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Mutational analysis of Ras hotspots in patients with urothelial carcinoma of the bladder

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World Journal of Clinical Oncology 2020年第8期11卷 614-628页

作者： kiran tripathi Apul Goel Atin Singhai Minal Garg Department of Biochemistry University of LucknowLucknow 226007India Department of Urology King George Medical UniversityLucknow 226003 Department of Pathology King George Medical UniversityLucknow 226003India

BACKGROUND Mutational activation of Ras genes is established as a prognostic factor for the genesis of a constitutively active RAS-mitogen activated protein kinase pathway that leads to *** among the distribution of the most frequent mutations in Ras isoforms is reported in different patient populations with urothelial carcinoma of the bladder(UCB).AIM To determine the presence/absence of mutations in Ras isoforms in patients with UCB in order to predict disease *** This study was performed to determine the mutational spectrum at the hotspot regions of H-Ras,K-Ras and N-Ras genes by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)and DNA sequencing followed by their clinical impact(if any)by examining the relationship of mutational spectrum with clinical histopathological variables in 87 UCB *** None of the 87 UCB patients showed point mutations in codon 12 of H-Ras gene;codon 61 of N-Ras gene and codons 12,13 of K-Ras gene by *** DNA sequencing of tumor and normal control bladder mucosal specimens followed by Blastn alignment with the reference wild-type sequences failed to identify even one nucleotide difference in the coding exons 1 and 2 of H-Ras,NRas and K-Ras genes in the tumor and control bladder mucosal *** Our findings on the lack of mutations in H-Ras,K-Ras and N-Ras genes could be explained on the basis of different etiological mechanisms involved in tumor development/progression,inherent genetic susceptibility,tissue specificity or alternative Ras dysfunction such as gene amplification and/or overexpression in a given cohort of patients.

关键词： Coding exons Oncogenic activation Polymerase chain reaction-restriction fragment length polymorphism Point mutations Ras genes Urothelial carcinoma of bladder

Methyl-salicylate:A surveillance system fortriggering immunity in neighboring plants

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Journal of Integrative Plant Biology 2024年第2期66卷 163-165页

作者： Saumya Jaiswal Durgesh Kumar tripathi Ravi Gupta JingHe Zhong-Hua Chen Vijay Pratap Singh Plant Physiology Laboratory Department of Botany C.M.P.Degree CollegeA Constituent Post Graduate College ofUniversity of AllahabadPrayagraj 211002India Crop Nanobiology and Molecular Stress Physiology LabAmity Institute of Organic Agriculture Amity University UttarPradeshNoida 201313India College of General Education Kookmin UniversitySeoul 02707South Korea School of Science Western Sydney UniversitySydney 2751New South WalesAustralia Hawkesbury Institute for the Environment Western SydneyUniversitySydney 2751New South WalesAustralia

Plant behavioral actions have been one of the major topicsof research in plant biology and *** actionsfrom plants are determined by their instant structural andphysical reactions to the circumstances(Bouwmeester et al.,2019).Upon sensing abiotic factors such as salinity,flooding,high temperature,drought,plants make suitable changes intheir physiology and behavior to survive such harsh conditions.

关键词： immunity neighboring salinity

One-Pot Green Synthesis of 1, 4-Dihydropyridine Derivatives Using Polyindole TiO2 Nanocatalyst by Solvent Free Method

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Open Journal of Composite Materials 2024年第3期14卷 109-123页

作者： Deepak Babasaheb Phasage Sanjay K. Sharma Balram tripathi Sonia Chahar Srivastava Department of Chemistry JECRC University Jaipur India S. S. Jain Subodh PG College Jaipur India

This study used a Polyindole in combination with TiO2 nanocatalyst as an efficient heterogeneous catalyst to carry out a multi-component Hantzsch reaction involving different aromatic aldehydes with methyl acetoacetate, and aqueous ammonium to create 1,4-dihydropyridine derivatives under solvent free condition at ambient temperature. A broad range of aldehydes and methyl acetoacetates, ranging from heteroaromatic to polyaromatic one, with high level of functional group tolerance can be used to provide the desired products possessing relevant medicinal moiety in high yields. This technology has prospective advantages over current protocols, including the utilization of a cheap, stable, recyclable, and safe catalyst, quicker reaction times with higher yields and simple product isolation.

关键词： TiO2 Nanocatalyst Green Synthesis Surface Morphology

Study of Structural, Optical, Electrical and Dielectric Properties of Gd-Doped ZnO Composites Synthesized by Solid State Reaction Method

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Open Journal of Composite Materials 2024年第2期14卷 91-108页

作者： Santosh Kumar Kundara Kanhaiya Chawla Dinesh Kumar Yadav Chhagan Lal Balram tripathi Narendra Jakhar Department of Physics University of Rajasthan Jaipur India Sw. P.N.K.S. Government PG College Dausa India Government PG College Pratapgarh India S.S. Jain Subodh PG (Autonomous) College Jaipur India

In this manuscript, we are reporting structural, bonding, optical, dielectric, and electrical properties of Gd-doped ZnO composite samples (Zn1−xGdxO, x = 0, 0.05, 0.10) prepared by solid-state reaction method. XRD spectra confirm the wurtzite hexagonal phase with a grain size distribution of 42 - 47 nm. The FT-IR spectra confirm bonding behavior like Zn-O, O=C=O, and O-H stretching modes. FESEM micrographs show that the grains of crystallites possess nearly spherical morphology. Optical absorption spectra confirm that the optical band gap decreases systematically from 3.19 eV to 3.15 eV for x = 0.0 to x = 0.10 samples. For all samples, PL spectra exhibited near-band emission, blue emission, and green emission peaks. The dielectric constant decreases as the applied frequency increases. Hall effect results show that with increasing doping concentration of Gd, mobility and resistivity increase while bulk concentration decreases. Current-Voltage study shows that current increases when temperature is increased. Rare earth-doped ZnO is potential material used for optoelectronics and spintronics device applications. Properties of Gd-doped ZnO are studied by various research groups, but dielectric studies are limitedly reported. Therefore, the present research work aims to study the change of electrical, optical, and dielectric properties of Gd-doped ZnO for device applications.

关键词： ZnO:Gd Composites Optical Band Gap Green Emission Dielectric Constant

Tuning of Optical Properties via Annealing of Bismuth Ferrite (BiFeO3) Thin Films

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Open Journal of Composite Materials 2024年第3期14卷 124-131页

作者： Harish Kumar Meena Khushbu Meena Reena Verma Karishma Jain Sushil Kumar Jain Kedar Babu Sharma Balram tripathi Department of Physics S S Jain Subodh PG College Jaipur India Department of Physics University of Rajasthan Jaipur India Department of Physics School of Physical Sciences Manipal University Jaipur Jaipur India

In this study we are reporting annealing induced optical properties of bismuth ferrite (BiFeO3) thin films deposited on glass substrate via spin coating at 5000 rpm. The structural, optical and surface morphology of BiFeO3 (BFO) thin films have been studied via X-ray diffraction (XRD), Fourier transform infrared (FT-IR), Optical absorption (UV-Vis) and Photoluminescence (PL) spectroscopy. XRD spectra confirm annealing induced phase formation of BiFeO3 possessing a rhombohedral R3c structure. The films are dense and without cracks, although the presence of porosity in BFO/glass was observed. Moreover, optical absorption spectra indicate annealing induced effect on the energy band structure in comparison to pristine BiFeO3. It is observed that annealing effect shows an intense shift in the UV-Vis spectra as diffuse absorption together with the variation in the optical band gap. The evaluated optical band gap values are approximately equal to the bulk band gap value of BiFeO3.

关键词： Optical Properties Annealing Ferroelectrics Photo Luminescence BFO Thin Films

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竞争激烈的防护涂料市场

中国涂料 2024年第6期39卷 75-76页

作者： Chirag tripathi Atul Yadav Surabhi Patankar Markets and Markets公司

在预测期内,防护涂料市场预计将从2023年的134亿欧元增长至2028年的159亿欧元,复合年增长率为3.5%。亚太地区包括了经济发展水平不同的各种经济体。按产值计算,2022年该地区防护涂料的份额占总收入的53%。该地区的增长主要归功于民用建... 详细信息

在预测期内,防护涂料市场预计将从2023年的134亿欧元增长至2028年的159亿欧元,复合年增长率为3.5%。亚太地区包括了经济发展水平不同的各种经济体。按产值计算,2022年该地区防护涂料的份额占总收入的53%。该地区的增长主要归功于民用建筑和基础设施、海洋和发电行业的发展,以及消费品和家电、建筑业和家具等各行各业的进步。将生产设施转移至亚太地区的主要好处在于生产成本低、可获得熟练且廉价的劳动力,并能够更好地服务于当地的新兴市场。

关键词：防护涂料复合年增长率基础设施新兴市场发电行业消费品经济发展水平竞争激烈

A novel slot scheduling technique for duty-cycle based data transmission for wireless sensor network

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Digital Communications and Networks 2022年第3期8卷 351-358页

作者： Yogesh tripathi Arun Prakash Rajeev tripathi Department of Electronics and Communication Engineering Motilal Nehru National Institute of Technology AllahabadPrayagraj211004India

The duty cycling process involves turning a radio into an active and dormant state for conserving energy. It is a promising approach for designing routing protocols for a resource-constrained Wireless Sensor Networks (WSNs). In the duty cycle-based WSNs, the network lifetime is improved and the network transmission is increased as compared to conventional routing protocols. In this study, the active period of the duty cycle is divided into slots that can minimize the idle listening problem. The slot scheduling technique helps determine the most efficient node that uses the active period. The proposed routing protocol uses the opportunistic concept to minimize the sender waiting problem. Therefore, the forwarder set will be selected according to the node's residual active time and energy. Further, the optimum routing path is selected to achieve the minimum forwarding delay from the source to the destination. Simulation analysis reveals that the proposed routing scheme outperforms existing schemes in terms of the average transmission delay, energy consumption, and network throughput.

关键词： Duty cycle Energy model Wireless sensor network Slot scheduling technique

Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.Hafeez Manish K.tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan Subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

Thermal Stability of Supercapacitor for Hybrid Energy Storage System in Lightweight Electric Vehicles:Simulation and Experiments

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 170-178页

作者： Vima Mali Brijesh tripathi Department of Electrical Engineering/Solar Energy Pandit Deendayal Petroleum UniversityGandhinagarIndia Department of Science Pandit Deendayal Petroleum UniversityGandhinagarIndia

Recent research findings indicate that the non-monotonic consumption of energy from lithium-ion(Li-ion)batteries results in a higher heat generation in electrical energy storage *** peak demands,a higher heat generation due to high discharging current increases the temperature from 80℃ to 120℃,thereby resulting in thermal *** address peak demands,an additional electrical energy storage component,namely supercapacitor(SC),is being investigated by various research *** paper provides insights into the capability of SCs in lightweight electric vehicles(EVs)to address peak demands using the worldwide harmonized light-duty driving test cycle(WLTC)driving profile in MATLAB/Simulink at different ambient *** results indicate that temperature imposes a more prominent effect on Li-ion batteries compared with SCs under peak demand *** effect of the discharging rate limit on the Li-ion battery current is *** result shows that SCs can accommodate the peak demands for a low discharging current limit on the battery,thereby reducing heat *** impedance spectroscopy and cyclic voltammetry are performed on SCs to analyze their thermal performance at different temperatures ranging from 0℃ to 75℃ under different bias values of-0.6,0,0.6,and 1 V,*** results indicate a higher specific capacitance of the SC at an optimum operation temperature of 25℃ for the studied *** study shows that the hybrid combination of the Li-ion battery and SC for a lightweight EV can address peak demands by reducing thermal stress on the Li-ion battery and increasing the driving range.

关键词： Electric vehicle lithium-ion battery supercapacitor thermal stability