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Hemoperfusion with polymyxin B-immobilized fiber column improves liver function after ischemia-reperfusion injury

6～(th) International Conference on Spoken Language Processing

作者： Tatsuya Kawahara Akinobu Lee Tetsunori Kobayashi Kazuya Takeda Nobuaki Minematsu Shigeki Sagayama Katsunobu Itou Akinori Ito Mikio Yamamoto Atsushi Yamada Takehito Utsuro kiyohiro shikano School of Informatics. Kyoto University 606-8501. Japan Kyoto Univ Waseda Univ Nagoya Univ Tokyo Univ Tokyo Univ ETL Yamagata Univ Tsukuba Univ ASTEM Toyohashi Univ. Tech Nara Inst. of Sci. ＆ Tech

＜正＞A sharable software repository for Japanese LVCSR （Large Vocabulary Continuous Speech Recognition） is introduced. It is designed as a baseline platform for research and developed by researchers of different academic institutes under a governmental support. The repository consists of a recognition engine （Julius）, Japanese acoustic models and statistical language models us well as Japanese morphological analysis tools. These modules can be easily integrated and replaced under a plug-and-play framework, which makes it possible to fairly evaluate components and to develop specific application systems. Assessment of these modules and systems in a 20000-word dictation task is reported. The software repository is freely available to the public.

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World Journal of Gastroenterology 2009年第36期15卷 4571-4575页

作者： Hiroaki Sato kiyohiro Oshima Katsumi Kobayashi Hodaka Yamazaki Yujin Suto Izumi Takeyoshi Department of Thoracic and Visceral Organ Surgery Gunma University Graduate School of Medicine3-39-15 Showa-machiMaebashiGunma 371-8511 Japan Intensive Care Unit Gunma University Hospital3-39-15 Showa-machiMaebashiGunma 371-8511 Japan

AIM： To investigate the usefulness of direct hemoperfusion with a polymyxin B-immobilized fiber column （DHP-PMX therapy） for warm hepatic ischemia-reperfusion （I/R） injury after total hepatic vascular exclusion （THVE） using a porcine model. METHODS： Eleven Mexican hairless pigs weighing 22-38 kg were subjected to THVE for 120 min and then observed for 360 min. The animals were divided into two groups randomly： the DHP-PMX group （n = 5） underwent DHP-PMX at a flow rate of 80 mL/min for 220 min （beginning 10 rain before reperfusion）, while the control group did not （n = 6）. The rate pressure product （RPP）： heart rate x end-systolic arterial blood pressure, hepatic tissue blood flow （HTBF）, portal vein blood flow （PVBF）, and serum aspartate aminotransferase （AST） levels were compared between the two groups. RESULTS： RPP and HTBF were significantly （P 〈 0.05） higher in the DHP-PMX group than in the control group 240 and 360 min after reperfusion. PVBF in the DHP-PMX group was maintained at about 70% of the flow before ischemia and differed significantly （P 〈 0.05） compared to the control group 360 min after reperfusion. The serum AST increased gradually after reperfusion in both groups, but the AST was significantly （P 〈 0.05） lower in the DHP-PMX group 360 min after reperfusion. CONCLUSION： DHP-PMX therapy reduced the hepatic warm I/R injury caused by THVE in a porcine model.

关键词： Ischemia-reperfusion injury Total hepaticvascular exclusion Polymyxin B-immobilized fiber column

Direct hemoperfusion with a polymyxin B-immobilized cartridge in intestinal warm ischemia reperfusion

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World Journal of Gastroenterology 2008年第35期14卷 5436-5441页

作者： Hiroaki Sato Kazuhisa Arakawa Katsumi Kobayashi Hodaka Yamazaki Yujin Suto Izumi Takeyoshi kiyohiro Oshima Department of Thoracic and Visceral Organ Surgery Gunma University Graduate School of MedicineMaebashiGunma 371-8511Japan Intensive Care Unit Gunma University HospitalMaebashiGunma 371-8511Japan

AIM： To investigate the effectiveness of direct hemoperfusion with polymyxin B-immobilized fibers （DHPPMX therapy） on warm ischemia-reperfusion （I/R） injury of the small intestine.METHODS： The proximal jejunum and distal ileum of mongrel dogs were resected. Warm ischemia was performed by clamping the superior mesenteric artery （SMA） and vein （SMV） for 2 h. Blood flow to the proximal small intestine was restored 1 h after reperfusion, and the distal small intestine was used as a stoma. The experiment was discontinued 6 h after reperfusion. The dogs were divided into two groups： the DHP-PMX group （n = 6, DHP-PMX was performed for 180 min; from 10 min prior to reperfusion to 170 rain after reperfusion） and the control group （n = 5）. The rate pressure product （RPP）, SMA blood flow, mucosal tissue blood flow, and intramucosal pH （pHi） were compared between the two groups. The serum interleukin （IL）-10 levels measured 170 min after reperfusion were also compared.RESULTS： The RPP at 6 h after reperfusion was significantly higher in the PMX group than in the control group （12174 ± 1832 mmHg/min vs 8929 ± 1797 mmHg/min, P 〈 0.05）. The recovery rates of the SMA blood flow at I and 6 h after reperfusion were significantly better in the PMX group than in the control group （61%±7% vs 44% ±4%, P 〈 0.05, and 59%±5% vs 35%±5%, P 〈 0.05, respectively）. The recovery rate of the mucosal tissue blood flow and the pHi levels at 6 h after reperfusion were significantly higher in the PMX group （61%±8% vs 31%±3%, P 〈 0.05 and 7.91±0.06 vs 7.69±0.08, P 〈 0.05, respectively）. In addition, the serum IL-IO levels just before DHP-PMX removal were significantly higher in the PMX group than in the control group （1 569 ± 253 pg/mL vs 211± 40 pg/mL, P 〈 0.05）.CONCLUSION： DHP-PMX therapy reduced warm I/R injury of the small intestine. IL-10 may play a role in inhibiting I/R injury during DHP-PMX therapy.

关键词： Ischemia-reperfusion injury Interleukin-10 Polymyxin B-immobilized hemoperfusion cartridge PMX

Impact of friction stir welding on recrystallization of oxide dispersion strengthened ferritic steel

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Journal of Materials Science & Technology 2018年第1期34卷 209-213页

作者： Wentuo Han Pingping Liu Xiaoou Yi Qian Zhan Farong Wan kiyohiro Yabuuchi Hisashi Serizawa Akihiko Kimura School of Materials Science and Engineering University of Science and Technology Beijing. Beijing 100083. China Institute of Advanced Energy. Kyoto University Gokasho Uji Kyoto 611-0011Japan Joining and Welding Research Institute. Osaka University Ibaraki Osaka567-0047Japan

Oxide dispersion strengthened （ODS） steels can be used as the structural materials in the future fusion reactors and the fuel cladding materials in the advanced fission reactors. However, the weldability of ODS steels is a severe problem. In the present study, defect-free joints of the 15Cr-ODS ferritic steel were achieved by friction stir welding at different rotation speeds. The recrystallization, hardness and tensile properties are highly related with the rotation speed of the stir tool. The higher rotation speed results in coarser grains in the top SZ, while the grain size exhibits more complicated relation with the rotation speed in the SZ center. The joint welded at 250 rpm exhibits a maximum tensile strength of 974 MPa that reaches about 84% of that of the base metal.

关键词： ODS ferritic steel Friction stir welding Recrystallization behavior Electron backscatter diffraction Vickers hardness

Severe liver trauma among pediatric patients in the Japan Trauma Registry

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World Journal of Pediatric Surgery 2021年第2期4卷 36-41页

作者： Makoto Aoki Toshikazu Abe Shuichi Hagiwara Daizoh Saitoh kiyohiro Oshima Emergency Medicine Gunma University Graduate School of MedicineMeabashiGunmaJapan Emergency and Critical Care Medicine Tsukuba Memorial HospitalTsukubaIbarakiJapan Emergency Medicine Kiryu Kosei General HospitalKiryuGunmaJapan Traumatology National Defense Medical CollegeTokorozawaSaitamaJapan

Background Limited information exists regarding the clinical characteristics,management practices,and outcomes of pediatric patients with liver injury in *** aim of this study is to evaluate the characteristics,management,and outcome of pediatric patients with liver injury in *** We conducted a multicenter,retrospective cohort study using data from the Japan Trauma Data Bank between 2004 and *** patients with liver injury were classified into the following management groups:nonoperative management(NOM);NOM with angioembolization(AE);operative management(OM).The primary outcome was in-hospital survival,and the secondary outcomes were dispositions,hospital length of stay(LOS),and rate of discharge to *** There were 308 pediatric patients with severe liver injury(organ injury scale grades≥Ⅲ)during the study period;135 patients had isolated liver injury and 173 patients had non-isolated liver *** rates of NOM,NOM with AE,and OM among all patients were 65%,23%,and 12%,*** was highly used both in patients with isolated liver injury(27%)and non-isolated liver injury(22%).In-hospital survival of patients with isolated liver injury and those with non-isolated liver injury were 99%and 88%,*** secondary outcomes among patients with isolated liver injury,82%were admitted to the intensive care *** was 11(8-14)days and 82%were discharged to *** Our retrospective observational study showed that management of pediatric patients with severe liver injury in Japan was characterized by high utilization of *** in-hospital survival rate in Japan was comparable with that of other developed countries.

关键词： patients pediatric admitted

Effect of atrial natriuretic peptide on ischemia-reperfusion injury in a porcine total hepatic vascular exclusion model

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World Journal of Gastroenterology 2007年第25期13卷 3487-3492页

作者： Katsumi Kobayashi kiyohiro Oshima Masato Muraoka Takahiko Akao Osamu Totsuka Hisashi Shimizu Hiroaki Sato Kazumi Tanaka Kenjiro Konno Koshi Matsumoto Izumi Takeyoshi Department of Thoracic and Visceral Organ Surgery Gunma University Graduate School of Medicine 3-39-15 Showa-Machi Maebashi Gunma 371-8511 Japan Intensive Care Unit Gunma University Hospital 3-39-15 Showa-Machi Maebashi Gunma 371-8511 Japan Animal Resource Project Center for Molecular Medicine Jichi Medical University Institute 3311-1 Yakushiji Shimotsuke Tochigi 329-0498 Japan Department of Pathology Nippon Medical School Musashi-Kosugi Hospital 1-396 Kosugi-chou Nakaharaku Kawasaki Kanagawa 211-8533 Japan

AIM： To evaluate the effect of ANP on warm I/R injury in a porcine THVE model.METHODS： Miniature pigs （mini-pigs） weighing 16-24 kg were observed for 120 min after reperfusion following 120 min of THVE. The animals were divided into two groups. ANP （0.1 μg/kg per min） was administered to the ANP group （n = 7）, and vehicle was administered to the control group （n = 7）. Either vehicle or ANP was intravenously administered from 30 min before the THVE to the end of the experiment. Arterial blood was collected to measure AST, LDH, and TNF-α. Hepatic tissue blood flow （HTBF） was also measured. Liver specimens were harvested for p38 MAPK analysis and histological study. Those results were compared between the two groups.RESULTS： The AST and LDH levels were lower in the ANP group than in the control group; the AST levels were significantly different between the two groups （60 min： 568.7 ± 113.3 vs 321.6 ± 60.1, P = 0.038 〈 0.05, 120 rain： 673.6± 148.2 vs 281.1±44.8, P = 0.004 〈 0.01）. No significant difference was observed in the TNF-α levels between the two groups. HTBF was higher in the ANP group, but the difference was not significant. A significantly higher level of phosphorylated p38 MAPK was observed in the ANP group compared to the control group （0min： 2.92± 1.1 vs 6.38 ±1.1,,P= 0.011 〈 0.05）.Histological tissue damage was milder in the ANP group than in the control group.CONCLUSION： Our results show that ANP has a protective role in I/R injury with p38 MAPK activation in a porcine THVE model.

关键词： Atrial natriuretic peptide p38 MAPK Ischemia-reperfusion injury Porcine liver Total hepaticvascular exclusion

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Reliable Multicast File Transfer on the Inter-University Sat...