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Sustainability assessment of solar drying systems:a comparative life-cycle analysis of phase-change material-based *** solar dryers

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Clean Energy 2024年第4期8卷 183-196页

作者： Nakum Divyangkumar kirtika sharma N.L.Panwar Gande Saichandhu Department of Renewable Energy Engineering Maharana Pratap University of Agriculture and TechnologyUdaipur(Rajasthan)313001India Environmental Management Jawaharlal Nehru University TechnologyHyderabadIndia

Solar drying systems are becoming a popular alternative to traditional energy-based drying systems for agricultural products due to their effectiveness and reduced fuel *** the efficiency of solar drying systems has been thoroughly investigated,their sustainability has not been studied *** study aims to fill that gap by conducting a life-cycle assessment of two new solar drying systems built in Udaipur,Rajasthan,*** environmental implications of an innovative cylindrical solar-assisted drying system and a phase-change material-based solar drying system were evaluated using cradle-to-gate life-cycle *** study uses the ReCiPe 2016 endpoints(H)technique to calculate various aspects such as midpoint,endpoint,single score,normalization result,and network diagram for phase-change material-based solar drying and cylindrical solar-assisted *** show that phase-change material-based solar drying has an average of 40%more impact on the environment than cylindrical solar-assisted drying,with a high impact found in human non-carcinogenic toxicity,mainly due to the production of phase-change ma***,cylindrical solar-assisted drying system crossover phase-change material based solar drying in terms of its impact on human carcinogenic toxicity and fossil resource *** contribution to global warming of phase-change material-based solar drying is 13.7%more than that of cylindrical solar-assisted *** endpoint characterization indicates that phase-change material-based solar drying exceeds in terms of human health(40%)and ecosystem(37.04%),whereas cylindrical solar-assisted drying surpasses phase-change material-based solar drying in terms of impacts on resources,at 14%.The early drying in phase-change material-based solar drying makes up for its higher impact than that in cylindrical solar-assisted drying,which takes 3 hours longer to *** study offers guidance and methods for making the best choice of

关键词： solar drying cylindrical hybrid solar dryer PCM-based solar dryer life-cycle assessment ReCiPe method impact assessment

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BACE1 inhibitors:A promising therapeutic approach for the management of Alzheimer’s disease

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Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 369-381页

作者： Richa Arya Smita Jain Sarvesh Paliwal kirtika Madan Swapnil sharma Achal Mishra Prashant Tiwari Sunil Kumar Kadiri Banasthali University Banasthali-304022(Raj.)India Department of Pharmacy Guru Ghasidas VishwavidyalayaBilaspurChhattisgarh-495009India Department of Pharmacology College of Pharmaceutical SciencesDayananda Sagar UniversityBengaluru-560111India

Alzheimer’s disease is a neurological disorder marked by the accumulation of amyloid beta(Aβ)aggregates,resulting from mutations in the amyloid precursor *** enzymeβ-secretase,also known asβ-site amyloid precursor protein cleaving enzyme 1(BACE1),plays a crucial role in generating Aβ*** no targeted therapy available for Alzheimer’s disease,inhibiting BACE1 aspartic protease has emerged as a primary treatment *** 1999,compounds demonstrating potential binding to the BACE1 receptor have advanced to human *** optimization of synthetically derived compounds,coupled with computational approaches,has offered valuable insights for developing highly selective leads with drug-like *** review highlights pivotal studies on the design and development of BACE1 inhibitors as anti-Alzheimer’s disease *** summarizes computational methods employed in facilitating drug discovery for potential BACE1 inhibitors and provides an update on their clinical status,indicating future directions for novel BACE1 *** promising clinical results of Elenbecestat(E-2609)catalyze the development of effective,selective BACE1 inhibitors in the future.

关键词： BACE1 inhibitors Amyloid precursor protein β-secretase Structure-based drug design 3D-QSAR β-amyloid precursor protein

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