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Large Deformation Analysis and Synthesis of Elastic Closed-loop Mechanism Made of a Certain Spring Wire Described by Free Curves

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Chinese Journal of Mechanical Engineering 2015年第4期28卷 756-762页

作者： iwatsuki Nobuyuki KOSAKI Takashi Department of Mechanical Sciences and Engineering Graduate School of Science and EngineeringTokyo Institute of Technology

Recently novel mechanisms with compact size and without many mechanical elements such as bearing are strongly required for medical devices such as surgical operation devices. This paper describes analysis and synthesis of elastic link mechanisms of a single spring beam which can be manufactured by NC coiling machines. These mechanisms are expected as disposable micro forceps. Smooth Curvature Model（SCM） with 3rd order Legendre polynomial curvature functions is applied to calculate large deformation of a curved cantilever beam by taking account of the balance between external and internal elastic forces and moments. SCM is then extended to analyze large deformation of a closed-loop curved elastic beam which is composed of multiple free curved beams. A closed-loop elastic link is divided into two free curved cantilever beams each of which is assumed as serially connected free curved cantilever beams described with SCM. The sets of coefficients of Legendre polynomials of SCM in all free curved cantilever beams are determined by taking account of the force and moment balance at connecting point where external input force is applied. The sets of coefficients of Legendre polynomials of a nonleaded closed-loop elastic link are optimized to design a link mechanism which can generate specified output motion due to input force applied at the assumed dividing point. For example, two planar micro grippers with a single pulling input force are analyzed and designed. The elastic deformation analyzed with proposed method agrees very well with that calculated with FEM. The designed micro gripper can generate the desired pinching motion. The proposed method can contribute to design compact and simple elastic mechanisms without high calculation costs.

关键词： elastic link mechanism closed-loop spring beam large deformation analysis smooth curvature model force balance equation synthesi

Effect of Microstructure of Cementite on Interphase Stress State in Carbon Steel

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Journal of Iron and Steel Research International 2007年第4期14卷 31-38页

作者： CHE Lei GOTOH Masahide horimoto Yoshiaki HIROSE Yukio Graduate School Kanazawa University Kanazawa 920-1192 Japan Department of Materials Science and Engineering Kanazawa University Kanazawa 920-1192 Japan

The experiments related to stress states of ferrite and cementite in carbon steels were carried out including in situ four-point bending and tensile test by X-ray diffraction technique. Stresses in the cementite phase can be measured by conventional X-ray diffraction instrument after a specific treatment on the specimen surface. In order to estimate the stress states in two phases, the X-ray elastic constants of two phases in single-phase state （PXEC） are determined by the experimental X-ray elastic constants of them in composite state （CXEC）. The effects of volume fraction and particle size of spheroidal cementite on the interphase stress state are estimated. The experimental results are in good agreement with the theoretical relationships reported in the previous studies.

关键词： multi-phase material surface treatment plastic deformation residual stress X-ray diffraction

On Using Physico-Chemical Properties of Amino Acids in String Kernels for Protein Classification via Support Vector Machines

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Journal of Systems Science & Complexity 2015年第2期28卷 504-516页

作者： LI Limin AOKI-KINOSHITA kiyoko F CHING Wai-Ki JIANG Hao Institute of Information and System Science Xi'an Jiaotong University Department of Bioinformatics Faculty of EngineeringSoka University Advanced Modeling and Applied Computing Laboratory Department of MathematicsThe University of Hong Kong Department of Mathematics School of InformationRenmin University of China

String kernels are popular tools for analyzing protein sequence data and they have been successfully applied to many computational biology problems. The traditional string kernels assume that different substrings are independent. However, substrings can be highly correlated due to their substructure relationship or common physico-chemical properties. This paper proposes two kinds of weighted spectrum kernels： The correlation spectrum kernel and the AA spectrum kernel. We evMuate their performances by predicting glycan-binding proteins of 12 glycans. The results show that the correlation spectrum kernel and the AA spectrum kernel perform significantly better than the spectrum kernel for nearly all the 12 glycans. By comparing the predictive power of AA spectrum kernels constructed by different physico-chemical properties, the authors can also identify the physico- chemical properties which contributes the most to the glycan-protein binding. The results indicate that physico-chemical properties of amino acids in proteins play an important role in the mechanism of glycamprotein binding.

关键词： AAindex AA spectrum kernel correlation spectrum kernel physico-chemical properties string kernel weighted spectrum kernel.

MODELING GENETIC REGULATORY NETWORKS:A DELAY DISCRETE DYNAMICAL MODEL APPROACH

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Journal of Systems Science & Complexity 2012年第6期25卷 1052-1067页

作者： Hao JIANG Wai-Ki CHING kiyoko F.AOKI-KINOSHITA Dianjing GUO Advanced Modeling and Applied Computing Laboratory Department of MathematicsThe University of Hong Kong Department of Bioinformatics Faculty of EngineeringSoka University Department of Biology The Chinese University of Hong Kong

Modeling genetic regulatory networks is an important research topic in genomic research and computationM systems biology. This paper considers the problem of constructing a genetic regula- tory network （GRN） using the discrete dynamic system （DDS） model approach. Although considerable research has been devoted to building GRNs, many of the works did not consider the time-delay effect. Here, the authors propose a time-delay DDS model composed of linear difference equations to represent temporal interactions among significantly expressed genes. The authors also introduce interpolation scheme and re-sampling method for equalizing the non-uniformity of sampling time points. Statistical significance plays an active role in obtaining the optimal interaction matrix of GRNs. The constructed genetic network using linear multiple regression matches with the original data very well. Simulation results are given to demonstrate the effectiveness of the proposed method and model.

关键词： Delay effect discrete dynamic system model genetic regulatory networks k-means clustering method linear multiple regression.

An Integrated Gene Regulatory Network Inference Pipeline

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An Integrated Gene Regulatory Network Inference Pipeline

Long-term efficacy of endoscopic coagulation for different types of gastric vascular ectasia

第三十届中国控制会议

作者： horimoto Katsuhisa Computational Biology Research Center（CBRC） National Institute of Advanced Industrial Science and Technology（AIST）Tokyo135-0064Japan

＜正＞Rapidly accumulated gene expression data put forward the development of numerous methods for inferring gene regulatory networks and the efforts for critical performance assessment of these *** this paper,we propose an integrated pipeline for gene regulatory network inference motivated by the results and follow-up analysis of a blinded,community-wide challenge DREAM（Dialogue on Reverse Engineering Assessment and Methods） *** particular,we categorize the gene expression data into three types,i.e.,steady-state gene expression profile of knockout or knockdown experiments,steady-state gene expression profiles after multi-factorial perturbations,and time-series data after multi-factorial *** we analyze the three types of gene expression data by using the combination of fold change and t-test,the path consistency algorithm based on conditional mutual information,and the ordinary differential equation model,*** we integrate the three procedures to a pipeline for gene regulatory network inference by considering their complementarities. Performance for the network inference will be improved in the proposed pipeline by maximally utilizing information in the available data,emphasizing the knock-out and knock-down data,and differentiating the direct and indirect regulatory interactions.

关键词： Gene regulatory network Reverse engineering Knock out Steady state Time series

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World Journal of Gastroenterology 2013年第18期19卷 2799-2805页

作者： Yukinori Imai Yoshie Mizuno kiyoko Yoshino Kazuhiro Watanabe Kayoko Sugawara Daisuke Motoya Masashi Oka Satoshi Mochida Department of Gastroenterology and Hepatology Faculty of Medicine Saitama Medical University Saitama 350-0495 Japan

AIM: To examine the long-term therapeutic efficacies of endoscopic cauterization for gastric vascular ectasia, according to the type of lesion. METHODS: Thirty-eight patients with hemorrhagic gastric vascular ectasia (VE) were treated by endoscopic cauterization: 13 by heater probe coagulationand 25 by argon plasma coagulation. Depending on the number of lesions, 14 and 24 patients were classified into localized VE (≤ 10; LVE) and extensive VE (> 10; EVE), respectively. The patients were followedup by repeated endoscopic examinations after the therapy, and the incidences of VE recurrence and rebleeding from the lesions were evaluated. RESULTS: Although the VE lesions disappeared initially in all the patients after the therapy, the recurrence of VE developed in 25 patients (66%) over a mid-term observation period of 32 mo, and re-bleeding occurred in 15 patients (39%). The recurrence of VE was found in all patients with EVE, with re-bleeding occurring in 14 patients (58%). In contrast, only 1 patient (7%) with LVE showed recurrence of the lesions and complicating hemorrhage. Both the cumulative recurrence-free rates and cumulative re-bleeding-free rates were significantly lower in the EVE group than in the LVE group (P < 0.001 and P < 0.001, respectively). Moreover, the cumulative re-bleeding-free rate in the EVE group was 47.6% at 1 year and 25.4% at 2 years in patients with chronic renal failure, which were significantly lower than the rates in the patients without chronic renal failure (83.3% and 74.1%, respectively) (P < 0.05). CONCLUSION: The recurrence of VE and re-bleeding from the lesions was more frequent in the patients with EVE, especially in those with complicating renal failure.

关键词： Gastric vascular ectasia Heater probe coagulation Argon plasma coagulation Renal failure Recurrence

System Identification Models for Gene Regulation System

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System Identification Models for Gene Regulation System

What Contributes to Satisfaction with Care for Family Caregivers of Terminal Cancer Patients Admitted to General Wards? A Qualitative Study

第二十九届中国控制会议

作者： horimoto Katsuhisa Computational Biology Research Center（CBRC） National Institute of Advanced Industrial Science and Technology（AIST）

Recent bio-technologies enable us to successfully discover the functional organization of a cell by simultaneously measuring the dynamic change of concentrations of thousands of bio-molecules after specific *** available input-output data offer system identification great chances and meanwhile challenges to build mathematical models of the dynamic transcriptional control system,which is fundamentally important in systems ***,we propose a general mathematical framework to describe the real world of transcriptional control system and the related system identification *** some existing models are briefly introduced within this unified framework to infer gene regulatory networks or transcriptional regulatory network by incorporating prior information both on network structure and heterogeneous data sources.

关键词： Gene Regulation System System Identification Optimization

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Open Journal of Nursing 2020年第11期10卷 1081-1094页

作者： Miki Morishita-Kawahara kiyoko Kamibeppu Division of Gerontological Nursing School of Nursing Tokyo Women’s Medical University Tokyo Japan Department of Family Nursing Graduate School of Health Sciences and Nursing Faculty of Medicine The University of Tokyo Tokyo Japan

Satisfaction with care is an important indicator for family caregivers of patients with terminal cancer and is linked to the quality of life. Despite this, few studies have examined the aspects of satisfaction with care of family caregivers of inpatients with cancer in general wards. This qualitative study aimed to elucidate the elements of satisfaction with the care that inpatients with terminal cancer in general wards and their family caregivers receive from medical staff, as perceived by the family caregivers. Semi-structured interviews were conducted with 10 family caregivers of inpatients with terminal cancer. Participants were asked about the care received until then from medical staff, the features of satisfactory care, and the aspects of care they felt were unsatisfactory or could become satisfactory with improvement. The data were analyzed with the content analysis method and the six categories were extracted. For family caregivers of inpatients with terminal cancer in general wards, along with the care identified as important in palliative care, the methods of alleviating symptoms and explaining the patient’s condition were also important. The results highlight the importance of determining a patient-oriented approach and explanations together with each patient and family caregiver, based on an understanding of the long treatment process.

关键词： Family Caregivers of Terminal Cancer Patients General Wards Qualitative Study Satisfaction with Care

Acute Stress Symptoms in Families of Patients Admitted to the Intensive Care Unit during the First 24 Hours Following Admission in Japan

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Open Journal of Nursing 2015年第4期5卷 325-335页

作者： Miyuki Komachi kiyoko Kamibeppu Department of Nurse Practitioner Training Division of Healthcare Graduate School of Medical Welfare International University of Health and Welfare Tokyo Japan Department of Family Nursing Division of Health Sciences & Nursing Graduate School of Medicine University of Tokyo Tokyo Japan

Families of patients in the intensive care unit often experience sever stress. Understanding their experience is important for providing family-centered care during this difficult period. Little is known about the experience of families of patients admitted to the intensive care unit (ICU). To evaluate the prevalence and factors associated with acute stress symptoms among families of patients admitted to the ICU, we carried out a cross-sectional study at a teaching and advanced treatment hospital. The mean total Impact of Event Scale-Revised (IES-R) score differed significantly between planned and unplanned ICU admissions (t = 4.03, p < 0.05), indicating a main effect of admission type (F = 18.5, p < 0.05). There was no significant main effect of relationship (F = 0.05, p = 0.82) or interaction effect of admission type and relationship (F = 0.54, p = 0.47). Multiple regression analysis indicated that admission type was significantly associated with acute stress symptoms (B = 18.09, β = 0.47, p < 0.01), and explained 22% of the variance in total IES-R score. Whether a patient had a planned or unplanned admission to the ICU influenced symptoms associated with acute stress symptoms of family members more than did getting support from nurses, being the patient’s spouse, or the severity of illness of the patient.

关键词： Intensive Care Unit Families within 24 Hours Acute Stress Symptoms Post-Traumatic Stress Disorder