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Rapid acupuncture for musculoskeletal pain in the emergency room of the Hospital Servidor Publico Estadual, Brazil: A quasi-experimental study

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Journal of Integrative Medicine 2020年第4期18卷 313-318页

作者： Luciana Aikawa Alexandre Massao Yoshizumi Mirian Matsura Shirassu Marcia kiyomi Koike Programa de Pós-Graduação em Ciências da Saúde Instituto de Assistência Médica ao Servidor Público Estadual(IAMSPE)Vila ClementinoSão PauloSP 04029-000Brazil Associação Médica Brasileira de Acupuntura Vila MarianaSão PauloSP 04011-002Brazil

Objective:To compare differences in self-reported musculoskeletal pain before and after receiving rapid acupuncture for pain at an outpatient emergency ***:Exactly 102 patients presenting to the emergency room of the Hospital Servidor Publico Estadual in Sao Paulo,Brazil,participated in this before-and-after *** participants had musculoskeletal pain and were treated with the technique proposed by Marques *** emergency acupuncture involved inserting a needle at a point defined by traditional Chinese medicine and applying intense stimulation for 10 s;no more than two points were used on any individual *** was measured using a numerical visual scale before and immediately after the ***:Participants in this study were mostly women(78%),had a college degree(47%)and were below the age of 60(56%).The most common region of pain was the lower back(31%),and the most common type of pain was acute and exacerbated chronic *** meridians most commonly involved were the eight extra meridians(40%),and the points most often used for treatment were Houxi(SI3),Shenmai(BL62)and Zulinqi(GB41).Almost all participants reported a decrease in pain intensity,independent of sex,education level,pain site and pain type(acute/chronic;P<0.05).At the end of the session,only4%of the participants reported a desire for allopathic ***:This emergency acupuncture technique for analgesia appears to reduce musculoskeletal *** registration:Brazilian Registry of Clinical Trials(http://***/)with ***-8 dmfjf.

关键词： Acupuncture analgesia Emergency medical services Acute pain Acupuncture therapy

Study of the Possible Use of a Home-Visit Nursing Interventional Lymphedema Care Program for Secondary Lymphedema in the Elderly at Home

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Health 2019年第11期11卷 1529-1541页

作者： kiyomi Morimoto Department of Nursing Science Seisen University Shiga Japan Doctoral Program Graduate School of Nursing Osaka Medical College Osaka Japan

Objective: This study aimed to clarify the possible use of and points to improve a home-visit nursing interventional lymphedema care program (plan) we developed. Methods: The subjects were visiting nurses with at least three years of home-visit nursing experience and experience with lymphedema care for the elderly at home. Semi-structured interviews were conducted, and the collected opinions were aggregated and summarized. Results: Based on interviews with nine subjects, opinions regarding the use of the program, such as “The assessment perspective at the time of introduction helps to grasp the needs for a wide variety of subjects”, and regarding points to improve, such as “It is necessary to set the duration and timing of the section considering the frequency of visits and degree of edema at the time of introduction” and “It is necessary to have a perspective concerning efforts to maintain motivation for care of the elderly and their families”, were aggregated. Discussion: The results of the interviews were generally useful for the structure and development of the program, care methods and content, and interventions for influencing factors. Consideration of setting the timing according to the degree of lymphedema, modification of the program’s development, development of a program that fully considers the degree of edema at the time of introduction and the acceptance of edema among the elderly, and the need to consider the care content that should be given priority were suggested as points for improvement.

关键词： Elderly at Home Secondary Lymphedema Home-Visit Nursing Lymphedema Care Program Possible Use

A Simplified Numerical Simulation Method Considering Active Devices for Opto-Electronic Mixed Modules

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光学学报 2003年第S1期23卷 321-322页

作者： Tomoaki Yoshida Hideaki Kimura Shuichiro Asakawa Akira Ohki kiyomi Kumozaki NTT Access Network Service Systems Laboratories NTT CorporationNTT Access Network Service Systems Laboratories NTT CorporationNTT Photonics Laboratories NTT Corporation. 11-6 Nakase Mihamaku Chiba-shi Chiba Japan 261-0023.NTT Photonics Laboratories NTT Corporation. 11-6 Nakase Mihamaku Chiba-shi Chiba Japan 261-0023.NTT Access Network Service Systems Laboratories NTT Corporation

A simplified simulation method based on the FDTD technique that can handle active devices is proposed. This method well suits the electrical crosstalk analysis of multi-channel integrated, opto-electronic mixed modules. We apply this method to an 8-channel integrated super-compact high-sensitivity optical module. The results show good agreement between simulations and measurements.

关键词：口口 of In FDTD as be by for A Simplified Numerical Simulation Method Considering Active Devices for Opto-Electronic Mixed Modules

Sleeping Conditions of Older Adults with Delirium Receiving Home Care

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Health 2023年第8期15卷 895-907页

作者： Masako Higo kiyomi Morimoto Department of Evidence-Based Clinical Nursing Division of Health Sciences Graduate School of Medicine Osaka University Osaka Japan Department of Nursing Science Seisen University Shiga Japan

We aimed to clarify the sleep status before delirium onset among older adults receiving home care. The sleep status of 21 participants aged ≥65 years was monitored while they slept with a sensor placed under their bedding, after ruling out insomnia and dementia. The incidence of delirium was 28.6%;delirium onset occurred within an average of 2.7 (SD = 12) days after the start of home care among those whose care environment was changed due to hospital discharge or moving. Increased interrupted sleep and activity during sleep indicated that sleep fragmentation occurred before delirium onset. In conclusion, individuals aged ≥65 years and those whose care environment has changed should be screened for delirium because the time to delirium onset is short. Further, interventions to monitor the sleep status and prevent delirium onset should be implemented from the day home care begins.

关键词： Patients in Home Care Elderly Delirium Sleep

Cancer immunotherapy for pancreatic cancer utilizing α-gal epitope/natural anti-Gal antibody reaction

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World Journal of Gastroenterology 2015年第40期21卷 11396-11410页

作者： Masahiro Tanemura Eiji Miyoshi Hiroaki Nagano Hidetoshi Eguchi Katsuyoshi Matsunami kiyomi Taniyama Nobutaka Hatanaka Hiroki Akamatsu Masaki Mori Yuichiro Doki Department of Surgery Osaka Police Hospital10-31 Kitayamacho Tennoujiku Department of Molecular Biochemistry and Clinical Investigation Osaka University Graduate School of Medicine Department of Digestive Surgery and Surgical Oncology Yamaguchi University Graduate School of Medicine Department of Gastroenterological Surgery Osaka University Graduate School of Medicine Department of Pharmacognosy Graduate School of Biomedical and Health SciencesHiroshima University Department of Surgery and Institute for Clinical Research National Hospital Organization Kure Medical Center and Chugoku Cancer Center

Pancreatic ductal adenocarcinoma(PDAC) has the poorest prognosis of all malignancies and is largely resistant to standard therapy. Novel treatments against PDAC are desperately needed. Anti-Gal is the most abundant natural antibody in humans,comprising about 1% of immunoglobulins and is also naturally produced in apes and Old World monkeys. The anti-Gal ligand is a carbohydrate antigen called "α-gal epitopes" with the structure Galα1-3Galβ1-4Glc NAc-R. These epitopes are expressed as major carbohydrate antigens in non-primate mammals,prosimians,and New World monkeys. Anti-Gal is exploited in cancer vaccines to increase the immunogenicity of antigen-presenting cells(APCs). Cancer cells or PDAC tumor lysates are processed to express α-gal epitopes. Vaccination with these components results in in vivo opsonization by anti-Gal Ig G in PDAC patients. The Fc portion of the vaccine-bound anti-Gal interacts with Fcγ receptors of APCs,inducing uptake of the vaccine components,transport of the vaccine tumor membranes to draining lymph nodes,and processing and presentation of tumor-associated antigens(TAAs). Cancer vaccines expressing α-gal epitopes elicit strong antibody production against multiple TAAs contained in PDAC cells and induce activation of multiple tumor-specific T cells. Here,we review new areas of clinical importance related to the α-gal epitope/anti-Gal antibody reaction and the advantages in immunotherapy against PDAC.

关键词： Pancreatic cancer Immunotherapy Cancer antigen MUC

Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study

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World Journal of Gastroenterology 2017年第19期23卷 3488-3495页

作者： Yasushi Adachi Masanori Nojima Mitsuru Mori Kentaro Yamashita Hiro-o Yamano Hiroshi Nakase Takao Endo Kenji Wakai kiyomi Sakata Akiko Tamakoshi Division of Gastroenterology Department of Internal MedicineSapporo Shirakaba-dai Hospital Department of Gastroenterology Sapporo Medical University The Institute of Medical Science Hospital The University of Tokyo Department of Public Health Sapporo Medical UniversitySchool of Medicine Department of Preventive Medicine Nagoya UniversityGraduate School of Medicine Department of Hygiene and Preventive Medicine Iwate Medical University School of Medicine Department of Public Health Hokkaido University School of Medicine

To assess the relationship between serum levels of insulin-like growth factor-1 (IGF1)/IGF-binding protein-3 (IGFBP3) and the risk of esophageal *** assessed the relationship between the serum levels of these molecules and the risk of esophageal cancer in a prospective, nested case-control study of participants from the Japan Collaborative Cohort Study. A baseline survey was conducted from 1988 to 1990. Of the 110585 enrolled participants, 35% donated blood samples. Those who had been diagnosed with esophageal cancer were considered cases for nested case-control studies. A conditional logistic model was used to estimate odds ratios for the incidence of esophageal cancer associated with serum IGF1 and IGFBP3 ***-one cases and 86 controls were eligible for the present assessment. The molar ratio of IGF1/IGFBP3, which represents the free and active form of IGF1, was not correlated with the risk of esophageal carcinoma. A higher molar difference between IGFBP3 and IGF1, which estimates the free form of IGFBP3, was associated with a decreased risk of esophageal carcinoma (P = 0.0146), and people in the highest tertile had the lowest risk (OR = 0.107, 95%CI: 0.017-0.669). After adjustment for body mass index, tobacco use, and alcohol intake, the molar difference of IGFBP3-IGF1 was inversely correlated with the risk of esophageal carcinoma (P = 0.0150).CONCLUSIONThe free form of IGFBP3, which is estimated by this molar difference, may be inversely associated with esophageal cancer incidence.

关键词： Esophageal cancer Insulin-like growth factor Insulin-like growth factor binding protein Nested case-control study Odds ratio

Precision Synthesis of a Long-Chain Silane Coupling Agent Using Micro Flow Reactors and Its Application in Dentistry

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Journal of Encapsulation and Adsorption Sciences 2016年第1期6卷 35-46页

作者： kiyomi Fuchigami Hidefumi Fujimura Mitsuji Teramae Toshiyuki Nakatsuka Research and Development Department Shofu Inc. Kyoto Japan

In dentistry, a wide range of materials is available for restorative treatment;a typical product of such restorative materials mainly consists of radically polymerizable monomer(s) and inorganic filler(s) (for added physical strength), as well as a surface modifier (e.g. silane coupling agent) for improved affinity between monomer and filler. It is favorable to use an optimal surface modifier depending on the respective restorative materials. However, commercially available surface modifiers, which are synthesized by the ton, are not always suited for what is required for properties of the many different dental restorative materials. As a potential solution to such a problem, we focused on the latest technology, “micro flow reactors” that enabled an on-demand low-volume synthesis of many types of surface modifiers. Using micro reaction fields of such flow reactors, we synthesized a novel long-chain silane coupling agent. Compared to the control system synthesized using a conventional reaction flask, the novel system enabled significant reduction in reaction time without inducing any major side reactions. A dental composite resin that was treated with the novel coupling agent exhibited higher toughness, suggesting that such a silane coupling agent was an effective surface modifier.

关键词： Micro Flow Reactor Precision Synthesis Composite Resins Molecular Design Urethanization Hydrosilylation

The effectiveness of Japanese sandals use on lower leg function among elderly women living in the community

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Health 2013年第12期5卷 1-7页

作者： Mizue Hiura Kazuko Nishisaka kiyomi Higashi Chiharu Matsumoto Department of Community Health Nursing Faculty of Life Sciences Kumamoto University Kumamoto Japan

The aim of this study was to investigate the efficacy of specially designed zori, a Japanese-style sandal, for enhancing walking performance. A total of 89 women aged 59-75 were randomly assigned to either the intervention or control group. The intervention group wore the zori for 6 months while the control group did not. We conducted physical assessments, including The Good Walker’s Index, which consisted of a 10-m walking time measurement, maximal step length, the 40/20-cm step test and tandem gait, and measurement of the toe-gap force (TGF). Additionally, bare foot plantar pressure distribution was measured using a foot-mapping sensor, while gait characteristics were measured using three dimensional sensors. In the intervention group, means for TGF improved significantly between baseline and three months and between baseline and six months, but this improvement was not evident in the control group. In the intervention group, the means for pressure and surface areas of both left and right feet significantly decreased over time compared with the control group. Three-dimensional analysis found that left and right ankle height was enhanced in the intervention group, and their walking speed was improved by the extension of their stride length and an increase in the height of the tiptoe in one cycle. The findings in our study indicate that zori can be useful in improving lower leg function through TGF enhancement and adjustment of the pressure pattern.

关键词： Japanese Elderly Footwear Toe-Gap Force Planter Pressure Distribution

Microencapsulation of Ascorbic Acid with Tripalmitin by Using Dry Coating Method

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Materials Sciences and Applications 2015年第2期6卷 130-139页

作者： Yoshinari Taguchi Hidetoshi Tanabe kiyomi Fuchigami Masato Tanaka Graduate School of Science and Technology Niigata University Niigata Japan Department of Research & Development Shofu Inc. Kyoto Japan

It was tried to microencapsulate the ascorbic acid powder as a redox initiator with tripalmitin by use of the dry coating method. In the experiment, the feed ratio of the amount of tripalmitin to that of ascorbic acid, the coating time and the concentration of ethyl alcohol of pulverizing solvent were changed stepwise. The characteristics of microcapsules such as the content of core material, the yield, the water proof degree, the microencapsulation efficiency and the mean diameter were estimated. The yield, the microencapsulation efficiency and the water proof degree gradually increased with the feed ratio, the coating time and the concentration of pulverizing solvent. The microcapsules showed the thermal responsibility and induced polymerization of methyl methacrylate monomer.

关键词： Ascorbic Acid Tripalmitin Microcapsules Dry Coating Redox Initiator Thermal Responsibility