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A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER+breast cancer cells

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Microsystems & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ortega Quesada Jonathan Cuccia Rachael Coates Blake Nassar Ethan littlefield Elizabeth C.Martin Adam t.Melvin Cain Department of Chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of Chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA Department Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metastatic breast cancer leads to poor prognoses and worse outcomes in patients due to its invasive behavior and poor response to *** is still unclear what biophysical and biochemical factors drive this more aggressive phenotype in metastatic cancer;however recent studies have suggested that exposure to fluid shear stress in the vasculature could cause *** this study a modular microfluidic platform capable of mimicking the magnitude of fluid shear stress(Fss)found in human vasculature was designed and *** device provides a platform to evaluate the effects of Fss on MCF-7 cell line,an estrogen receptor positive(ER+)breast cancer cell line,during circulation in the *** of the effects of Fss on MCF-7 cells was carried out utilizing two approaches:single cell analysis and bulk *** single cell analysis,cells were trapped in a microarray after exiting the serpentine channel and followed by immunostaining on the device(on-chip).Bulk analysis was performed after cells were collected in a microtube at the outlet of the microfluidic serpentine channel for western blotting(off-chip).It was found that cells exposed to an Fss magnitude of 10 dyn/cm^(2) with a residence time of 60 s enhanced expression of the proliferation marker Ki67 in the MCF-7 cell line at a single cell *** understand possible mechanisms for enhanced Ki67 expression,on-chip and off-chip analyses were performed for pro-growth and survival pathways ERK,AKt,and JAK/*** demonstrated that after shearing the cells phosphorylation of p-AKt,p-mtOR,and p-stAt3 were ***,there was no change in p-ERK1/*** is a mediator of ER rapid signaling,analysis of phosphorylated ERαwas carried out and no significant differences between sheared and non-sheared populations were *** together these results demonstrate that Fss can increase phosphorylation of proteins associated with a more aggressive phenotype in circulating cancer *** findin

关键词： fluid breast estrogen

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盖瑟勒公司的产品:被美军特战司令部选为Mk1ModO狙击步枪

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轻兵器 2024年第1期 14-21页

作者： lb 不详

2023年9月29日,美军宣布盖瑟勒(Geissele)公司中标“中距离导气枪械-狙击型”步枪,美军特战司令部赋予该枪编号“Mk1Modo”,合同价值约2926.3万美元。MklModo步枪源于何枪?有哪些创新之处?

关键词：狙击步枪合同价值瑟勒创新之处司令部中距离

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sANC Monte Carlo programs for small-angle Bhabha scattering

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Chinese Physics C 2024年第4期48卷 14-19页

作者： A.B.Arbuzov s.G.Bondarenko I.R.Boyko l.V.Kalinovskaya A.A.Kampf R.R.sadykov V.l.Yermolchyk Bogoliubov laboratory of theoretical Physics JINRDubna141980 Russia Dzhelepov laboratory of Nuclear Problems JINRDubna141980 Russia Dubna state University Dubna141982 Russia

luminosity monitoring at e^(+)e^(−)colliders was investigated using sANC Monte Carlo event generator RenesANCe and integrator MCsANC for simulation of Bhabha scattering at low *** are presented for center-of-mass energies of the Z boson resonance and at 240 GeV for the conditions of typical luminosity *** is shown that bremsstrahlung events with extremely low electron scattering angles are relevant to match the precision tags of future electron-positron colliders.

关键词： luminosity Bhabha scattering QED Monte Carlo simulation

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stCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai l.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.t.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen l.l.Chen P.Chen s.l.Chen s.M.Chen s.Chen s.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng s.Cheng t.G.Cheng J.P.Dai l.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding l.Y.Dong W.H.Dong V.Druzhinin D.s.Du Y.J.Du Z.G.Du l.M.Duan D.Epifanov Y.l.Fan s.s.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.t.Feng J.l.Fu J.Gao Y.N.Gao P.s.Ge C.Q.Geng l.s.Geng A.Gilman l.Gong t.Gong B.Gou W.Gradl J.l.Gu A.Guevara l.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.l.Han l.Han M.Han X.Q.Hao J.B.He s.Q.He X.G.He Y.l.He Z.B.He Z.X.Heng B.l.Hou t.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.s.Huang J.s.Huang M.Huang Q.Y.Huang W.Q.Huang X.t.Huang X.J.Huang Y.B.Huang Y.s.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia s.Jia Z.K.Jia H.B.Jiang J.Jiang s.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.l.Kang X.s.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.lei E.levichev C.H.li C.li D.Y.li F.li G.li G.li H.B.li H.li H.N.li H.J.li H.l.li J.M.li J.li l.li l.li l.Y.li N.li P.R.li R.H.li s.li t.li W.J.li X.li X.H.li X.Q.li X.H.li Y.li Y.Y.li Z.J.li H.liang J.H.liang Y.t.liang G.R.liao l.Z.liao Y.liao C.X.lin D.X.lin X.s.lin B.J.liu C.W.liu D.liu F.liu G.M.liu H.B.liu J.liu J.J.liu J.B.liu K.liu K.Y.liu K.liu l.liu Q.liu s.B.liu t.liu X.liu Y.W.liu Y.liu Y.l.liu Z.Q.liu Z.Y.liu Z.W.liu I.logashenko Y.long C.G.lu J.X.lu N.lu Q.F.lü Y.lu Y.lu Z.lu P.lukin F.J.luo t.luo X.F.luo Y.H.luo H.J.lyu X.R.lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas s.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov s.l.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng l.Peng X.Y.Peng X.J.Peng K.Peters s.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin l.Q.Qin X.s.Qin t.l.Qiu J.Rademacker C.F.Redmer H.Y.sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAs Key laboratory of theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central south University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and technology Xuzhou 221116China École Polytechnique Fédérale de lausanne(EPFl) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher school of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of science and technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

the superτ-charm facility(stCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** stCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the standard *** stCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the stCF,describes conceptual designs of the stCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity stCF detector conceptual design

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Metrology for sub-Rayleigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

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High Power laser science and Engineering 2024年第3期12卷 90-105页

作者： E.A.Vishnyakov A.sagisaka K.Ogura t.Zh.Esirkepov B.Gonzalez-Izquierdo C.D.Armstrong t.A.Pikuz s.A.Pikuz W.Yan t.M.Jeong s.singh P.Hadjisolomou O.Finke G.M.Grittani M.Nevrkla C.M.lazzarini A.Velyhan t.Hayakawa Y.Fukuda J.K.Koga M.Ishino K.Kondo Y.Miyasaka A.Kon M.Nishikino Y.V.Nosach D.Khikhlukha I.P.tsygvintsev D.Kumar J.Nejdl D.Margarone P.V.sasorov s.Weber M.Kando H.Kiriyama Y.Kato G.Korn K.Kondo s.V.Bulanov t.Kawachi A.s.Pirozhkov ElI Beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon science(KPsI) QSTKyotoJapan Central laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and transdisciplinary Research Initiatives Osaka UniversityOsakaJapan HB11 Energy Holdings FreshwaterAustralia Key laboratory for laser Plasmas(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFsA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Physics AsCR PragueCzech Republic FZU-Institute of Physics AsCR PragueCzech Republic Czech technical University in Prague FNSPEPragueCzech Republic Institute of laser Engineering Osaka UniversityOsakaJapan Institute of Physics National Academy of Sciences of UkraineKyivUkraine IstEQ AR YerevanArmenia

tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a~10^(22)W/cm^(2)laser±plasma *** used nearly 10 J total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy(i.e.,around half of the short Rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-rays

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德国特种部队新手枪:瓦尔特PDP

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轻兵器 2024年第10期 22-26页

作者： lb

2024年5月,德国国防军宣布卡尔·瓦尔特公司的PDP手枪赢得德国陆军特种部队(KsK)和海军特种部队(KsM)的“特种部队手枪系统”(system Pistole spezialkrafte)竞标合约。德国国防军采用的2款PDP手枪枪管长分别为114mm、102mm,依次赋予编... 详细信息

2024年5月,德国国防军宣布卡尔·瓦尔特公司的PDP手枪赢得德国陆军特种部队(KsK)和海军特种部队(KsM)的“特种部队手枪系统”(system Pistole spezialkrafte)竞标合约。德国国防军采用的2款PDP手枪枪管长分别为114mm、102mm,依次赋予编号P14、P14K。

关键词： PDP 德国国防军瓦尔特特种部队

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巴西陶鲁斯“第一”:“远征”(Expedition)栓动步枪

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轻兵器 2024年第9期 14-17页

作者： lb 不详

2024年1月,陶鲁斯美国公司在拉斯维加斯举办的2024年sHOt show上推出陶鲁斯“远征”栓动步枪,这是公司第一支栓动步枪——陶鲁斯公司溯源陶鲁斯公司是一家巴西综合企业,总部位于巴西南里奥格兰德州圣利奥波尔杜。该公司最初是一家锻造厂... 详细信息

2024年1月,陶鲁斯美国公司在拉斯维加斯举办的2024年sHOt show上推出陶鲁斯“远征”栓动步枪,这是公司第一支栓动步枪——陶鲁斯公司溯源陶鲁斯公司是一家巴西综合企业,总部位于巴西南里奥格兰德州圣利奥波尔杜。该公司最初是一家锻造厂(taurus Forge,Forjas taurus ltda.——葡萄牙语)。

关键词：锻造厂陶鲁拉斯维加斯美国公司巴西步枪

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Ion heat transport in electron cyclotron resonance heated l-mode plasma on the t-10 tokamak

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Plasma science and technology 2024年第4期26卷 52-60页

作者： V.A.KRUPIN M.R.NURGAlIEV A.R.NEMEts I.A.ZEMtsOV s.D.sUNtsOV t.B.MYAltON D.s.sERGEEV N.A.sOlOVEV D.V.sARYCHEV D.V.RYJAKOV s.N.tUGARINOV N.N.NAUMENKO National Research Centre“Kurchatov Institute” Moscow 123182Russia Bauman Moscow state technical University Moscow 105005Russia Institution“Project Center ItER” Moscow 123098Russia JsC“sOlAR” Minsk 220034Belarus

Anomalous ion heat transport is analyzed in the t-10 tokamak plasma heated with electron cyclotron resonance heating(ECRH) in second-harmonic extra-ordinary mode. Predictive modeling with empirical scaling for Ohmical heat conductivity shows that in ECRH plasmas the calculated ion temperature could be overestimated, so an increase of anomalous ion heat transport is required. to study this effect two scans are presented: over the EC resonance position and over the ECRH power. the EC resonance position varies from the high-field side to the low-field side by variation of the toroidal magnetic field. the scan over the heating power is presented with on-axis and mixed ECRH regimes. Discharges with high anomalous ion heat transport are obtained in all considered regimes. In these discharges the power balance ion heat conductivity exceeds the neoclassical level by up to 10 times. the high ion heat transport regimes are distinguished by three parameters: the ratio te/ti, the normalized electron density gradient R/■, and the ion–ion collisionality νii~*. the combination of high te/ti, high νii~*, and R/■=6-10 results in values of normalized anomalous ion heat fluxes up to 10 times higher than in the low transport scenario.

关键词： tokamak l-mode electron cyclotron resonance heating ion heat transport

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再获军方订单:德国G210短程狙击步枪

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轻兵器 2024年第11期 16-19页

作者： lb 不详

2024年8月24日,德国HK公司发布公告,公司与德国联邦国防军签署协议,为后者提供500支G210短程狙击步枪(scharfsch u tzengewehr kurze Reichweite,缩写为sschtzWa kRW)。这是继今年4月德国国防军特种部队采购HK公司G39sD步枪后,HK公司再... 详细信息

2024年8月24日,德国HK公司发布公告,公司与德国联邦国防军签署协议,为后者提供500支G210短程狙击步枪(scharfsch u tzengewehr kurze Reichweite,缩写为sschtzWa kRW)。这是继今年4月德国国防军特种部队采购HK公司G39sD步枪后,HK公司再次获得德国军方订单.

关键词：狙击步枪特种部队德国联邦国防军德国国防军 G2 订单

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史册记忆:史密斯-韦森M1854杠杆枪机式步枪

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轻兵器 2024年第5期 26-30页

作者： lb 不详

杠杆枪机式步枪,美国西部开拓时期的象征作为美国枪械发展史上最经典的设计之一,杠杆枪机式步枪伴随着美国西部开拓的历史,它的形象通过西部影片传遍世界。现今,尽管杠杆枪机式步枪已经退出历史舞台的中央,但在民间市场仍拥有一部分拥趸。

关键词：枪机步枪枪械杠杆史密斯-韦森发展史

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