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Specific targeting of lung ILC2s via NRP1 in pulmonary fibrosis

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Cellular & Molecular Immunology 2022年第8期19卷 869-871页

作者： Takuro Nii kiyoharu fukushima Hiroshi Kida Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical Center5-1-1 ToneyamaOsakaJapan Department of Respiratory Medicine and Clinical Immunology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsakaJapan Laboratory of Host Defense World Premier Institute Immunology Frontier Research Center(WPI-IFReC)Osaka University3-1 YamadaokaSuitaOsakaJapan Department of Host Defense Research Institute for Microbial Diseases(RIMD)Osaka UniversityOsaka565-0871Japan Global Center for Medical Engineering and Informatics 2-2 YamadaokaSuitaOsakaJapan

Innate lymphoid cells are predominantly tissue-resident immune cells that have diverse functions similar to T-cell subsets and regulate tissue homeostasis and innate immunity without specific antigen recognition. Prev... 详细信息

关键词： ILC2s immunity homeostasis

Revealing the diversity of neutrophil functions and subsets

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Cellular & Molecular Immunology 2021年第4期18卷 781-783页

作者： kiyoharu fukushima Hiroshi Nabeshima Hiroshi Kida Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical CenterOsakaJapan Department of Respiratory Medicine and Clinical immunology Osaka University Graduate School of MedicineOsakaJapan Laboratory of Host Defense World Premier Institute Im m unology Frontier Research Center(WPIIFReC)Osaka UniversityOsakaJapan Fujii Memorial Research Institute Otsuka Pharmaceutical CompanyLtdShigaJapan

Several recent studies have shown that diverse neutrophil subsets exhibit distinct phenotypic and functional properties in terms of disease onset and progression.1,2 In a study published in Nature Immunology,Sas et al.3 discovered a new neutrophil subset that promotes neuronal survival and axonal regeneration in the central nervous system(CNS).

关键词： neutrophil Immunology

Invariant natural killer T cells and iron metabolism orchestrate skin development and homeostasis

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Cellular & Molecular Immunology 2023年第10期20卷 1095-1097页

作者： Hiroshi Nabeshima Takayuki Niitsu kiyoharu fukushima Hiroshi Kida Laboratory of Host Defense World Premier Institute Immunology Frontier Research Center(WPI-IFReC)Osaka University3-1 YamadaokaSuitaOsakaJapan Department of Respiratory Medicine and Clinical Immunology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsakaJapan Department of Host Defense Research Institute for Microbial Diseases(RIMD)Osaka University3-1 YamadaokaSuitaOsakaJapan Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical Center5-1-1 ToneyamaOsakaJapan Global Center for Medical Engineering and Informatics 2-2 YamadaokaSuitaOsakaJapan

In recent years,innate-like T-cell populations,such as invariant natural killer T(iNKT)cells and mucosal-associated invariant T(MAIT)cells,have been identified[1].These cells are different from conventional T cells in that they reside in tissues such as the liver,lung,and skin,rather than the lymph node and spleen[2].Although iNKT and MAIT cells are abundant in the skin immediately after birth,the detailed functions or the mechanisms regulating their localization have not been clarified[3].In a study published in Nature Immunology,Wang et *** that the early homing of iNKT cells to the skin was dependent on CCR10 expression during the stage of thymic development and was critical for proper commensal bacterial colonization and skin development[4].

关键词： killer metabolism homeostasis

Nature:单核细胞SatM导致组织纤维化

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现代生物医学进展 2017年第3期17卷 I0001-I0001页

作者： Takashi Satoh, Katsuhiro Nakagawa, Fumihiro Yamane, kiyoharu fukushima, Isao Ebina Shizuo Akira Takashi Satoh, Katsuhiro Nakagawa, Fumihiro Yamane, kiyoharu fukushima, Isao Ebina Shizuo Akira Fuminori Sugihara Yoshichika Yoshioka Ryusuke Kuwahara Motooki Ashihara, Yosuke Minowa Isao Ebina Atsushi Kumanogoh Atsushi Kumanogoh Laboratory of Host Defense World Premier Institute Immunology Frontier Research Center Osaka University Osaka 565-0871 Japan Department of Host Defense Research Institute for Microbial Diseases (RIMD) Osaka University Osaka 565-0871 Japan Laboratory of Biofunctional Imaging World Premier Institute Immunology Frontier Research Center Osaka University Osaka 565-0871 Japan Research Center for Ultra-high Voltage Electron Microscopy Osaka University Osaka 567-0047 Japan Discovery Research Department Research Division Chugai Pharmaceutical Co. Ltd. Kanagawa 247-8530 Japan Core Research for Evolutional Science and Technology Japan Agency for Medical Research and Development Tokyo 100-0004 Japan Department of Respiratory Medicine Allergy and Rheumatic Diseases Graduate School of Medicine Osaka University Osaka 565-0871 Japan

在一项新的研究中，来自日本大阪大学免疫学前沿研究中心（IFReC）的研究人员报道了一类新的他们称之为SatM的单核细胞。针对小鼠的研究表明SatNI可能是导致组织纤维化的原因，而且成为一种治疗很少有有效疗法的疾病的新药物靶标。

关键词：单核细胞纤维化组织日本大阪大学研究人员药物靶标免疫学