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Journ.l of Wuhan.Un.versity of Techn.logy(Materials Scien.e) 2024年第1期39卷 196-205页

作者：李励杜凤山 n.tion.l En.in.erin. Research Cen.er for Equipmen. an. Techn.logy of Cold Strip Rollin. Yanshan UniversityQinhuangdao 066004China College of Mechan.cal En.in.erin. Yanshan UniversityQinhuangdao 066004China

A n.w,in.ovative vibration.cast-rollin. techn.logy of “electromagn.tic stirrin.+den.rite breakin.+asyn.hron.us rollin.” was proposed with the adoption.of sin.soidal vibration.of crystallization.roller to prepare Ti/Al lamin.ted composites,an. the effect of sin.soidal vibration.of crystallization.roller on.composite microstructure was in.estigated in.*** results show that the metallurgical bon.in. of titan.um an. alumin.m is realized by mesh in.erweavin. an. mosaic meshin.,in.tead of tran.ition.bon.in. by formin. metal compoun. *** meshin. depth between.titan.um an. alumin.m layers (6.6μm) of cast-rollin. materials with stron. vibration.of crystallization.roller (amplitude 0.87 mm,vibration.frequen.y 25 Hz) is doubled compared with that of tradition.l cast-rollin. materials (3.1μm),an. the composite in.erfacial stren.th(27.0 n.mm) is twice as high as that of tradition.l cast-rollin. materials (14.9 n.mm).This is because with the action.of high-speed superposition.of stron. ten.ion.alon. the rollin. direction.stron. pressure alon. the width direction.an. rollin. force,the composite lin.arity evolves from "straight lin." with tradition.l castin.-rollin. to "curved lin.",an. the depth an. n.mber of cracks in.the in.erface in.reases greatly compared with those with tradition.l cast-rollin.,which leads to the deep expan.ion.of the meshin. area between.in.erfacial layers an. promotes the stable en.an.emen. of composite quality.

关键词： lamin.ted composites sin.soidal vibration composite microstructure

Room-temperature ferrimagn.tism an. size-modulated electron.c structures in.two-dimen.ion.l cluster-based metal-organ.c frameworks

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Scien.e Chin. Chemistry 2024年第4期67卷 1334-1340页

作者： Jin. Chen. Xin.xin. li Jin.on. Yan. Key Laboratory of Precision.an. In.elligen. Chemistry University of Science and Technology of ChinaHefei 230026China Departmen. of Chemical Physics University of Science and Technology of ChinaHefei 230026China Hefei n.tion.l Research Cen.er for Physical Scien.es at the Microscale University of Science and Technology of ChinaHefei 230026China Hefei n.tion.l Laboratory University of Science and Technology of ChinaHefei 230088China

Cluster-assembled materials have attracted particular atten.ion.for their complex hierarchical structures an. un.que ***,the majority of cluster-based assemblies developed so far are either n.n.magn.tic or on.y exhibit magn.tic orderin. with a relatively low Curie temperature,limitin. their application. in.***,two-dimen.ion.l(2D)cluster-assembled materials with room-temperature magn.tism remain.highly *** this purpose,based on.first prin.iples calculation.,we design.a series of thermodyn.mically stable 2D cluster-based metal-organ.c frameworks(MOFs)Fe_(n.-(pyz)(n.1-6)by utilizin. Fen.etal clusters as n.des an. n.trogen.con.ain.n. pyrazin. ligan.s as organ.c *** 2D cluster-based MOFs exhibit robust ferrimagn.tic orderin. due to the stron. d-p direct exchan.e in.eraction.between.d-electron.spin.of Fe_(n.(n.1-6)clusters an. charge tran.fer-in.uced p-electron.spin.of pyrazin. *** particular,the ferrimagn.tic Curie temperatures are well above room temperature(up to 836 K).Addition.lly,alterin. the size of Fe_(n.clusters in.Fe_(n.-(pyz)(n.1-6)MOFs results in.diverse fun.tion.l spin.ron.c properties,in.ludin. bipolar magn.tic semicon.uctors,half semicon.uctors an. Dirac half ***,these 2D assembled MOFs possess sizable magn.tic an.sotropy en.rgies,up to 9.16 me V per formula.

关键词： metal-organ.c framework two-dimen.ion.l material half metal bipolar magn.tic semicon.uctor magn.t

Efficien. guidin. an. focusin. of in.en.e laser pulse usin. periodic thin.slits

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Matter an. Radiation.at Extremes 2024年第4期9卷 29-39页

作者： L.Xu T.W.Huan. K.Jian. C.n.Wu H.Pen. P.C.hen.R.li H.B.Zhuo C.T.Zhou Shen.hen.Key Laboratory of Ultrain.en.e Laser an. Advan.ed Material Techn.logy Center for Intense Laser ApplicationTechnologyand College of Engineering PhysicsShenzhen Technology UniversityShenzhen 518118People’s Republic of China

Slits have been.widely used in.laser-plasma in.eraction. as plasma optical compon.n.s for gen.ratin. high-harmon.c light an. con.rollin. laser-driven.particle ***,we propose an. demon.trate that periodic thin.slits can.be regarded as a n.w breed of optical elemen.s for efficien. focusin. an. guidin. of in.en.e laser *** fun.amen.al physics of in.en.e laser in.eraction.with thin.slits is studied,an. it is revealed that relativistic effects can.lead to en.an.ed laser focusin. far beyon. the pure diffractive focusin. *** addition.the in.eraction.of an.in.en.e laser pulse with periodic thin.slits makes it feasible to achieve multifold en.an.emen. in.both laser in.en.ity an. en.rgy tran.fer efficien.y compared with con.en.ion.l *** results provide a n.vel method for man.pulatin. ultra-in.en.e laser pulses an. should be of in.erest for man. laser-based application..

关键词： laser pulse in.en.e

Impact of n.xt-gen.ration.sequen.in. on.an.imicrobial treatmen. in.immun.compromised adults with suspected in.ection.

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World Journ.l of Emergen.y Medicin. 2024年第2期15卷 105-110页

作者： Jia li Jiazhen.Luo Tao Hu lin. Chen. Weiwei Shan. li Yan Departmen. of In.en.ive Care Un.t Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Departmen. of Emergen.y Medicin. Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Ton.ji Medical College Huazhong University of Science and TechnologyWuhan 430030China Departmen. of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

BACKGROUn.:Prompt pathogen.iden.ification.can.have a substan.ial impact on.the optimization.of an.imicrobial *** objective of the study was to assess the diagn.stic value of n.xt-gen.ration.sequen.in.(n.S)for iden.ifyin. pathogen.an. its clin.cal impact on.an.imicrobial in.erven.ion.in.immun.compromised patien.s with suspected ***:This was a retrospective *** Jan.ary an. August 2020,47 adult immun.compromised patien.s un.erwen. n.S testin. un.er the followin. clin.cal con.ition.:1)prolon.ed fever an. n.gative con.en.ion.l cultures;2)n.w-on.et fever despite empiric an.imicrobial treatmen.;an. 3)afebrile with suspected in.ection. on.*** data,in.ludin. con.en.ion.l microbial test results an. an.imicrobial treatmen. before an. after n.S,were *** were an.lyzed accordin. to documen.ed chan.es in.an.imicrobial treatmen.(escalated,n. chan.e,or deescalated)after the n.S ***:The median.time from hospitalization.to n.S samplin. was 19 *** relevan. pathogen. were detected via n.S in.61.7% of patien.s(29/47),more than.half of whom suffered from fun.emia(n.17),resultin. in.an.an.imicrobial escalation.in.53.2% of patien.s(25/47)an. an.imicrobial de-escalation.in.0.2% of patien.s(1/47).An.imicrobial chan.es were mostly due to the iden.ification.of fastidious organ.sms such as Legion.lla,Pn.umocystis jirovecii,an. *** the remain.n. three cases,n.S detected clin.cally relevan. pathogen. also detected by con.en.ion.l cultures a few days *** an.imicrobial treatmen. was subsequen.ly adjusted accordin. to the susceptibility test ***,n.S chan.ed an.imicrobial man.gemen. in.55.3%(26/47)of patien.s,an. con.en.ion.l culture detected clin.cally relevan. pathogen. in.14.9% of the patien.s(7/47).COn.LUSIOn.With its rapid iden.ification.an. high sen.itivity,n.S could be a promisin. tool for iden.ifyin. relevan. pathogen. an. en.blin. rapid appropriate treatmen. in.immun.compromised patien.s w

关键词： Immun.compromised patien.s n.xt-gen.ration.sequen.in. An.imicrobial man.gemen.

Local failure mechan.sm of san.-blockin. fen.e in.latticed dun. alon. desert roads

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Journ.l of Moun.ain.Scien.e 2024年第2期21卷 526-537页

作者： li lian.yin. LV Lele li Qi WAn. Zhen.ian. YAn. Youhai YIn.Wen.ua School of Civil En.in.erin. Lanzhou Jiaotong UniversityLanzhou 730070China n.n.xia Highway Survey an. Design.In.titute Co Ltd Yinchuan 750001China

The latticed dun.s in.the Ten.ger Desert are widely distributed,an. the san.-blockin. fen.e placed here are highly susceptible to local failure due to complex win.-san. activities,posin. a serious threat to the safe operation.of the *** explore the local failure mechan.sm of san.-blockin. fen.e in.the latticed dun. area,the local failure of san.-blockin. fen.e in.the latticed dun. areas alon. the Wuhai-Maqin.Highway in.Chin. was *** the first main.ridge of the latticed dun. as the placemen. location.the structure of the win.-san. flow field of san.-blockin. fen.e placed at top,the bottom an. the middle of win.ward slope was an.lyzed by Computation.l Fluid Dyn.mics(CFD).The results show that when.placed at top of the first main.ridge,the win. speed n.ar the san.-blockin. fen.e is the highest,up to 15.23 m/***,the win. load stren.th on.the san. barrier is correspon.in.ly larger,up to 232.61 n.*** the stren.th of material con.in.es to decrease,the n.lon.n.t is pron. to *** roots of the an.le steel posts are susceptible to hollowin. by vortex action.which can.cause san.-blockin. fen.e to fall over in.stron. win. *** placed at the bottom of win.ward slope,win. speed drop n.ar san.-blockin. fen.e is greatest,with the decrease of 12.48-14.32 m/s compared to the origin.l win. *** is highly likely to lead to large-scale deposition.of san. particles an. burial of the san.-blockin. *** placed in.the middle of win.ward slope,san.-blockin. fen.e is subjected to less win. load stren.th(168.61n.m-2)an. san. particles are mostly deposited at the bottom of win.ward slope,with on.y a small amoun. of san. accumulatin. at the root of san.-blockin. *** on.field observation. an. n.merical modellin. results,when.the san.-blockin. fen.e is placed in.latticed dun. area,it should be placed in.the middle of the win.ward slope of the first main.ridge as a matter of *** the san.-blockin. fen.e should be placed

关键词： Latticed dun. San.-blockin. fen.e Local failure n.merical simulation Desert roads

Pogostemon.cablin.essen.ial oil as feed additive promotes the repair of the rumen.epithelial barrier in.heat-stressed beef cattle

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An.mal n.trition 2024年第3期18卷 433-440页

作者： Huan.Chen.Min.rui Yan. Xian.lon. Shan. Hao Chen.Yi li Yan.iao li lin.li Min.ren.Qu Xiaozhen.Son. Jian.xi Provin.e Key Laboratory of An.mal n.trition Engineering Research Center of Feed DevelopmentJiangxi Agricultural UniversityNanchang 330045China

Pogostemon.cablin.essen.ial oil(PEO),extracted from ***,has an.i-oxidan.,an.i-in.lammatory,an. an.i-stress properties,as well as the ability to improve gastroin.estin.l *** study aims to evaluate the effects of PEO on.the performan.e,rumen.epithelial morphology,an. barrier fun.tion.in.heat-stressed beef ***-six male Jin.jian. cattle at 18 mon.hs old were ran.omly assign.d in.o four groups an. fed a diet con.ain.n. PEO at 0(con.rol),50,100,or 150 mg/kg in.the feed con.en.rate(n.9).All experimen.al cattle were fed un.er high temperature an. humidity in.summer for 60 *** results in.icated that 50 mg/kg of PEO treatmen. en.an.ed the average daily gain.of beef cattle compared with the con.rol group(P=0.032).All PEO treatmen.s reduced the diamin. oxidase activity(P=0.004)an. malon.ialdehyde con.en.(P=0.008)in.*** addition.the con.en. of 70 kDa heat shock protein.in.the 100 mg/kg group was in.reased,an. the activity of glutathion. peroxidase an. total an.ioxidan. capacity in.both 100 mg/kg an. 150 mg/kg groups were en.an.ed compared to the con.rol group(Pn.ly,PEO treatmen. with 50 mg/kg en.an.ed the mRn. relative expression. of occludin.in.rumin.l epithelia but decreased the mRn. relative expression. of c-Jun.n.termin.l kin.se,P38 mitogen.activated protein.kin.ses,caspase-3,Beclin.(Pn. extremely sign.fican. declin.d the mRn. relative expression. of extracellular regulated protein.kin.ses an. ubiquitin.bin.in. protein.in.con.rast to the con.rol group(Pn.in.s in.icated that dietary PEO supplemen.ation.might be favorable to improve growth performan.e an. repairin. damaged rumen.epithelium of heat-stressed cattle by down.regulatin. the mitogen.activated protein.kin.se sign.lin. pathway.

关键词： Beef cattle Heat stress Rumen.epithelial barrier Pogostemon.cablin.essen.ial oil Growth performan.e MAPK sign.lin. pathway

Effects of in.rgan.c n.trien.s an. en.iron.en.al factors on.the removal of n.propylben.en. an. isopropylben.en. in.seawater by cryptophytes Rhin.mon.s reticulata S6A

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Journ.l of Ocean.logy an. limn.logy 2024年第4期42卷 1200-1215页

作者： Jiali CUI Shuhao DU Yumei li Haipin. li Pin. ZHAn. Fan.in. MEn. Key Laboratory of Marin. En.iron.en. an. Ecology Ministry of EducationOcean University of ChinaQingdao 266100China College of En.iron.en.al Scien.e an. En.in.erin. Ocean University of ChinaQingdao 266100China

To effectively remove n.propylben.en.(n.PBZ)an. isopropylben.en.(i-PBZ)leaked in.o seawater usin. Rhin.mon.s reticulata S6A(a n.wly isolated marin. microalga),the effects of three in.rgan.c n.trien.s an. four en.iron.en.al factors on.their degradation.were determin.d after 7 d of *** show that n.n._(3) at 300 mg/L caused a higher removal efficien.y of both n.PBZ an. i-PBZ(44.79%an. 39.26%),while for n.H_(2) PO_(4)·H_(2) O,greater removal rates of two PBZs(47.30%an. 42.23%)were achieved at 30 an. 20 mg/L,***_(3) supplemen.ation.500-750 mg/L)resulted in.a large reduction.43.67%-45.04%)in.i-PBZ *** chan.e in.seawater pH(from 6 to 9)did n.t affect the elimin.tion.of n.PBZ an. *** most suitable salin.ty an. temperature were 30 an. 25-30℃,respectively,leadin. to the PBZs removal of~40%.light in.en.ity exhibited sign.fican. in.luen.e on.elimin.tion.of PBZs,an. the maximum removal efficien.ies of 56.07%(n.PBZ)an. 55.00%(i-PBZ)were recorded un.er 200 an. 600μmol/(m^(2)·s),*** addition.the microalga could still remove PBZs when.it failed to grow well due to darkn.ss,stron. light,low temperature,or low salin.ty,which might mean.that good growth of alga is n.t always a n.cessary con.ition.for PBZs ***,atten.ion.should be paid to the suitability of n.trien. levels an. en.iron.en.al con.ition.(excludin. pH)in.seawater when.usin. microalgae for bioremediatin. PBZs-con.amin.ted seawater.

关键词： propylben.en.(PBZ) Rhin.mon.s reticulata seawater in.rgan.c n.trien. en.iron.en.al factor

Cobalt-Catalyzed Switchable[4+1]an.[4+1+1]Spirocyclization.of Aromatic Amides with 2-Diazo-1H-in.en.-1,3(2H)-dion.:Access to Spiro In.en.-2,1'-isoin.olin.n.s an. Spiro Isochroman.3,1'-isoin.olin.n.s

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Chin.se Journ.l of Chemistry 2024年第4期42卷 363-369页

作者： Bin.li Men.men. Xie Jin.yu li n.n. Shen.Xin.in. Zhan. Xuesen.Fan State Key Laboratory of An.iviral Drugs Pingyuan LaboratoryKey Laboratory of Green Chemical Media and ReactionsKey Laboratory for Yellow River and Huai River Water Environmental Pollution ControlMinistry of EducationSchool of EnvironmentSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan453007 China

Herein.we report a con.ition.con.rolled divergen. syn.hesis of spiro in.en.-2,1'-isoin.olin.n.s an. spiro isochroman.3,1'-isoin.olin.n.s through cobalt-catalyzed formal[4+1]an.[4+1+1]spirocyclization.of aromatic amides with 2-diazo-1H-in.en.-1,3(2H)-*** the reaction.is carried out un.er air in.ethyl acetate,spiro in.en.-2,1'-isoin.olin.n.s are formed through Co(II)-catalyzed C—H/n.H[4+1]*** the reaction.is run.un.er O2 in.CH3Cn.on.the other han.,spiro isochroman.3,1'-isoin.olin.n.s are gen.rated through Baeyer-Villiger oxidation.of the in.situ formed spiro in.en.-2,1'-isoin.olin.n.s with O2 as a cheaper an. en.iron.en.al-frien.ly oxygen.*** gen.ral,these protocols have advan.ages such as usin. n.n.precious an. earth-abun.an. metal catalyst,n. extra additive,high efficien.y an. regioselectivity.A gram-scale syn.hesis an. the removal of the directin. group further highlight its utility.

关键词： Spiro in.en.-2,1'-isoin.olin.n.s Spiro isochroman.3,1'-isoin.olin.n.s 3d Tran.ition.metals Cobalt-catalyzed C-H Activation.Switchable[4+1]an.[4+1+1]spirocyclization Aromatic amides 2-Diazo-1H-in.en.-1,3(2H)-dion.

Effi cacy of partial an. complete resuscitative en.ovascular balloon.occlusion.of the aorta in.the hemorrhagic shock model of liver in.ury

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World Journ.l of Emergen.y Medicin. 2024年第1期15卷 10-15页

作者： Yi Shan.Yan. Zhao Chen.chen. li Jian.in.Gao Guogen. Son. Tan.hi li Departmen. of Emergen.y Medicin. Chinese PLA Medical SchoolBeijing 100853China Departmen. of Emergen.y Medicin. the Sixth Medical Center of PLA General HospitalBeijing 100048China Departmen. of Emergen.y Medicin. School of MedicineSouth China University of TechnologyGuangzhou 510006China Departmen. of Emergen.y Medicin. the First Medical Center of PLA General HospitalBeijing 100853China

BACKGROUn.:Resuscitative en.ovascular balloon.occlusion.of the aorta(REBOA)can.temporarily con.rol traumatic ***,its prolon.ed use poten.ially leads to ischemia-reperfusion.in.ury(IRI).Partial REBOA(pREBOA)can.alleviate ischemic burden.however,its security an. eff ectiven.ss prior to operative hemorrhage con.rol remain. ***,we aimed to estimate the effi cacy of pREBOA in.a swin. model of liver in.ury usin. an.experimen.al slidin.-chamber ballistic ***:Twen.y Lan.race pigs were ran.omized in.o con.rol(n. aortic occlusion.(n.5),in.erven.ion.with complete REBOA(cREBOA)(n.5),con.in.ous pREBOA(C-pREBOA)(n.5),an. sequen.ial pREBOA(S-pREBOA)(n.5)*** the cREBOA an. C-pREBOA groups,the balloon.was in.lated for 60 *** hemodyn.mic an. laboratory values were compared at various observation.time *** samples immediately after an.mal euthan.sia from the myocardium,liver,kidn.ys,an. duoden.m were collected for histological assessmen. usin. hematoxylin.an. eosin.***:Compared with the con.rol group,the survival rate of the REBOA groups was promin.n.ly improved(all Pn.the cREBOA group(493.14±127.31 mL)compared with other groups(Pn.fican.ly lower at 180 min.in.the cREBOA an. S-pREBOA groups(Pn.the S-pREBOA group showed higher alan.n. amin.tran.ferase(Pn.trogen.compared with the cREBOA group(Pn.LUSIOn.In.this trauma model with liver in.ury,a 60-min.te pREBOA resulted in.improved survival rate an. was effective in.main.ain.n. reliable aortic pressure,despite persisten. *** toleran.e time for aortic occlusion.in.Zon. I for n.n.compressible torso hemorrhage was feasible with both con.in.ous partial an. sequen.ial partial measures,an. the sign.fican. improvemen. in.the severity of acidosis an. distal organ.in.ury was observed in.the sequen.ial pREBOA.

关键词： n.n.compressible torso hemorrhage liver in.ury Ischemia-reperfusion.in.ury Resuscitative en.ovascular balloon.occlusion.of the aorta

Protein.lipidation.in.health an. disease:molecular basis,physiological fun.tion.an. pathological implication

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Sign.l Tran.duction.an. Targeted Therapy 2024年第4期9卷 1423-1465页

作者： Yuan.Yuan.Peiyuan.li jian.hui li Qiu Zhao Yin. Chan. Xin.xin. He Departmen. of Gastroen.erology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Departmen. of Gastroen.erology Zhongnan Hospital of Wuhan UniversityWuhanChina Hubei Clin.cal Cen.er an. Key Laboratory of In.estin.l an. Colorectal Diseases WuhanChina

Posttran.lation.l modification. in.rease the complexity an. fun.tion.l diversity of protein. in.respon.e to complex extern.l stimuli an. in.ern.l *** these,protein.lipidation. which refer to lipid attachmen. to protein. are promin.n.,which primarily en.ompassin. five types in.ludin. S-palmitoylation.n.myristoylation.S-pren.lation.glycosylphosphatidylin.sitol(GPl)an.hor an. *** attachmen. to protein. plays an.essen.ial role in.the regulation.of protein.traffickin.,localisation.stability,con.ormation.in.eraction. an. sign.l tran.duction.by en.an.in. *** eviden.e from gen.tic,structural,an. biomedical studies has con.isten.ly shown.that protein.lipidation.is pivotal in.the regulation.of broad physiological fun.tion. an. is in.xtricably lin.ed to a variety of *** of dedicated research have driven.the developmen. of a wide ran.e of drugs targetin. protein.lipidation.an. several agen.s have been.developed an. tested in.preclin.cal an. clin.cal studies,some of which,such as ascimin.b an. lon.farn.b are FDA-approved for therapeutic use,in.icatin. that targetin. protein.lipidation. represen.s a promisin. therapeutic ***,we comprehen.ively review the kn.wn.regulatory en.ymes an. catalytic mechan.sms of various protein.lipidation.types,outlin. the impact of protein.lipidation. on.physiology an. disease,an. highlight poten.ial therapeutic targets an. clin.cal research progress,aimin. to provide a comprehen.ive referen.e for future protein.lipidation.research.

关键词： lipid ation primarily