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Journal of Clinical and Nursing Research 2024年第4期8卷 264-283页

作者： kirubanandan shanmugam Independent Research Professional ChennaiIndia

Enzyme inhibition therapy uses specific molecules to inhibit enzyme activity, targeting disease-related enzymes in medical treatments like cancer treatment and infectious disease management. Different types of inhibitors, competitive and non-competitive, bind to different sites and alter enzyme function. The success of this therapy depends on the inhibitor’s specificity and delivery to the target site. Further research could lead to more effective treatments. Nowadays, the majority of medications are enzyme inhibitors and are in the clinical or pre-clinical stages of drug development. Enzyme inhibitors are often prescribed medications for a variety of illnesses, including neurological problems. There is only symptomatic therapy available for many neurological conditions, particularly neuro-degenerative disorders, as opposed to therapy based on knowledge of the underlying mechanisms of these diseases. Enzyme inhibitors are useful as they block the function of certain enzymes whose aberrant activity could be contributing to the illness. They also alleviate the symptoms and stop the disease’s progression. This review discusses the mechanism of action of several enzyme inhibitors that have been prescribed as medications for neurological illnesses as well as some that are still in research stages.

关键词： Enzyme inhibitors Neurology Mechanism of action Enzymes

Utilization Management:Walking the Line Between Patient Needs and Healthcare Economics-Short Communication

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Journal of Clinical and Nursing Research 2024年第9期8卷 152-158页

作者： kirubanandan shanmugam Independent Research Professional ChennaiIndia

Utilization management plays a crucial role in healthcare by optimizing resource allocation,improving patient outcomes,and effectively controlling *** balancing patient needs with economic considerations,healthcare institutions can ensure efficient and sustainable service *** management encompasses various strategies,including prior authorization,concurrent review,and clinical pathways,to enhance care quality,manage expenses,and streamline resource *** benefits of utilization management include cost containment,improved care standards,and the implementation of consistent treatment guidelines,thereby increasing the overall efficiency and effectiveness of healthcare delivery.

关键词： Utilization management Patient outcomes Cost control Clinical pathways Care standards

Tissue Regeneration in Infected Wounds of Albino Rats Using Ciprofloxacin-Loaded Gelatin Microspheres Incorporated Collagen Scaffold: A Histological Approach with H&E Staining

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Journal of Clinical and Nursing Research 2024年第5期8卷 156-168页

作者： kirubanandan shanmugam Independent Research Professional Chennai 600116India

A wound care system consisting of ciprofloxacin-loaded gelatin microspheres impregnated in a macroporous collagen scaffold was created to effectively control wound infection and regenerate soft tissue at the wound *** and biochemical alterations were observed in infected wounds treated with these scaffolds in Albino Wistar ***,the study examined the immediate and prolonged release of ciprofloxacin from the scaffolds,as well as their function in eliminating bacterial infections and expediting the process of skin healing and *** developed technique was followed in the streamlined process of creating these collagen *** to untreated wounds,the group receiving scaffold treatment experienced a faster rate of wound *** was noted that the rate of infections was considerably reduced and that full soft tissue regeneration occurred within 12 *** development of well-deposited collagen bundles in the treated groups was demonstrated by H&E staining,which verified the flawless regeneration of the dermis and *** antimicrobial agent-loaded gelatin microspheres impregnated into the porous collagen scaffold demonstrated remarkable soft tissue regeneration and efficient infection control at the wound site.

关键词： Gelatin microspheres Collagen Controlled release Wound healing

Nanobioceramics for Tissue Engineering Application

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Journal of Clinical and Nursing Research 2024年第6期8卷 359-372页

作者： kirubanandan shanmugam Independent Research Scholar ChennaiIndia

Nanobiomaterials demonstrate great potential in bone and dental tissue *** materials mimic the natural extracellular matrix in the human body,promoting the controlled release of growth factors and other bioactive molecules to enhance tissue regeneration and *** mimic the structure and composition of natural bone.A major challenge in hard tissue healing is creating scaffolds that incorporate stem cells for bone tissue *** and implants for regenerative medicine should be designed using computer-aided design(CAD)and three-dimensional(3D)printing to replicate the tissue's anatomical *** studies should examine the relationship between the size of bioceramics and biological *** more interacting nature of nanoceramics better triggers the cellular processes,facilitating the regeneration of calcified *** and osteoclasts are crucial in the development and maintenance of calcified tissue in vivo,and nanoceramics enhance the functionality of orthopedic and dental implants.

关键词： Nanobioceramics Bone repair Orthopedic and dental application

Fabrication of Free Standing Nanocellulose Film via Spray Coating and its Biomedical Application: A Review

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Journal of Clinical and Nursing Research 2024年第4期8卷 411-447页

作者： kirubanandan shanmugam Independent Research Professional ChennaiIndia

Spraying nanocellulose onto films provides a quick and scalable way to create free-standing films with exceptional consistency and customizable thickness. This method increases the application of nanocellulose films in various industries and satisfies the requirements of large-scale production. In the field of biomedicine, spray-coated free-standing nanocellulose films hold great promise for applications such as drug delivery, tissue engineering, wound healing, device coatings, and biosensing. They are excellent nanomaterials for a variety of biomedical applications due to their special qualities, including biocompatibility, high mechanical strength, porous structure, large surface area, and adaptability. This paper reviewed the detailed exposure of the spray coating process of nanocellulose suspension onto free- standing films and its biomedical applications.

关键词： Spraying Nanocellulose Film Free Standing Film Thickness Basis weight

3D Collagen Gels:A Promising Platform for Dendritic Cell Culture in Biomaterials Research

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Proceedings of Anticancer Research 2024年第4期8卷 124-134页

作者： kirubanandan shanmugam Independent Research Scholar ChennaiIndia.

The three-dimensional(3D)cell culture system has garnered significant attention in recent years as a means of studying cell behavior and tissue development,as opposed to traditional two-dimensional *** systems can induce specific cell reactions,promote specific tissue functions,and serve as valuable tools for research in tissue engineering,regenerative medicine,and drug *** paper discusses current developments in the field of three-dimensional cell culture and the potential applications of 3D type 1 collagen gels to enhance the growth and maturation of dendritic cells.

关键词： Three-dimensional cell culture Dendritic cells Type 1 collagen gels Bovine tendons and rat tails

Ultrasonic-Assisted Extraction of Fucoxanthin from Marine Macroalga Padina australis:Optimization,Bioactivity,and Structural Characterization

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Proceedings of Anticancer Research 2024年第5期8卷 89-104页

作者： L.Antony Catherine Flora kirubanandan shanmugam Renganathan Sahadevan Department of Chemical Engineering Alagappa College of TechnologyAnna UniversityChennai 600025India Independent Research Professional ChennaiTamil NaduIndia Department of Biotechnology Alagappa College of TechnologyAnna UniversityChennai 600025India

Macroalgae serve as a potential feedstock for fucoxanthin ***,a bioactive pigment found in the chloroplasts of marine algae,exhibits significant pharmacological *** a member of the carotenoid family,fucoxanthin plays a crucial role in both the food and pharmaceutical *** research explores the effects of ultrasonics on the extraction of fucoxanthin from the marine macroalga Padina *** addition,various extraction techniques and the influence of solvents on the efficient separation of fucoxanthin from algae have been studied and *** methanol,chloroform,and a combination of methanol and chloroform(1:1,v/v),conventional fucoxanthin extraction from Padina australis yielded 8.12 mg of fucoxanthin per gram of ***,the ultrasonic-assisted extraction resulted in a significantly higher yield of 16.9 mg of fucoxanthin per gram of biomass,demonstrating that the use of ultrasonics enhances the extraction rate compared to conventional ***,the efficient separation of fucoxanthin from Padina australis is highly dependent on ultrasonic-assisted *** process conditions for the extraction were optimized to maximize the yield of fucoxanthin from *** following parameters were selected for optimization studies:moisture content,particle size,mixing speed,extraction temperature,extraction duration,and solid-to-solvent *** extracted fucoxanthin exhibited various biological activities,including antimicrobial and antioxidant properties,and its structure was elucidated through FTIR and NMR ***,thin-layer chromatography of the crude algae extracts confirmed the presence of fucoxanthin in the marine *** these findings,the optimized extraction process holds the potential for scaling up to large-scale fucoxanthin ***,as a potent pharmacological agent,offers promising applications in the treatment of various ailments.

关键词： Marine algae Fucoxanthin Ultrasonics Extraction Optimization TLC DPPH Antimicrobial antioxidant activities

Anti-Diabetic Activity of an Extract of Syzygium Jambolanum - A Review

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Journal of Clinical and Nursing Research 2024年第3期8卷 220-231页

作者： kirubanandan shanmugam Independent Research Professional ChennaiTamil NaduIndia

Syzygium jambolanum is a promising natural treatment for *** potential benefits of S jambolanum for diabetes include lowering blood sugar levels,increasing insulin sensitivity,protecting pancreatic beta cells,and slowing the absorption of glucose into the *** anti-diabetic activity of the crude extract of S jambolanum was evaluated in L6 myotubes and the lipid deposition in tissue was measured using Nile red *** red staining confirmed that a considerable quantity of lipids had been deposited in the tissue treated with a crude extract of S jambolanum,comparable to the quantity of lipids deposited with a standard drug known as *** study analyzed the anti-diabetic activity of a crude extract of S jambolanum to understand its potential as a feedstock for extracting bioactive constituents to screen for bioactive molecules in the treatment of diabetes.

关键词： Syzygium jambolanum L6 myoblasts Column chromatography Nile red staining

Biosynthesis of Copper Nanoparticles using an Extract of the root of Asparagus racemosus:Basic Synthesis,Antimicrobial,and Anti-oxidant Potentials

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Journal of Clinical and Nursing Research 2024年第2期8卷 137-148页

作者： Subha Veeramani kirubanandan shanmugam National Centre for Nano science and Nanotechnology University of MadrasGuindy CampusChennai 600025.India. Saveetha School of Engineering SIMATSThandalamChennai 602105India

Copper nanoparticles(CuNPs)have emerged as a promising alternative due to their unique antimicrobial *** synthesis of CuNPs using Asparagus racemosus,commonly known as Shatavari,offers a sustainable and environmentally friendly approach to producing ***,the resulting CuNPs have been found to possess excellent antibacterial,and antioxidant properties,which further expands their potential applications in medicine and environmental *** this article,we discussed the in vitro characterization of the *** vitro studies revealed that CuNPs have the potential for biomedical applications and as a base nanomaterial for the construction of drug delivery and targeting vehicles.

关键词： Copper nanoparticles Green Synthesis Asparagus racemosus Antimicrobial and antioxidant activities

Evaluation of Phytochemical Analysis and Total Phenol Content of Proso Millet and Barnyard Millet

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Proceedings of Anticancer Research 2024年第2期8卷 13-19页

作者： Deepa Priya Ramadoss kirubanandan shanmugam Department of Biotechnology School of BioengineeringSRM Institute of Science and TechnologyKattankulathur 603203KancheepuramTamil NaduIndia Independent Research Professional ChennaiTamil NaduIndia

Whole grains of proso and barnyard millets were sequentially extracted using different solvents(hexane,chloroform,ethyl acetate,and methanol).Phytochemical analysis was performed qualitatively,and the total phenolic content in the extracts of proso and barnyard millets was *** and cardiac glycosides were identified in all solvent extracts of both *** and glycosides yielded negative results in all solvent extracts of both *** all the solvent extracts,methanol extracts of proso and barnyard millets showed the presence of major compounds such as flavonoids,terpenoids,amino acids,tannins,and phenolics *** maximum amount of phenols was found in methanolic extracts of proso and barnyard millets(0.669±0.003 and 0.625±0.003),followed by the chloroform extract of proso and barnyard millets(0.284±0.002 and 0.257±0.003).The minimum amount of phenolics was found in the acetone extract of proso and barnyard *** methanol extract of both millets showed the presence of major compounds with high phenolic content.

关键词： Proso millet Barnyard millet Sequential solvent extraction Phytochemical analysis Total phenolic content