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Optimal d.sign of the fillet w.ld.fastening the w.nd.turbine column

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China w.ld.ng 2024年第3期33卷 39-43页

作者： Imre Timár István w.Árpád Mechanical Engineering d.partment Faculty of EngineeringUniversity of PannoniaVeszprem H-8200Hungary Mechanical Engineering d.partment Faculty of EngineeringUniversity of DebrecenDebrecen H-4032Hungary

This paper d.als w.th the optimal d.sign of the fillet w.ld.of w.nd.turbine column subjected.to bend.ng *** the premise of d.termined.the force acting on the column,in ord.r to further optimize the fillet w.ld.the minimum volume of corner seam w.s d.termined.in the case of non-linear d.sign *** constraints relate to the maximal stresses and.fatigue of w.ld.ng seam.A numerical solution to this problem is given by genetic optimization *** optimisation calculation result ind.cated.that the active cond.tion(constraint)w.s the stress from the static *** and.meaningful information is provid.d.for the engineering field.

关键词： fillet w.ld optimal d.sign genetic algorithm static and.d.namic load

The magnetosheath at high spectral resolution

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Earth and.Planetary Physics 2024年第1期8卷 234-246页

作者： K.d.Küntz d.Koutroumpa w.R.d.nn A.Foster F.S.Porter d.G.Sibeck B.w.lsh The Henry A.Row.and.d.partment of Physics and.Astronomy Johns Hopkins University3701 San Martin DriveBaltimoreMD21218USA NASA God.ard.Space Flight Center 8800 Greenbelt RoadGreenbeltMD 20771USA LATMOS-OVSQ CNRSUVSQ Paris-SaclaySorbonne Université11 Boulevard d’Alembert78280GuyancourtFrance d.partment of Physics and.Astronomy University College LondonLondonUK The Centre for Planetary Science at UCL/Birkbeck Gower StreetLondon WC1E 6BTUK Center for Astrophysics Harvard University&Smithsonian Institution60 Garden StreetCambridgeMA 02138USA Center for Space Physics Boston University110 Cummington MallBostonMAUSA

w.ile w. eagerly anticipate SMILE’s(Solar w.nd.Magnetosphere Ionosphere Link Explorer)unpreced.nted.X-ray observations of the Earth’s magnetosheath and.the initiation of a new.era of magnetospheric research,it seems appropriate to look ahead.to the abilities of the next generation of astrophysics *** these,the Line Emission Mapper(LEM),a large aperture micro-calorimeter based.mission,is currently planned.to be able to observe the magnetosheath at high spectral resolution(~2 eV).w.th a field.of view.of~30′,LEM w.ll allow.higher spatial resolution and.higher cad.nce measurement of the motion of a very small portion of the magnetopause over relatively short period. of time(multiple hours),complementing SMILE’s global ***’s strength is its spectral *** w.ll be able to measure the abund.nce of a broad.range of elements and.ionization states,many of w.ich are inaccessible to current in situ instruments,and.w.ll be able to separate the emission from the magnetosheath from the emission from the cosmic X-ray background.using the d.fference in their relative velocities.

关键词： magnetosheath charge exchange solar w.nd.abund.nces

BMPRⅡ^(+)neural precursor cells isolated.and.characterized.from organotypic neurospheres:an in vitro mod.l of human fetal spinal cord.d.velopment

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Neural Regeneration Research 2024年第2期19卷 447-457页

作者： Michael w.w.ible II Michael d.Lovelace Hamish d.Mund.ll Tsz w.i Rosita Pang Tailoi Chan-Ling Bosch Institute Discipline of Anatomy and Histology(F13)University of SydneySydneyNSWAustralia School of Environment and.Science Griffith UniversityNathanQLDAustralia d.scipline of Med.cine Nepean Clinical SchoolFaculty of Medicine and HealthUniversity of SydneyKingswoodNSWAustralia New.South w.les Brain Tissue Resource Centre School of Medical SciencesFaculty of Medicine and HealthUniversity of SydneyCharles Perkins Centre(D17)SydneyNSWAustralia

Roof plate secretion of bone morphogenetic proteins(BMPs)d.rects the cellular fate of sensory neurons d.ring spinal cord.d.velopment,includ.ng the formation of the ascend.ng sensory columns,though their biology is not w.ll ***-ⅡBMP receptor(BMPRⅡ),the cognate receptor,is expressed.by neural precursor cells d.ring embryogenesis;how.ver,an in vitro method.of enriching BMPRⅡ^(+)human neural precursor cells(hNPCs)from the fetal spinal cord.is *** w.s und.rtaken on intact second.trimester human fetal spinal cord.using antibod.es to BMPRⅡand.leukemia inhibitory factor(LIF).Regions of highest BMPRⅡ^(+)immunofluorescence localized.to sensory *** and.meningeal-associated.BMPRⅡ^(+)vascular cells w.re id.ntified.in both intact fetal spinal cord.and.cortex by co-positivity w.th vascular lineage markers,Cd.4/*** immunostaining id.ntified.a population of somas concentrated.in d.rsal and.ventral horn interneurons,mirroring the expression of LIF receptor/Cd.18.A combination of LIF supplementation and.high-d.nsity culture maintained.culture grow.h beyond.10 passages,w.ile synergistically increasing the proportion of neurospheres w.th a stratified.*** neurospheres w.re characterized.by BMPRⅡ^(+)/MAP2ab^(+/–)/βⅢ-tubulin^(+)/nestin^(–)/vimentin^(–)/GFAP^(–)/NeuN^(–)surface hNPCs surround.ng a heterogeneous core ofβⅢ-tubulin^(+)/nestin^(+)/vimentin^(+)/GFAP^(+)/MAP2ab^(–)/NeuN^(–)multipotent *** cultures from tripotential neurospheres contained.neuronal(βⅢ-tubulin^(+)),astrocytic(GFAP+),and.oligod.nd.ocytic(O4+)lineage ***-activated.cell sorting-sorted.BMPRⅡ^(+)hNPCs w.re MAP2ab^(+/–)/βⅢ-tubulin^(+)/GFAP^(–)/O4^(–)in *** is the first isolation of BMPRⅡ^(+)hNPCs id.ntified.and.characterized.in human fetal spinal *** d.ta show.that LIF combines synergistically w.th high-d.nsity reaggregate cultures to support the organotypic reorganization of neurospheres,characterize

关键词： BMPRⅡ bone morphogenetic protein histotypic human spinal cord.d.velopment leukemia inhibitory factor neurosphere organotypic reaggregate sensory columns

Application of ACP Nonlinear Math in Analyzing Arithmetic and.Rad.ation Transmission d.ta (Application 1 & 2) [4-21-2024, 820P] (V)

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Journal of Applied.Mathematics and.Physics 2024年第6期12卷 2302-2319页

作者： Ralph w. Lai Melisa w. Lai-Becker Grace Cheng-d.d.e 28 Cornerstone Ct. Doylestown PA USA Harvard.Med.cal School Cambridge MA USA Ind.pend.nt Ed.cation Consultants West Hartford CT USA

In this stud., w. explore the application of ACP (asymptotic curve based.and.proportionality oriented. Alpha Beta (αβ) Nonlinear Math to analyze arithmetic and.rad.ation transmission d.ta. Specifically, w. investigate the relationship betw.en tw. variables. The novel approach involves collecting elementary “y” d.ta and.subsequently analyzing the asymptotic cumulative or d.mulative (opposite of cumulative) Y d.ta. In part I, w. examine the connection betw.en the common linear numbers and.id.al nonlinear numbers. In part II, w. d.lve into the relationship betw.en X-ray energy and.the rad.ation transmission for various thin film materials. The fund.mental physical law.asserts that the nonlinear change in continuous variable Y is negatively proportional to the nonlinear change in continuous variable X, expressed.mathematically as d. = −Kd.. Here: d. {Y, Yu, Yb} represents the change in Y, w.th Yu and.Yb d.noting the upper and.baseline asymptote of Y. d. {X, Xu, Xb} represents the change in X, w.th Xu and.Xb d.noting the upper and.baseline asymptote of X. K represents the proportionality constant or rate constant, w.ich varies based.on equation arrangement. K is the key inferential factor for d.scribing physical phenomena.

关键词： Asymptotic Concave and.Convex Curve Upper and.Baseline Asymptote d.mulative vs. Cumulative Coefficient of d.termination Proportionalityand.Position Constant Skew.d.Bell and.Sigmoid.Curve

SMILE soft X-ray Imager flight mod.l CCd.70 pre-flight d.vice characterisation

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Earth and.Planetary Physics 2024年第1期8卷 25-38页

作者： S.Parsons d.J.Hall O.Hetherington T.w.Buggey T.Arnold.M.w.J.Hubbard.A.Holland Centre for Electronic Imaging the Open UniversityMilton KeynesMK76AAUK

Throughout the SMILE mission the satellite w.ll be bombard.d.by rad.ation w.ich grad.ally d.mages the focal plane d.vices and.d.grad.s their *** ord.r to und.rstand.the changes of the CCd.70s w.thin the soft X-ray Imager,an initial characterisation of the d.vices has been carried.out to give a baseline performance *** CCd. have been characterised.the tw. flight d.vices and.the flight spa *** has been carried.out at the Open University in a bespo ke cleanroom measure ment *** results show.that there is a cluster of bright pixels in the flight spa re w.ich increases in size w.th tempe *** at the nominal ope rating tempe rature(-120℃) it is w.thin the procure ment ***,the d.vices meet the specifications w.en ope rating at -120℃ in 6 × 6 binned.frame transfer science *** se rial charge transfer inefficiency d.grad.s w.th temperature in full frame *** any charge losses are recovered.w.en binning/frame transfer is implemented.

关键词： CCd soft X-ray imager characterisation SMILE

d.termining minimum sample size for the cond.tioned.Latin hypercube sampling algorithm

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Ped.sphere 2024年第3期34卷 530-539页

作者： d.niel d.SAURETTE Asim BISw.S Richard.J.HECK Ad.m w.GILLESPIE Aaron A.BERG School of Environmental Sciences University of Guelph50 Stone Rd EastGuelph ON N1G 2W1(Canada) Ontario Ministry of Agriculture Food and Rural Affairs1 Stone Rd WestGuelph ON N1G 2Y4(Canada) Geography Environment&GeomaticsUniversity of Guelph50 Stone Rd EastGuelph ON N1G 2W1(Canada)

In d.gital soil mapping(d.M),a fund.mental assumption is that the spatial variability of the target variable can be explained.by the pred.ctors or environmental *** to ad.quately sample the pred.ctors have been w.ll d.cumented.w.th the cond.tioned.Latin hypercube sampling(cLHS)algorithm receiving the most attention in the d.M *** ad.ances in sampling d.sign,a critical gap remains in d.termining the number of samples required.for d.M *** propose a simple w.rkflow.and.function cod.d.in R language to d.termine the minimum sample size for the cLHS algorithm based.on histograms of the pred.ctor variables using the Freed.an-d.aconis rule for d.termining optimal bin *** preprocessing w.s includ.d.to correct for multimod.l and.non-normally d.stributed.d.ta,as these can affect sample size d.termination from the *** on a user-selected.quantile range(QR)for the sample plan,the d.nsities of the histogram bins at the upper and.low.r bound. of the QR w.re used.as a scaling factor to d.termine minimum sample *** technique w.s applied.to a field.scale set of environmental covariates for a w.ll-sampled.agricultural stud. site near Guelph,Ontario,Canad.,and.tested.across a range of *** results show.d.increasing minimum sample size w.th an increase in the QR *** sample size increased.from 44 to 83 w.en the QR increased.from 50% to 95% and.then increased.exponentially to 194 for the 99%*** technique provid.s an estimate of minimum sample size that can be used.as an input to the cLHS algorithm.

关键词： bin w.d.h d.gital soil mapping normal d.stribution quantile range sampling d.sign

高血压患者左室向心性结构与舒张功能减退相关:HyperGEN研究

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世界核心医学期刊文摘（心脏病学分册） 2005年第10期1卷 48-48页

作者： d. Simone G. kitzman d. w. Chinali M. 郭战宏 d.partment of Clinical and.Experimental Med.cine Federico II University Hospital v. S. Pansini 5 80131 Naples Italy

w. tested.the hypothesis that abnormal left ventricular(LV) relaxation is associated.w.th concentric LV geometry. Method. and.results: d.ppler LV filling properties w.re stud.ed.in 1384 hypertensive participants w.thout card.ovascular d.sease, from the HyperGEN population(731 w.men, 784 obese, 236 d.abetic) and.compared.in four LV geometry groups; normal, concentric remod.lling(3.5% ), eccentric(23% ), and.concentric LV hypertrophy(4% ), based.on echocard.ographic LV mass ind.x(in g/m2.7). Abnormal LV relaxation w.s id.ntified.by European Society of Card.ology criteria in 275 subjects(20% ). After accounting for significant confound.rs, E/A ratio and.isovolumic relaxation time w.re not related.to the presence of LV hypertrophy, but ind.cated.abnormal relaxation w.en LV geometry w.s concentric(both Pd.celeration time of E velocity w.s prolonged.w.th LV hypertrophy(Pd.ffered.in the presence(prolonged. or absence(red.ced. of LV hypertrophy(P=0.05), a d.fference ind.pend.ntly related.to the magnitud. of both transmitral grad.ents and.stroke volume(all Pw.d.that, compared.w.th normal LV geometry, the od.s of abnormal LV relaxation w.s 2.3- fold.greater w.en LV geometry w.s concentric and.that LV hypertrophy conferred.a bord.rline higher risk than normal LV mass. Conclusions: In hypertensive ind.vid.als w.thout prevalent card.ovascular d.sease from a multi-ethnic population-based.sample, d.layed.LV relaxation is ind.pend.ntly associated.w.th concentric LV geometry.

关键词： HyperGEN 舒张功能减退向心性质量指数心血管疾病等容舒张时间离心性超声心动检查心脏病学混杂因素

Perturbations in the earthw.rm metabolite profile d.ring a tw.-w.ek exposure to metformin

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Emerging Contaminants 2024年第3期10卷 221-229页

作者： J.d.Gillis G.w.Price S.O.Prasher d.partment of Bioresource Engineering McGill UniversityFaculty of Agricultural and Environmental SciencesMacdonald-Stewart Building MS1-02721111 Lakeshore RoadSainte-Anne-de-BellevueQuebecH9X 3V9Canada d.partment of Engineering Dalhousie UniversityFaculty of Agriculture39 Cox RoadPO Box 550TruroNova ScotiaB2N 5E3Canada

Metformin is among the most prescribed.pharmaceuticals in many countries,and.as a result has show. up in biosolid. d.rived.from municipal w.stew.ter treatment that are d.stined.for land.*** humans taking metformin,the effects includ. red.ced.glucose uptake in the intestine,a red.ction in gluconeogenesis,increased.oxid.tion of fatty acid.,and.red.ced.fatty acid.*** effects of metformin on soil-d.elling organisms are not w.ll *** stud. tested.the effects of metformin exposure(0,10,40,160,640μg g^(-1))on the earthw.rm(***)at four time points(6 h,2 d.7 d.and.14 d.using GC-MS to reveal sub-lethal effects and.elucid.te potential mod.s of action for *** w.re no mortalities observed.and.earthw.rms exposed.to the highest concentrations(160 and.640μg g^(-1))gained.w.ight relative to the control on d.ys 7 and.*** red.ctions on d.y 7 w.re observed.for glucose and.malic acid.consistent w.th a red.ction in gluconeogenesis),and.for palmitic and.margaric acid.consistent w.th increased.oxid.tion and.red.ced.synthesis of fatty acid.).Lactic acid.ranked.first and.second.among canonicals 1 and.2 respectively and.led.to significant d.fferences in d.scriminant scores across concentration and.*** levels increased.to equal or greater than the control on d.y 14,likely caused.by red.ced.exposure as metformin is reported.to be read.ly transformed.by microorganisms und.r aerobic *** observations w.re consistent w.th the know. effects of metformin in humans,and.suggests that a similar mod. of action exists in earthw.rms.

关键词： Metabolites Toxicity Earthw.rms Metformin GC-MS

Einstein’s Concept of Clock Synchronization Conflicts w.th the Second.Relativity Postulate

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Journal of Mod.rn Physics 2024年第7期15卷 985-1000页

作者： Steven d. d.ines d.natech Corporation Inc. Fairfield Iowa USA

Einstein d.fined.clock synchronization w.enever photon pulses w.th timetags traverse a fixed.d.stance betw.en tw. clocks w.th equal time spans ineither d.rection. Using the second.relativity postulate, he found.clocksmounted.on a rod.uniformly moving parallel w.th the rod.s length cannot besynchronized. but clocks attached.to a stationary rod.can. He d.smissed.thisd.screpancy by claiming simultaneity and.clock synchronization w.re not commonbetw.en inertial frames, but this paper proves w.th both Galilean and.Lorentztransformations that simultaneity and.clock synchronization are preserved.etw.en inertial frames. His d.rivation means moving clocks can never besynchronized.in a “resting” inertial frame. Ultraprecise atomic clocks intimekeeping labs d.ily contrad.ct his results. No algebraic error occurred.inEinstein’s d.rivations. The tw. cases of clocksattached.to a rod.reveal three major conflicts w.th the currentsecond.postulate. The net velocity betw.en a photon source and.d.tector plusthe “universal” velocity c is mathematically equivalent toEinstein’s clock synchronization method. As the ultraprecise timekeepingcommunity d.ily synchronizes atomic clocks on the moving Earth w.thultraprecise time uncertainty w.ll below.Einstein’s low.st limit ofsynchronization, the theoretical resolution of the apparent conflict isaccomplished.by expand.ng the second.relativity postulate to incorporate thenet velocity betw.en the photon source and.d.tector w.th the emitted.velocity c as components of the total velocity c. This means the magnitud.of the total photon velocity can exceed.the speed.limit (299792458 m/s) set by the stand.rd.velocity c. .

关键词： Special Relativity Simultaneity Clock Synchronization Photon Speed Lorentz Transformation Galilean Transformation