研究。研究结果表明:空洞对浅基础承载力与沉降的影响存在一个极限范围。只有当空洞存在于这个影响极限范围之内时,空洞的存在才会显著地影响基础的承载力和沉降。另外,基于有限元量化分析结果,还提出一个简单实用的浅基础承载力的空洞影响效果计算方法。

关键词：土力学空洞浅基础承载力数值分析

Recent Progress in JAXA Project of Boiling Two-Phase Flow Experiment onboard ISS

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Journal of Physical Science and Application 2012年第4期2卷 71-79页

作者： kiyosumi Fujii Masato Komasaki Takashi Kurimoto Haruo Kawasaki Kenichiro Sawada Koichi Suzuki Hitoshi Asano Osamu Kawanami Ryoji Imai Yasuhisa Shinmoto Haruhiko Ohta ISS Science Project Office Japan Aerospace Exploration Agency(JAXA) Tsukuba Ibaraki Japan Thermal System Group Japan Aerospace Exploration Agency(JAXA) Tsukuba Ibaraki Japan Tokyo Univ. Sci. Yamaguchi Yamaguchi Japan Kobe University Kobe Hyogo Japan University of Hyogo Himeji Hyogo Japan IHI Corporation Yokohama Kanagawa Japan Dept. Aeronautics and Astronautics Kyushu University Fukuoka Japan

The amount of waste heat in a space facility became larger, because of increase in the space platform size and its power consumption. It requires development of high-performance space thermal management systems handling a large amount of waste. Boiling two-phase flow could become powerful means for this system because a boiling and condensation system is one of the most efficient modes of heat transfer due to phase change (liquid-vapor). However, gravity effects on boiling two-phase flow phenomena and the corresponding heat transfer characteristics are not clear. Therefore, we prepare the experiments of boiling two-phase flow utilizing a long-term microgravity environment onboard a Japanese Experimental Module "KIBO" in the International Space Station (ISS) as one of the JAXA official projects. In this paper, recent progress of the preparation for the project is reported.

关键词：国际空间站研究开发机构两相流实验板沸腾日本航空宇宙