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拉坦前列素、噻吗洛尔治疗日本正常眼压性青光眼患者的疗效对比:3年前瞻性、随机、开放对照研究

世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 46-47页

作者： Tomita G. Araie M. kitazaway. Tsukahara S. 陈立军 Department of Ophthalmology University of Tokyo School of Med. 7-3-1 Hongo Bunkyo ku Tokyo 113-8655 Japan Dr

Purpose. To compare the longitudinal effects of treatment on intraocular pressure (IOP) and visual field performance in Japanese normal tension glaucoma (NTG) between latanoprost and timolol. Pati ents and methods. This is an open label, randomized, study. A total of 62 NTG p atients were prospectively, consecutively enrolled. All study subjects were rand omly assigned to 0.005%latanoprost instillation once daily in the morning or 0. 5%timolol instillation twice daily for a prospective 3 year follow up, and un derwent a routine ocular examination every month. Automated perimetry was perfor med every 6 months using Humphrey field analysers. Stereophotographs of optic di scs were also obtained every 6 months. Results. Percentage of IOP reduction or t he magnitude of IOP reduction showed no intergroup differences either at any tim e point (13-15%). In the visual field, the estimated rate of change in the MD value (dB/year) was-0.34±0.17 (SE) for the latanoprost group, and-0.10±0.18 (SE) for the timolol group. The estimated rate of change in MD showed no signifi cant difference fromzero in both groups, and there were no statistical intergroup differences. No changes in the optic nerve head topography in the vertical cup to disc ratio and rim area measured by imageanalysis techniques were observed in either group. There were no patient s who dropped out due to the side effects of treatment regimens. Conclusion. Bot h latanoprost and timolol single treatments reduced IOP by 13-15%at their trou gh effects for 3 years in Japanese NTG patients; both showed similar effects on visual field performance.

关键词：拉坦噻吗洛尔视野计 Humphrey 垂直杯盘比立体照相常规眼部检查视野分析视神经盘素点

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