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Clinical study using novel endoscopic system for measuring size of gastrointestinal lesion

World Journal of Gastroenterology 2014年第14期20卷 4050-4058页

作者： kiyoshi oka Takeshi Seki Tomohiro Akatsu Takao Wakabayashi Kazuo Inui Junji Yoshino OK Fiber Technology Co. Ltd. Graduate School of engineering and Resource Science Akita University A-tech Co. Ltd. Department of Internal Medicine Banbuntane Hotokukai HospitalFujita Health University

AIM:To verify the performance of a lesion size measurement system through a clinical ***:Our proposed system,which consists of a conventional endoscope,an optical device,an optical probe,and a personal computer,generates a grid scale to measure the lesion size from an endoscopic *** width of the grid scale is constantly adjusted according to the distance between the tip of the endoscope and lesion because the lesion size on an endoscopic image changes according to the *** shape of the grid scale was corrected to match the distortion of the endoscopic *** distance was calculated using the amount of laser light reflected from the lesion through an optical probe inserted into the instrument channel of the *** endoscopist can thus measure the lesion size without contact by comparing the lesion with the size of the grid scale on the endoscopic image.(1)A basic test was performed to verify the relationship between the measurement error eM and the tilt angle of the endoscope;and(2)The sizes of three colon polyps were measured using our system during *** sizes were immediately measured by scale after their ***:There was no error atα=0°.In addition,the values of eM(mean±SD)were 0.24±0.11 mm(α=10°),0.90±0.58 mm(α=20°)and 2.31±1.41mm(α=30°).According to these results,our system has been confirmed to measure accurately when the tilt angle is less than 20°.The measurement error was approximately 1 mm in the clinical ***,it was concluded that our proposed measurement system was also effective in clinical ***:By combining simple optical equipment with a conventional endoscope,a quick and accurate system for measuring lesion size was established.

关键词： Lesion size Non-contact measurement Endoscope Grid

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Comparison of PPIs and H_2-receptor antagonists plus prokinetics for dysmotility-like dyspepsia

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World Journal of Gastroenterology 2012年第13期18卷 1517-1524页

作者： Masahiro Sakaguchi Miyuki Takao Yasuo Ohyama Hiroshi oka Hiroshi Yamashita Takumi Fukuchi kiyoshi Ashida Masahiro Murotani Masuyo Murotani Kazuo Majima Hiroshi Morikawa Takashi Hashimoto Keisuke Kiyota Hirohiko Esaki Kanji Amemoto Gouhei Isowa Fumiyuki Takao Department of Gastroenterology Moriguchi Keijinkai HospitalMoriguchiOsaka 570-0021Japan Department of Gastroenterology Osaka Saiseikai Nakatsu HospitalOsaka 530-0012Japan Murotani Clinic KadomaOsaka 571-0008Japan Majima Clinic NeyagawaOsaka 572-0084Japan Morikawa Clinic HirakataOsaka 573-0058Japan Hashimoto Clinic MoriguchiOsaka 570-0079Japan Kiyota Clinic MatsubaraOsaka 580-0004Japan Department of Gastroenterology Arisawa General HospitalHirakataOsaka 573-1195Japan Amemoto Clinic MoriguchiOsaka 570-0021Japan Isowa Clinic NeyagawaOsaka 572-0062Japan Mii Clinic NeyagawaOsaka 572-0019Japan

AIM:To compare efficacy of proton pump inhibitors(PPIs)with H2-receptor antagonists(H2RAs)plus prokinetics(Proks)for dysmotility-like symptoms in functional dyspepsia(FD).METHODS:Subjects were randomized to receive openlabel treatment with either rabeprazole 10 mg od(n= 57)or famotidine 10 mg bid plus mosapride 5 mg tid(n=57)for 4 *** primary efficacy endpoint was change(%)from baseline in total dysmotility-like dyspepsia symptom *** secondary efficacy endpoint was patient satisfaction with ***:The improvement in dysmotility-like dyspep-sia symptom score on day 28 was significantly greater in the rabeprazole group(22.5%±29.2%of baseline) than the famotidine+mosapride group(53.2%± 58.6%of baseline,P<0.0001).The superior benefit of rabeprazole treatment after 28 d was consistent regardless of Helicobacter pylori *** more subjects in the rabeprazole group were satisfied or very satisfied with treatment on day 28 than in the famotidine+mosapride group(87.7%vs 59.6%,P= 0.0012).Rabeprazole therapy was the only significant predictor of treatment response(P<0.0001),defined as a total symptom score improvement≥50%.CONCLUSION:PPI monotherapy improves dysmotility-like symptoms significantly better than H2RAs plus Proks,and should be the treatment of first choice for Japanese FD.

关键词： H2受体拮抗剂消化不良功能障碍指数和生产者配合治疗不良症状运动

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