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KoNA:Korean Nucleotide Archive as A New Data Repository for Nucleotide Sequence Data

Genomics, Proteomics & Bioinformatics 2024年第1期22卷 161-167页

作者： Gunhwan Ko Jae Ho Lee Young Mi Sim Wangho Song Byung-Ha Yoon Iksu Byeon Bang Hyuck Lee Sang-Ok Kim Jinhyuk Choi Insoo jang Hyerin Kim Jin Ok Yang kiwon jang Sora Kim Jong-Hwan Kim Jongbum Jeon Jaeeun Jung Seungwoo Hwang Ji-Hwan Park Pan-Gyu Kim Seon-Young Kim Byungwook Lee Korea Bioinformation Center Korea Research Institute of Bioscience&BiotechnologyDaejeon 34141Republic of Korea

During the last decade,the generation and accumulation of petabase-scale high-throughput sequencing data have resulted in great challenges,including access to human data,as well as transfer,storage,and sharing of enormous amounts of *** promote data-driven biological research,the Korean government announced that all biological data generated from government-funded research projects should be deposited at the Korea BioData Station(K-BDS),which consists of multiple databases for individual data ***,we introduce the Korean Nucleotide Archive(KoNA),a repository of nucleotide sequence *** of July 2022,the Korean Read Archive in KoNA has collected over 477 TB of raw next-generation sequencing data from national genome *** ensure data quality and prepare for international alignment,a standard operating procedure was adopted,which is similar to that of the International Nucleotide Sequence Database *** standard operating procedure includes quality control processes for submitted data and metadata using an automated pipeline,followed by manual *** ensure fast and stable data transfer,a high-speed transmission system called GBox is used in ***,the data uploaded to or downloaded from KoNA through GBox can be readily processed using a cloud computing service called *** seamless coupling of KoNA,GBox,and Bio-Express enhances the data experience,including submission,access,and analysis of raw nucleotide *** not only satisfies the unmet needs for a national sequence repository in Korea but also provides datasets to researchers globally and contributes to advances in *** KoNA is available at https://***/kona/.

关键词： Korea BioData Station Nucleotide sequence Next-generation sequencing repository Genomics Deposition and access of big data

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Spider-inspired tunable mechanosensor for biomedical applications

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npj Flexible Electronics 2023年第1期7卷 444-452页

作者： Taewi Kim Insic Hong Yeonwook Roh Dongjin Kim Sungwook Kim Sunghoon Im Changhwan Kim kiwon jang Seongyeon Kim Minho Kim Jieun Park Dohyeon Gong Kihyeon Ahn Jingoo Lee Gunhee Lee Hak-Seung Lee Jeehoon Kang Ji Man Hong Seungchul Lee Sungchul Seo Bon-Kwon Koo Je-sung Koh Seungyong Han Daeshik Kang Department of Mechanical Engineering Ajou UniversitySuwonKorea Department of Mechanical Engineering Pohang University of Science and TechnologyPohangKorea Department of Sustainable Environment Research Korea Institute of Machinery&MaterialsDaejeonKorea Department of Internal Medicine and Cardiovascular Center Seoul National University HospitalSeoulKorea Department of Neurology and Neurosurgery Ajou University School of MedicineSuwonKorea Department of Nano-chemical Biological and Environmental EngineeringSeokyeong UniversitySeoulKorea Institute on Aging Seoul National UniversitySeoulKorea

The recent advances of wearable sensors are remarkable but there are still limitations that they need to be refabricated to tune the sensor for target ***,biological sensory systems have the inherent potential to adjust their sensitivity according to the external environment,allowing for a broad and enhanced ***,we developed a Tunable,Ultrasensitive,Nature-inspired,Epidermal Sensor(TUNES)that the strain sensitivity was dramatically increased(GF~30k)and the pressure sensitivity could be tuned(10–254 kPa^(−1))by preset membrane *** sensor adjusts the sensitivity to the pressure regime by preset tension,so it can measure a wide range(0.05 Pa–25 kPa)with the best performance:from very small signals such as minute pulse to relatively large signals such as muscle contraction and *** verified its capabilities as a wearable health monitoring system by clinical trial comparing with pressure wire which is considered the current gold standard of blood pressure(r=0.96)and home health care system by binary classification of Old’s/Young’s pulse waves via machine learning(accuracy 95%).

关键词： Sensor adjust Spider

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