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Social Deprivation of Newborn Rats Modifies Exploratory and Defensive Behavior at Mature Age

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Journal of Behavioral and Brain Science 2019年第10期9卷 375-384页

作者： Anna Yu. Shishelova kirill S. Smirnov vladimir v. Raevskiy Institute of Higher Nervous Activity and Neurophysiology of RAS Moscow Moscow Russia

The effect of complete social deprivation in early postnatal ontogenesis on adult behavior in Wag/Rij rats with a genetic predisposition to the development of absence epilepsy was studied. From the 2nd to the 8th day of life, a 3-hour daily isolation of the pups from the mother and siblings was performed, the control animals were handled. In adulthood, offspring behavior was tested in an elevated plus-maze, an open field, and for an ability to learn the conditioned reflex of active avoidance. In isolated earlier rats, an increase in emotional reactivity, exploratory behavior in a potentially dangerous space, the speed of learning a conditioned reflex with negative painful reinforcement, and a disturbance of the formation of a defensive reaction were revealed. It is assumed that high emotional reactivity creates the prerequisites for the development of absence epilepsy.

关键词： Ontogenesis Absence Epilepsy Behavior Wag/Rij Rats

Neural network-based image reconstruction in swept-source optical coherence tomography using undersampled spectral data

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Light(Science & Applications) 2021年第9期10卷 1658-1671页

作者： Yijie Zhang Tairan Liu Manmohan Singh EgeÇetintaş Yilin Luo Yair Rivenson kirill v.Larin Aydogan Ozcan Electrical and Computer Engineering Department University of CaliforniaLos AngelesCA90095USA Department of Bioengineering University of CaliforniaLos AngelesCA90095USA California NanoSystems Institute University of CaliforniaLos AngelesCA90095USA Department of Biomedical Engineering University of HoustonHoustonTX77204USA Department of Molecular Physiology and Biophysics Baylor College of MedicineUniversity of HoustonHoustonTX77204USA Department of Surgery David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA90095USA

Optical coherence tomography(OCT)is a widely used non-invasive biomedical imaging modality that can rapidly provide volumetric images of ***,we present a deep learning-based image reconstruction framework that can generate swept-source OCT(SS-OCT)images using undersampled spectral data,without any spatial aliasing *** neural network-based image reconstruction does not require any hardware changes to the optical setup and can be easily integrated with existing swept-source or spectral-domain OCT systems to reduce the amount of raw spectral data to be *** show the efficacy of this framework,we trained and blindly tested a deep neural network using mouse embryo samples imaged by an SS-OCT *** 2-fold undersampled spectral data(i.e.,640 spectral points per A-line),the trained neural network can blindly reconstruct 512 A-lines in 0.59 ms using multiple graphics-processing units(GPUs),removing spatial aliasing artifacts due to spectral undersampling,also presenting a very good match to the images of the same samples,reconstructed using the full spectral OCT data(i.e.,1280 spectral points per A-line).We also successfully demonstrate that this framework can be further extended to process 3×undersampled spectral data per A-line,with some performance degradation in the reconstructed image quality compared to 2×spectral ***,an A-line-optimized undersampling method is presented by jointly optimizing the spectral sampling locations and the corresponding image reconstruction network,which improved the overall imaging performance using less spectral data points per A-line compared to 2×or 3×spectral undersampling *** deep learning-enabled image reconstruction approach can be broadly used in various forms of spectral-domain OCT systems,helping to increase their imaging speed without sacrificing image resolution and signal-to-noise ratio.

关键词： graphics hardware image

Measurement of Electrical Resistance of Liquid Electrolytes and Materials Containing Them

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Journal of Electromagnetic Analysis and Applications 2020年第2期12卷 7-14页

作者： kirill v. Dobrego Mikhail A. Chumachenko Olga v. Boiprav Nikolay N Grinchik Halina A. Pukhir Belarusian National Technical University Minsk Belarus Belarusian State University of Informatics and Radioelectronics Minsk Belarus A.v. Luikov Heat and Mass Transfer Institute of NAS of Belarus Minsk Belarus

Measurement of the electrical conductivity of electrolytes and heterogeneous materials containing them is accompanied by numerous physical and electrochemical processes, complicating measuring and interpretation of data. As a result, the measurement of the electrical conductivity of such a system is a difficult and not finally resolved problem. The new method of resistance measurement of the electrolytic systems is substantiated and tested on example of heterogeneous electrolytic system “lignin-calcium chloride water solution” in this article. The method is based on measurement of resistance of the electrolytic system at different voltages (DC) on the cell and the consequent approximation of the acquired data taking into consideration volume charges and potential barriers arising on the boarders of electrodes and electrolytic materials. Extrapolation of the resistance to the limiting small current lets one obtain a characteristic value of the active resistance of the electrolytic system. The method is technically simple, inexpensive and has several advantages compared to the methods based on AC measurements.

关键词： Electrolyte Conductivity Conductometry Resistance

Mathematical Models of Receptivity of a Robot and a Human to Education

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Intelligent Control and Automation 2014年第3期5卷 97-101页

作者： Oleg G. Pensky vladimir O. Michailov kirill v. Chernikov Perm State University Perm Russia

The paper gives general definitions of the mathematical theory of emotional robots able to forget older information. A formalized concept of relative receptivity of the robot to education is introduced. An algorithm of a voice training program for public speakers described in the paper is based on the theory of emotional robots. Also the paper presents a method of estimation of a coefficient of human emotional memory and estimation of a relative receptivity of a robot and a human to education;the method is based on application of the voice training program.

关键词： Robot Robot’s Education Receptivity to Education Memory Emotions of Robots

Bound states in the continuum and Fano resonances in the strong mode coupling regime

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Advanced Photonics 2019年第1期1卷 33-44页

作者： Andrey A.Bogdanov kirill LKoshelev Polina vKapitanova Mikhail vRybin Sergey AGladyshev Zarina FSadrieva kirill BSamusev Yuri SKivshar a Mikhail FLimonov ITMO University Department of Nanophotonics and MetamaterialsSt.PetersburgRussia Ioffe Institute St.PetersburgRussia Australian National University Nonlinear Physics CenterCanberraAustralia

The study of resonant dielectric nanostructures with a high refractive index is a new research direction in the nanoscale optics and metamaterial-inspired *** of the unique optically induced electric and magnetic Mie resonances,high-index nanoscale structures are expected to complement or even replace different plasmonic components in a range of potential *** study a strong coupling between modes of a single subwavelength high-index dielectric resonator and analyze the mode transformation and Fano resonances when the resonator’s aspect ratio *** demonstrate that strong mode coupling results in resonances with high-quality factors,which are related to the physics of bound states in the continuum when the radiative losses are almost suppressed due to the Friedrich–Wintgen scenario of destructive *** explain the physics of these states in terms of multipole decomposition,and show that their appearance is accompanied by a drastic change in the far-field radiation *** reveal a fundamental link between the formation of the high-quality resonances and peculiarities of the Fano parameter in the scattering cross-section *** theoretical findings are confirmed by microwave experiments for the scattering of high-index cylindrical resonators with a tunable aspect *** proposed mechanism of the strong mode coupling in single subwavelength high-index resonators accompanied by resonances with high-quality factors helps to extend substantially functionalities of all-dielectric nanophotonics,which opens horizons for active and passive nanoscale metadevices.

关键词： Fano resonance bound states in the continuum Mie resonance dielectric resonator meta-optics

Primer-Like Inhibitors for DNA Repair Enzymes of the AML-HL60 and WERI-1A/Y79 Malignant Cells

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Advances in Enzyme Research 2019年第3期7卷 27-44页

作者： Sergei v. Stovbun kirill v. Ermakov Alexander A. Bukhvostov Alexander S. vedenkin Dmitry A. Kuznetsov N.N. Semenov Institute of Chemical Physics Russian Academy of Sciences Moscow Russia Faculty of Biomedicine N.I. Pirogov Russian National Research Medical University Moscow Russia

A conventionally synthesized thio- and cyano-modified single-stranded poly(dNTP) sequences of different molecular sizes (20n - 200n) and the same lengths routine poly(dNTP) and poly(NTP) species were obtained through the good services provided by the Russian Federal Bioorganic Products Group and by the ThermoFischer, Inc., and then tested for their impact on catalytic activities of β-like DNA polymerases from chromatin of HL-60, WERI-1A and Y-79 cells as well as for the affinity patterns in DNApolβ-poly(dNTP)/ (NTP) pairs, respectively. An essential link between the lengths of ultrashort (50n - 100n) single-stranded poly(dNTP) sequences of different structures and their inhibitory effects towards the cancer-specific DNA polymerases β has been found. A possible significance of this phenomenon for both DNA repair suppression in tumors and a consequent anti-cancer activity of the DNA repair related short poly(dNTP) fragments has been for the first time emphasized with a respect to their pharmacophore revealing potential. Thus, this work presents an experimental attempt to upgrade a contemporary attitude towards the DNA derived products applied for anti-cancer agenda, particularly, for acute myeloid leukemia and retinoblastoma cell DNA repair machinery breakdown. In this study, tumor specific DNA polymerases β were found of being the targets for attack promoted with the primer-like single-stranded DNA fragments followed by consequent cytostatic phenomena. A novel concept of the DNA related anti-cancer medicines is under discussion.

关键词： Magnetic Isotope Effects (MIE) DNA Repair DNA Polymerases DNA-Enzyme Binding

Attenuation correction technique for fluorescence analysis of biological tissues with significantly different optical properties

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Frontiers of Optoelectronics 2020年第4期13卷 360-370页

作者： Tatiana A.SAvELIEvA Marina N.KURYANOvA Ekaterina v.AKHLyusTINA kirill G.LInkov Gennady A.MEEROvICH victor B.LOSCHENOv Prokhorov General Physics Institute of the Russian Academy of Sciences Moscow 119991Russia National Research Nuclear University MEPhl Moscow 115409Russia

During intraoperative fluorescence navigation to remove various neoplasms and during pharmacokinetic studies of photosensitizers in laboratory animals,in many cases,the ratio of photosensitizer accumulation in the tumor and normal tissue can reach>10-fold,which inevitably changes their optical *** the same time,the tumor formation process causes various metabolic and structural changes at cellular and tissue levels,which lead to changes in optical properties.A hardwaresoftware complex for the spectral-fluorescence studies of the content of fluorochromes in biological tissues with significantly different optical properties was developed,and it was tested on optical phantoms with various concentrations of photosensitizers,absorbers,and *** correct the influence of optical properties on the photosensitizer concentration analysis by fluorescence spectroscopy,we propose the spectrum-processing algorithm,which combines empirical and theory-based approaches.

关键词： fluorescence spectroscopy scattering absorption attenuation correction optical phantoms

Regularities of Nanofocusing of the Electromagnetic Field of a Fractal Rough Surface

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Journal of Electromagnetic Analysis and Applications 2019年第8期11卷 117-133页

作者： Nikolay N. Grinchik Galina M. Zayats Olga v. Boiprav kirill v. Dobrego volha A. Prykhodzka A.v. Luikov Heat and Mass Transfer Institute of the National Academy of Sciences of Belarus Minsk Belarus Institute of Mathematics of the National Academy of Sciences of Belarus Minsk Belarus Belarusian State University of Informatics and Radioelectronics Minsk Belarus Belarusian National Technical University Minsk Belarus Belarusian State University Minsk Belarus

A consistent physical and mathematical model of the propagation of electromagnetic waves in an inhomogeneous medium with strong discontinuities of the electromagnetic field at the interface of two media, which is a rough surface, was developed. Mathematical modeling of rough surfaces and their profiles was carried out using fractal geometry, which allows us to display the topology of the object as close as possible to reality. For real heterogeneous rough structures, we have developed a through-counting method that takes into account the continuity of the total current at the interfaces of adjacent media, the effect of induced surface charge and surface current. This approach lets one avoid the necessity to set surface impedances depending on the structure of the field being determined and on the material properties.

关键词： Nonstationary Broadening of the Spectral Line Fractal Roughness Surface Charge Surface Current Electromagnetic Wave Soliton-Like Electromagnetic Pulse

Terahertz technology in intraoperative neurodiagnostics:A review

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Opto-Electronic Advances 2023年第5期6卷 41-67页

作者： Nikita v.Chernomyrdin Guzel R.Musina Pavel v.Nikitin Irina N.Dolganova Anna S.Kucheryavenko Anna I.Alekseeva Yuye Wang Degang Xu Qiwu Shi valery v.Tuchin kirill I.Zaytsev Prokhorov General Physics Institute of the Russian Academy of Sciences Moscow 119991Russia Bauman Moscow State Technical University Moscow 105005Russia Institute for Regenerative Medicine Sechenov UniversityMoscow 119991Russia Institute of Solid State Physics of the Russian Academy of Sciences Chernogolovka 142432Russia Research Institute of Human Morphology Moscow 117418Russia School of Precision Instrument and Optoelectronic Engineering Tianjin UniversityTianjin 300000China College of Materials Science and Engineering Sichuan UniversityChengdu 610000China Science Medical Center Saratov State UniversitySaratov 410012Russia Institute of Precision Mechanics and Control FRC"Saratov Scientific Centre of the Russian Academy of Sciences"Saratov 410028Russia

Terahertz(THz)technology offers novel opportunities in biology and medicine,thanks to the unique features of THzwave interactions with tissues and *** them,we particularly notice strong sensitivity of THz waves to the tissue water,as a medium for biochemical reactions and a main endogenous marker for THz spectroscopy and *** of the brain have an exceptionally high content of *** factor,along with the features of the structural organization and biochemistry of neuronal and glial tissues,makes the brain an exciting subject to study in the THz *** this paper,progress and prospects of THz technology in neurodiagnostics are overviewed,including diagnosis of neurodegenerative disease,myelin deficit,tumors of the central nervous system(with an emphasis on brain gliomas),and traumatic brain *** and applied challenges in study of the THz-wave–brain tissue interactions and development of the THz biomedical tools and systems for neurodiagnostics are discussed.

关键词： THz technology THz spectroscopy and imaging superresolution imaging biophotonics brain neurodiagnosis tumor glioma neurodegenerative diseases brain injury light scattering