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Filariasis presenting as a scrotal nodule in a 2 year old child:A case report

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Asian Pacific Journal of Tropical Medicine 2011年第2期4卷 167-168页

作者： kiran Yagain Mary Mathew Department of Pathology Kasturba Medical CollegeManipal

A two year old boy from southwestern village of India presented with a 2 cm×1 cm size swelling in scrotum for 8 *** was excised surgically and the histopathological examination revealed a gravid filarial *** occurrence of adult filarial worm in 2 year old boy signifies the endemicity and high larval load of insect vectors in western coast of south India.

关键词： Filariasis Scrotum India

Formulation and evaluation of co-prodrug of flurbiprofen and methocarbamol

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Asian Journal of Pharmaceutical Sciences 2016年第3期11卷 449-458页

作者： Neela Bhatia kiran Katkar Snehal Ashtekar Department of Quality Assurance Bharati Vidyapeeth College of Pharmacy Near Chitranagari Shivaji University

The current work envisages synthesis of an ester prodrug of flurbiprofen whereby its carboxylic group was condensed with a skeletal muscle relaxant methocarbamol, with the aim of synergistic activity of two drugs, avoid flurbiprofen mediated gastro-intestinal damage and minimize the ulceration tendency of flurbiprofen. The synthesized prodrug was characterized and confirmed by physicochemical and spectroscopic studies. Solubility and partition coefficient studies indicated an increased lipophilicity and thus better suitability for oral administration than the parent drugs and the protein binding studies revealed a low protein binding capacity of the mutual prodrug. Subsequently, in-vitro hydrolysis was studied in different pH, simulated gastric fluid, simulated intestinal fluid and plasma and quantitative evaluation was performed by high performance liquid chromatography. It was found that the prodrug remained unhydrolyzed in the stomach after absorption however, underwent rapid cleavage by the esterases in blood to give the parent drug. Furthermore, the mutual ester prodrug was evaluated for its anti-inflammatory, analgesic, skeletal muscle relaxation, ulcerogenic and total acid content activity and was found to possess comparable activity with that of the parent drugs. Microscopic structures of the stomach tissues revealed significant reduction in gastric ulcer formation of mice gastric mucosa as compared to parent carboxylic acid drug.

关键词： NSAIDs Flurbiprofen Skeletal muscle relaxant Methocarbamol, Ester prodrug RP-HPLC Ulcerogenicity

Tumor microenvironment pathways:Cross regulation in breast cancer metastasis

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Genes & Diseases 2022年第2期9卷 310-324页

作者： Rama Rao Malla P.kiran Cancer Biology Lab Department of Biochemistry and BioinformaticsInstitute of ScienceGITAM(Deemed to be University)Visakhapatnam 530045India

The tumor microenvironment(TME)is heterogeneous and contains a multiple cell population with surrounded immune cells,which plays a major role in regulating *** multifunctional pathways,Hedgehog(Hh),Wnt,Notch,and NF-kB,cross-regulates metas-tasis in breast *** review presents substantial evidence for cross-regulation of TME components and signaling pathways,which makes breast TME more heterogeneous and com-plex,promoting breast cancer progression and metastasis as a highly aggressive *** discoursed the importance of stromal and immune cells as well as their crosstalk in bridging the *** also discussed the role of Hh and Notch pathways in the intervention be-tween breast cancer cells and macrophages to support TME;Notch signaling in the bidirec-tional communication between cancer cells and components of TME;Wnt signal pathway in controlling the factors responsible for EMT and NF-kB pathway in the regulation of genes con-trolling the inflammatory *** also present the role of exosomes and their miRNAs in the cross-regulation of TME cells as well as pathways in the reprogramming of breast TME to support ***,we examined and discussed the targeted small molecule inhibitors and natural compounds targeting developmental pathways and proposed small molecule nat-ural compounds as potential therapeutics of TME based on the multitargeting *** conclu-sion,the understanding of the molecular basis of the cross-regulation of TME pathways and their inhibitors helps identify molecular targets for rational drug discovery to treat breast can-cers.

关键词： Breast cancer Cross-regulation Hedgehog NF-kB Notch Tumor microenvironment Wnt

Darks and Stripes:Effects of Clothing on Weight Perception

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Journal of Social Computing 2020年第1期1卷 53-70页

作者： Kirill Martynov kiran Garimella Robert West D-80636 Munich Germany work done at Ecole Polytechnique Federale de Lausanne(EPFL)and Technische Universit at Munchen(TUM) Institute of Technology(MIT) CambridgeMA 02139USA EPFL CH-1004 LausanneSwitzerland

In many societies,appearing slim(corresponding to a small body-mass index)is considered *** fashion industry has been attempting to cater to this trend by designing outfits that can enhance the appearance of *** anecdotal rules,widespread in the world of fashion,are to choose dark clothes and avoid horizontal stripes,in order to appear *** far,empirical evidence has been unable to conclusively determine the validity of these rules,and there is consequently much controversy regarding the impact of both color and patterns on the visual perception of *** this paper,we aim to close this gap by presenting the results from a series of large-scale crowdsourcing studies that investigate the above two *** gathered a dataset of around 1000 images of people from the Web together with their ground-truth weight and height as well as clothing attributes about colors and *** elicit the effects of colors and patterns,we asked crowd workers to estimate the weight in each *** the analysis,we controlled potential confounds by matching images in pairs where the two images differ with respect to color or pattern,but are similar with respect to other relevant *** created image pairs in two ways:firstly,observationally,i.e.,from two real images;and secondly,experimentally,by manipulating the color or pattern of clothing in a real image via photo *** on our analysis,we conclude that dark clothes indeed decrease perceived weight slightly but statistically significantly,and horizontal stripes have no discernible effect compared to solid light-colored *** results contribute to advancing the debate around the effect of specific clothing colors and patterns and thus provide empirical grounds for everyday fashion ***,our work gives an outlook on the vast opportunities of using crowd sourcing in the modern fashion industry.

关键词： clothing fashion weight perception body size crowdsourcing

Impacts of Coriaria nepalensis colonization on vegetation structure and regeneration dynamics in a mixed conifer forest of Indian Central Himalaya

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Journal of Forestry Research 2019年第1期30卷 305-317页

作者： Nidhi Rani Mourya kiran Bargali Surendra Singh Bargali Department of Botany DSB Campus Kumaun University

This study evaluated impacts of Coriaria nepalensis *** on soil characteristics,vegetation structure and composition,regeneration status and expected future compositional changes,biomass and carbon stock in tree species of a mixed conifer forest of Central *** sites(1 ha each in an old landslide area)differing in Coriaria density(low:20 individuals ha^(-1);medium:120 ***^(-1);high:190 ***^(-1))were used to enumerate the tree species.A total of 9 tree species and 2830 individuals were recorded from the three study sites that represented a gradient of Coriaria *** of species varied from 3 to 7 and the individuals from 690 to 1270 per site with lowest numbers at low Coriaria density and highest at medium Coriaria *** number of seedlings increased with increasing Coriaria density,and the sites were unique in their seedling composition,indicating marked temporal *** wise regeneration analysis showed that regeneration was poor at the site with low Coriaria density and good at the high-density site where many species emerged as *** results indicate that the ameliorative effects of Coriaria in terms of soil buildup,and accumulation of nutrients and organic matter helped more species to colonize the *** facilitative ability of Coriaria can be used to restore degraded forest ecosystems of Indian Central Himalaya.

关键词： Basal area Conifer Coriaria Density Facilitation Species richness

Electromechanical Fields and Their Influence on the Internal Quantum Efficiency of GaN-Based Light-Emitting Diodes

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Acta Mechanica Solida Sinica 2018年第3期31卷 383-390页

作者： Muhammad Usman kiran Saba Adnan Jahangir Muhammad Kamran Nazeer Muhammad Department of Engineering Sciences Ghulam Ishaq Khan Institute of Engineering Sciences and Technology Swabi 23460 Pakistan Department of Mathematics COMSATS Institute of Information Technology Wah Cantt 47040 Pakistan Department of Electrical Engineering COMSATS Institute of Information Technology Wah Cantt 47040 Pakistan

The effect ofelectromechanical fields, i.e., polarization fields, on the efficiency droop of GaN-based light-emitting diodes is presented using both experimental and numerical analyses. The role of incorporating such polarization charge density in device performance is numerically investigated and further compared with the experimental results of internal quantum efficiency of three different devices in consideration.

关键词： Optoelectronic devices Photonic bandgap materials Visible and ultraviolet sources Light-emitting devices

The simplest route to generating a train of attosecond pulses

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Light(Science & Applications) 2013年第1期2卷 204-208页

作者： Kazumichi Yoshii John kiran Anthony Masayuki Katsuragawa Department of Engineering Science University of Electro-CommunicationsTokyoJapan

We report on two novel routes to generating a train of attosecond pulses from a broad discrete spectrum in the near-infrared–visible–ultraviolet *** extends an integer-temporal-Talbot(ITT)concept to include high-order spectral dispersions and generates a pulse train that completely satisfies the transform-limited *** other numerically explores the optimum conditions under which we can obtain an attosecond pulse train that approximately satisfies the transform-limited *** second method is more practical than the *** of these methods is extremely simple and robust;we need only to place a few thin dispersive materials in the optical path and to adjust their thicknesses without spatially dispersing the frequency *** numerically demonstrate the generation of a train of attosecond pulses with a transform-limited pulse duration of 728 as and a repetition period of 8.03 fs in gaseous parahydrogen.

关键词： adiabatic excitation of Raman transition attosecond pulse generation integer-temporal-Talbot(ITT)method molecular modulation

Multi-objective optimization of oil well drilling using elitist non-dominated sorting genetic algorithm

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Petroleum Science 2014年第1期11卷 97-110页

作者： Chandan Guria kiran K Goli Akhilendra K Pathak Department of Petroleum Engineering Indian School of Mines

A multi-objective optimization of oil well drilling has been carried out using a binary coded elitist non-dominated sorting genetic algorithm.A Louisiana offshore field with abnormal formation pressure is considered for *** multi-objective optimization problems involving twoand three-objective functions were formulated and solved to fix optimal drilling *** important objectives are：（i） maximizing drilling depth,（ii） minimizing drilling time and （iii） minimizing drilling cost with fractional drill bit tooth wear as a *** time dependent decision variables are：（i） equivalent circulation mud density,（ii） drill bit rotation,（iii） weight on bit and （iv） Reynolds number function of circulating mud through drill bit nozzles.A set of non-dominated optimal Pareto frontier is obtained for the two-objective optimization problem whereas a non-dominated optimal Pareto surface is obtained for the three-objective optimization *** on the trade-offs involved,decision makers may select any point from the optimal Pareto frontier or optimal Pareto surface and hence corresponding values of the decision variables that may be selected for optimal drilling *** minimizing drilling time and drilling cost,the optimum values of the decision variables are needed to be kept at the higher values whereas the optimum values of decision variables are at the lower values for the maximization of drilling depth.

关键词： Drilling performance rate of penetration abnormal pore pressure genetic algorithm multi-objective optimization

Melting heat and thermal radiation effects in stretched flow of an Oldroyd-B fluid

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Applied Mathematics and Mechanics(English Edition) 2017年第7期38卷 957-968页

作者： T.HAYAT A.kiran M.IMTIAZ A.ALSAEDI Department of Mathematics Quaid-i-Azam University Nonlinear Analysis and Applied Mathematics (NAAM) Research Group Department of Mathematics Faculty of Science King Abdulaziz University

The incompressible flow of a non-Newtonian fluid with mixed convection along a stretching sheet is analyzed. The heat transfer phenomenon is discussed through thermal radiation. The effects of the melting heat transfer and heat generation/absorption are also taken. Suitable transformations are utilized to attain the nonlinear ordinary differential expressions. The convergent series solutions are presented. The fluid flow, temperature, and surface heat transfer rate are examined graphically. It is observed that the velocity decreases when the relaxation time increases while increases when the retardation time is constant. The results also reveal that the temperature distribution reduces when the radiation parameter increases.

关键词： magnetohydrodynamic (MHD) Oldroyd-B fluid mixed convection meltingheat transfer thermal radiation heat generation/absorption