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国际医学放射学杂志 2019年第5期 625-626页

作者： k.kitajima M.Okada T.kashiwagi k.Yoshihara T.Tokugawa A.Sawada 赵一婷 Division of Nuclear Medicine and PET Center Department of Radiology Hyogo College of Medicine

摘要目的寻找FDG-PET/CT评估非霍奇金淋巴瘤(NHL)病人放射免疫治疗(RIT)早期治疗反应的最佳时间点。方法共纳入55例病例。所有病人在RIT治疗前1周

关键词：复发/难治非霍奇金淋巴瘤 FDG-PET/CT PET 放射免疫法早期疗效时间点

结直肠癌黏膜下浸润病变中淋巴结转移与浸润深度的相关性:一项日本协作研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 52-53页

作者： kitajima k. Fujimori T. Fuji S. 姜建涛 Dept. of Surgical/Molec. Pathology Dokkyo University School of Medicine 880 Kitakobayashi Mibu Shimotsuga Tochigi 321-0293 Japan

Background. Depth of submucosal invasion (SM depth) in submucosal invasive colorectal carcinoma (SICC) is considered an important predictive factor for lymph node ***, no nationwide reports have clarified the relationship between SM depth and rate of lymph node metastasis. Our aim was to investigate the correlations between lymph node metastasis and SM depth in SICC. Methods. SM depth was measured for 865 SICCs that were surgically resected at six institutions throughout Japan. For pedunculated SICC, the level 2 line according to Haggitt s classification was used as baseline and the SM depth was measured from this baseline to the deepest portion in the submucosa. When the deepest portion of invasion was limited to above the baseline, the case was defined as a head invasion. For nonpedunculated SICC, when the muscularis mucosae could be identified, the muscularis mucosae was used as baseline and the vertical distance from this line to the deepest portion of invasion represented SM *** the muscularis mucosae could not be identified due to carcinomatous invasion, the superficial aspect of the SICC was used as baseline, and the vertical distance from this line to the deepest portion was determined. Results. For pedunculated SICC, rate of lymph node metastasis was 0% in head invasion cases and stalk invasion cases with SM depth < 3000 μ if lymphatic invasion was negative. For nonpedunculated SICC, rate of lymph node metastasis was also 0% if SM depth was < 1000μ . Conclusions. These results clarified rates of lymph node metastasis in SICC according to SM depth, and may contribute to defining therapeutic strategies for SICC.

关键词：结直肠癌浸润深度淋巴结转移协作研究黏膜肌层垂直距离医疗机构

FDG-PET/增强CT作为头颈部鳞状细胞癌治疗后评估工具:FDG-PET/平扫及增强CT比较

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国际医学放射学杂志 2016年第3期 332-333页

作者： Y.Suenaga k.kitajima T.Ishihara R.Sasaki N.Otsuki k.Nibu 罗松 Department of Radiology Kobe University Graduate School of Medicine

摘要目的评估静脉注射18F-脱氧葡萄糖(FDG)增强PET/CT对怀疑复发头颈部鳞状细胞癌(HNSCC)的准确性。材料与方法 170例治疗过的HNSCC病人行PET/CT,包括平扫和增强CT,以诊断可能的复发。PET/增强CT(PET/ce CT),PET/平扫CT(PET/nc CT)和ce... 详细信息

摘要目的评估静脉注射18F-脱氧葡萄糖(FDG)增强PET/CT对怀疑复发头颈部鳞状细胞癌(HNSCC)的准确性。材料与方法 170例治疗过的HNSCC病人行PET/CT,包括平扫和增强CT,以诊断可能的复发。PET/增强CT(PET/ce CT),PET/平扫CT(PET/nc CT)和ce CT对原位、局部复发、远处转移、总复发和第2原发癌进行评价。参考标准包括组织病理

关键词： PET 头颈部 FDG-PET 鳞状细胞癌 CT 平扫

诊断侵袭性前置胎盘新的MRI表现:与65例病人临床和组织病理学的相关性评价

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国际医学放射学杂志 2014年第3期 303-304页

作者： Y .Ueno k.kitajima F.kawakami T.Maeda Y.Suenaga S.Takahashi 王鹤 Department of Radiology Kobe University Graduate School of Medicine7-5-2 Kusunoki-choChuo-kuKobe 650-0017Japan

摘要目的复习侵袭性前置胎盘的原有MRI诊断标准,并描述一种新的MRI表现。方法回顾性复习65例病人(年龄中位数为35岁)产前筛查侵袭性前置胎盘的MR影

关键词：前置胎盘分娩合并症侵袭性 MRI 病人

长期重度溃疡性结肠炎患者肠道非肿瘤上皮的雌激素受体基因甲基化可预示结肠直肠癌肿瘤的发生

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世界核心医学期刊文摘（胃肠病学分册） 2006年第1期2卷 38-38页

作者： Fujii S. Tominaga k. kitajima k. T. Fujimori 廖新华 Department of Surgical and Molecular Pathology Dokkyo University School of Medicine 880 Kitakobayashi Mibu Shimotsuga Tochigi 321-0293 Japan Dr.

Background: Surveillance colonoscopy is widely recommended in patients with longstanding and extensive ulcerative colitis (UC) in order to detect colorectalneoplasia at an early stage. However, it still remains questionable whether surveillance colonoscopy effectively enables early detection of UC associated neoplasia. There is a great need for sensitive markers to identify individuals at increased risk of neoplasia. The oestrogen receptor (OR) gene shows age related methylation in the colorectal epithelium and is methylated frequently in sporadic colorectal neoplasia, suggesting that OR methylation may predispose to colorectal neoplasia. Aim: To clarify whether analysis of methylation of the OR gene in non-neoplastic epithelium can contribute to prediction of increased neoplasia risk in UC patients. Materials and methods: Atotal of 165 non-neoplastic colorectal epithelia from 30 patients with longstanding and extensive UC, including 13 UC patients with neoplasia and 17 patients without, were evaluated. Methylation specific polymerase chain reaction was performed to determine the methylation status of the OR gene. Results: Methylation of the OR gene was detected in 54 of 70 (77.1% ) non-neoplastic colorectal epithelia in UC with neoplasia but in only 23 of 95 (24.2% ) without neoplasia. Methylation of the OR gene was significantly more frequent in non-neoplastic epithelium from UC with neoplasia than in chronic colitic epithelium from UC without neoplasia. Furthermore, in UC with neoplasia, the OR gene was extensively methylated in non-neoplastic epithelia throughout the colorectum compared with those in UC without neoplasia. Conclusion: These results suggest that analysis of OR gene methylation may have potential as a useful marker for identifying individuals at increased risk of neoplasia among those with longstanding and extensive UC.

关键词：溃疡性结肠炎结肠直肠癌雌激素受体基因甲基化纤维结肠镜早期癌变非肿瘤患者

在子宫癌病人联合应用FDG-PET和增强CT成像对检出盆腔与主动脉旁淋巴结转移的准确性

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国际医学放射学杂志 2009年第4期32卷 415-415页

作者： k. kitajima k. Murakami E. Yamasaki Y. kaji k. Sugimura 杨秀娟（译）刘筠（校） Department of Radiology Dokkyo University School of Medicine 880 Kita-kobayashi Mibu Shimotuka-gun Tochigi 321- 0293 Japan. 不详

本研究的目的是以外科手术和组织病理为标准,评估联合应用18FFDG—PET／增强CT成像对检出子宫癌病人盆腔与主动脉旁淋巴结转移的准确性。45例子宫内膜癌或宫颈癌的病人行PET／CT检查后,行子宫根治术,包括盆腔淋巴结清扫伴或不伴主动脉... 详细信息

本研究的目的是以外科手术和组织病理为标准,评估联合应用18FFDG—PET／增强CT成像对检出子宫癌病人盆腔与主动脉旁淋巴结转移的准确性。45例子宫内膜癌或宫颈癌的病人行PET／CT检查后,行子宫根治术,包括盆腔淋巴结清扫伴或不伴主动脉旁淋巴结切除。PET／CT表现由2位有经验的放射医生解释,并达成一致意见。在PET／CT影像上．以淋巴结示踪剂摄取的增加而非淋巴结的大小作为判断恶性标准。以淋巴结为单位,PET／CT检测淋巴结转移的总体敏感度、

关键词：子宫癌淋巴结转移 FDG PET/CT

平扫T1加权MR成像上齿状核和苍白球高信号:与增加的钆类对比剂的累积剂量的关系

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国际医学放射学杂志 2014年第3期 277-277页

作者： T.kanda k.Ishii H.kawaguchi k.kitajima D.Takenaka 许玉峰 Department of Radiology Teikyo University School of MedicineItabashi2-11-1 KagaItabashi-kuTokyo 173-8605Japan

摘要目的研究既往钆类对比剂注射次数和平扫T1加权MR成像上齿状核和苍白球高信号强度(SI)的相关性。方法本研究由机构审查委员会批准,免除书面知情同意通知。

关键词：苍白球齿状核丘脑 SI 间脑对比剂 T1 MR 平扫

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FDG-PET/CT诊断子宫颈癌复发

国际医学放射学杂志 2008年第A6期31卷 517-517页

作者： k.kitajima k.Murakami E.Yamasaki Y.Domeki Y.kaji k.Sugimura 成丽娜 Departments of Radiology Dokkyo University School of Medicine 880 Kita-kobayashiMibu Shimotka-gun Tochigi 321-0293 Japan.

评价FDG-PET/CT、PET单独诊断可疑子宫颈癌复发的准确性。52例女性病人经组织病理学证实为宫颈癌并经过治疗,因可疑复发进行PET/CT检查。

关键词：子宫颈癌肿瘤复发 18F-FDG-PET/CT

Induction of antitumor immunity against mouse carcinoma by baculovirus-infected dendritic cells

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Cellular & Molecular Immunology 2010年第6期7卷 440-446页

作者： Tomoyuki Suzuki Myint Oo Chang Masayuki kitajima Hiroshi Takaku Department of Life and Environmental Sciences Chiba Institute of TechnologyChibaJapan High Technology Research Center Chiba Institute of TechnologyChibaJapan Immunology Program Benaroya Research InstituteSeattleWAUSA

A dendritic cell(DC)vaccine strategy has been developed as a new cancer immunotherapy,but the goal of complete tumor eradication has not yet been *** have previously shown that baculoviruses potently infect DCs and induce antitumor immunity against hepatomas in a mouse ***-infected,bone marrow-derived DCs(BMDCs)display increased surface expression of costimulatory molecules,such as CD80,CD86 and major histocompatibility complex(MHC)classes I and II,and secrete interferons and other proinflammatory *** this study,we evaluated the induction of antitumor immunity in mice by baculovirus-infected BMDCs against lung cancer and *** treatment with baculovirus-infected BMDCs,murine lung tumors caused by Lewis lung carcinoma(LLC)cells were significantly reduced in size,and the survival of the mice was *** addition,experiments using a melanoma mouse model showed that baculovirus-infected BMDCs inhibited tumor growth and improved survival compared with *** alanine aminotransferase(ALT),aspartate aminotransferase(AST)and creatinine levels remained normal in baculovirus-infected BMDC-treated *** findings show that baculovirus-infected DCs induce antitumor immunity and pave the way for the use of this technique as an effective tool for DC immunotherapy against malignancies.

关键词： dendritic cells natural killer cells T cells tumor Immunity