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Additive manufacturing(3D printing)of electrically conductive polymers and polymer nanocomposites and their applications

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eScience 2022年第4期2卷 365-381页

作者： kirstie r.ryan Michael P.Down Nicholas J.Hurst Edmund M.Keefe Craig E.Banks Faculty of Science and Engineering Manchester Metropolitan UniversityChester StreetManchesterM15GDUK

Additive manufacturing,or three-dimensional(3D)printing,offers a unique solution for fabricating complex geometries with high ***,many commercial additive manufacturing machines focus on the printing of polymers with limited ***,conductive polymers(CPs)can be processed to enable the additive manufacturing of conductive,low-density,and low-cost parts for a myriad of *** review summarizes the relevant achievements in the additive manufacturing of conductive polymers(CPs)and conductive polymer nanocomposites,with a discussion of the advantages and limitations of processing and printing these materials compared with alternative traditional manufacturing methods and their ***,the prospective applications of these additive manufacturing printed conductive materials are explored.

关键词： Conducting polymers Additive manufacturing Electrochemcial applications Supercapacitors Batteries

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Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-βinduced retinal pigmented epithelium degeneration

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1526-1534页

作者： Siddharth Narendran Felipe Pereira Praveen Yerramothu Ivana Apicella Shao-bin Wang Kameshwari Ambati Shuichiro Hirahara Younghee Kim Meenakshi Ambati Vidya L.Ambati Peirong Huang Akhil Varshney Yosuke Nagasaka Shinichi Fukuda kirstie L.Baker Kenneth M.Marion Jan M.Deussing Srinivas r.Sadda Bradley D.Gelfand Jayakrishna Ambati Center for Advanced Vision Science University of Virginia School of MedicineCharlottesvilleVAUSA Department of Ophthalmology University of Virginia School of MedicineCharlottesvilleVAUSA Aravind Eye Care System MaduraiIndia Departamento de Oftalmologia e Ciências Visuais Escola Paulista de MedicinaUniversidade Federal de São PauloSão PauloBrazil Center for Digital Image Evaluation CharlottesvilleVAUSA Doheny Eye Institute Los AngelesLos AngelesCAUSA Molecular Neurogenetics Department of Stress Neurobiology and NeurogeneticsMax Planck Institute of PsychiatryMunichGermany Department of Ophthalmology David Geffen School of MedicineUniversity of California–Los AngelesLos AngelesCAUSA Department of Biomedical Engineering University of Virginia School of MedicineCharlottesvilleVAUSA Department of Pathology University of Virginia School of MedicineCharlottesvilleVAUSA Department of Microbiology Immunologyand Cancer BiologyUniversity of Virginia School of MedicineCharlottesvilleVAUSA

Nonfibrillar amyloid-βoligomers(AβOs)are a major component of drusen,the sub-retinal pigmented epithelium(rPE)extracellular deposits characteristic of age-related macular degeneration(AMD),a common cause of global *** report that AβOs induce rPE degeneration,a clinical hallmark of geographic atrophy(GA),a vision-threatening late stage of AMD that is currently *** demonstrate that AβOs induce activation of the NLrP3 inflammasome in the mouse rPE in vivo and that rPE expression of the purinergic ATP receptor P2rX7,an upstream mediator of NLrP3 inflammasome activation,is required for AβO-induced rPE *** classes of small molecule inflammasome inhibitors—nucleoside reverse transcriptase inhibitors(NrTIs)and their antiretrovirally inert modified analog Kamuvudines—both inhibit AβOs-induced rPE *** findings crystallize the importance of P2rX7 and NLrP3 in a disease-relevant model of AMD and identify inflammasome inhibitors as potential treatments for GA.

关键词： degeneration activation upstream

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