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Phytochemically rich dietary components and the risk of colorectal cancer:A systematic review and meta-analysis of observational studies

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World Journal of Clinical Oncology 2021年第6期12卷 482-499页

作者： Pia Borgas Guadalupe Gonzalez kirill veselkov Reza Mirnezami Faculty of Medical Sciences University College LondonLondon WC1E 6BTUnited Kingdom Department of Computing Imperial College LondonLondon SW72RHUnited Kingdom Department of Surgery and Cancer Faculty of MedicineImperial College LondonLondon SW72AZUnited Kingdom Department of Colorectal Surgery Royal Free HospitalLondon NW32QGUnited Kingdom

BACKGROUND Personalized nutrition and protective diets and lifestyles represent a key cancer research *** association between consumption of specific dietary components and colorectal cancer(CRC)incidence has been evaluated by a number of population-based studies,which have identified certain food items as having protective potential,though the findings have been *** we present a systematic review and meta-analysis on the potential protective role of five common phytochemically rich dietary components(nuts,cruciferous vegetables,citrus fruits,garlic and tomatoes)in reducing CRC *** To investigate the independent impact of increased intake of specific dietary constituents on CRC risk in the general *** Medline and Embase were systematically searched,from time of database inception to January 31,2020,for observational studies reporting CRC incidence relative to intake of one or more of nuts,cruciferous vegetables,citrus fruits,garlic and/or tomatoes in the general *** were extracted by two independent reviewers and analyzed in accordance with the Meta-analysis of Observational Studies in Epidemiology(MOOSE)and Preferred Reporting Items for Systematic Review and Meta-analysis(PRISMA)reporting guidelines and according to predefined inclusion/exclusion *** sizes of studies were pooled using a random-effects *** Forty-six studies were *** risk was significantly reduced in patients with higher vs lower consumption of cruciferous vegetables[odds ratio(OR)=0.90;95%confidence interval(CI):0.85-0.95;P<0.005],citrus fruits(OR=0.90;95%CI:0.84-0.96;P<0.005),garlic(OR=0.83;95%CI:0.76-0.91;P<0.005)and tomatoes(OR=0.89;95%CI:0.84-0.95;P<0.005).Subgroup analysis showed that this association sustained when looking at case-control studies alone,for all of these four food items,but no significant difference was found in analysis of cohort studies *** consumption exhibited a similar trend,but

关键词： Colorectal cancer Disease prevention Diet Risk Nutrigenomics Metaanalysis

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Libration-Generated Average Convection in a Rotating Flat Layer with Horizontal Axis

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Fluid Dynamics & Materials Processing 2024年第10期20卷 2235-2249页

作者： kirill Rysin Laboratory of Vibrational Hydromechanics Perm State Humanitarian Pedagogical UniversityPerm614990Russia

The study of average convection in a rotating cavity subjected to modulated rotation is an interesting area for the development of both fundamental and applied *** phenomenon finds application in the field of mass transfer and fluid flow control,relevant examples being crystal growth under reduced gravity and fluid mixing in microfluidic devices for cell *** this study,the averaged flow generated by the oscillating motion of a fluid in a planar layer rotating about a horizontal axis is experimentally *** boundaries of the layer are maintained at constant temperatures,while the lateral cylindrical wall is thermally *** is demonstrated that libration results in intense oscillatory fluid motion,which in turn produces a time-averaged *** the first time,quantitative measures for the instantaneous velocity field are obtained using the Particle Image Velocimetry *** is revealed that the flow has the form of counter-rotating *** vortex circulations sense changes during a libration *** increase in the rotation rate and amplitude of the cavity libration results in an increase in the flow *** heat transfer and time-averaged velocity are examined accordingly as a function of the dimensionless oscillation frequency,and resonant excitation of heat transfer and average oscillation velocity are *** threshold curve for the onset of the averaged convection is identified in the plane of control parameters(dimensionless rotational velocity and pulsation Reynolds number).It is found that an increase in the dimensionless rotational velocity has a stabilizing effect on the onset of convection.

关键词： Rotation libration oscillations mass transfer stability averaged convection

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Architecture of the Graphics System for Embedded Real-Time Operating Systems

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Tsinghua Science and Technology 2023年第3期28卷 541-551页

作者： Alexander Giatsintov kirill Mamrosenko Pavel Bazhenov Center of Visualization and Sattelite Information Technologies SRISA RASMoscow 117218Russia

This paper presents a new architecture of a graphics system for microkernel operating systems,including real-time operating *** following major parts of the architecture are presented:a user-level subsystem responsible for interaction with user applications;a bottom-level subsystem providing the functionality for graphics drivers,such as managing graphics output,video memory management,etc.;a kernel-level subsystem providing interaction with the kernel,and performing low-level operations,such as working with physical memory,processes,*** mechanisms of interaction of user applications with the user level of the graphics system,as well as interaction of the different levels of the graphics subsystem are *** paper pays much attention to various approaches to testing:the use of unit testing,testing using hardware and software *** important characteristic of a graphics system is its performance,in particular the performance of low-level operations such as memory allocation:the developed architecture suggests using a separate memory allocator which is faster than standard memory allocation *** of the performances of graphics system implementation for microkernel real-time operating system and graphics server Xorg is presented,showing significant superiority of the proposed architecture in a number of work scenarios.

关键词： operating system graphics system visualization system programming real-time operating system(RTOS) real-time

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Improving on Linear Scan Register Allocation

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International Journal of Automation and computing 2018年第2期15卷 228-238页

作者： Shahrzad Kananizadeh kirill Kononenko Department of Computer Science Saarland University Saarbrticken Germany Ecole Normale Superieure/French Institute for Research in Computer Science and Automation (INRIA) Paris France

Register allocation is a major step for all compilers. Various register allocation algorithms have been developed over the dec- ades. This work describes a new class of rapid register allocation algorithms and presents experimental data on their behavior. Our re- search encourages the avoidance of graphing and graph-coloring based on the fact that precise graph-coloring is nondeterministic poly- nomial time-complete （NP-complete）, which is not suitable for real-time tasks. In addition, practical graph-coloring algorithms tend to use polynomial-time heuristics. In dynamic compilation environments, their super linear complexity makes them unsuitable for register allocation and code generation. Existing tools for code generation and register allocation do not completely fulfill the requirements of fast compilation. Existing approaches either do not allow for the optimization of register allocation to be achieved comprehensively with a sufficient degree of performance or they require an unjustifiable amount of time and/or resources. Therefore, we propose a new class of register allocation and code generation algorithms that can be performed in linear time. These algorithms are based on the mathematic- al foundations of abstract interpretation and the computation of the level of abstraction. They have been implemented in a specialized library for just-in-time compilation. The specialization of this library involves the execution of common intermediate language （CIL） and low level virtual machine （LLVM） with a focus on embedded systems.

关键词： Register allocation just-in-time compilation code generation static analysis dynamic analysis.

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Meta-optics and bound states in the continuum

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Science Bulletin 2019年第12期64卷 836-842页

作者： kirill Koshelev Andrey Bogdanov Yuri Kivshar Nonlinear Physics Centre Australian National UniversityCanberra ACT 2601Australia ITMO University St. Petersburg 197101Russia

We discuss the recent advances in meta-optics and nanophotonics associated with the physics of bound states in the continuum(BICs). Such resonant states appear due to a strong coupling between leaky modes in optical guiding structures being supported by subwavelength high-index dielectric Mieresonant nanoantennas or all-dielectric metasurfaces. First, we review briefly very recent developments in the BIC physics in application to isolated subwavelength particles. We pay a special attention to novel opportunities for nonlinear nanophotonics due to the large field enhancement inside the particle volume creating the resonant states with high-quality(high-Q) factors, the so-called quasi-BIC, that can be supported by the subwavelength particles. Second, we discuss novel applications of the BIC physics to alldielectric optical metasurfaces with broken-symmetry meta-atoms when tuning to the BIC conditions allows to enhance substantially the Q factor of the flat-optics dielectric structures. We also present the original results on nonlinear high-Q metasurfaces and predict that the frequency conversion efficiency can be boosted dramatically by smart engineering of the asymmetry parameter of dielectric metasurfaces in the vicinity of the quasi-BIC regime.

关键词： Bound states in the continuum Meta-optics Second-harmonic generation Nanoresonator Metasurfaces

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Architecture of Graphics System with 3D Acceleration Support for Embedded Operating Systems

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Tsinghua Science and Technology 2024年第3期29卷 863-873页

作者： Alexander Giatsintov kirill Mamrosenko Pavel Bazhenov Center of Visualization and Sattelite Information Technologies Scientific Research Institute for System Analysis of the Russian Academy of Sciences(SRISA RAS)Moscow 117218Russia

An increasing number of tasks now require the use of hardware accelerators to reduce the time required for computation and display the computational *** paper presents a new graphics system architecture for operating systems(OSs)with microkernel architecture,including real-time *** proposed system architecture provides capabilities for displaying graphical images on various information display devices and for accelerating graphical operations on *** architecture of the graphics system uses a concept of allocators to manage system and video memory,provides an abstraction of memory operations with a single interface for video memory management,and simplifies memory handling where incorrect operation is the cause of many failures.A comparison between the performance of a real-time OS and Linux OS implementing the graphics system using the example of a glmark2 benchmark is presented,thereby the superiority of the proposed architecture in several scenarios is demonstrated.

关键词： real-time operating system(RTOS) graphics system rendering system architecture operatingsystem visualization system programming

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Female answer specificity to male drumming calls in three closely related species of the stonefly genus Zwicknia (Plecoptera: Capniidae)

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Insect Science 2021年第1期28卷 215-223页

作者： kirill Mark Orci David Muranyi MTA-ELTE-MTM Ecology Research Group Hungarian Academy of SciencesEotvos Lorand University and the Hungarian Natural History MuseumBudapestHungary Department of Zoology Eszterhazy Karoly UniversityEgerHungary Department of Zoology Hungarian Natural History MuseumBudapestHungary

This study examines the rate of female answers to conspecific versus heterospecific male vibratory calls in three,closely related stonefly species:Zwicknia bifrons,***,and *** a previous study those three species were recognized on the basis of their distinct male drumming calls along with differences in genital morphology and genetic *** this study no-choice playback experiments using original male call samples from each species were performed,and the answer rate of females to con・specific and heterospecific signal variants was *** effect logistic regression models were used to test if male call species identity had a statistically significant effect on female answer *** answered conspecific male calls with significantly higher probability than heterospecific calls in all the three examined species,suggesting that the divergence of vibrational communication can be an important component of the prezygotic isolation between ***,but well detectable responsiveness to heterospecific calls was observable between *** and ***,the two species closest to each other regarding mitochondrial genetic divergence and male call pattern ***,our results are most congruent with a tight,gradual coevolution of male calls and female preferences.

关键词： biotremology drumming call Plecoptera reproductive isolation species recognition vibrational communication

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Pressure Boundary Conditions for Blood Flows

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Chinese Annals of Mathematics,Series B 2015年第5期36卷 829-842页

作者： kirill P.GOSTAF Olivier PIRONNEAU Department of Mathematics Simon Fraser University Laboratoire Jacques-Louis Lions Université Pierre et Marie Curie

Simulations of blood flows in arteries require numerical solutions of fluidstructure interactions involving Navier-Stokes equations coupled with large displacement visco-elasticity for the *** the various simplifications which have been proposed, the surface pressure model leads to a hierarchy of simpler models including one that involves only the pressure. The model exhibits fundamental frequencies which can be computed and compared with the pulse. Yet unconditionally stable time discretizations can be constructed by combining implicit time schemes with Galerkin-characteristic discretization of the convection terms in the Navier-Stokes equations. Such problems with prescribed pressure on the walls will be shown to be efficient and accurate as an approximation of the full fluid structure interaction problem.

关键词： Fluid-structure interaction Compliant walls Finite element method Navier-Stokes equations Blood flow

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Phase Transition in a Dense Swarm of Self-Propelled Bots

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Fluid Dynamics & Materials Processing 2024年第8期20卷 1785-1798页

作者： Dmitry Bratsun kirill Kostarev Applied Physics Department Perm National Research Polytechnic UniversityPerm614990Russia

Swarms of self-organizing bots are becoming important elements in various technical systems,which include the control of bacterial cyborgs in biomedical applications,technologies for creating new metamaterials with internal structure,self-assembly processes of complex supramolecular structures in disordered media,*** this work,we theoretically study the effect of sudden fluidization of a dense group of bots,each of which is a source of heat and follows a simple algorithm to move in the direction of the gradient of the global temperature *** show that,under certain conditions,an aggregate of self-propelled bots can fluidize,which leads to a second-order phase *** bots’program,which forces them to search for the temperature field maximum,acts as an effective buoyancy *** a consequence,one can observe a sudden macroscopic circulation of bots from the edge of the group to its center and back again,which resembles classical Rayleigh-Benard thermal *** the continuum approximation,we have developed a mathematical model of the phenomenon,which reduces to the equation of a self-gravitating porous disk saturated with an incompressible fluid that generates *** derive governing equations in the Darcy-Boussinesq approximation and formulate a nonlinear boundary value *** exact solution to the linearized problem for infinitesimal perturbations of the base state is obtained,and the critical values of the control parameter for the onset of the bot circulation are *** we apply weakly nonlinear analysis using the method of multiple time *** found that as the number of bots increases,the swarm exhibits increasingly complex patterns of circulation.

关键词： Active matter collective behavior self-organization convection

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Coronary revascularization in the elderly with stable angina

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Journal of Geriatric Cardiology 2015年第5期12卷 555-568页

作者： kirill Lenarovich Kozlov Aleksandr Andreevich Bogachev Laboratory of Age-Related Clinical Pathology Department of Clinical Gerontology and Geriatrics St. Petersburg Institute of Bioregulation and Gerontology Northwestern Branch Russian Academy of Medical Sciences Saint-Petersburg Russia Department of Cardiovascular Medicine Kirov Military Medical Academy Saint-Petersburg Russia

A proportion of elderly with coronary artery disease is rapidly growing. They have more severe coronary artery disease, therefore, derive more benefit fi＇om revascularization and have a greater need for it. The elderly is a heterogeneous group, but compared to the younger cohort, the choice of the optimal revascularization method is much more complicated among them. In recent decades, results has improved dramatically both in surgery and percutaneous coronary intervention （PCI）, even in very old persons. Despite the lack of evidence in elderly, it is obvious, that coronary artery bypass surgery （CABG） has a more pronounced effect on long-term survival in price of more strokes, while PCI is certainly less invasive. Age itself is not a criterion for the selection of treatment strategy, but the elderly are often more interested in quality of life and personal independence instead of longevity. This article discusses the factors that influence the choice of the revascularization method in the elderly with stable angina and presents a complex algorithm for making an individual risk-benefit profile. As a consequence the features of CABG and PCI in elderly patients are exposed. Emphasis is centered on the frailty and non-medical factors, including psychosocial, as essential components in making the decision of what strategy to choose. Good communication with the patients and giving them unbiased information is encouraged.

关键词： Angina Cardiopulmonary bypass Coronary artery disease Stents The elderly

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